• The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • The University of Western Australia (M316), 35 Stirling Highway,

    6009 Perth

    Australia

  • 13579 Citations
  • 36 h-Index
20012024
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Personal profile

Previous positions

2009-2011: California Institute for Regenerative Medicine Postdoctoral Trainee (Joseph Ecker), The Salk Institute for Biological Studies, La Jolla, CA, USA.

2006-2009: Human Frontier Science Project Postdoctoral Fellow (Joseph Ecker), The Salk Institute for Biological Studies, La Jolla, CA, USA.

2005-2006: Postdoctoral Fellow (James Whelan), Department of Biochemistry and Molecular Biology, The University of Western Australia, Perth, Australia.

2001-2005: Ph.D. (James Whelan), Department of Biochemistry and Molecular Biology, The University of Western Australia, Perth, Australia.

Research

Exploring the Epigenome

Just as the fixed notes of a musical instrument can be played in different combinations, orders and strengths to create unique songs, different cells in a complex multicellular organism can produce their distinctive form and function by each expressing particular combinations of genes from the genome. By modulating accessibility to the information encoded in the genome, epigenetic modifications can affect gene activation and repression to execute distinct transcriptional programs and impart a heritable state of transcriptional activity. In essence, the epigenome is a regulatory code that is superimposed upon the genome that can modify the cellular readout of the underlying information encoded in the DNA sequence. Developing a comprehensive understanding of how the cell utilizes epigenetic modifications is essential in order to both understand the critical roles it plays in eukaryotic development and stress response, and to develop effective strategies to remedy its disruption in disease states.

We use advanced DNA sequencing, molecular, genetic and computational techniques in a diverse range of complex multicellular organisms, including plants, humans, mice, and social insects, to study the epigenome and epigenetic mechanisms at the molecular scale. Recent advances in DNA sequencing technology now enable us to rapidly identify precisely where epigenetic modifications, such as DNA methylation and histone modifications, occur throughout entire plant and animal genomes1-3. The research in my laboratory aims to understand how the information encoded in the DNA of plant and animal genomes is controlled by epigenetic mechanisms during development, how the epigenome may be altered by the surrounding environment, and to develop molecular tools to reprogram it.

Keywords

  • Epigenetics
  • Epigenomics
  • DNA methylation
  • Genomics (plant, animal)
  • Stem cells
  • Induced pluripotent stem cells

Fingerprint Dive into the research topics where Ryan Lister is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
DNA Methylation Medicine & Life Sciences
Arabidopsis Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Genome Medicine & Life Sciences
Mitochondrial Proteins Medicine & Life Sciences
Genes Medicine & Life Sciences
Cytosine Medicine & Life Sciences
Methylation Medicine & Life Sciences

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Research Output 2001 2019

150 Downloads (Pure)
Open Access
File
Retroelements
Arthropods
Spiders
Genome
DNA Methylation

Convergent evolution of a vertebrate-like methylome in a marine sponge

de Mendoza, A., Hatleberg, W. L., Pang, K., Leininger, S., Bogdanovic, O., Pflueger, J., Buckberry, S., Technau, U., Hejnol, A., Adamska, M., Degnan, B. M., Degnan, S. M. & Lister, R., Oct 2019, In : Nature Ecology and Evolution. 3, 10, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

convergent evolution
Porifera
sponge
vertebrate
genome
1 Citation (Scopus)

HOME: A histogram based machine learning approach for effective identification of differentially methylated regions

Srivastava, A., Karpievitch, Y. V., Eichten, S. R., Borevitz, J. O. & Lister, R., 16 May 2019, In : BMC Bioinformatics. 20, 1, 253.

Research output: Contribution to journalArticle

Open Access
Methylation
Histogram
Learning systems
Identification (control systems)
Machine Learning
1 Citation (Scopus)

LINE-1 evasion of epigenetic repression in humans

Sanchez-Luque, F. J., Kempen, M-J. H. C., Gerdes, P., Vargas-Landin, D. B., Richardson, S. R., Troskie, R-L., Jesuadian, J. S., Cheetham, S. W., Carreira, P. E., Salvador-Palomeque, C., García-Cañadas, M., Muñoz-Lopez, M., Sanchez, L., Lundberg, M., Macia, A., Heras, S. R., Brennan, P. M., Lister, R., Garcia-Perez, J. L., Ewing, A. D. & 1 othersFaulkner, G. J., 8 Aug 2019, In : Molecular Cell. 75, 3, p. 590-604 e12.

Research output: Contribution to journalArticle

Epigenetic Repression
Yin-Yang
Binding Sites
Mosaicism
Brain
2 Citations (Scopus)

Retention of paternal DNA methylome in the developing zebrafish germline

Skvortsova, K., Tarbashevich, K., Stehling, M., Lister, R., Irimia, M., Raz, E. & Bogdanovic, O., 11 Jul 2019, In : Nature Communications. 10, 1, 3054.

Research output: Contribution to journalArticle

Open Access
Zebrafish
DNA Methylation
methylation
deoxyribonucleic acid
DNA

Datasets

Data from: Stress induced gene expression drives transient DNA methylation changes at adjacent repetitive elements

Secco, D. (Creator), Wang, C. (Creator), Shou, H. (Creator), Schultz, M. D. (Creator), Chiarenza, S. (Creator), Nussaume, L. (Creator), Ecker, J. R. (Creator), Whelan, J. (Creator), Lister, R. (Creator), Dryad Digital Repository, 6 Aug 2015

Dataset

GSM1977638: xl_st10.5_MethylC-seq

Bogdanovic, O. (Creator), Lister, R. (Creator), Gene Expression Omnibus (NCBI), 26 Aug 2016

Dataset

Projects 2013 2024