Simon Brown

Professor, BMedSc MB BS Tas., PhD Flin., DA (UK), FACEM

  • The University of Western Australia (M516), 35 Stirling Highway,

    6009 Perth

    Australia

  • 4650 Citations
  • 32 h-Index
20012020
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Research Output 2001 2018

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Article
2018
1 Citation (Scopus)
Open Access
Neutrophil Activation
Anaphylaxis
Innate Immunity
Myeloid Cells
Toll-Like Receptor 4
2017
8 Citations (Scopus)

Australian taipan (Oxyuranus spp.) envenoming: clinical effects and potential benefits of early antivenom therapy–Australian Snakebite Project (ASP-25)

Johnston, C. I., Ryan, N. M., O’Leary, M. A., Brown, S. G. A. & Isbister, G. K., 7 Feb 2017, In : Clinical Toxicology. 55, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

Antivenins
Snake Bites
Venoms
Acute Kidney Injury
Snakes
1 Citation (Scopus)
39 Downloads (Pure)
Transient Ischemic Attack
Granzymes
Stroke
Matrix Metalloproteinase 9
Neutrophils
2 Citations (Scopus)

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2016: the Influenza Complications Alert Network (FluCAN)

Cheng, A. C., Holmes, M., Dwyer, D. E., Irving, L. B., Korman, T., Senanayake, S., Macartney, K., Blyth, C. C., Brown, S., Waterer, G. W., Cooley, L., Friedman, N. D., Wark, P., Simpson, G., Upham, J., Bowler, S., Brady, S., Kotsimbos, T. & Kelly, P. M., Dec 2017, In : Communicable Diseases Intelligence. 41, 4, p. E337-E347 11 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
99 Downloads (Pure)

Neutrophil activation during acute human anaphylaxis: Analysis of MPO and sCD62L

Francis, A., Bosio, E., Stone, S. F., Fatovich, D. M., Arendts, G., Nagree, Y., Macdonald, S. P. J., Mitenko, H., Rajee, M., Burrows, S. & Brown, S. G. A., 13 Jan 2017, In : Clinical and Experimental Allergy. n/a, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Neutrophil Activation
Anaphylaxis
Tryptases
Histamine
Peroxidase
10 Citations (Scopus)
Resistin
Sepsis
Septic Shock
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
12 Citations (Scopus)

REstricted Fluid REsuscitation in Sepsis-associated Hypotension (REFRESH): Study protocol for a pilot randomised controlled trial

Macdonald, S. P. J., Taylor, D. M., Keijzers, G., Arendts, G., Fatovich, D. M., Kinnear, F. B., Brown, S. G. A., Bellomo, R., Burrows, S., Fraser, J. F., Litton, E., Ascencio-Lane, J. C., Anstey, M., McCutcheon, D., Smart, L., Vlad, I., Winearls, J. & Wibrow, B., 29 Aug 2017, In : Trials. 18, 1, 399.

Research output: Contribution to journalArticle

Open Access
Resuscitation
Hypotension
Sepsis
Randomized Controlled Trials
Biomarkers
2 Citations (Scopus)
17 Downloads (Pure)
Open Access
File
Tryptases
Anaphylaxis
Hospital Emergency Service
Shock
Sensitivity and Specificity
10 Citations (Scopus)

The Australian Snakebite Project, 2005-2015 (ASP-20)

Johnston, C. I., Ryan, N. M., Page, C. B., Buckley, N. A., Brown, S. G. A., O'Leary, M. A. & Isbister, G. K., 7 Aug 2017, In : Medical Journal of Australia. 207, 3, p. 119-125 7 p.

Research output: Contribution to journalArticle

2016
1 Citation (Scopus)

A randomized-controlled trial of a patient-centred intervention in high-risk discharged older patients

Arendts, G., Bullow, K., Etherton-Beer, C., MacDonald, E., Dumas, S., Nagree, Y., Brown, S. G. A. & Almeida, O. P., 23 Dec 2016, In : European Journal of Emergency Medicine. 00, p. 1-5 5 p.

