No photo of Timothy Isaacs
  • The University of Western Australia (M517), 35 Stirling Highway,

    6009 Perth

    Australia

  • 448 Citations
  • 5 h-Index
20112019
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Research Output 2011 2019

  • 448 Citations
  • 5 h-Index
  • 7 Article
  • 1 Abstract/Meeting Abstract
  • 1 Review article
2019

A panel of circulating MicroRNAs detects uveal melanoma with high precision

Stark, M. S., Gray, E. S., Isaacs, T., Chen, F. K., Millward, M., McEvoy, A., Zaenker, P., Ziman, M., Soyer, H. P., Glasson, W. J., Warrier, S. K., Stark, A. L., Rolfe, O. J., Palmer, J. M. & Hayward, N. K., Nov 2019, In : Translational Vision Science and Technology. 8, 6, 12.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Nevus
Blood
Biopsy
Real time systems

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

Int Age-Related Macular Degenerati, Sep 2019, In : Investigative ophthalmology & visual science. 60, 12, p. 4041-4051 11 p.

Research output: Contribution to journalArticle

2018

Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma

Beasley, A., Isaacs, T., Khattak, M. A., Freeman, A. B., Allcock, R., Chen, F. K., Pereira, M. R., Yau, K., Bentel, J., Vermeulen, T., Calapre, L., Millward, M., Ziman, M. R. & Gray, E. S., 17 May 2018, In : JCO precision oncology. 2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
2017

DETECTION OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH PROGNOSIS OF UVEAL MELANOMA USING CIRCULATING TUMOUR CELLS

Isaacs, T., Beasley, A., Allcok, R., Khattak, A., Vermeulen, T., Freeman, J., Chen, F., Bentel, J., Calapre, L., Pereira, M., Yau, K., Mirzai, B., Erber, W., Ziman, M. & Gray, E., Oct 2017, In : Clinical & Experimental Ophthalmology. 45, p. 61-61 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

23 Citations (Scopus)
113 Downloads (Pure)

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

International AMD Genomics Consortium (IAMDGC), 27 Mar 2017, In : Genome Medicine. 9, 1, 29.

Research output: Contribution to journalArticle

Open Access
File
Genetic Pleiotropy
Macular Degeneration
Autoimmune Diseases
Lipid Metabolism Disorders
Genome
2016
335 Citations (Scopus)

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., Elee, K., Hunter, D. J., Sardell, R. J., Mitchell, P. & 56 othersMerriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., Mcallister, I., Isaacs, T., Hall, J., Lake, S., Mackey, D., Constable, I., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Etsironi, E., Park, K. H., Farrer, L. A., Orlin, A. & Brucker, A., 2016, In : Nature Genetics. 48, 2, p. 134-143

Research output: Contribution to journalArticle

Genome-Wide Association Study
Macular Degeneration
Blindness
Proteins
Therapeutics
9 Citations (Scopus)

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

Cuellar-Partida, G., Craig, J. E., Burdon, K. P., Wang, J. J., Vote, B. J., Souzeau, E., Mcallister, I. L., Isaacs, T., Lake, S., Mackey, D. A., Constable, I. J., Mitchell, P., Hewitt, A. W. & Macgregor, S., 31 May 2016, In : Scientific Reports. 6, p. 1-6 26885.

Research output: Contribution to journalArticle

Open Access
Macular Degeneration
Genome
Genome-Wide Association Study
Blindness
Primary Open Angle Glaucoma
74 Citations (Scopus)
198 Downloads (Pure)

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

Johansson, P., Aoude, L. G., Wadt, K., Glasson, W. J., Warrier, S. K., Hewitt, A., Kiilgaard, J. F., Heegaard, S., Isaacs, T., Franchina, M., Ingvar, C., Vermeulen, T., Whitehead, K. J., Schmidt, C. W., Palmer, J. M., Symmons, J., Gerdes, A. M., Jönsson, G. & Hayward, N. K., 26 Jan 2016, In : Oncotarget. 7, 4, p. 4624-4631

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Nucleotide Sequencing
Mutation
Uveal melanoma
Genes
Exome
2011
7 Citations (Scopus)
Macular Degeneration
Visual Acuity
Intravitreal Injections
Injections
Therapeutics