Thomas Ledowski

Professor, M.D., P.D., DEAA, FANZCA

  • The University of Western Australia (M572), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1521 Citations
  • 21 h-Index
19972019
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Research Output 1997 2019

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Article
2019

Cheaper drugs and techniques to fulfill chief executive officer perspectives - any choices?

Thomas, B. E. & Ledowski, T., 1 Apr 2019, In : Current Opinion in Anaesthesiology. 32, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Budgets
Administrative Personnel
Health Care Sector
Patents
Quality of Health Care
Acute Pain
Postoperative Pain
Arousal
Observational Studies
Prospective Studies
1 Citation (Scopus)

Surgical pleth index: prospective validation of the score to predict moderate-to-severe postoperative pain

Ledowski, T., Schneider, M., Gruenewald, M., Goyal, R. K., Teo, S. R. & Hruby, J., 12 Mar 2019, In : British Journal of Anaesthesia. 5 p.

Research output: Contribution to journalArticle

Postoperative Pain
Arterial Pressure
Heart Rate
Sensitivity and Specificity
Pain
2018
9 Citations (Scopus)

Cuffed vs. uncuffed tracheal tubes in children: a randomised controlled trial comparing leak, tidal volume and complications

Chambers, N. A., Ramgolam, A., Sommerfield, D., Zhang, G., Ledowski, T., Thurm, M., Lethbridge, M., Hegarty, M. K. & von Ungern-Sternberg, B. S., 1 Feb 2018, In : Anaesthesia. 73, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Tidal Volume
Ventilation
Randomized Controlled Trials
Pressure
Mechanical Ventilators
1 Citation (Scopus)

Effects of muscle relaxants on ischaemia damage in skeletal muscle

Ledowski, T., Nißler, S., Wenk, M., Pogatzki-Zahn, E. M. & Segelcke, D., 11 Apr 2018, In : Scientific Reports. 8, 1, 7 p.

Research output: Contribution to journalArticle

Open Access
Skeletal Muscle
Ischemia
Muscles
Dystrophin
Muscle Cells
2017
7 Citations (Scopus)

Surgical pleth index: Prediction of postoperative pain in children?

Ledowski, T., Sommerfield, D., Slevin, L., Conrad, J. & Von Ungern-Sternberg, B. S., 1 Nov 2017, In : British Journal of Anaesthesia. 119, 5, p. 979-983 5 p.

Research output: Contribution to journalArticle

Postoperative Pain
Postoperative Care
Acute Pain
Anesthesia
Sensitivity and Specificity
Open Access
Reconstructive Surgical Procedures
Muscle Relaxation
Superficial Back Muscles
Observational Studies
Dissection
2016
7 Citations (Scopus)

Current Trends in Neuromuscular Blockade, Management, and Monitoring amongst Singaporean Anaesthetists

Teoh, W. H., Ledowski, T. & Tseng, P. S., 2016, In : Anesthesiology Research and Practice. 2016, 7284146.

Research output: Contribution to journalArticle

Open Access
Neuromuscular Monitoring
Practice Guidelines
Singapore
Patient Safety
Costs and Cost Analysis
17 Citations (Scopus)

Surgical pleth index: Prediction of postoperative pain and influence of arousal

Ledowski, T., Burke, J. & Hruby, J., 2016, In : British Journal of Anaesthesia. 117, 3, p. 371-374 4 p.

Research output: Contribution to journalArticle

Postoperative Pain
Arousal
Anesthesia
Entropy
Pain
2015
4 Citations (Scopus)

A comparison of the i-gel™ and the PRO-Breathe® laryngeal mask during pressure support ventilation in children

Drake-Brockman, T., Ledowski, T., Hegarty, M., Gessner, M. & von Ungern-Sternberg, B. S., 2015, In : Anaesthesia. 70, 12, p. 1412-1417

Research output: Contribution to journalArticle

Laryngeal Masks
Ventilation
Gels
Pressure
Positive-Pressure Respiration
21 Citations (Scopus)

Deep neuromuscular block reduces intra-abdominal pressure requirements during laparoscopic cholecystectomy: A prospective observational study

Van Wijk, R. M. A. W., Watts, R. W., Ledowski, T., Trochsler, M. I., Moran, J. L. & Arenas, G. W. N., 2015, In : ACTA Anaesthesiologica Scandinavica. 59, 4, p. 434-440

Research output: Contribution to journalArticle

Neuromuscular Blockade
Laparoscopic Cholecystectomy
Observational Studies
Prospective Studies
Pressure
3 Citations (Scopus)

Effect of muscle relaxation on the oxygenation of human skeletal muscle: A prospective in-vivo experiment using an isolated forearm technique

