Valerie Verhasselt

Professor, Chair in Human Lactology

  • The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 3045 Citations
  • 26 h-Index
1994 …2021
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Research Output 1994 2019

19 Citations (Scopus)

Allergy prevention by breastfeeding: Possible mechanisms and evidence from human cohorts

Munblit, D. & Verhasselt, V., 2016, In : Current Opinion in Allergy and Clinical Immunology. 16, 5, p. 427-433 7 p.

Research output: Contribution to journalReview article

Breast Feeding
Hypersensitivity
Human Milk
Mothers
Microbiota

Antigens in breast milk: possible impact on immune system education

Macchiaverni, P., Tulic, M. K. & Verhasselt, V., 2013, Handbook of dietary and nutritional aspects of human breast milk. Zibadi, S., Watson, RR. & Preedy, VR. (eds.). Netherlands: Wageningen Academic Publishers, Vol. 5. p. 447-459 13 p. (Human Health Handbooks).

Research output: Chapter in Book/Conference paperChapter

A role for early oral exposure to house dust mite allergens through breast milk in food allergy susceptibility

Rekima, A., Macchiaverni, P., Bonnart, C., Metcalfe, J., Tulic, M., Halloin, N., Genuneit, J., Zanelli, S., Medeiros, S., Palmer, D., Prescott, S. & Verhasselt, V., Aug 2019, In : Allergy. 74, p. 355-355 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

4 Citations (Scopus)

A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development

Mothe-Satney, I., Murdaca, J., Sibille, B., Rousseau, A. S., Squillace, R., Le Menn, G., Rekima, A., Larbret, F., Pelé, J., Verhasselt, V., Grimaldi, P. A. & Neels, J. G., 29 Sep 2016, In : Scientific Reports. 6, 12 p., 34317.

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
T-Lymphocytes
Thymocytes
Fatty Acids
Lymphoid Tissue
365 Citations (Scopus)

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells - Evidence for a soluble CD14-dependent pathway

Verhasselt, V., Buelens, C., Willems, F., DeGroote, D., HaeffnerCavaillon, N. & Goldman, M., 15 Mar 1997, In : Journal of Immunology. 158, 6, p. 2919-2925 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Breast milk and its impact on maturation of the neonatal immune system

Turfkruyer, M. & Verhasselt, V., 6 Jun 2015, In : Current Opinion in Infectious Diseases. 28, 3, p. 199-206 8 p.

Research output: Contribution to journalReview article

Human Milk
Immune System
proctolin
Milk
Lymphoid Tissue
116 Citations (Scopus)

Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

Mosconi, E., Rekima, A., Seitz-Polski, B., Kanda, A., Fleury, S., Tissandie, E., Monteiro, R., Dombrowicz, D. D., Julia, V., Glaichenhaus, N. & Verhasselt, V., Sep 2010, In : Mucosal Immunology. 3, 5, p. 461-474 14 p.

Research output: Contribution to journalArticle

Human Milk
Antigen-Antibody Complex
Asthma
Antigens
Milk
269 Citations (Scopus)

Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma

Verhasselt, V., Milcent, V., Cazareth, J., Kanda, A., Fleury, S., Dombrowicz, D., Glaichenhaus, N. & Julia, V., Feb 2008, In : Nature Medicine. 14, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines

Vosters, O., Beuneu, C., Nagy, N., Movahedi, B., Aksoy, E., Salmon, B., Pipeleers, D., Goldman, M. & Verhasselt, V., Apr 2004, In : Diabetologia. 47, 4, p. 660-668 9 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains

Samson, M., Edinger, AL., Stordeur, P., Rucker, J., Verhasselt, V., Sharron, M., Govaerts, C., Mollereau, C., Vassart, G., Doms, RW. & Parmentier, M., May 1998, In : European Journal of Immunology. 28, 5, p. 1689-1700 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory T cells

Vosters, O., Neve, J., Willems, F., Goldman, M., Verhasselt, V. & De Wit, D., 15 Feb 2003, In : Transplantation. 75, 3, p. 383-389 7 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

Muraro, A., Halken, S., Arshad, S. H., Beyer, K., Dubois, A. E. J., Du Toit, G., Eigenmann, P. A., Grimshaw, K. E. C., Hoest, A., Lack, G., O'Mahony, L., Papadopoulos, N. G., Panesar, S., Prescott, S., Roberts, G., De Silva, D., Venter, C., Verhasselt, V., Akdis, A. C. & Sheikh, A., 2014, In : Allergy. 69, p. 590-601

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Early exposure to respiratory allergens by placental transfer and breastfeeding

Macchiaverni, P., Ynoue, L. H., Arslanian, C., Verhasselt, V. & Condino-Neto, A., 23 Sep 2015, In : PLoS One. 10, 9, 14 p., e0139064.

