Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Breast Cancer Association Consortium (BCAC), Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON), Colon Cancer Family Registry (CCFR), Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT), Endometrial Cancer Association Consortium (ECAC), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Melanoma Genetics Consortium (GenoMEL), Glioma International Case-Control Study (GICC), International Lung Cancer Consortium (ILCCO), Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium, International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph), Ovarian Cancer Association Consortium (OCAC), Oral Cancer GWAS, Pancreatic Cancer Case-Control Consortium (PanC4), Pancreatic Cancer Cohort Consortium (PanScan), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), Renal Cancer GWAS, Testicular Cancer Consortium (TECAC), Zhang, Y. D., Hurson, A. N. & 197 others, Zhang, H., Choudhury, P. P., Easton, D. F., Milne, R. L., Simard, J., Hall, P., Michailidou, K., Dennis, J., Schmidt, M. K., Chang-Claude, J., Gharahkhani, P., Whiteman, D., Campbell, P. T., Hoffmeister, M., Jenkins, M., Peters, U., Hsu, L., Gruber, S. B., Casey, G., Schmit, S. L., O’Mara, T. A., Spurdle, A. B., Thompson, D. J., Tomlinson, I., De Vivo, I., Landi, M. T., Law, M. H., Iles, M. M., Demenais, F., Kumar, R., MacGregor, S., Bishop, D. T., Ward, S. V., Bondy, M. L., Houlston, R., Wiencke, J. K., Melin, B., Barnholtz-Sloan, J., Kinnersley, B., Wrensch, M. R., Amos, C. I., Hung, R. J., Brennan, P., McKay, J., Caporaso, N. E., Berndt, S. I., Birmann, B. M., Camp, N. J., Kraft, P., Rothman, N., Slager, S. L., Berchuck, A., Pharoah, P. D. P., Sellers, T. A., Gayther, S. A., Pearce, C. L., Goode, E. L., Schildkraut, J. M., Moysich, K. B., Amundadottir, L. T., Jacobs, E. J., Klein, A. P., Petersen, G. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Wolpin, B. M., Li, D., Eeles, R. A., Haiman, C. A., Kote-Jarai, Z., Schumacher, F. R., Al Olama, A. A., Purdue, M. P., Scelo, G., Dalgaard, M. D., Greene, M. H., Grotmol, T., Kanetsky, P. A., McGlynn, K. A., Nathanson, K. L., Turnbull, C., Wiklund, F., Easton, D. F., Milne, R. L., Simard, J., Hall, P., Michailidou, K., Dennis, J., Schmidt, M. K., Chang-Claude, J., Gharahkhani, P., Whiteman, D., Campbell, P. T., Hoffmeister, M., Jenkins, M., Peters, U., Hsu, L., Gruber, S. B., Casey, G., Schmit, S. L., Campbell, P. T., Hoffmeister, M., Jenkins, M., Peters, U., Hsu, L., Gruber, S. B., Casey, G., Schmit, S. L., O’Mara, T. A., Spurdle, A. B., Thompson, D. J., Tomlinson, I., De Vivo, I., Campbell, P. T., Hoffmeister, M., Jenkins, M., Peters, U., Hsu, L., Gruber, S. B., Casey, G., Schmit, S. L., Landi, M. T., Law, M. H., Iles, M. M., Demenais, F., Kumar, R., MacGregor, S., Bishop, D. T., Ward, S. V., Bondy, M. L., Houlston, R., Wiencke, J. K., Melin, B., Barnholtz-Sloan, J., Kinnersley, B., Wrensch, M. R., Amos, C. I., Hung, R. J., Brennan, P., McKay, J., Caporaso, N. E., Amos, C. I., Hung, R. J., Brennan, P., McKay, J., Caporaso, N. E., Berndt, S. I., Birmann, B. M., Camp, N. J., Kraft, P., Rothman, N., Slager, S. L., Berchuck, A., Pharoah, P. D. P., Sellers, T. A., Gayther, S. A., Pearce, C. L., Goode, E. L., Schildkraut, J. M., Moysich, K. B., Amos, C. I., Brennan, P., McKay, J., Amundadottir, L. T., Jacobs, E. J., Klein, A. P., Petersen, G. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Wolpin, B. M., Li, D., Amundadottir, L. T., Jacobs, E. J., Klein, A. P., Petersen, G. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Wolpin, B. M., Li, D., Eeles, R. A., Haiman, C. A., Kote-Jarai, Z., Schumacher, F. R., Al Olama, A. A., Purdue, M. P., Scelo, G., Dalgaard, M. D., Greene, M. H., Grotmol, T., Kanetsky, P. A., McGlynn, K. A., Nathanson, K. L., Turnbull, C., Wiklund, F., Chanock, S. J., Chatterjee, N. & Garcia-Closas, M., 1 Dec 2020, In : Nature Communications. 11, 1, 3353.