Rhee, K. Y., Kim, T-Y., Oh, I., Lee, S-J. & Ledowski, T., 2015, In : Korean Journal of Anesthesiology. 68, 1, p. 13-16

Research output: Contribution to journalArticle

Open Access
Tourniquets
Muscle Relaxation
Forearm
Skeletal Muscle
Near-Infrared Spectroscopy
7 Citations (Scopus)
Open Access
Neuromuscular Monitoring
Tertiary Care Centers
Teaching Hospitals
Muscles
Neuromuscular Blocking Agents
12 Citations (Scopus)

Postoperative residual neuromuscular paralysis at an Australian tertiary children's hospital

Ledowski, T., O'Dea, B., Meyerkort, L., Hegarty, M. & von Ungern-Sternberg, B. S., 2015, In : Anesthesiology Research and Practice. 2015, p. 1-4

Research output: Contribution to journalArticle

Open Access
Delayed Emergence from Anesthesia
Neostigmine
Tertiary Care Centers
Paralysis
Neuromuscular Blocking Agents
15 Citations (Scopus)
Anesthesia
Pharmacology
Research
Sugammadex
2014
27 Citations (Scopus)

Analgesia Nociception Index (ANI) to predict intraoperative haemodynamic changes: Results of a pilot investigation

Ledowski, T., Averhoff, L., Tiong, W. S. & Lee, C., 2014, In : ACTA Anaesthesiologica Scandinavica. 58, 1, p. 74-79

Research output: Contribution to journalArticle

Nociception
Analgesia
Hemodynamics
Heart Rate
Blood Pressure
59 Citations (Scopus)

Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal

Ledowski, T., Falke, L., Johnston, F., Gillies, E., Greenaway, M., De Mel, A., Tiong, E. & Phillips, M., 2014, In : European Journal of Anaesthesiology. 31, 8, p. 423-429

Research output: Contribution to journalArticle

Open Access
Delayed Emergence from Anesthesia
Neostigmine
Length of Stay
Neuromuscular Nondepolarizing Agents
Postoperative Nausea and Vomiting
2013
11 Citations (Scopus)
242 Downloads (Pure)

Acute effects of red wine on cytochrome P450 eicosanoids and blood pressure in men

Barden, A., Croft, K., Beilin, L., Phillips, M., Ledowski, T. & Puddey, I., Nov 2013, In : Journal of Hypertension. 31, 11, p. 2195-2202

Research output: Contribution to journalArticle

Open Access
File
Eicosanoids
Wine
Cytochrome P-450 Enzyme System
Blood Pressure
Acids
43 Citations (Scopus)

Analgesia nociception index: Evaluation as a new parameter for acute postoperative pain

Ledowski, T., Tiong, E., Lee, C., Wong, B., Fiori, T. & Parker, N., 2013, In : British Journal of Anaesthesia. 111, 4, p. 627-629

Research output: Contribution to journalArticle

28 Citations (Scopus)

Introduction of sugammadex as standard reversal agent: Impact on the incidence of residual neuromuscular blockade and postoperative patient outcome

Ledowski, T., Hillyard, S., O'Dea, B., Archer, R., Vilas-Boas, F. & Kyle, B., 2013, In : Indian Journal of Anaesthesia. 57, 1, p. 46-51

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Long-term quality of sleep after remifentanil-based anaesthesia: A randomized controlled trial

Wenk, M., Pöpping, D. M., Chapman, G., Grenda, H. & Ledowski, T., 2013, In : British Journal of Anaesthesia. 110, 2, p. 250-257

Research output: Contribution to journalArticle

2012
44 Citations (Scopus)

Effects of acute postoperative pain on catecholamine plasma levels, hemodynamic parameters, and cardiac autonomic control

Ledowski, T., Reimer, M., Chavez, V., Kapoor, V. & Wenk, M., 2012, In : Pain. 153, p. 759-764

Research output: Contribution to journalArticle

Is acute postoperative pain reflected by a change in parasympathetic cardiac tone? Evaluation of the Analgesia Nociception Index

T., L., W.S., T., C., L., B., W., T., F. & N., P., 2012, In : Anaesthesia and Intensive Care. 40, 6, p. 1064

Research output: Contribution to journalArticle

Nociception
Acute Pain
Postoperative Pain
Analgesia
Recovery Room
2 Citations (Scopus)

Long-term postoperative quality of sleep after fentanyl- and remifentanil-based anaesthesia - a randomised controlled trial

Pöpping, D. M., Chapman, G., Grenda, H., Ledowski, T. & Wenk, M., Jun 2012, In : European Journal of Anaesthesiology. 29, p. 28-29 2 p.

