Photo of Wayne Davies

Wayne Davies

Dr

  • The University of Western Australia (M470), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1297 Citations
  • 18 h-Index
20032019
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Personal profile

Biography

Wayne I. L. Davies received his PhD from Cambridge University, UK. Professionally linked to many internationally renowned research institutions, Wayne Davies is currently an Australian Research Council Future Fellow and an Associate Professor at the School of Animal Sciences, University of Western Australia, Australia. His main research interests broadly encompass the molecular evolution and functional characterisation of gene families, and the mechanisms that regulate gene expression. Specifically, A/Prof. Davies investigates the evolutionary origins, molecular ecology, function and spectral tuning of photopigments that mediate chordate visual and non-visual light detection, and their phototransduction cascades. His work also extends to determining genetic mutations in retinal and neurological diseases. Other interests include tissue-specific regulation of ABC transporters, in particular the cystic fibrosis (CFTR) gene, novel mechanisms of gene regulation (e.g. post-transcriptional regulation and non-coding RNA networks of gene expression), and the phylogenetic relationships that exist between and across large protein superfamilies (e.g. GPCRs, ABC transporters, ion channels).

Roles and responsibilities

Australian Research Council (ARC) Future Fellow.

Associate Editor for Frontiers in Ecology and Evolution: Frontiers in Behavioral and Evolutionary Ecology.

Academic Editor for PLOS ONE.

Editorial Board Member for the Journal of Clinical Research and Ophthalmology.

Editorial Board Member for the HSOA Journal of Ophthalmology and Clinical Research.

Editorial Board Member for Dataset Papers in Science: Genetics.

Funding overview

Australian Research Council (ARC) Future Fellowship (2011-2016): "Investigating the molecular mechanisms underlying non-visual photoreception and their implications in the
treatment of human neurological disease."

ARC Discovery Project Grant (2014-2017) [Lead CI]: "Transcriptome Sequencing & Functional Characterisation of Craniate Non Visual Sensory Systems & their Adaptation to Diverse Light Environments."

ARC Linkage Infrastructure, Equipment and Facilities (LIEF) Grant (2014) [co-CI]: "Western Australian Zebrafish Facility."

Previous positions

Senior Research Associate: University of Oxford (2008-2012).

Senior Research Associate: University College London (2005-2008).

Senior Post-doctoral Research Scientist: University of Cambridge (2005).

Post-doctoral Research Scientist: University of Queensland (2002-2004).

Current projects

Molecular evolution of image-formation, colour vision and phototransduction.

Functional genomics of non-visual sensory systems.

Circadian photobiology.

Retinal disease and circadian dysfunction.

Gene evolution, expression and regulatory mechanisms (e.g. post-transcriptional regulation and non-coding RNA networks).

Next-generation sequencing and transcriptomes (RNA-Seq).

ABC transporters and ion channels (e.g. cystic fibrosis and the CFTR gene).

Structure/function of GPCRs and optogenetics.

Teaching overview

Honours and PhD teaching.

Research

Molecular evolution of image-formation, colour vision and phototransduction.

Functional genomics of non-visual sensory systems.

Circadian photobiology.

Retinal disease and circadian dysfunction.

Gene evolution, expression and regulatory mechanisms (e.g. post-transcriptional regulation and non-coding RNA networks).

Next-generation sequencing and transcriptomes (RNA-Seq).

ABC transporters and ion channels (e.g. cystic fibrosis and the CFTR gene).

Structure/function of GPCRs and optogenetics.

Languages

English.

Keywords

  • Molecular evolution
  • Gene expression and regulation
  • Vision
  • Circadian rhythms
  • Photobiology
  • Pigments
  • Opsins
  • Cystic fibrosis

Fingerprint Dive into the research topics where Wayne Davies is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Opsins Medicine & Life Sciences
Vertebrates Medicine & Life Sciences
Retinal Pigments Medicine & Life Sciences
opsin Agriculture & Biology
Genes Medicine & Life Sciences
Birds Medicine & Life Sciences
pigments Agriculture & Biology
Retinal Diseases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2019

Differential stability of variant OPN1LW gene transcripts in myopic patients

Mountford, J. K., Davies, W. I. L., Griffiths, L. R., Yazar, S., Mackey, D. A. & Hunt, D. M., 1 Jan 2019, In : Molecular Vision. 25, p. 183-193 11 p.

Research output: Contribution to journalArticle

Open Access
File
Opsins
Genes
Nucleotides
Melanesia
RNA

The diversity and adaptive evolution of visual photopigments in reptiles

Katti, C., Stacey-Solis, M., Coronel-Rojas, N. A. & Davies, W. I. L., 1 Jan 2019, In : Frontiers in Ecology and Evolution. 7, SEP, 352.

Research output: Contribution to journalReview article

Open Access
cones (retina)
rods (retina)
photoreceptors
retina
reptile

The evolution of amphibian photoreception

Mohun, S. M. & Davies, W. I. L., 27 Aug 2019, In : Frontiers in Ecology and Evolution. 7, AUG, 321.

Research output: Contribution to journalArticle

Open Access
photoreception
amphibian
amphibians
Caudata
vertebrate
5 Citations (Scopus)

Vision using multiple distinct rod opsins in deep-sea fishes

Musilova, Z., Cortesi, F., Matschiner, M., Davies, W. I. L., Patel, J. S., Stieb, S. M., de Busserolles, F., Malmstrom, M., Torresen, O. K., Brown, C. J., Mountford, J. K., Hanel, R., Stenkamp, D. L., Jakobsen, K. S., Carleton, K. L., Jentoft, S., Marshall, J. & Salzburger, W., 10 May 2019, In : Science. 364, 6440, p. 588-+ 104 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Leber Congenital Amaurosis Associated with Mutations in CEP290, Clinical Phenotype, and Natural History in Preparation for Trials of Novel Therapies

Sheck, L., Davies, W. I. L., Moradi, P., Robson, A. G., Kumaran, N., Liasis, A. C., Webster, A. R., Moore, A. T. & Michaelides, M., Jun 2018, In : Ophthalmology. 125, 6, p. 894-903

Research output: Contribution to journalArticle

Open Access
Leber Congenital Amaurosis
Natural History
Phenotype
Mutation
Visual Acuity

Projects 2011 2017