Research output per year
Research output per year
Personal profile
Biography
Lab group web site: barnettlab.com
Dr Tim Barnett is a Senior Lecturer at the University of Western Australia and Honorary Research Fellow at the Telethon Kids Institute. His work centres on the disease-causing mechanisms of Streptococcus pyogenes (Group A Streptococcus, Strep A), including molecular interactions with host cells, transcriptional responses to infection, antibiotic resistance and epidemiology.
Dr Barnett has worked in the area of Strep A research since his PhD. He has pursued postdoctoral studies in two of the leading Strep A research laboratories at Emory University (June Scott) and the University of Queensland (Mark Walker), and made a number of significant contributions to this field. These include the first characterisation of the enzymes (sortases) that covalently attach proteins to the Strep A cell wall, demonstration that stationary phase gene expression is mediated by changes in mRNA stability, and the description of a novel mechanism that Strep A uses to evade the innate immune pathway that protects host cells from intracellular bacteria (autophagy).
Dr Barnett's recent work has uncovered entirely new mechanisms of antibiotic resistance that are only active in the context of an infection, and not currently able to be detected in pathology laboratories.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Microbiology, Pathology, Doctor of Philosophy, University of Tasmania
1 Jul 1995 → 31 Dec 1999
Award Date: 1 Aug 2000
Microbiology and Biochemistry, BSc.Honours, The University of Western Australia
31 Mar 0001 → 31 Dec 2015
Award Date: 15 Dec 1994
External positions
Deputy Director, Wesfarmers Centre of Vaccines and Infectious Diseases
1 Jul 2022 → …
Team Leader, The Kids Research Institute Australia (Telethon Kids Institute)
1 Jan 2022 → …
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Collaborations and top research areas from the last five years
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Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter
Rodrigo, M. K. D., Saiganesh, A., Hayes, A. J., Wilson, A. M., Anstey, J., Pickering, J. L., Iwasaki, J., Hillas, J., Winslow, S., Woodman, T., Nitschke, P., Lacey, J. A., Breese, K. J., van der Linden, M. P. G., Giffard, P. M., Tong, S. Y. C., Gray, N., Stubbs, K. A., Carapetis, J. R., Bowen, A. C., & 2 others, Dec 2022, In: Nature Communications. 13, 1, 6557.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
Brouwer, S., Barnett, T. C., Ly, D., Kasper, K. J., De Oliveira, D. M. P., Rivera-Hernandez, T., Cork, A. J., McIntyre, L., Jespersen, M. G., Richter, J., Schulz, B. L., Dougan, G., Nizet, V., Yuen, K. Y., You, Y., McCormick, J. K., Sanderson-Smith, M. L., Davies, M. R. & Walker, M. J., 1 Dec 2020, In: Nature Communications. 11, 1, 5018.Research output: Contribution to journal › Article › peer-review
Open Access37 Citations (Scopus) -
Describing skin health and disease in urban-living Aboriginal children: co-design, development and feasibility testing of the Koolungar Moorditj Healthy Skin pilot project
Ricciardo, B. M., Kessaris, H. L., Nannup, N., Tilbrook, D., Farrant, B., Michie, C., Hansen, L., Douglas, R., Walton, J., Poore, A., Whelan, A., Barnett, T. C., Kumarasinghe, P. S., Carapetis, J. R. & Bowen, A. C., Dec 2024, In: Pilot and Feasibility Studies. 10, 1, 14 p., 6.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A Streptococcus population
Bessen, D. E., Beall, B. W., Hayes, A., Huang, W., DiChiara, J. M., Velusamy, S., Tettelin, H., Jolley, K. A., Fallon, J. T., Chochua, S., Alobaidallah, M. S. A., Higgs, C., Barnett, T. C., Steemson, J. T., Proft, T. & Davies, M. R., May 2024, In: mBio. 15, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Antibiotic consumption for sore throat and the potential effect of a vaccine against group A Streptococcus: a systematic review and modelling study
Miller, K. M., Barnett, T. C., Cadarette, D., Bloom, D. E., Carapetis, J. R. & Cannon, J. W., Dec 2023, In: EBioMedicine. 98, 104864.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Web of Science)
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Developing probiotics to prevent childhood pneumonia
Nicol, M., Kar Bahal, R., Garratt, L., Laucirica, D., Kicic, A., Pickering, J., Barnett, T., Chooi, H. & Kirkham, L.
Department of Health (Western Australia)
1/01/24 → 31/12/26
Project: Research
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Harnessing natural protection to improve Group A Streptococcus vaccine design and primary prevention of Acute Rheumatic Fever
Pickering, J., Barnett, T., Bowen, A., Fulurija, A. & Davies, M.
Department of Health (Western Australia)
15/05/23 → 20/05/26
Project: Research
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Characterising a novel molecular pathway to reduce penicillin failure for Strep throat - Copy of 2021/GR000627
Barnett, T., Martin, J. & Iwasaki, J.
NHMRC National Health and Medical Research Council
1/03/23 → 28/02/26
Project: Research