Research output: Contribution to journalArticle

Hospital Emergency Service
Randomized Controlled Trials
Institutionalization
Nomograms
Risk Reduction Behavior
1 Citation (Scopus)

Changes in differential gene expression during a fatal stroke

Stone, S., Armstrong, C., van Eeden, P., Arendts, G., Hankey, G. J., Brown, S. & Fatovich, D., Jan 2016, In : Journal of Clinical Neuroscience. 23, p. 130-134 5 p.

Research output: Contribution to journalArticle

Stroke
Gene Expression
Hospital Emergency Service
Monozygotic Twins
Messenger RNA
8 Citations (Scopus)

Incidence of serum sickness after the administration of Australian snake antivenom (ASP-22)

Ryan, N. M., Kearney, R. T., Brown, S. & Isbister, G. K., Jan 2016, In : Clinical Toxicology. 54, 1, p. 27-33 8 p.

Research output: Contribution to journalArticle

Serum Sickness
Antivenins
Snakes
Incidence
Headache
7 Citations (Scopus)

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2015: the Influenza Complications Alert Network

Cheng, A. C., Holmes, M., Dwyer, D. E., Irving, L. B., Korman, T. M., Senenayake, S., Macartney, K. K., Blyth, C. C., Brown, S., Waterer, G., Hewer, R., Friedman, N. D., Wark, P. A. B., Simpson, G., Upham, J., Bowler, S. D., Lessing, A., Kotsimbos, T. & Kelly, P. M., 24 Dec 2016, In : Communicable Diseases Intelligence Quarterly Report. 40, 4, p. E521-E526

Research output: Contribution to journalArticle

Human Influenza
Epidemiology
cyhalothrin
Immunization Programs
Nucleic Acids
15 Citations (Scopus)

Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement

Kowalski, M. L. L., Ansotegui, I., Aberer, W., Al-Ahmad, M., Akdis, M., Ballmer-Weber, B. K. K., Beyer, K., Blanca, M., Brown, S., Bunnag, C., Capriles Hulett, A., Castells, M., Chng, H. H. H., De Blay, F., Ebisawa, M., Fineman, S., Golden, D. B. K. B. K., Haahtela, T., Kaliner, M., Katelaris, C. & 29 othersLee, B. W. W., Makowska, J., Muller, U., Mullol, J., Oppenheimer, J., Park, H-S. S., Parkerson, J., Passalacqua, G., Pawankar, R., Renz, H., Rueff, F., Sanchez-Borges, M., Sastre, J., Scadding, G., Sicherer, S., Tantilipikorn, P., Tracy, J., van Kempen, V., Bohle, B., Canonica, G. W. W., Carabello, L., Gomez, M., Ito, K., Jensen-Jarolim, E., Larche, M., Melioli, G., Poulsen, L. K. K., Valenta, R. & Zuberbier, T., 2016, In : The World Allergy Organization Journal. 9, 1, p. 1-42 42 p.

Research output: Contribution to journalArticle

Hypersensitivity
Safety
Therapeutics
Equipment Safety
Immunologic Desensitization
2015
151 Citations (Scopus)

2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Simons, F. E. R., Ebisawa, M., Sanchez-Borges, M., Thong, B. Y., Worm, M., Tanno, L. K., Lockey, R. F., El-Gamal, Y. M., Brown, S., Park, H. S. & Sheikh, A., 2015, In : World Allergy Organization Journal. 8, 1, p. 1-16

Research output: Contribution to journalArticle

Open Access
Anaphylaxis
Guidelines
Immunomodulation
Publications
Hypersensitivity
8 Citations (Scopus)

Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014

Cheng, A. C., Kotsimbos, T., Kelly, P. M., Wark, P., Hunter, C., Hewagama, S., Friedman, N. D., Korman, T. M., Simpson, G., Upham, J. W., Bowler, S., Senenayake, S. J., Holmes, M., Irving, L., Brown, S., Waterer, G., Dwyer, D. E., Macartney, K. & Blyth, C., 2015, In : Vaccine. 33, 51, p. 7352-7356

Research output: Contribution to journalArticle

Influenza Vaccines
influenza
Human Influenza
Hospitalization
vaccines
8 Citations (Scopus)

Intracranial haemorrhages associated with venom induced consumption coagulopathy in Australian snakebites (ASP-21)

Berling, I., Brown, S., Miteff, F., Levi, C. & Isbister, G. K., Aug 2015, In : Toxicon. 102, p. 8-13

Research output: Contribution to journalArticle

Snake Bites
Intracranial Hemorrhages
Disseminated Intravascular Coagulation
Venoms
Snakes
16 Citations (Scopus)

Pilosulins: A review of the structure and mode of action of venom peptides from an Australian ant Myrmecia pilosula

Wanandy, T., Gueven, N., Davies, N. W., Brown, S. & Wiese, M. D., 2015, In : Toxicon. 98, p. 54-61

Research output: Contribution to journalArticle

9 Citations (Scopus)

Use of a risk nomogram to predict emergency department reattendance in older people after discharge: a validation study

Arendts, G., Etherton-Beer, C., Jones, R., Bullow, K., Macdonald, E., Dumas, S., Parker, D., Hutton, M., Burrows, S., Brown, S. & Almeida, O., 2015, In : INTERNAL AND EMERGENCY MEDICINE. 10, 4, p. 481-487

Research output: Contribution to journalArticle

Nomograms
Validation Studies
Hospital Emergency Service
Independent Living
ROC Curve
2014
4 Citations (Scopus)

Ant venom immunotherapy in Australia: The unmet need

Mullins, R. J. & Brown, S., 2014, In : Medical Journal of Australia. 201, 1, p. 33-34

Research output: Contribution to journalArticle

Ant Venoms
Immunotherapy
Venoms
Anaphylaxis
Hypersensitivity
3 Citations (Scopus)
105 Downloads (Pure)

Clinical research is a priority for emergency medicine but how do we make it happen, and do it well?

Brown, S. G. A. & Isbister, G. K., Feb 2014, In : Emergency Medicine Australasia. 26, 1, p. 14-18 5 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
Open Access
Septic Shock
Hospital Emergency Service
Sepsis
Mortality
Organ Dysfunction Scores
9 Citations (Scopus)

Genomic Responses during Acute Human Anaphylaxis Are Characterized by Upregulation of Innate Inflammatory Gene Networks

Stone, S., Bosco, A., Jones, A., Cotterell, C., Van Eeden, P., Arendts, G., Fatovich, D. & Brown, S., 1 Jul 2014, In : PLoS One. 9, 7, 10 p., e101409.

Research output: Contribution to journalArticle

Open Access
anaphylaxis
Gene Regulatory Networks
Anaphylaxis
Up-Regulation
Genes
14 Citations (Scopus)

Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network

Cheng, A. C., Dwyer, DE., Holmes, M., Irving, L. B., Brown, S., Waterer, G., Korman, T. M., Hunter, C., Hewagama, S., Friedman, N. D., Wark, P. A., Simpson, G., Upham, J. W., Bowler, S. D., Senenayake, S. N., Kotsimbos, T. C. & Kelly, P. M., 2014, In : Communicable Diseases Intelligence Quarterly Report. 38, 2, p. E143-149

Research output: Contribution to journalArticle

11 Citations (Scopus)
19 Citations (Scopus)

Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: The second redback antivenom evaluation (RAVE-II) study

Isbister, G. K., Page, C. B., Buckley, N. A., Fatovich, D., Pascu, O., Macdonald, S., Calver, L. A. & Brown, S., Dec 2014, In : Annals of Emergency Medicine. 64, 6, p. 620-628

