• The University of Western Australia (M408), 35 Stirling Highway,

    6009 Perth


  • 1982 Citations
  • 20 h-Index

Research output per year

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Personal profile


Research Fellow at the University of Sydney, Cardiology / Kolling Institute - Jul 2013 - Jun 2015
Postdoctoral Scholar at the University of California, San Diego (UCSD) Bioengineering (#2 USA) / Sanford Consortium for Regenerative Medicine - Apr 2010 - Jun 2013
PhD at the University of Melbourne, Surgery / O'Brien Institute - Sep 2006 - Feb 2010

Funding overview

18. Department of Health WA - Medical and Health Research Infrastructure Fund Round 23 – CI: Choi YS, 2020, AU$23,412)

17. Sir Charles Gairdner Hospital and Osborne Park Health Care Group Research Advisory Committee’s 2019/20 Research Grant - Application of an ex-vivo hydrogel model to assess and reverse airway smooth muscle cell stiffness in COPD – (CIA: James AL, CIB: Wang K, CIC: Choi YS, CID: Cairncross A, 2020, $30,000)

16. UWA Research Income Growth Grant - Extending UWA/Yonsei University collaboration into new Category 2 and 3 funding to develop spatiotemprally dynamic 4D microenvironments for cancer mechanobiology – (CI: YS Choi, 2019, AU$8,140)

15. Universities Australia DAAD German Research Cooperation – Biaxial substrates combining linear stiffness gradients with nanoscale spacing gradients for mechanobiology – (CI: Choi YS, 2019-2020, AU$20,920)

14. NHMRC CDF1 – stem cell mechanobiology for cardiac regeneration – (CI: Choi YS, 2018-2021 AU$431,000) – relinquished to accept Heart Foundation Future Leader Fellowship

13. Marsden Fund (Royal Society NZ) - Stiffness matters: Unravelling the reciprocal relationship between tissue mechanical stiffness and cellular mechanosensitivity – (CIA: McGlashan S, CIB: Choi YS, 2018-2020 NZ$920,000)

12. Department of Health, Western Australia, Merit Award – Projects – Force of Nature: 3D cell-matrix force-microscopy for stem cell mechanobiology – (CI: Choi YS, 2017-2018 AU$37,500)

11. Department of Health, Western Australia, Merit Award – Fellowship – Stem cell mechanobiology for cardiac regeneration – (CI: Choi YS, 2017-2018 AU$25,000)


10. Heart Foundation Future Leader Fellowship – Stem cell mechanobiology for heart regeneration – (CI: Choi YS, 2017-2021 AU$520,000)

9. UWA Research Collaboration Awards 2017 – Developing a 3D Mimic of the Brain – (UWA: Swaminatha-Iyer K, Fitzgerals M, Choi YS, Smith N; UNSW: Evans C, Thordarson P, Martin A; University of Cape Town: Franz T, Davies N / 2017 AU$ 28,000)

8. UHU collaborative Research Network Seed Funding Award – TIPS for generating layered and porous silk membranes suitable for eardrum repair (CIs: Dilley RJ, Day R, Choi YS / Nov 2015 AU$20,000)

7. NHMRC Equipment Grant (UWA) – Philips Premium Portable CX50 Ultrasound System (CIs: Noble P, Pillow J, Gill A, Laing N, Nowak K, McLaughlin R, Kennedy B, Hodgetts S, Pinniger G, Choi YS, Wang K / 2016 AU$ 47,500)

6. NHMRC Project Grant 1098449 - Using mechanotransduction to regulate stem cell fate in heart tissue - YS Choi, AJ Engler, and XL Guan (2016-2018)

5. Atomic Force Microscope – Mill House Foundation for Equipment Grant 2014 (CI: Dr. Choi YS / May 2014 AU$ 132,000)

4. Cardiac differentiation of stem cells by mechanotransduction – Sydney Medical School Early Career Researcher Grant 2014 (CI: Dr. Choi YS / Feb 2014 AU$ 24,766.9)

3. Live cell imaging system - Norma Louise Cordell Blue Equipment Grant (Australia) (CI: Dr. Choi YS / Feb 2014 AU$93,357)

2. ECM stiffness driven cardiac induction of stem cells – Heart Research Australia (Australia) 2014-07 (CI: Dr. Choi YS / Jan 2014 – Dec 2016 AU$147,706.80)

