Research output per year
Research output per year
Personal profile
Biography
Dr. Willem (Joost) Lesterhuis is an NHMRC EL2 Investigator, a Simon Lee Fellow and an Adjunct Associate Professor at the University of Western Australia. Dr Lesterhuis is Program Head Cancer Reseach at the Telethon Kids Institute, where he leads the Sarcoma Translational Research team. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.
Dr Lesterhuis' research sits at the crossroads of tumour immunology, cancer biology, drug discovery and systems biology, with a particular focus on sarcoma.
Research
Current research projects include:
- Developing local immunotherapeutic approaches to treat sarcoma
- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression
- Combining chemotherapy and immunotherapy to treat cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Industry keywords
- Drug Discovery
- Medicine and Pharma
Research expertise keywords
- Cancer immunology
- Immunotherapy
- Drug development
- Biomarkers
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Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action
Tilsed, C. M., Fisher, S. A., Nowak, A. K., Lake, R. A. & Lesterhuis, W. J., 29 Jul 2022, In: Frontiers in Oncology. 12, 18 p., 960317.Research output: Contribution to journal › Review article › peer-review
Open Access -
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy
Tilsed, C. M., Principe, N., Kidman, J., Chin, W. L., Orozco Morales, M. L., Zemek, R. M., Chee, J., Islam, R., Fear, V. S., Forbes, C., Aston, W. J., Jansen, M., Chopra, A., Lassmann, T., Nowak, A. K., Fisher, S. A., Lake, R. A. & Lesterhuis, W. J., 27 Dec 2022, In: Cell Reports. 41, 13, 19 p., 111874.Research output: Contribution to journal › Article › peer-review
Open Access -
Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations
Principe, N., Aston, W. J., Hope, D. E., Tilsed, C. M., Fisher, S. A., Boon, L., Dick, I. M., Chin, W. L., McDonnell, A. M., Nowak, A. K., Lake, R. A., Chee, J. & Lesterhuis, W. J., 11 May 2022, In: Frontiers in Immunology. 13, 872295.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Gummer, J. P. A., Olasz, B., Nambiar, S., Hope, D. E., Casey, T. H., Lee, Y. C. G., Leslie, C., Nealon, G., Shackleford, D. M., Powell, A. K., Grimaldi, M., Balaguer, P., Zemek, R. M., Bosco, A., Piggott, M. J., Vrielink, A., & 2 others, 21 Jan 2022, In: Iscience. 25, 1, 103571.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Protocol of DREAM3R: DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma-a phase 3 randomised trial
Kok, P. S., Forde, P. M., Hughes, B., Sun, Z., Brown, C., Ramalingam, S., Cook, A., Lesterhuis, W. J., Yip, S., O'Byrne, K., Pavlakis, N., Brahmer, J., Anagnostou, V., Ford, K., Fitzpatrick, K., Bricker, A., Cummins, M. M., Stockler, M. & Nowak, A. K., 25 Jan 2022, In: BMJ Open. 12, 1, e057663.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
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Small molecule drug in immuno-oncology
Setonix Pharmaceuticals Pty Ltd
1/07/22 → 31/12/23
Project: Research
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Research Excellence Award - Joost Lesterhuis
Department of Health (Western Australia)
30/06/22 → 29/06/24
Project: Research
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Intraoperative immunotherapy to prevent cancer recurrence after surgery (2.)
Lesterhuis, W., Veedu, R., Bond, C., Swaminatha Iyer, K. & Wang, T.
Department of Health (Western Australia)
28/06/22 → 27/06/24
Project: Research
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A phase I veterinary trial of an immunotherapy gel to prevent cancer relapse after sarcoma surgery
Swaminatha Iyer, K., Lesterhuis, W., Wyatt, K. & Wylie, B.
Children’s Leukaemia and Cancer Research Foundation
14/03/22 → 14/03/23
Project: Research
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Immune checkpoint induced tumor and autoimmunity: Can we separate them?
Chee, J., Nowak, A., Lake, R., Lesterhuis, W., Waithman, J. & Chopra, A.
Mesothelioma Applied Research Foundation
2/08/21 → 30/09/23
Project: Research