Research output: Contribution to journalArticle

Antivenins
Randomized Controlled Trials
Placebos
Pain
Analgesia
13 Citations (Scopus)

Spontaneous pneumothorax; a multicentre retrospective analysis of emergency treatment, complications and outcomes

Brown, S., Ball, E. L., Macdonald, S., Wright, C. A. & Mcd Taylor, D., May 2014, In : Internal Medicine Journal. 44, 5, p. 450-457

Research output: Contribution to journalArticle

Emergency Treatment
Pneumothorax
Drainage
Air
Hospital Emergency Service
30 Citations (Scopus)
Open Access
resistin
Resistin
Lipocalins
septic shock
Gelatinases
2013
115 Citations (Scopus)

Anaphylaxis: Clinical patterns, mediator release, and severity

Brown, S., Stone, S. F., Fatovich, D. M., Burrows, S. A., Holdgate, A., Celenza, A., Coulson, A., Hartnett, L., Nagree, Y., Cotterell, C. & Isbister, G. K., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1141-1149.e5

Research output: Contribution to journalArticle

Anaphylaxis
1-Alkyl-2-acetylglycerophosphocholine Esterase
Tryptases
Preexisting Condition Coverage
Tumor Necrosis Factor Receptors
24 Citations (Scopus)
464 Downloads (Pure)

A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18)

Isbister, G. K., Buckley, N. A., Page, C. B., Scorgie, F. E., Lincz, L. F., Seldon, M. & Brown, S., 15 Jul 2013, In : Journal of Thrombosis and Haemostasis. 11, 7, p. 1310-1318

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)

Immune Response to Snake Envenoming and Treatment with Antivenom; Complement Activation, Cytokine Production and Mast Cell Degranulation

Stone, S., Isbister, G. K., Shahmy, S., Mohamed, F., Abeysinghe, C., Karunathilake, H., Ariaratnam, A., Jacoby-Alner, T. E., Cotterell, C. & Brown, S., 25 Jul 2013, In : PLoS Neglected Tropical Diseases. 7, 7, 9 p.

Research output: Contribution to journalArticle

Open Access
Antivenins
Cell Degranulation
Snakes
Complement Activation
Mast Cells
12 Citations (Scopus)

Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2012: the Influenza Complications Alert Network (FluCAN )

Cheng, A. C., Brown, S., Waterer, G., Holmes, M., Senenayake, S., Friedman, N. D., Hewagama, S., Simpson, G., Wark, P. A., Upham, J. W., Korman, T. M., Dwyer, D. E., Wood-Baker, R., Irving, L., Bowler, S. D., Kotsimbos, T. & Kelly, P. M., 2013, In : Communicable Diseases Intelligence Quarterly Report. 37, 3, p. E246-E252

Research output: Contribution to journalArticle

29 Citations (Scopus)

Influenza Vaccine Effectiveness against Hospitalisation with Confirmed Influenza in the 2010-11 Seasons: A Test-negative Observational Study

Cheng, A. C., Holmes, M. D., Irving, L. B., Brown, S., Waterer, G., Korman, T. M., Friedman, N. D., Senanayake, S. N., Dwyer, D. E., Brady, S. J., Simpson, G., Wood-Baker, R. R., Upham, J. W., Paterson, D. L., Jenkins, C. R., Wark, P. A. B., Kelly, P. M. & Kotsimbos, T. C., 2013, In : PLoS One. 8, 7, p. e68760

Research output: Contribution to journalArticle

Open Access
Influenza Vaccines
observational studies
influenza
Human Influenza
Observational Studies
21 Citations (Scopus)

Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy – Australian Snakebite Project (ASP-19)

Johnston, C. I., Brown, S., O'Leary, M. A., Currie, B. J., Greenberg, R., Taylor, M., Barnes, C., White, J. & Isbister, G. K., 2013, In : Clinical Toxicology. 51, p. 417-424

Research output: Contribution to journalArticle

7 Citations (Scopus)
2012
10 Citations (Scopus)
44 Downloads (Pure)

Bites in Australian snake handlers - Australian snakebite project (ASP-15)

