• The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth


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Personal profile


Dr. Willem (Joost) Lesterhuis is an NHMRC RD Wright Research Fellow with the School of Biomedical Sciences and the National Centre for Asbestos Related Diseases at the University of Western Australia. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.

His research focuses on identifying new effective treatment combinations in cancer, in particular in mesothelioma, and focusing on immunotherapy. Using network analysis of gene expression data from tumours in mouse models and patient samples, his research aims to identify predictive biomarkers for clinical efficacy of immuno-oncology drugs, as well as new context-specific targets for pharmacological intervention and novel combination treatments.

His research combines several lines of science; systems biology, network science, cancer biology, pharmacology/drug discovery, immunology and translational oncology.


Current research projects include:
1- Combining chemotherapy and immunotherapy to treat cancer, in particular mesothelioma and lung cancer.
2- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression, using systems biology approaches.
3- Identification of the molecular processes that drive mesothelioma invasion using network analysis of high-dimensional molecular data from mouse models and patient samples.

Fingerprint Dive into the research topics where Willem Lesterhuis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Neoplasms Medicine & Life Sciences
Mesothelioma Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences
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Tumors Chemical Compounds
Cross-Priming Medicine & Life Sciences
Vaccination Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2008 2019

Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discovery

Chin, W. L., Zemek, R. M., Lesterhuis, W. J. & Lassmann, T., 1 Aug 2019, In : Molecular Systems Design and Engineering. 4, 4, p. 689-700 12 p.

Research output: Contribution to journalReview article

Feature extraction
Pharmaceutical Preparations
Drug Discovery
4 Citations (Scopus)
366 Downloads (Pure)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R., de Jong, E., Chin, M., Schuster, I., Fear, V., Casey, T., Forbes, C., Dart, S., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., O Muiri, D., Degli-Esposti, M., Millward, M., Nowak, A., Lassmann, T., Bosco, A., Lake, R. & 1 othersLesterhuis, W., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 14 p., eaav7816.

Research output: Contribution to journalArticle

Open Access
STAT1 Transcription Factor
Tumor Microenvironment
Toll-Like Receptor 3
5 Citations (Scopus)

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Fear, V., Tilsed, C. M., Chee, H. E. J., Forbes, C., Casey, T., Solin, J., Lansley, S., Lesterhuis, W., Dick, I., Nowak, A., Robinson, B., Lake, R. & Fisher, S., 30 Jul 2018, In : Oncolmmunology. 14 p., e1494111.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
1 Citation (Scopus)
Open Access
Pleural Effusion

Projects 2014 2021