Research output: Contribution to journalArticle

Open Access
breast feeding
allergens
Breast Feeding
Allergens
Fetal Blood
1 Citation (Scopus)

Early-Life Nutrition and Gut Immune Development

van den Elsen, L. W. J., Rekima, A. & Verhasselt, V., 1 Jan 2019, In : Nestle Nutrition Institute workshop series. 90, p. 137-149 13 p.

Research output: Contribution to journalArticle

proctolin
Immune System
Nutritional Physiological Phenomena
digestive system
nutrition
14 Citations (Scopus)
1 Citation (Scopus)

Editorial: Human Milk Composition and Health Outcomes in Children

Munblit, D., Verhasselt, V. & Warner, J. O., 30 Jul 2019, In : Frontiers in Pediatrics. 7, 3 p., 319.

Research output: Contribution to journalEditorial

Open Access
101 Citations (Scopus)

Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide

Willems, F., Amraoui, Z., Vanderheyde, N., Verhasselt, V., Aksoy, E., Scaffidi, C., Peter, ME., Krammer, PH. & Goldman, M., 1 Jun 2000, In : Blood. 95, 11, p. 3478-3482 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Extracellular matrix protease activity is altered in the irritable bowel syndrome

Piche, T., Boyer, J., Hastier, A., Vivinus, M. H., Bioueche, H., Tulic, M. & Verhasselt, V., Jun 2015, In : Neurogastroenterology and Motility. 27, p. 92-92 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

9 Citations (Scopus)

From autoimmune responses to autoimmune disease: What is needed?

Verhasselt, V. & Goldman, M., May 2001, In : Journal of Autoimmunity. 16, 3, p. 327-330 4 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Functional bowel symptoms in quiescent inflammatory bowel diseases: Role of epithelial barrier disruption and low-grade inflammation

Vivinus-Nébot, M., Frin-Mathy, G., Bzioueche, H., Dainese, R., Bernard, G., Anty, R., Filippi, J., Saint-Paul, M. C., Tulic, M. K., Verhasselt, V., Hébuterne, X. & Piche, T., 1 May 2014, In : Gut. 63, 5, p. 744-752 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Inflammatory Bowel Diseases
Inflammation
Catenins
Permeability
166 Citations (Scopus)

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10

Buelens, C., Verhasselt, V., DeGroote, D., Thielemans, K., Goldman, M. & Willems, F., Aug 1997, In : European Journal of Immunology. 27, 8, p. 1848-1852 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Human pancreatic duct cells exert tissue factor-dependent procoagulant activity - Relevance to islet transplantation

Beuneu, C., Vosters, O., Movahedi, B., Remmelink, M., Salmon, B., Pipeleers, D., Pradier, O., Goldman, M. & Verhasselt, V., Jun 2004, In : Diabetes. 53, 6, p. 1407-1411 5 p.

Research output: Contribution to journalArticle

Immune status of the mother and early exposure through breastfeeding both influence the protection of the progeny from food allergy development to a major cow's milk allergen

Adel-Patient, K., Ah-Leung, S., Bernard, H. & Verhasselt, V., Sep 2015, In : Allergy. 70, p. 61-61 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

113 Citations (Scopus)

Induction of FOXP3-expressing regulatory CD4(pos) T cells by human mature autologous dendritic cells

Verhasselt, V., Vosters, O., Beuneu, C., Nicaise, C., Stordeur, P. & Goldman, M., Mar 2004, In : European Journal of Immunology. 34, 3, p. 762-772 11 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Inhibition of human dendritic cell functions by methylprednisolone

Vanderheyde, N., Verhasselt, V., Goldman, M. & Willems, F., 27 May 1999, In : Transplantation. 67, 10, p. 1342-1347 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

INTERACTION OF AMILORIDE WITH RAT PAROTID MUSCARINIC AND ALPHA-ADRENERGIC RECEPTORS

DEHAYE, JP. & VERHASSELT, V., Jan 1995, In : General Pharmacology. 26, 1, p. 155-159 5 p.

Research output: Contribution to journalArticle

192 Citations (Scopus)

Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor

Buelens, C., Verhasselt, V., DeGroote, D., Thielemans, K., Goldman, M. & Willems, F., Mar 1997, In : European Journal of Immunology. 27, 3, p. 756-762 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Is infant immunization by breastfeeding possible?

