Research output per year
Research output per year
Personal profile
Biography
Dr. Willem (Joost) Lesterhuis is an NHMRC EL2 Investigator, a Simon Lee Fellow and an Adjunct Associate Professor at the University of Western Australia. Dr Lesterhuis is Program Head Cancer Reseach at the Telethon Kids Institute, where he leads the Sarcoma Translational Research team. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.
Dr Lesterhuis' research sits at the crossroads of tumour immunology, cancer biology, drug discovery and systems biology, with a particular focus on sarcoma.
Research
Current research projects include:
- Developing local immunotherapeutic approaches to treat sarcoma
- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression
- Combining chemotherapy and immunotherapy to treat cancer
Industry keywords
- Drug Discovery
- Medicine and Pharma
Research expertise keywords
- Cancer immunology
- Immunotherapy
- Drug development
- Biomarkers
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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Gummer, J. P. A., Olasz, B., Nambiar, S., Hope, D. E., Casey, T. H., Lee, Y. C. G., Leslie, C., Nealon, G., Shackleford, D. M., Powell, A. K., Grimaldi, M., Balaguer, P., Zemek, R. M., Bosco, A., Piggott, M. J., Vrielink, A. & 2 others, , 21 Jan 2022, In: Iscience. 25, 1, 103571.Research output: Contribution to journal › Article › peer-review
Open Access -
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery
Creemers, J. H. A., Lesterhuis, W. J., Mehra, N., Gerritsen, W. R., Figdor, C. G., de Vries, I. J. M. & Textor, J., 31 May 2021, In: Journal for ImmunoTherapy of Cancer . 9, 5, e002032.Research output: Contribution to journal › Article › peer-review
Open Access -
Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
Principe, N., Kidman, J., Lake, R. A., Lesterhuis, W. J., Nowak, A. K., McDonnell, A. M. & Chee, J., 27 Apr 2021, In: Frontiers in Oncology. 11, 672747.Research output: Contribution to journal › Review article › peer-review
Open Access -
A mouse model of incompletely resected soft tissue sarcoma for testing (Neo)adjuvant therapies
Rwandamuriye, F. X., Weston, B. J., Johns, T. G., Lesterhuis, W. J. & Zemek, R. M., Jul 2020, In: Journal of Visualized Experiments. 161, p. 1-11 11 p., e60882.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial
Boudewijns, S., Bloemendal, M., de Haas, N., Westdorp, H., Bol, K. F., Schreibelt, G., Aarntzen, E. H. J. G., Lesterhuis, W. J., Gorris, M. A. J., Croockewit, A., van der Woude, L. L., van Rossum, M. M., Welzen, M., de Goede, A., Hato, S. V., van der Graaf, W. T. A., Punt, C. J. A., Koornstra, R. H. T., Gerritsen, W. R., Figdor, C. G. & 1 others, , 1 Mar 2020, In: Cancer immunology, immunotherapy. 69, 3, p. 477-488 12 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus)
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iXon Life Camera with SRFF-Stream for High-Speed Live-Cell Single Molecule Imaging
Swaminatha Iyer, K., Lister, R., Fox, A., Smith, N., Choi, Y. S., Stubbs, K., Lesterhuis, W., Blancafort, P., Bond, C., Jiang, H., Geddes, D., Chooi, H., Sarkar-Tyson, M., Evans, C., Chen, K., Rassell, A., Waryah, C., Golden, E. & Woodward, E.
National Health & Medical Research Council NHMRC
3/01/22 → 6/06/22
Project: Research
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Immune checkpoint induced tumor and autoimmunity: Can we separate them?
Chee, J., Nowak, A., Lake, R., Lesterhuis, W., Waithman, J. & Chopra, A.
Mesothelioma Applied Research Foundation
2/08/21 → 30/09/23
Project: Research
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Tipping the balance - improving response rates to cancer immunotherapy
National Health & Medical Research Council NHMRC
1/01/21 → 31/12/25
Project: Research
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Centre of Research Excellence in Clinical Research: National Centre for Asbestos Related Diseases
Nowak, A., Creaney, J., Lee, G., Lesterhuis, W., Waddell, N., Brims, F., Francis, R., Lake, R., Takahashi, K. & Robinson, B.
National Health & Medical Research Council NHMRC
1/11/20 → 31/10/25
Project: Research