Research output: Contribution to journalArticle

Fentanyl
Sleep
Anesthesia
Randomized Controlled Trials
Opioid Analgesics
34 Citations (Scopus)

Unrestricted access to sugammadex: Impact on neuromuscular blocking agent choice, reversal practice and associated healthcare costs

Ledowski, T., Hillyard, S., Kozman, A., Johnston, F., Gillies, E., Greenaway, M. & Kyle, B. C., 2012, In : Anaesthesia and Intensive Care. 40, p. 340-343

Research output: Contribution to journalArticle

2011

Introduction of sugammadex: Influence on the incidence of residual paralysis at a tertiary teaching hospital

Ledowski, T., O'Dea, B., Boas, F. V., Archer, R., Hillyard, S. & Kyle, B., 2011, In : Anaesthesia and Intensive Care. 39, 5, p. 963

Research output: Contribution to journalArticle

Tertiary Care Centers
Teaching Hospitals
Paralysis
Recovery Room
Neostigmine
7 Citations (Scopus)
18 Citations (Scopus)
2010
10 Citations (Scopus)
24 Citations (Scopus)

Monitoring of intra-operative nociception: skin conductance and surgical stress index versus stress hormone plasma levels

Ledowski, T., Pascoe, M., Ang, B., Schmarbeck, T., Clarke, M., Fuller, C. & Kapoor, V., 2010, In : Anaesthesia. 65, 10, p. 1001-1006

Research output: Contribution to journalArticle

2009
19 Citations (Scopus)

Effects of clonidine and midazolam premedication on bispectral index and recovery after elective surgery

Paris, A., Kaufmann, M., Tonner, P. H., Renz, P., Lemke, T., Ledowski, T., Scholz, J. & Bein, B., 2009, In : European Journal of Anaesthesiology. 26, 7, p. 603-610

Research output: Contribution to journalArticle

Premedication
Midazolam
Clonidine
Placebos
Pain Measurement
20 Citations (Scopus)

Induction dose of propofol in patients using cannabis

Flisberg, P. E., Paech, M., Shah, T., Ledowski, T., Kurowski, I. & Parsons, R., 2009, In : European Journal of Anaesthesiology. 26, 3, p. 192-195

Research output: Contribution to journalArticle

Propofol
Cannabis
Laryngeal Masks
Unconsciousness
Anesthetics
46 Citations (Scopus)

Monitoring electrical skin conductance: A tool for the assessment of postoperative pain in children

Hullett, B., Chambers, N., Preuss, J., Zamudio, I., Lange, J., Pascoe, M. & Ledowski, T., 2009, In : Anesthesiology. 111, 3, p. 513-7

Research output: Contribution to journalArticle

Postoperative Pain
Skin
Pain Measurement
Pediatrics
Pain
57 Citations (Scopus)

Monitoring of sympathetic tone to assess postoperative pain : skin conductance vs surgical stress index

Ledowski, T., Ang, Y. L. B., Schmarbeck, T. & Rhodes, J., 2009, In : Anaesthesia. 64, 7, p. 727-731

Research output: Contribution to journalArticle

Postoperative Pain
Pain
Skin
Recovery Room
Aptitude
9 Citations (Scopus)

The effects of neostigmine and glycopyrrolate on skin conductance as a measure of pain

Ledowski, T., Preuss, J. M. H. & Schug, S., 2009, In : European Journal of Anaesthesiology. 26, 9, p. 777-781

Research output: Contribution to journalArticle

Glycopyrrolate
Neostigmine
Pain
Skin
Recovery Room
9 Citations (Scopus)

Vitamin E Supplementation and Hepatic Drug Metabolism in Humans

Clarke, M., Burnett, J., Wu, J., Hodgson, J., Ledowski, T., Puddey, I. & Croft, K., 2009, In : Journal of Cardiovascular Pharmacology. 54, 6, p. 491-96

Research output: Contribution to journalArticle

Tocopherols
Vitamin E
Midazolam
Cytochrome P-450 CYP3A
Liver
2008
11 Citations (Scopus)
167 Downloads (Pure)

Bronchial mucus transport velocity in patients receiving desflurane and fentanyl vs sevoflurane and fentanyl

Ledowski, T., Manopas, A. & Lauer, S., 2008, In : European Journal of Anaesthesiology. 25, 9, p. 752-755

Research output: Contribution to journalArticle

File
Fentanyl
Mucus
Irritants
Mucociliary Clearance
Methylene Blue
5 Citations (Scopus)

Skin conductance as a means to predict hypotension following spinal anaesthesia

Ledowski, T., Preuss, J. M. H., Kapila, R. & Ford, A., 2008, In : ACTA Anaesthesiologica Scandinavica. 52, 10, p. 1342-1347