Verhasselt, V., 19 Jun 2015, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 370, 1671, 20140139.

Research output: Contribution to journalReview article

Immunization
breastfeeding
immunization
breast feeding
antigen
2 Citations (Scopus)

L'allaitement maternel peut-il prévenir les maladies allergiques par l'induction de tolérance orale?

Macchiaverni, P., Rekima, A., Tulic, M. K. & Verhasselt, V., Nov 2012, In : Revue Francaise d'Allergologie. 52, 7, p. 489-495 7 p.

Research output: Contribution to journalShort survey

Breast Feeding
Human Milk
Antigens
Immune System
Immune System Diseases
9 Citations (Scopus)

Long-term reduction in food allergy susceptibility in mice by combining breastfeeding-induced tolerance and TGF-β-enriched formula after weaning

Rekima, A., Macchiaverni, P., Turfkruyer, M., Holvoet, S., Dupuis, L., Baiz, N., Annesi-Maesano, I., Mercenier, A., Nutten, S. & Verhasselt, V., 1 Apr 2017, In : Clinical and Experimental Allergy. 47, 4, p. 565-576 12 p.

Research output: Contribution to journalArticle

Food Hypersensitivity
Ovalbumin
Weaning
Breast Feeding
Diarrhea
27 Citations (Scopus)

Lung-gut cross-talk: Evidence, mechanisms and implications for the mucosal inflammatory diseases

Tulic, M. K., Piche, T. & Verhasselt, V., 1 Apr 2016, In : Clinical and Experimental Allergy. 46, 4, p. 519-528 10 p.

Research output: Contribution to journalReview article

Immune System
Mucosal Immunity
Lung
Irritable Bowel Syndrome
Gastrointestinal Diseases
31 Citations (Scopus)

Maternal immunisation: collaborating with mother nature

Marchant, A., Sadarangani, M., Garand, M., Dauby, N., Verhasselt, V., Pereira, L., Bjornson, G., Jones, C. E., Halperin, S. A., Edwards, K. M., Heath, P., Openshaw, P. J., Scheifele, D. W. & Kollmann, T. R., Jul 2017, In : The Lancet Infectious Diseases. 17, 7, p. e197–e208 12 p.

Research output: Contribution to journalArticle

Immunization
Mothers
Streptococcus agalactiae
Whooping Cough
Human Influenza

Maternal Transfer Of Der p 1 and Blo t 5 Allergens and Their Respective Specific Antibodies Trough Placenta and Colostrum

Macchiaverni, P., Arslanian, C., Verhasselt, V. & Condino-Neto, A., Feb 2014, In : Journal of Allergy and Clinical Immunology. 133, 2, p. AB286-AB286 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

14 Citations (Scopus)

Mother to child transfer of IgG and IgA antibodies against Dermatophagoides pteronyssinus

Macchiaverni, P., Arslanian, C., Frazão, J. B., Palmeira, P., Russo, M., Verhasselt, V. & Condino-Neto, A., Dec 2011, In : Scandinavian Journal of Immunology. 74, 6, p. 619-627 9 p.

Research output: Contribution to journalArticle

Dermatophagoides pteronyssinus
Immunoglobulin A
Immunoglobulin G
Mothers
Antibodies
4 Citations (Scopus)

N-acetylcysteine derivative inhibits CD40-dependent proinflammatory properties of human pancreatic duct cells

Vosters, O., Beuneu, C., Goldman, M. & Verhasselt, V., May 2008, In : Pancreas. 36, 4, p. 363-368 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

N-Acetylcysteine derivative inhibits procoagulant activity of human islet cells.

Beuneu, C., Vosters, O., Ling, Z., Pipeleers, D., Pradier, O., Goldman, M. & Verhasselt, V., 1 Feb 2007, In : Diabetologia. 50, 2, p. 343-347 5 p.

Research output: Contribution to journalArticle

Acetylcysteine
Islets of Langerhans
Human Activities
Thromboplastin
Islets of Langerhans Transplantation

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level

Verhasselt, V., Vanden Berghe, W., Vanderheyde, N., Willems, F., Haegeman, G. & Goldman, M., 1998, In : Journal of Leukocyte Biology. p. 33-33 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citation (Scopus)

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-kappa B inhibition. (vol 162, pg 2569, 1999)

Verhasselt, V., Vanden Bergh, W., Vanderheyde, N., Willems, F., Haegeman, G. & Goldman, M., 15 Jul 1999, In : Journal of Immunology. 163, 2, p. 1093-1093 1 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-κB inhibition

Verhasselt, V., Vanden Berghe, W., Vanderheyde, N., Willems, F., Haegeman, G. & Goldman, M., 1 Mar 1999, In : Journal of Immunology. 162, 5, p. 2569-2574 6 p.

