• The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 3199 Citations
  • 25 h-Index
20012021
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Research Output 2001 2019

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Article
2019
1 Citation (Scopus)

Immune-mediated ECM depletion improves tumour perfusion and payload delivery

Yeow, Y. L., Kotamraju, V. R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T. D., Delaney, D. S., Feindel, K., Li, J., Kennedy, K. M., Allen, W. M., Kennedy, B. F., Larma, I., Sampson, D. D., Mahakian, L. M., Fite, B. Z., Zhang, H., Friman, T., Mann, A. P. & 11 othersAziz, F. A., Kumarasinghe, M. P., Johansson, M., Ee, H. C., Yeoh, G., Mou, L., Ferrara, K. W., Billiran, H., Ganss, R., Ruoslahti, E. & Hamzah, J., 11 Nov 2019, In : EMBO Molecular Medicine. e10923.

Research output: Contribution to journalArticle

Open Access
Extracellular Matrix
Perfusion
Neoplasms
Tumor Necrosis Factor-alpha
Peptides
2018
11 Citations (Scopus)
326 Downloads (Pure)

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

He, B., Jabouille, A., Steri, V., Johansson-Percival, A., Michael, I. P., Kotamraju, V. R., Junckerstorff, R., Nowak, A. K., Hamzah, J., Lee, G., Bergers, G. & Ganss, R., 1 Jun 2018, In : Journal of Pathology. 245, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

Open Access
File
Venules
Brain Neoplasms
Blood Vessels
Glioblastoma
Light
2017
38 Citations (Scopus)

De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

Johansson-Percival, A., He, B., Li, Z. J., Kjellén, A., Russell, K., Li, J., Larma, I. & Ganss, R., 18 Oct 2017, In : Nature Immunology. 18, 11, p. 1207-1217 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Blood Vessels
Neoplasms
T-Lymphocytes
Light
15 Citations (Scopus)

Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell–mediated immunotherapy

Zhao, Y., Ting, K. K., Li, J., Cogger, V. C., Chen, J., Johansson-Percival, A., Ngiow, S. F., Holst, J., Grau, G., Goel, S., Muller, T., Dejana, E., McCaughan, G., Smyth, M. J., Ganss, R., Vadas, M. A. & Gamble, J. R., 15 Aug 2017, In : Cancer Research. 77, 16, p. 4434-4447 14 p.

Research output: Contribution to journalArticle

Vascular Tissue Neoplasms
Immunotherapy
Neoplasms
T-Lymphocytes
cadherin 5
7 Citations (Scopus)

Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta

Wijesinghe, P., Johansen, N. J., Curatolo, A., Sampson, D. D., Ganss, R. & Kennedy, B. F., 5 Dec 2017, In : Biophysical Journal. 113, 11, p. 2540-2551 12 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Aorta
Elastic Modulus
Mechanics
Vascular Smooth Muscle
7 Citations (Scopus)

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: Towards in vivo imaging of cellular-scale mechanics

Fang, Q., Curatolo, A., Wijesinghe, P., Yeow, Y. L., Hamzah, J., Noble, P. B., Karnowski, K., Sampson, D. D., Ganss, R., Kim, J. K., Lee, W. M. & Kennedy, B. F., 1 Nov 2017, In : Biomedical Optics Express. 8, 11, p. 5127-5138 12 p., 304351.

Research output: Contribution to journalArticle

Open Access
Elasticity Imaging Techniques
endoscopes
Endoscopes
Mechanics
Biological Phenomena
2016
15 Citations (Scopus)
2015
31 Citations (Scopus)

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

Johansson-Percival, A., Li, J., Lakhiani, D., He, B., Wang, J., Hamzah, J. & Ganss, R., 29 Dec 2015, In : Cell Reports. 13, 12, p. 2687-2698

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
GTP-Binding Protein Regulators
G-Protein-Coupled Receptors
Blood Vessels
Pathology
Vascular Smooth Muscle
33 Citations (Scopus)

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

Elsegood, C., Chan, D., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J. K. & Yeoh, G., 29 Sep 2015, In : Hepatology. 62, 4, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Liver Regeneration
Kupffer Cells
Cell Communication
Monocytes
Stem Cells
22 Citations (Scopus)
255 Downloads (Pure)

Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia

Holobotovskyy, V., Chong, Y. S., Burchell, J., He, B., Phillips, M., Leader, L., Murphy, T. V., Sandow, S. L., Mckitrick, D., Charles, A., Tare, M., Arnolda, L. F. & Ganss, R., 3 Jun 2015, In : Science Translational Medicine. 7, 290, p. 1-11

Research output: Contribution to journalArticle

Open Access
File
GTP-Binding Protein Regulators
Pregnancy Induced Hypertension
Pre-Eclampsia
Angiotensin II
Blood Vessels
2013
34 Citations (Scopus)
252 Downloads (Pure)

Regulator of G-Protein Signaling 5 Controls Blood Pressure Homeostasis and Vessel Wall Remodeling

Holobotovskyy, V., Manzur, M., Tare, M., Burchell, J., Bolitho, E., Viola, H., Hool, L., Arnolda, L., McKitrick, D. & Ganss, R., 2013, In : Circulation Research. 112, 5, p. 781-791

Research output: Contribution to journalArticle

Open Access
File
2012
7 Citations (Scopus)

Intratumoral TNFα improves immunotherapy

Johansson, A., Hamzah, J. & Ganss, R., 2012, In : OncoImmunology. 1, p. 1395-1397

