Research output per year
Research output per year
Personal profile
Biography
Dr. Willem (Joost) Lesterhuis is an NHMRC EL2 Investigator, a Simon Lee Fellow and an Adjunct Associate Professor at the University of Western Australia. Dr Lesterhuis is Program Head Cancer Reseach at the Telethon Kids Institute, where he leads the Sarcoma Translational Research team. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.
Dr Lesterhuis' research sits at the crossroads of tumour immunology, cancer biology, drug discovery and systems biology, with a particular focus on sarcoma.
Research
Current research projects include:
- Developing local immunotherapeutic approaches to treat sarcoma
- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression
- Combining chemotherapy and immunotherapy to treat cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Industry keywords
- Drug Discovery
- Medicine and Pharma
Research expertise keywords
- Cancer immunology
- Immunotherapy
- Drug development
- Biomarkers
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy
Chin, W. L., Cook, A. M., Chee, J., Principe, N., Hoang, T. S., Kidman, J., Hmon, K. P. W., Yeow, Y., Jones, M. E., Hou, R., Denisenko, E., McDonnell, A. M., Hon, C. C., Moody, J., Anderson, D., Yip, S., Cummins, M. M., Stockler, M. R., Kok, P. S. & Brown, C. & 10 others, , 21 Jan 2025, In: Cell Reports Medicine. 6, 1, p. 1-18 18 p., 101882.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Web of Science) -
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade
Principe, N., Phung, A. L., Stevens, K. L. P., Elaskalani, O., Wylie, B., Tilsed, C. M., Sheikh, F., Orozco Morales, M. L., Kidman, J., Marcq, E., Fisher, S. A., Nowak, A. K., McDonnell, A. M., Lesterhuis, W. J. & Chee, J., 28 Sept 2024, In: Journal for immunotherapy of cancer. 12, 9, 15 p., e008568.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)39 Downloads (Pure) -
Exploiting temporal aspects of cancer immunotherapy
Zemek, R. M., Anagnostou, V., Pires da Silva, I., Long, G. V. & Lesterhuis, W. J., Jul 2024, In: Nature Reviews Cancer. 24, 7, p. 480-497 18 p.Research output: Contribution to journal › Review article › peer-review
41 Citations (Scopus) -
Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
Kidman, J., Zemek, R. M., Sidhom, J. W., Correa, D., Principe, N., Sheikh, F., Fear, V. S., Forbes, C. A., Chopra, A., Boon, L., Zaitouny, A., de Jong, E., Holt, R. A., Jones, M., Millward, M. J., Lassmann, T., Forrest, A. R. R., Nowak, A. K., Watson, M. & Lake, R. A. & 2 others, , 26 Apr 2024, In: OncoImmunology. 13, 1, 14 p., 2345859.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade
Rwandamuriye, F. X., Wang, T., Zhang, H., Elaskalani, O., Kuster, J., Ye, X., Vitali, B., Schreurs, J., Orozco Morales, M. L., Norret, M., Evans, C. W., Zemek, R. M., Iyer, K. S., Lesterhuis, W. J. & Wylie, B., Aug 2024, In: OncoImmunology. 13, 1, 10 p., 2395067.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
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Kids are not small adults: identifying age-dependent drug targets in paediatric oncology
Endersby, R. (Investigator 01), Elaskalani, O. (Investigator 02), Wouters, M. (Investigator 03) & Lesterhuis, W. (Investigator 04)
Department of Health (Western Australia)
1/01/23 → 31/12/25
Project: Research
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Small molecule drug in immuno-oncology
Lesterhuis, W. (Investigator 01) & Piggott, M. (Investigator 02)
Setonix Pharmaceuticals Pty Ltd
1/07/22 → 31/05/26
Project: Research
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Tipping the balance - improving response rates to cancer immunotherapy
Lesterhuis, W. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/21 → 31/12/25
Project: Research
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Core infrastructure: high-throughput nanodrop spectrophotometer
Kretzmann, J. (Investigator 01), Evans, C. (Investigator 02), Choi, Y. S. (Investigator 03), Waryah, C. (Investigator 04), Sarkar-Tyson, M. (Investigator 05), Wang, T. (Investigator 06), Bond, C. (Investigator 07), Vrielink, A. (Investigator 08), Smith, N. (Investigator 09), Lesterhuis, W. (Investigator 10), Marshall, A. (Investigator 11), Stubbs, K. (Investigator 12), Deane, K. (Investigator 13), Chen, K. (Investigator 14), Smithers, L. (Investigator 15), Wylie, B. (Investigator 16), Wang, E. (Investigator 17) & Blancafort, P. (Investigator 18)
NHMRC National Health and Medical Research Council
15/03/24 → 31/12/24
Project: Research
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Paediatric Cancer Immunotherapy for Australia
Lesterhuis, W. (Investigator 01), Gottardo, N. (Investigator 02), Endersby, R. (Investigator 03), Kotecha, R. (Investigator 04), Cheung, L. (Investigator 05), Malinge, S. (Investigator 06), McDonnell, A. (Investigator 07) & Elaskalani, O. (Investigator 08)
Australian Lions Childhood Cancer Research Foundation (ALCCRF)
1/07/23 → 30/06/25
Project: Research