Isbister, G. K. & Brown, S., 1 Nov 2012, In : QJM: an international journal of medicine. 105, 11, p. 1089-1095

Research output: Contribution to journalArticle

Open Access
File
Snake Bites
Snakes
Bites and Stings
Antivenins
Venoms
47 Citations (Scopus)

Clinical Effects and Antivenom Dosing in Brown Snake (Pseudonaja spp.) Envenoming - Australian Snakebite Project (ASP-14)

Allen, G. E., Brown, S., Buckley, N. A., O'Leary, M. A., Page, C. B., Currie, B. J., White, J. & Isbister, G. K., 28 Dec 2012, In : PLoS One. 7, p. 9pp

Research output: Contribution to journalArticle

Open Access
antivenoms
snake bites
Antivenins
Snake Bites
Snakes
20 Citations (Scopus)
16 Citations (Scopus)

Death Adder Envenoming Causes Neurotoxicity Not Reversed by Antivenom - Australian Snakebite Project (ASP-16)

Johnston, C., O'Leary, M. A., Brown, S., Currie, B. J., Halkidis, L., Whitaker, R., Close, B. & Isbister, G. K., 27 Sep 2012, In : PLoS Neglected Tropical Diseases. 6, 9, p. 8pp

Research output: Contribution to journalArticle

Open Access
Antivenins
Snake Bites
Venoms
Bites and Stings
Intercostal Muscles
32 Citations (Scopus)

Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)

Isbister, G. K., O'Leary, M. A., Elliott, M. & Brown, S., 2012, In : Medical Journal of Australia. 197, p. 173-177

Research output: Contribution to journalArticle

30 Citations (Scopus)

Ultrarush versus semirush initiation of insect venom immunotherapy: A randomized controlled trial.

Brown, S., Wiese, M., Van Eeden, P., Stone, S., Chuter, C., Gunner, G., Wanandy, T., Phillips, M. & Heddle, R., 2012, In : Journal of Allergy and Clinical Immunology. 130, 1, p. 162-168

Research output: Contribution to journalArticle

19 Citations (Scopus)

Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study

Brown, S., Van Eeden, P., Wiese, M. D., Mullins, R. J., Solley, G. O., Puy, R., Taylor, R. W. & Heddle, R. J., 2011, In : Medical Journal of Australia. 195, p. 69-73

Research output: Contribution to journalArticle

13 Citations (Scopus)

Clinical effects and treatment of envenoming by Hoplocephalus spp. snakes in Australia: Australian Snakebite Project (ASP-12)

Isbister, G. K., White, J., Currie, B. J., O'Leary, M. A. & Brown, S., 2011, In : Toxicon. 58, p. 634-640

Research output: Contribution to journalArticle

25 Citations (Scopus)

FluCAN 2009: initial results from sentinel surveillance for adult influenza and pneumonia in eight Australian hospitals

Kelly, PM., Kotsimbos, T., Reynolds, A., Wood-Baker, R., Hancox, B., Brown, S., Holmes, M., Simpson, G., Bowler, S., Waterer, G., Irving, LB., Jenkins, C., Thompson, P. & Cheng, AC., 2011, In : Medical Journal of Australia. 194, p. 169-174

Research output: Contribution to journalArticle

8 Citations (Scopus)

Histopathological analysis and in situ localisation of Australian tiger snake venom in two clinically envenomed domestic animals

Jacoby-Alner, T. E., Stephens, N., Davern, K., Balmer, L., Brown, S. & Swindells, K., 2011, In : Toxicon. 58, p. 304-314

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stability of Myrmecia pilosula (Jack Jumper) Ant venom for use in immunotherapy

Wiese, M. D., Davies, N. W., Chataway, T. K., Milne, R. W., Brown, S. & Heddle, R. J., 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 54, p. 303-310

Research output: Contribution to journalArticle