Yuben Moodley

Associate Professor, MB BS MD Natal , PhD W.Aust. , FRACP

  • The University of Western Australia (M582), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1994 Citations
  • 22 h-Index
20012021
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Research Output 2001 2020

2001
55 Citations (Scopus)

Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins

Scaffidi, A. K., Moodley, Y. P., Weichselbaum, M., Thompson, P. & Knight, D. A., 2001, In : Journal of Cell Science. 114, 19, p. 3507-3516

Research output: Contribution to journalArticle

Vitronectin
Integrins
Smooth Muscle
Actins
Fibroblasts
2002
74 Citations (Scopus)

Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts

Scaffidi, A. K., Mutsaers, S. E., Moodley, Y. P., Mcanulty, R. J., Laurent, G. J., Thompson, P. & Knight Da, N. V., 2002, In : British Journal of Pharmacology. 136, p. 793-801

Research output: Contribution to journalArticle

Oncostatin M
Collagen
Fibroblasts
Apoptosis
Lung
2003
90 Citations (Scopus)

Fibroblasts Isolated from Normal Lungs and Those with Idiopathic Pulmonary Fibrosis Differ in Interleukin-6/gp 130-Medicated Cell Signaling and Proliferation

Moodley, Y. P., Scaffidi, A. K., Misso, N., Keerthisingam, C., Mcanulty, R. J., Lauren, G. J., Mutsaers, S. E., Thompson, P. & Knight D.a., N. V., 2003, In : American Journal of Pathology. 163, 1, p. 345-354

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Interleukin-6
Fibroblasts
Cell Proliferation
Lung
100 Citations (Scopus)

Inverse Effects of Interleukin-6 on Apoptosis of Fibroblasts from Pulmonary Fibrosis and Normal Lungs

Moodley, Y. P., Misso, N., Scaffidi, A. K., Fogel-Petrovic, M., Mcanulty, R. J., Laurent, G. J., Thompson, P. & Knight, D. A., 2003, In : American Journal of Respiratory Cell and Molecular Biology. 29, 4, p. 490-498

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
Fibroblasts
Interleukin-6
Apoptosis
76 Citations (Scopus)

Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36

Moodley, Y., Rigby, P., Bundell, C., Bunt, S., Hayashi, H., Misso, N., Mcanulty, R., Laurent, G., Scaffidi, A., Thompson, P. & Knight, D., 2003, In : American Journal of Pathology. 162, 3, p. 177-179

Research output: Contribution to journalArticle

Thrombospondin 1
Phagocytosis
Fibroblasts
Macrophages
Phagocytes
38 Citations (Scopus)
2004
74 Citations (Scopus)

Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis

Moodley, Y. P., Caterina, P., Scaffidi, A. K., Misso, N., Papadimitriou, J., Mcanulty, R. J., Laurent, G. J., Thompson, P. & Knight, D. A., 2004, In : Journal of Pathology. 202, 4, p. 486-495

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Fibroblasts
Apoptosis
Lung
Caspase 3
84 Citations (Scopus)

αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts

Scaffidi, A. K., Petrovic, N., Moodley, Y. P., Fogel-Petrovic, M., Kroeger, K. M., Seeber, R. M., Eidne, K. A., Thompson, P. & Knight, D. A., 2004, In : Journal of Biological Chemistry. 279, 36, p. 37726-37733

Research output: Contribution to journalArticle

Bioluminescence
Tenascin
Energy Transfer
Transforming Growth Factors
Fibroblasts
2008
2 Citations (Scopus)

Lung Cell Biology

Upham, J. W., Stick, S. & Moodley, Y., 2008, Pediatric Respiratory Medicine. Taussig, L. M. L. L. I. (ed.). Second ed. Philadephia, PA: Mosby International, p. 35-44

Research output: Chapter in Book/Conference paperChapter

2009
167 Citations (Scopus)

Human Fetal Membranes: A Source of Stem Cells for Tissue Regeneration and Repair?

Illancheran, S., Moodley, Y. & Manuelpillai, U., 2009, In : Placenta. 30, 1, p. 2-10

Research output: Contribution to journalReview article

213 Citations (Scopus)

Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury

Moodley, Y., Atienza, D., Manuelpillai, U., Samuel, CS., Tchongue, J., Ilancheran, S., Boyd, R. & Trounson, A., 2009, In : American Journal of Pathology. 175, 1, p. 303-313

Research output: Contribution to journalArticle

209 Citations (Scopus)

The Peopling of the Pacific from a Bacterial Perspective

Moodley, Y., Linz, B., Yamaoka, Y., Windsor, H., Breurec, S., Wu, J-Y., Maady, A., Bernhoft, S., Thiberge, J-M., Phuanukoonon, S., Jobb, G., Siba, P., Graham, D. Y., Marshall, B. & Achtman, M., 2009, In : Science. 323, 5913, p. 527-530

Research output: Contribution to journalArticle

Melanesia
New Guinea
Helicobacter pylori
Language
Polynesia
2010
128 Citations (Scopus)

Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair.

