Willem Lesterhuis — the UWA Profiles and Research Repository

Personal profile

Biography

Dr. Willem (Joost) Lesterhuis is an NHMRC RD Wright Research Fellow with the School of Biomedical Sciences and the National Centre for Asbestos Related Diseases at the University of Western Australia. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.

His research focuses on identifying new effective treatment combinations in cancer, in particular in mesothelioma, and focusing on immunotherapy. Using network analysis of gene expression data from tumours in mouse models and patient samples, his research aims to identify predictive biomarkers for clinical efficacy of immuno-oncology drugs, as well as new context-specific targets for pharmacological intervention and novel combination treatments.

His research combines several lines of science; systems biology, network science, cancer biology, pharmacology/drug discovery, immunology and translational oncology.

Research

Current research projects include:
1- Combining chemotherapy and immunotherapy to treat cancer, in particular mesothelioma and lung cancer.
2- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression, using systems biology approaches.
3- Identification of the molecular processes that drive mesothelioma invasion using network analysis of high-dimensional molecular data from mouse models and patient samples.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2008 2018

31 Article
7 Review article
4 Letter
1 Chapter

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Fear, V., Tilsed, C. M., Chee, H. E. J., Forbes, C., Casey, T., Solin, J., Lansley, S., Lesterhuis, W., Dick, I., Nowak, A., Robinson, B., Lake, R. & Fisher, S., 30 Jul 2018, In : Oncolmmunology. 14 p., e1494111.

Research output: Contribution to journal › Article

Open Access

Mesothelioma

Neoplasms

Therapeutics

Asbestos

Regulatory T-Lymphocytes

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

Chee, J., Watson, M. W., Chopra, A., Nguyen, B., Cook, A. M., Creaney, J., Lesterhuis, W. J., Robinson, B. W., Gary Lee, Y. C., Nowak, A. K., Lake, R. A. & McDonnell, A. M., 5 Dec 2018, In : BMC Research Notes. 11, 1, 6 p., 864.

Research output: Contribution to journal › Article

Open Access

Lymphocytes

Mesothelioma

Pleural Effusion

Tumors

Blood

10 Citations (Scopus)

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

Aston, W. J., Hope, D. E., Nowak, A. K., Robinson, B. W., Lake, R. A. & Lesterhuis, W. J., 16 Oct 2017, In : BMC Cancer. 17, 1, 684.

Research output: Contribution to journal › Article

Open Access

Maximum Tolerated Dose

Drug Therapy

Inbred C57BL Mouse

Dexamethasone

Weight Loss

5 Citations (Scopus)

58 Downloads (Pure)

Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity

Hato, S. V., Figdor, C. G., Takahashi, S., Pen, A. E., Halilovic, A., Bol, K. F., Vasaturo, A., Inoue, Y., Haas, N. D., Verweij, D., Van Herpen, C. M. L., Kaanders, J. H., van Krieken, J. H. J. M., Van Laarhoven, H. W. M., Hooijer, G. K. J., Punt, C. J. A., Asai, A., de Vries, I. J. M. & Lesterhuis, W. J., 1 Jan 2017, In : Oncotarget. 8, 33, p. 54434-54443 10 p.

Research output: Contribution to journal › Article

Open Access

File

STAT Transcription Factors

Platinum

Transducers

Cisplatin

Pharmaceutical Preparations

38 Citations (Scopus)

298 Downloads (Pure)