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Personal profile

Biography

Dr Lin is an early-mid career cancer biologist. He obtained a PhD degree in Cancer Biology at the University of Hong Kong in 2017 and joined Edith Cowan University as a postdoctoral research fellow (2018-2022). Since 2023, he has been a Research Fellow and the wet-lab lead at the Systems Biology and Genomics Laboratory (Forrest Lab) at Harry Perkins Institute of Medical Research and UWA.

He has a strong track record in cancer research with over 13 years of experience in primary tissue culture using tumour samples. His research provided extremely fundamental models for the research communities of nasopharyngeal carcinoma and Epstein-Barr virus, leading to multiple publications during PhD training, including a first-author publication in Nature Communications.

After relocating to Australia, he has taken the lead in a project funded by Cancer Council of Western Australia (CCWA) to analyse uveal melanoma tumours. This project allowed him to develop expertise on tumour dissociation and single-cell analyses to study tumour microenvironment. He was further awarded a Spatial Pioneers Fellowship and a Visium Spatial Biology Kickstarter Award by 10x Genomics that enabled him to implement and master the Visium technology. Now he is leading the use of advanced spatial platforms (VisiumHD, MERSCOPE, Xenium) to study the tumour microenvironment. He also utilises ex vivo tumour slice culture models to predict chemosensitivity in ovarian cancer.

Funding overview

Since 2019, Dr Lin has attracted grant funding as chief investigators from WA Future Health Research and Innovation Fund, CCWA and the Spinnaker Health Research Foundation, totalling over $370,000 in research funding.

Engagement

Dr Lin is a member of the Animal Ethics Committee at the Kids Research Institute Australia (2021 - present), Harry Perkins Institute-Royal Perth Hospital Combined Biosafety Committee (2024 - present). He was a member of multiple committees including the Pre-doctoral Grants Advisory Subcommittee at Cancer Council WA (2021 - 2024), the Harry Perkins Institute of Medical Research EMCR Committee (2023 - 2025), School of Medical and Health Sciences Ethics Subcommittee at ECU (2020 - 2022), and the early-career research symposium organising committee of Human Genome Meeting in 2020. He served as a guest editor for Frontiers in Cellular and Infection Microbiology, and as a reviewer for journals such as Communications Biology, Cancers, Frontiers in Microbiology and Scientific Reports.

Teaching overview

Dr Lin has supervised 3 PhD students (2 completed).

Languages

English, Mandarin, Cantonese, Teochew

Education/Academic qualification

Cancer Biology, PhD, Establishment and characterization of patient-derived xenografts and cell lines from nasopharyngeal carcinoma, The University of Hong Kong

Award Date: 17 Dec 2017

Research expertise keywords

  • Single-cell RNA sequencing
  • Spatial transcriptomics
  • Primary tissue culture
  • Patient-derived xenograft
  • Molecular biology
  • Cell biology

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