Moodley, Y., Ilancheran, S., Samuel, C., Vaghjiani, V., Atienza, D., Williams, E. D., Jenkin, G., Wallace, E., Trounson, A. & Manuelpillai, U., 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 5, p. 643-651

Research output: Contribution to journalArticle

54 Citations (Scopus)

Prostaglandin E-2 and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammation

Aggarwal, S., Moodley, Y., Thompson, P. & Misso, N., 2010, In : Clinical and Experimental Allergy. 40, 1, p. 85-93

Research output: Contribution to journalArticle

2011
103 Citations (Scopus)

Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis?

Manuelpillai, U., Moodley, Y., Borlongan, C. V. & Parolini, O., 2011, In : Placenta. 32, p. S320-325

Research output: Contribution to journalArticle

39 Citations (Scopus)

Cellular therapies for lung disease: a distant horizon

Moodley, Y., Manuelpillai, U. & Weiss, DJ., 2011, In : Respirology. 16, 2, p. 223-237

Research output: Contribution to journalArticle

Open Access
2012
2013
57 Citations (Scopus)

Anti-Inflammatory Effects of Adult Stem Cells in Sustained Lung Injury: A Comparative Study

Moodley, Y., Vaghjiani, V., Chan, J., Baltić, S., Ryan, M., Tchongue, J., Samuel, C. S., Murthi, P., Parolini, O. & Manuelpillai, U., 2013, In : PLoS One. 8, 8, p. e69299

Research output: Contribution to journalArticle

Open Access
Adult Stem Cells
Amnion
Lung Injury
Stem cells
anti-inflammatory activity
66 Citations (Scopus)

Introduction to stem cells and regenerative medicine

Kolios, G. & Moodley, Y., 2013, In : Respiration. 2013, 85, p. 3-10

Research output: Contribution to journalArticle

9 Citations (Scopus)

Stem cells: A recapitulation of development

Moodley, Y., Thompson, P. & Warburton, D., 2013, In : Respirology. 18, 8, p. 1167-1176

Research output: Contribution to journalReview article

Open Access
Stem Cells
Embryonic Stem Cells
Lung
Octamer Transcription Factors
sry Genes
2 Citations (Scopus)

The burden of lung disease: The need for stem cell therapy - A review series prologue

Moodley, Y. & Thompson, P., 2013, In : Respirology. 18, 3, p. 393-396

Research output: Contribution to journalReview article

Open Access
2014
10 Citations (Scopus)

A pilot study of a mobile-phone-based home monitoring system to assist in remote interventions in cases of acute exacerbation of COPD

Ding, H., Karunanithi, M., Kanagasingam, Y., Vignarajan, J. & Moodley, Y., 2014, In : Journal of Telemedicine and Telecare. 20, 3, p. 128-134

Research output: Contribution to journalArticle

19 Citations (Scopus)

Australian idiopathic pulmonary fibrosis registry: Vital lessons from a national prospective collaborative project

Moodley, Y., Goh, N., Glaspole, I. N., Macansh, S., Haydn Walters, E., Chapman, S. A., Hopkins, P. M. A., Reynolds, P. N., Zappala, C. J., Cooper, W., Mahar, A. M., Ellis, S. J., Mccormack, S., Darbishire, W., Wood-Baker, R. R. & Corte, T. J., 2014, In : Respirology. 19, 7, p. 1088-1091

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Registries
Research
4 Citations (Scopus)

Impaired CTLA-4 responses in COPD are associated with systemic inflammation

Tan, D., Fernández, S., Price, P., French, M., Thompson, P. J. & Moodley, Y., 2014, In : Cellular and Molecular Immunology. 11, 6, p. 606-608

Research output: Contribution to journalArticle

16 Citations (Scopus)

Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD)

Tan, D., Fernández, S., Price, P., French, M., Thompson, P. & Moodley, Y., 2014, In : Immunobiology. 219, 12, p. 975-979

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Chronic Obstructive Pulmonary Disease
T-Lymphocytes
Blood Cells
Body Mass Index
32 Citations (Scopus)

