Research Output per year
Research Output per year
Personal profile
Biography
Dr. Willem (Joost) Lesterhuis is an NHMRC RD Wright Research Fellow with the School of Biomedical Sciences and the National Centre for Asbestos Related Diseases at the University of Western Australia. He has a background as a dual-trained medical oncologist and basic researcher in tumour immunology and cancer biology.
His research focuses on identifying new effective treatment combinations in cancer, in particular in mesothelioma, and focusing on immunotherapy. Using network analysis of gene expression data from tumours in mouse models and patient samples, his research aims to identify predictive biomarkers for clinical efficacy of immuno-oncology drugs, as well as new context-specific targets for pharmacological intervention and novel combination treatments.
His research combines several lines of science; systems biology, network science, cancer biology, pharmacology/drug discovery, immunology and translational oncology.
Research
Current research projects include:
1- Combining chemotherapy and immunotherapy to treat cancer, in particular mesothelioma and lung cancer.
2- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression, using systems biology approaches.
3- Identification of the molecular processes that drive mesothelioma invasion using network analysis of high-dimensional molecular data from mouse models and patient samples.
1- Combining chemotherapy and immunotherapy to treat cancer, in particular mesothelioma and lung cancer.
2- Unravelling the cellular and molecular processes that govern successful immunotherapy-induced cancer regression, using systems biology approaches.
3- Identification of the molecular processes that drive mesothelioma invasion using network analysis of high-dimensional molecular data from mouse models and patient samples.
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Research Output
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A mouse model of incompletely resected soft tissue sarcoma for testing (Neo)adjuvant therapies
Rwandamuriye, F. X., Weston, B. J., Johns, T. G., Lesterhuis, W. J. & Zemek, R. M., Jul 2020, In : Journal of Visualized Experiments. 161, p. 1-11 11 p., e60882.Research output: Contribution to journal › Article
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Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial
Boudewijns, S., Bloemendal, M., de Haas, N., Westdorp, H., Bol, K. F., Schreibelt, G., Aarntzen, E. H. J. G., Lesterhuis, W. J., Gorris, M. A. J., Croockewit, A., van der Woude, L. L., van Rossum, M. M., Welzen, M., de Goede, A., Hato, S. V., van der Graaf, W. T. A., Punt, C. J. A., Koornstra, R. H. T., Gerritsen, W. R., Figdor, C. G. & 1 others, , 1 Mar 2020, In : Cancer immunology, immunotherapy. 69, 3, p. 477-488 12 p.Research output: Contribution to journal › Article
Open Access2 Citations (Scopus) -
Bilateral murine tumor models for characterizing the response to immune checkpoint blockade
Zemek, R. M., Fear, V. S., Forbes, C., de Jong, E., Casey, T. H., Boon, L., Lassmann, T., Bosco, A., Millward, M. J., Nowak, A. K., Lake, R. A. & Lesterhuis, W. J., 1 Apr 2020, In : Nature Protocols.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses
Kidman, J., Principe, N., Watson, M., Lassmann, T., Holt, R. A., Nowak, A. K., Lesterhuis, W. J., Lake, R. A. & Chee, J., 14 Oct 2020, In : Frontiers in Immunology. 11, 587014.Research output: Contribution to journal › Review article
Open Access -
Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in
Nowak, A. K., Lesterhuis, W. J., Kok, P. S., Brown, C., Hughes, B. GM., Karikios, D. J., John, T., Kao, S. C. H., Leslie, C., Cook, A. M., Pavlakis, N., Briscoe, K., O'Byrne, K. J., Karapetis, C. S., Lam, W. S., Langford, A., Yip, S. & Stockler, M. R., Sep 2020, In : The Lancet Oncology. 21, 9, p. 1213-1223 11 p.Research output: Contribution to journal › Article
5 Citations (Scopus)
Projects
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Tipping the balance - improving response rates to cancer immunotherapy
National Health & Medical Research Council NHMRC
1/01/21 → 31/12/25
Project: Research
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Centre of Research Excellence in Clinical Research: National Centre for Asbestos Related Diseases
Nowak, A., Creaney, J., Lee, G., Lesterhuis, W., Waddell, N., Brims, F., Francis, R., Lake, R., Takahashi, K. & Robinson, B.
National Health & Medical Research Council NHMRC
1/11/20 → 31/10/25
Project: Research
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Interoperative immunotherapy to prevent relapse in soft tissue sarcoma
Lesterhuis, W., Swaminatha Iyer, K. & Wyatt, K.
1/01/20 → 31/03/22
Project: Research
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Analysis of T cell receptor diversity in animal models of mesothelioma
Lake, R., Chee, J., Lesterhuis, W., Robinson, B., Fisher, S., Watson, M., Chopra, A. & Holt, R.
1/04/18 → 31/03/21
Project: Research