Research output: Contribution to journalArticle

Spinal Anesthesia
Hypotension
Skin
Area Under Curve
Arterial Pressure
2007
28 Citations (Scopus)

Changes in heart rate variability may reflect sympatholysis during spinal anaethesia

Hanss, R., Ohnesorge, H., Kaufmann, M., Gaupp, R., Ledowski, T., Steinfath, M., Scholz, J. & Bein, B., 2007, In : ACTA Anaesthesiologica Scandinavica. 51, 10, p. 1297-1304

Research output: Contribution to journalArticle

Spinal Anesthesia
Heart Rate
Blood Pressure
Hypotension
Blood Group Antigens
8 Citations (Scopus)

New parameters of skin conductance compared with bispectral index monitoring to assess emergence from total intravenous anaesthesia

Ledowski, T., Preuss, J., Ford, A., Paech, M., Mcternan, C., Kapila, R. & Schug, S., 2007, In : British Journal of Anaesthesia. 99, 4, p. 547-551

Research output: Contribution to journalArticle

Intravenous Anesthesia
Area Under Curve
Skin
Anesthesia
Physiologic Monitoring
60 Citations (Scopus)

The assessment of postoperative pain by monitoring skin conductance : results of a prospective study

Ledowski, T., Bromilow, J., Wu, J., Paech, M., Storm, H. & Schug, S., 2007, In : Anaesthesia. 62, 10, p. 989-993

Research output: Contribution to journalArticle

Postoperative Pain
Prospective Studies
Skin
Recovery Room
Pain
2006
9 Citations (Scopus)

Bronchial mucus transport velocity in patients receiving anaesthesia with propofol and morphine or propofol and remifentanil

Ledowski, T., Hilmi, S. & Paech, M., 2006, In : Anaesthesia. 61, 8, p. 747-751

Research output: Contribution to journalArticle

Propofol
Mucus
Morphine
Anesthesia
Intubation
33 Citations (Scopus)
Propofol
Mucus
Anesthesia
Lung
Methylene Blue
48 Citations (Scopus)

Monitoring of skin conductance to assess postoperative pain intensity

Ledowski, T., Bromilow, J., Paech, M., Storm, H., Hacking, R. & Schug, S., 2006, In : British Journal of Anaesthesia. 97, 6, p. 862-865

Research output: Contribution to journalArticle

Postoperative Pain
Skin
Reading
Recovery Room
Pain
16 Citations (Scopus)
General Anesthesia
Skin
Anesthesia
Minor Surgical Procedures
General Anesthetics
16 Citations (Scopus)

Skin conductance monitoring compared with Bispectral Index to assess emergence from total i.v. anaesthesia using propofol and remifentanil

Ledowski, T., Bromilow, J., Paech, M., Storm, H., Hacking, R. & Schug, S., 2006, In : British Journal of Anaesthesia. 97, 6, p. 817-821

Research output: Contribution to journalArticle

Propofol
Anesthesia
Skin
Blood Pressure
Arousal
Pseudocholinesterase
Catecholamines
Chronic Pain
Epinephrine
Anxiety
2005
103 Citations (Scopus)

Heart rate variability predicts severe hypotension after spinal anesthesia for elective cesarean delivery

Hanss, R., Bein, B., Ledowski, T., Lehmkuhl, M., Ohnesorge, H., Scherkl, W., Steinfath, M., Scholz, J. & Tonner, P. H., 2005, In : Anesthesiology. 102, 6, p. 1086-93

Research output: Contribution to journalArticle

Spinal Anesthesia
Hypotension
Heart Rate
Blood Pressure
Vasodilation
108 Citations (Scopus)

Neuroendocrine stress response and heart rate variability: a comparison of total intravenous versus balance anesthesia

Ledowski, T., Bein, B., Hanss, R., Paris, A., Fudickar, W., Scholz, J. & Tonner, P. H., 1 Jan 2005, In : Anesthesia and Analgesia. 101, 6, p. 1700-1705 6 p.

Research output: Contribution to journalArticle

Balanced Anesthesia
Anesthesia
Heart Rate
Airway Extubation
Propofol
14 Citations (Scopus)

Pseudocholinesterase activity increases and heart rate variability decreases with preoperative anxiety

Ledowski, T., Bein, B., Hanss, R., Tonner, P. H., Roller, N. & Scholz, J., 2005, In : European Journal of Anaesthesiology. 22, 5, p. 289-292

Research output: Contribution to journalArticle

Pseudocholinesterase
Anxiety
Heart Rate
Cholinesterases
Visual Analog Scale