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Royce, S. G., Moodley, Y. & Samuel, C. S., Mar 2014, In : Pharmacology & Therapeutics. 141, 3, p. 250-260 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Prevalence and prognosis of unclassifiable interstitial lung disease

Troy, L., Glaspole, I., Goh, N., Zappala, C., Hopkins, P., Wilsher, M., Moodley, Y. & Corte, T., 2014, In : European Respiratory Journal. 43, p. 1529

Research output: Contribution to journalLetter

1 Citation (Scopus)

Reflection of stem cell therapy: An epilogue to the 'Stem cells and the lung' review series

Moodley, Y. & Thompson, P., 2014, In : Respirology. 19, 1, p. 5-8

Research output: Contribution to journalLetter

Open Access
4 Citations (Scopus)
Chronic Obstructive Pulmonary Disease
Inflammation
Blood Cells
Myeloid-Derived Suppressor Cells
Cytokines
2015
41 Citations (Scopus)
Nitrates
Randomized Controlled Trials
Blood Pressure
Nitrites
Placebos
6 Citations (Scopus)

Do all patients with idiopathic pulmonary fibrosis warrant a trial of therapeutic intervention? A pro-con perspective

Moodley, Y., Corte, T. J., Richeldi, L. & King, T. E., 2015, In : Respirology. 20, 3, p. 389-394

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
Therapeutics
Safety
Gases
2016
3 Citations (Scopus)

An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD

Tan, D., Ong, N. E., Zimmermann, M., Price, P. & Moodley, Y., 2016, In : Human Immunology. 77, 10, p. 916-920

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
T-Lymphocytes
Histocompatibility
Tumor Necrosis Factor Receptors
Virus Diseases
16 Citations (Scopus)

Evaluating the interstitial lung disease multidisciplinary meeting: A survey of expert centres

Jo, H. E., Corte, T. J., Moodley, Y., Levin, K., Westall, G., Hopkins, P., Chambers, D. & Glaspole, I., 2016, In : BMC Pulmonary Medicine. 16, 1, 22.

Research output: Contribution to journalArticle

Open Access
Interstitial Lung Diseases
Constitution and Bylaws
North America
Documentation
Internet
12 Citations (Scopus)

Human mesenchymal stem cells attenuate early damage in a ventilated pig model of acute lung injury

Moodley, Y., Sturm, M., Shaw, K., Shimbori, C., Tan, D., Kolb, M. & Graham, R., 2016, In : Stem Cell Research. 17, 1, p. 25-31

Research output: Contribution to journalArticle

Open Access
Acute Lung Injury
Mesenchymal Stromal Cells
Swine
Oleic Acid
Adult Respiratory Distress Syndrome
14 Citations (Scopus)

Idiopathic Pulmonary Fibrosis and the Elderly: Diagnosis and Management Considerations

Jo, H. E., Randhawa, S., Corte, T. J. & Moodley, Y., 2016, In : Drugs and Aging. 33, 5, p. 1-14

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Morbidity
Biopsy
Polypharmacy
Terminal Care
1 Citation (Scopus)

Integrated Multidisciplinary Community Service for Chronic Obstructive Pulmonary Disease Reduces Hospitalisations

Chung, L. P., Lake, F., Hyde, E., Mccamley, C., Phuangmalai, N., Lim, M., Waterer, G., Summers, Q. & Moodley, Y., 2016, In : Internal Medicine Journal. 46, 4, p. 427-434

Research output: Contribution to journalArticle

The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung

Moodley, Y. P., Armitage, J. D. & Tan, D. B. A., 2016, The Biology and Therapeutic Application of Mesenchymal Cells. Atkinson, K. (ed.). United States: John Wiley & Sons, p. 770-786

Research output: Chapter in Book/Conference paperChapter

Mesenchymal Stromal Cells
Lung Diseases
Anti-Inflammatory Agents
Lung
Umbilical Cord
2017
43 Citations (Scopus)

Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry

Jo, H. E., Glaspole, I., Grainge, C., Goh, N., Hopkins, P. M. A., Moodley, Y., Reynolds, P. N., Chapman, S., Walters, E. H., Zappala, C., Allan, H., Keir, G. J., Hayen, A., Cooper, W. A., Mahar, A. M., Ellis, S., Macansh, S. & Corte, T. J., Feb 2017, In : The European Respiratory Journal. 49, 2, 1601592.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Registries
Mortality
Lung Volume Measurements
Cohort Effect
4 Citations (Scopus)

Determinants and outcomes of prolonged anxiety and depression in idiopathic pulmonary fibrosis

Glaspole, I. N., Watson, A. L., Allan, H., Chapman, S., Cooper, W., Corte, T. J., Ellis, S., Grainge, C., Goh, N., Hopkins, P., Keir, G., Macansh, S., Mahar, A., Moodley, Y., Reynolds, P., Ryerson, C. J., Walters, E. H., Zappala, C. J. & Holland, A. E., 1 Aug 2017, In : European Respiratory Journal. 50, 2, 4 p., 1700168.