1. Mechanically programmed adipose-derived stem cells to treat muscular dystrophy – Muscular Dystrophy Association (USA) 241665. (PI: Prof. Engler AJ, Co-investigator: Dr. Choi YS / Oct 2012 – Jul 2015 US$390,000)

Current projects

1. Developing stiffness gradient hydrogel to study stem cell fate controlling
2. Stretch bioreactor for lung regeneration using adipose stem cells
3. Stem cell mechanotransduction in osteochondral tissue engineering
4. Using Mechanotransduction to Regulate Stem Cell Fate in Heart Tissue

Teaching overview


Unit Coordinator
ANHB3323 Cells, Tissues, and Development
ANHB3320 Human Biology: Applications and Investigations

SCIE1106 Molecular Biology of the Cell
ANHB2217 Human Neurobiology
PHYL2002 Physiology of the Cell
PHYL3001 Physiology of Membranes, Muscles and Signalling
PHYL3004 Physiology of Integrated Organ Function

Guest lecture / USyd Biomed Eng - Tissue Engineering
Guest lecture / USyd Biomed Eng - Biomechanics
Lecture / UCSD - BENG087 freshman seminar
Lab module / UCSD - BENG277 tissue eng lab module


Stem cell mechanotransduction - differentiation, migration, and proliferation for stem cell therapy, tissue engineering, and regenerative medicine

Research expertise keywords

  • Stem cell biology
  • Regenerative medicine
  • Biomaterials
  • Mechanobiology
  • Tissue Engineering

Industry keywords

  • Bioengineering
  • Biotechnology
  • Health

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Research Output

  • 1982 Citations
  • 20 h-Index
  • 32 Article
  • 5 Chapter
  • 3 Review article
  • 1 Conference paper

Volume adaptation controls stem cell mechanotransduction

Major, L., Holle, A. W., Young, J. L., Hepburn, M., Jeong, K., Chin, I., Sanderson, R., Jeong, J. H., Aman, Z., Kennedy, B., Hwang, Y., Han, D-W., Park, H. W., Guan, K-L., Spatz, J. P. & Choi, Y. S., 11 Dec 2019, In : ACS Applied Materials and Interfaces. 11, 49, p. 45520-45530 11 p.

Research output: Contribution to journalArticle

Open Access
  • 5 Citations (Scopus)

    Stem Cell Mechanosensation on Gelatin Methacryloyl (GelMA) Stiffness Gradient Hydrogels

    Kim, C., Young, J. L., Holle, A. W., Jeong, K., Major, L. G., Jeong, J. H., Aman, Z. M., Han, D. W., Hwang, Y., Spatz, J. P. & Choi, Y. S., 1 Feb 2020, In : Annals of Biomedical Engineering. 48, 2, p. 893-902

    Research output: Contribution to journalArticle

  • 6 Citations (Scopus)

    Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography

    Hepburn, M., Wijesinghe, P., Major, L., Li, J., Mowla, A., Astell, C., Park, H. W., Hwang, Y., Choi, Y. S. & Kennedy, B., 20 Dec 2019, In : Biomedical Optics Express. p. 867-884

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

    Hadden, W. J., Young, J. L., Holle, A. W., McFetridge, M. L., Kim, D. Y., Wijesinghe, P., Taylor-Weiner, H., Wen, J. H., Lee, A. R., Bieback, K., Vo, B-N., Sampson, D. D., Kennedy, B. F., Spatz, J. P., Engler, A. J. & Choi, Y. S., 30 May 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5647-5652

    Research output: Contribution to journalArticle

  • 127 Citations (Scopus)

    Matrix stiffness-sensitive long-non coding RNA NEAT1 seeded paraspeckles in cancer cells

    Todorovski, V., Fox, A. H. & Choi, Y. S., 21 Jul 2020, In : Molecular Biology of the Cell. 31, 16, p. 1654-1662 28 p.

    Research output: Contribution to journalArticle

    Open Access
  • 31 Downloads (Pure)



    Barbara Ell Seminar Series Lecturer

    Choi, Yu Suk (Recipient), 2017

    Prize: Other distinction

    Global Center of Excellence Program Lecturer

    Choi, Yu Suk (Recipient), 2012

    Prize: Other distinction

    Press / Media