Research output: Contribution to journal › Article

Association of IRF4 single-nucleotide polymorphism rs12203592 with melanoma-specific survival

Ward, S. V., Gibbs, D. C., Orlow, I., Thomas, N. E., Kanetsky, P. A., Luo, L., Cust, A. E., Anton-Culver, H., Gruber, S. B., Gallagher, R. P., Rosso, S., Zanetti, R., Dwyer, T., Begg, C. B. & Berwick, M., 1 Jul 2020, In : British Journal of Dermatology. 183, 1, p. 163-165 3 p.

Research output: Contribution to journal › Letter

Association of known melanoma risk factors with primary melanoma of the scalp and neck

Wood, R., Heyworth, J., McCarthy, N., Mauguen, A., Berwick, M., Thomas, N. E., Millward, M., Anton-Culver, H., Cust, A. E., Dwyer, T., Gallagher, R. P., Gruber, S. B., Kanetsky, P. A., Orlow, I., Rosso, S., Moses, E. K., Begg, C. B. & Ward, S., 1 Nov 2020, In : Cancer Epidemiology, Biomarkers & Prevention. 29, 11, p. 2203-2210

Research output: Contribution to journal › Article

Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

GenoMEL Consortium, Q-MEGA Investigator, QTWIN Investigator, ATHENS Melanoma Study Grp, 23andMe, SDH Study Grp, IBD Investigators, Essen-Heidelberg Investigators, AMFS Investigators, MelaNostrum Consortium, Landi, M. T., Bishop, D. T., MacGregor, S., Machiela, M. J., Stratigos, A. J., Ghiorzo, P., Brossard, M., Calista, D., Choi, J., Fargnoli, M. C. & 142 others, Zhang, T., Rodolfo, M., Trower, A. J., Menin, C., Martinez, J., Hadjisavvas, A., Song, L., Stefanaki, I., Scolyer, R., Yang, R., Goldstein, A. M., Potrony, M., Kypreou, K. P., Pastorino, L., Queirolo, P., Pellegrini, C., Cattaneo, L., Zawistowski, M., Gimenez-Xavier, P., Rodriguez, A., Elefanti, L., Manoukian, S., Rivoltini, L., Smith, B. H., Loizidou, M. A., Del Regno, L., Massi, D., Mandala, M., Khosrotehrani, K., Akslen, L. A., Amos, C., Andresen, P. A., Avril, M-F., Azizi, E., Soyer, H. P., Bataille, V., Dalmasso, B., Bowdler, L. M., Burdon, K. P., Chen, W., Codd, V., Craig, J. E., Debniak, T., Falchi, M., Fang, S., Friedman, E., Simi, S., Galan, P., Garcia-Casado, Z., Gillanders, E. M., Gordon, S., Green, A., Gruis, N. A., Hansson, J., Harland, M., Harris, J., Helsing, P., Henders, A., Hocevar, M., Hoiom, V., Hunter, D., Ingvar, C., Kumar, R., Lang, J., Lathrop, G. M., Lee, J. E., Li, X., Lubinski, J., Mackie, R. M., Malt, M., Malvehy, J., McAloney, K., Mohamdi, H., Molven, A., Moses, E. K., Neale, R. E., Novakovic, S., Nyholt, D. R., Olsson, H., Orr, N., Fritsche, L. G., Anton Puig-Butille, J., Qureshi, A. A., Radford-Smith, G. L., Randerson-Moor, J., Requena, C., Rowe, C., Samani, N. J., Sanna, M., Schadendorf, D., Schulze, H-J., Simms, L. A., Smithers, M., Song, F., Swerdlow, A. J., van der Stoep, N., Kukutsch, N. A., Visconti, A., Wallace, L., Ward, S., Wheeler, L., Sturm, R. A., Hutchinson, A., Jones, K., Malasky, M., Vogt, A., Zhou, W., Pooley, K. A., Elder, D. E., Han, J., Hicks, B., Hayward, N. K., Kanetsky, P. A., Brummett, C., Montgomery, G. W., Olsen, C. M., Hayward, C., Dunning, A. M., Martin, N. G., Evangelou, E., Mann, G. J., Long, G., Pharoah, P. D. P., Easton, D. F., Barrett, J. H., Cust, A. E., Abecasis, G., Duffy, D. L., Whiteman, D. C., Gogas, H., De Nicolo, A., Tucker, M. A., Newton-Bishop, J. A., Peris, K., Chanock, S. J., Demenais, F., Brown, K. M., Puig, S., Nagore, E., Shi, J., Iles, M. M. & Law, M. H., May 2020, In : Nature Genetics. 52, 5, p. 494-504

Research output: Contribution to journal › Article

Germline variants are associated with increased primary melanoma tumor thickness at diagnosis

Mangantig, E., MacGregor, S., Iles, M. M., Scolyer, R. A., Cust, A. E., Hayward, N. K., Montgomery, G. W., Duffy, D. L., Thompson, J. F., Henders, A., Bowdler, L., Rowe, C., Cadby, G., Mann, G. J., Whiteman, D. C., Long, G. V., Ward, S. V., Khosrotehrani, K., Barrett, J. H. & Law, M. H., 1 Nov 2020, In : Human Molecular Genetics. 29, 21, p. 3578-3587 10 p.

Research output: Contribution to journal › Article