Research output: Contribution to journalLetter

11 Citations (Scopus)

Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation

Tan, D. B. A., Armitage, J., Teo, T. H., Ong, N. E., Shin, H. & Moodley, Y. P., Nov 2017, In : Respiratory Medicine. 132, p. 261-264

Research output: Contribution to journalArticle

Exosomes
Chronic Obstructive Pulmonary Disease
Inflammation
Tumor Necrosis Factor Receptors
C-Reactive Protein
31 Citations (Scopus)

Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry

Glaspole, I. N., Chapman, S. A., Cooper, W. A., Ellis, S. J., Goh, N. S., Hopkins, P. M., Macansh, S., Mahar, A., Moodley, Y. P., Paul, E., Reynolds, P. N., Walters, E. H., Zappala, C. J. & Corte, T. J., Jul 2017, In : Respirology. 22, 5, p. 950-956

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Registries
Quality of Life
Dyspnea
Linear Models
4 Citations (Scopus)

Increased CTLA-4+ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary disease

Tan, D., Teo, T. H., Setiawan, A. M., Ong, N., Zimmermann, M., Price, P., Kirkham, L. A. S. & Moodley, Y. P., Jun 2017, In : Immunology. 151, 2, p. 219-226

Research output: Contribution to journalArticle

CTLA-4 Antigen
Chronic Obstructive Pulmonary Disease
T-Lymphocytes
Regulatory T-Lymphocytes
Blood Cells
14 Citations (Scopus)
2018
1 Citation (Scopus)

A high COPD assessment test score may predict anxiety in COPD

Harryanto, H., Burrows, S. & Moodley, Y., 21 Mar 2018, In : International Journal of COPD. 13, p. 955-957 3 p.

Research output: Contribution to journalLetter

Open Access
1 Citation (Scopus)

An alternative approach to the current diagnostic guidelines for fibrotic interstitial lung disease

Moodley, Y., 1 Jun 2018, In : Respirology. 23, 6, p. 564-566 3 p.

Research output: Contribution to journalComment/debate

Open Access

A standardized diagnostic ontology for fibrotic interstitial lung disease

Moodley, Y., 15 May 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 10, p. 1365-1366 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Diagnosis and management of idiopathic pulmonary fibrosis: Thoracic society of Australia and New Zealand and lung foundation australia position statements summary

Jo, H. E., Prasad, J. D., Troy, L. K., Mahar, A., Bleasel, J., Ellis, S. J., Chambers, D. C., Holland, A. E., Lake, F. R., Keir, G., Goh, N. S., Wilsher, M., de Boer, S., Moodley, Y., Grainge, C., Whitford, H. M., Chapman, S. A., Reynolds, P. N., Beatson, D., Jones, L. J. & 4 othersHopkins, P., Allan, H. M., Glaspole, I. & Corte, T. J., 5 Feb 2018, In : Medical Journal of Australia. 208, 2, p. 82-88 7 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
New Zealand
Thorax
Lung
Interstitial Lung Diseases
15 Citations (Scopus)

Disease progression in idiopathic pulmonary fibrosis with mild physiological impairment: Analysis from the Australian IPF registry

Jo, H. E., Glaspole, I., Moodley, Y., Chapman, S., Ellis, S., Goh, N., Hopkins, P., Keir, G., Mahar, A., Cooper, W., Reynolds, P., Haydn Walters, E., Zappala, C., Grainge, C., Allan, H., Macansh, S. & Corte, T. J., 25 Jan 2018, In : BMC Pulmonary Medicine. 18, 1, 19.

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Registries
Disease Progression
Lung Diseases
Survival
5 Citations (Scopus)

Epithelial disruption: A new paradigm enabling human airway stem cell transplantation

Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Moodley, Y., Bertoncello, I. & Parsons, D., 13 Jun 2018, In : Stem Cell Research and Therapy. 9, 1, 153.

Research output: Contribution to journalArticle

Open Access
Stem Cell Transplantation
Stem cells
Transplantation
Luciferases
Cystic Fibrosis

How do new molecular tools apply to my clinical practice?

Yang, I. A. & Moodley, Y., 1 Nov 2018, In : Respirology. 23, 11, p. 991-992 2 p.

Research output: Contribution to journalEditorial