• The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • The University of Western Australia (M316), 35 Stirling Highway,

    6009 Perth

    Australia

  • 15070 Citations
  • 38 h-Index
20012020

Research output per year

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Personal profile

Previous positions

2009-2011: California Institute for Regenerative Medicine Postdoctoral Trainee (Joseph Ecker), The Salk Institute for Biological Studies, La Jolla, CA, USA.

2006-2009: Human Frontier Science Project Postdoctoral Fellow (Joseph Ecker), The Salk Institute for Biological Studies, La Jolla, CA, USA.

2005-2006: Postdoctoral Fellow (James Whelan), Department of Biochemistry and Molecular Biology, The University of Western Australia, Perth, Australia.

2001-2005: Ph.D. (James Whelan), Department of Biochemistry and Molecular Biology, The University of Western Australia, Perth, Australia.

Research

Exploring the Epigenome

Just as the fixed notes of a musical instrument can be played in different combinations, orders and strengths to create unique songs, different cells in a complex multicellular organism can produce their distinctive form and function by each expressing particular combinations of genes from the genome. By modulating accessibility to the information encoded in the genome, epigenetic modifications can affect gene activation and repression to execute distinct transcriptional programs and impart a heritable state of transcriptional activity. In essence, the epigenome is a regulatory code that is superimposed upon the genome that can modify the cellular readout of the underlying information encoded in the DNA sequence. Developing a comprehensive understanding of how the cell utilizes epigenetic modifications is essential in order to both understand the critical roles it plays in eukaryotic development and stress response, and to develop effective strategies to remedy its disruption in disease states.

We use advanced DNA sequencing, molecular, genetic and computational techniques in a diverse range of complex multicellular organisms, including plants, humans, mice, and social insects, to study the epigenome and epigenetic mechanisms at the molecular scale. Recent advances in DNA sequencing technology now enable us to rapidly identify precisely where epigenetic modifications, such as DNA methylation and histone modifications, occur throughout entire plant and animal genomes1-3. The research in my laboratory aims to understand how the information encoded in the DNA of plant and animal genomes is controlled by epigenetic mechanisms during development, how the epigenome may be altered by the surrounding environment, and to develop molecular tools to reprogram it.

Research expertise keywords

  • Epigenetics
  • Epigenomics
  • DNA methylation
  • Genomics (plant, animal)
  • Stem cells
  • Induced pluripotent stem cells

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Research Output

Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

Martin, S., Poppe, D., Olova, N., O'Leary, C., Ivanova, E., Pflueger, J., Dechka, J., Simmons, R. K., Cooper, H. M., Reik, W., Lister, R. & Wolvetang, E., 9 Jan 2020, bioRxiv, 2020, 01.08 61 p.

Research output: Contribution to specialist publicationArticle

Open Access
  • Evolution of DNA methylome diversity in eukaryotes

    de Mendoza, A., Lister, R. & Bogdanovic, O., 13 Mar 2020, In : Journal of Molecular Biology. 432, 6, p. 1687-1705

    Research output: Contribution to journalReview article

  • 3 Citations (Scopus)

    Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings

    Almudi, I., Vizueta, J., Wyatt, C. D. R., de Mendoza, A., Marlétaz, F., Firbas, P. N., Feuda, R., Masiero, G., Medina, P., Alcaina-Caro, A., Cruz, F., Gómez-Garrido, J., Gut, M., Alioto, T. S., Vargas-Chavez, C., Davie, K., Misof, B., González, J., Aerts, S., Lister, R. & 6 others, Paps, J., Rozas, J., Sánchez-Gracia, A., Irimia, M., Maeso, I. & Casares, F., 26 May 2020, In : Nature Communications. 11, 1, 2631.

    Research output: Contribution to journalArticle

    Open Access
  • Mitochondrial CLPP2 assists coordination and homeostasis of respiratory complexes

    Petereit, J., Duncan, O., Murcha, M. W., Fenske, R., Cincu, E., Cahn, J., Pruzinska, A., Ivanova, A., Kollipara, L., Wortelkamp, S., Sickmann, A., Lee, J., Lister, R., Millar, A. H. & Huang, S., 22 Jun 2020, In : Plant Physiology.

    Research output: Contribution to journalArticle

  • Open Access
  • Datasets

    Data from: Stress induced gene expression drives transient DNA methylation changes at adjacent repetitive elements

    Secco, D. (Creator), Wang, C. (Creator), Shou, H. (Creator), Schultz, M. D. (Creator), Chiarenza, S. (Creator), Nussaume, L. (Creator), Ecker, J. R. (Creator), Whelan, J. M. (Creator) & Lister, R. (Creator), Dryad Digital Repository, 6 Aug 2015

    Dataset

    GSM1977638: xl_st10.5_MethylC-seq

    Bogdanovic, O. (Creator) & Lister, R. (Creator), Gene Expression Omnibus (NCBI), 26 Aug 2016

    Dataset

    Projects