Research output: Contribution to journalArticle

Acetylcysteine
Dendritic Cells
T-Lymphocytes
HLA-DR Antigens
Endocytosis
68 Citations (Scopus)

Neonatal tolerance under breastfeeding influence

Verhasselt, V., Oct 2010, In : Current Opinion in Immunology. 22, 5, p. 623-630 8 p.

Research output: Contribution to journalReview article

Human Milk
Breast Feeding
Antigens
Maternal Exposure
Immune System Diseases
38 Citations (Scopus)
Transforming Growth Factors
Human Milk
Breast Feeding
Allergens
Asthma
2 Citations (Scopus)

New concepts on the pathogenesis of autoimmune disease

Verhasselt, V. & Goldman, M., Aug 2001, In : The Israel Medical Association journal : IMAJ. 3, 8, p. 599-602 4 p.

Research output: Contribution to journalReview article

59 Citations (Scopus)

Oral tolerance in neonates: From basics to potential prevention of allergic disease

Verhasselt, V., Jul 2010, In : Mucosal Immunology. 3, 4, p. 326-333 8 p.

Research output: Contribution to journalReview article

Antigens
Immune Tolerance
Food Hypersensitivity
Celiac Disease
Breast Feeding
26 Citations (Scopus)

Oral tolerance is inefficient in neonatal mice due to a physiological Vitamin A deficiency

Turfkruyer, M., Rekima, A., Macchiaverni, P., Le Bourhis, L., Muncan, V., Van Den Brink, G. R., Tulic, M. K. & Verhasselt, V., 1 Mar 2016, In : Mucosal Immunology. 9, 2, p. 479-491 13 p.

Research output: Contribution to journalArticle

Vitamin A Deficiency
Vitamin A
Ovalbumin
Hypersensitivity
Retinaldehyde
98 Citations (Scopus)

Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells

Verhasselt, V., Goldman, M. & Willems, F., Nov 1998, In : European Journal of Immunology. 28, 11, p. 3886-3890 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice

Bernard, H., Ah-Leung, S., Drumare, M. F., Feraudet-Tarisse, C., Verhasselt, V., Wal, J. M., Créminon, C. & Adel-Patient, K., 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 7, p. 888-897 10 p.

Research output: Contribution to journalArticle

Human Milk
Allergens
Eating
Antigen-Antibody Complex
Immunoglobulin E
19 Citations (Scopus)

Presence of commensal house dust mite allergen in human gastrointestinal tract: A potential contributor to intestinal barrier dysfunction

Tulic, M. K., Vivinus-Nébot, M., Rekima, A., Medeiros, S. R., Bonnart, C., Shi, H., Walker, A., Dainese, R., Boyer, J., Vergnolle, N., Piche, T. & Verhasselt, V., 1 May 2016, In : Gut. 65, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

Dermatophagoides Antigens
Pyroglyphidae
Gastrointestinal Tract
Cysteine Proteinase Inhibitors
Inflammation

Pseudo-thrombotic thrombocytopenic purpura in an HIV-positive patient

Efira, A., DesGrottes, JM., Verhasselt, V., Cantinieaux, B., Gottlob, R. & Hermans, P., Jun 1996, In : British Journal of Haematology. 93, p. 675-675 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

64 Citations (Scopus)

REGULATION OF C3 AND FACTOR-H SYNTHESIS OF HUMAN GLOMERULAR MESANGIAL CELLS BY IL-1 AND INTERFERON-GAMMA

VANDENDOBBELSTEEN, MEA., VERHASSELT, V., KAASHOEK, JGJ., TIMMERMAN, JJ., SCHROEIJERS, WEM., VERWEIJ, CL., VANDERWOUDE, FJ., VANES, LA. & DAHA, MR., Jan 1994, In : Clinical and Experimental Immunology. 95, 1, p. 173-180 8 p.

Research output: Contribution to journalArticle

Reply

Macchiaverni, P., Baiz, N., Rekima, A., Annesi-Maesano, I. & Verhasselt, V., Feb 2019, In : The Journal of Allergy and Clinical Immunology. 143, 2, p. 808-809 2 p.

Research output: Contribution to journalLetter