Research output: Contribution to journalArticle

24 Citations (Scopus)

Matrigel Basement Membrane Matrix influences expression of microRNAs in cancer cell lines

Price, K., Tsykin, A., Giles, K., Sladic, R. T., Epis, M., Ganss, R., Goodall, G. J. & Leedman, P., 2012, In : Biochemical and Biophysical Research Communications. 427, p. 343-348

Research output: Contribution to journalArticle

93 Citations (Scopus)

Tumor-targeted TNFα stabilizes tumor vessels and enhances active immunotherapy

Johansson, A., Hamzah, J., Payne, C. J. & Ganss, R., 2012, In : NATIONAL ACADEMY OF SCIENCES. PROCEEDINGS. 109, p. 7841-7846

Research output: Contribution to journalArticle

2010
36 Citations (Scopus)

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury

Viebahn, C., Benseler, V., Holz, L. E., Elsegood, C., Vo, M., Bertolino, P., Ganss, R. & Yeoh, G., 2010, In : Journal of Hepatology. 53, 3, p. 500-507

Research output: Contribution to journalArticle

61 Citations (Scopus)

Secreted Frizzled-Related Protein 4. An Angiogenesis Inhibitor

Muley, A., Majumder, S., Kolluru, G. K., Parkinson, S., Viola, H., Hool, L., Arfuso, F., Ganss, R., Dharmarajan, A. & Chatterjee, S., 2010, In : The American Journal of Pathology: cellular and molecular biology of disease. 176, 3, p. 1505-1516

Research output: Contribution to journalArticle

2009
19 Citations (Scopus)

Modulation of G Proetin Signaling Normalizes Tumor Vessels

Manzur, M., Hamzah, J. & Ganss, R., 2009, In : Cancer Research. 69, 2, p. 396-399

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Biological Phenomena
Neoplasms
Pericytes
Tumor Biomarkers
35 Citations (Scopus)

Regulator of G Protein Signaling 5: A New Player in Vasular Remodeling

Manzur, M. & Ganss, R., 2009, In : Trends in Cardiovascular Medicine. 19, 1, p. 26-30

Research output: Contribution to journalArticle

RGS Proteins
GTP-Binding Protein Regulators
Pericytes
G-Protein-Coupled Receptors
Cardiovascular System
39 Citations (Scopus)

Targeted Liposomal Delivery of TLR9 Ligands Activates Spontaneous Antitumour in an Autochthonous Cancer Model

Hamzah, J., Altin, J. G., Herringson, T., Parish, C. R., Hammerling, G. J., O'Donoghue, H. & Ganss, R., 2009, In : Journal of Immunology. 183, p. 1091-1098

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Ligands
Liposomes
Neoplasms
Blood Vessels
15 Citations (Scopus)

Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma

Stahl, S., Sacher, T., Bechtold, A., Protzer, U., Ganss, R., Hammerling, G. J., Arnold, B. & Garbi, N., 2009, In : Immunology Letters. 123, 1, p. 31-37

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Viral Tumor Antigens
Peptides
Neoplasms
Immunization
2008
764 Citations (Scopus)
312 Downloads (Pure)

HIF1 a Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C., Liu, P., Ganss, R., Passegue, E., Song, H., Vendenburg, S., Johnson, R. S., Werb, Z. & Bergers, G., 2008, In : Cancer Cell. 13, 3, p. 206-220

Research output: Contribution to journalArticle

File
Vascular Endothelial Growth Factor A
Blood Vessels
Bone Marrow
Matrix Metalloproteinases
Neoplasms
59 Citations (Scopus)

Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM

Du, R., Petritsch, C., Lu, K., Liu, P., Haller, A., Ganss, R., Song, H., Vandenburg, S. & Bergers, G., 2008, In : Neuro-Oncology. 10, 3, p. 254-264

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Glioblastoma
Matrix Metalloproteinases
Blood Vessels
Cell Survival
21 Citations (Scopus)

Modulation of the "blood-tumor" barrier improves immunotherapy

Manzur, M., Hamzah, J. & Ganss, R., 2008, In : Cell Cycle. 7, 16, p. 2452-2455

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Vascular Tissue Neoplasms
GTP-Binding Protein Regulators
Cell Movement
331 Citations (Scopus)

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

Hamzah, J., Jugold, M., Kiessling, F., Rigby, P., Manzur, M., Marti, H. H., Rabie, T., Kaden, S., Grone, H-J., Hammerling, G. J., Bernd, A. & Ganss, R., 2008, In : Nature. 453, 15, p. 410-414

Research output: Contribution to journalArticle

Tumors
Proteins
Bearings (structural)
Genes
Demonstrations
51 Citations (Scopus)

Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumours enhances immunotherapy in mice

Hamzah, J., Nelson, D., Moldenhauer, D., Arnold, G., Hammerling, G. J. & Ganss, R., 2008, In : The Journal of clinical investigation. 118, 5, p. 1691-1699

Research output: Contribution to journalArticle

Immunotherapy
Interleukin-2
Blood Vessels
Anti-Idiotypic Antibodies
Neoplasms
2006
30 Citations (Scopus)

CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen

Riebke, R., Garbi, N., Ganss, R., Hammerling, G. J., Arnold, B. & Oelert, T., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 41, p. 15142-15147

Research output: Contribution to journalArticle

Autoantigens
Regulatory T-Lymphocytes
T-Lymphocytes
Antigens
Transforming Growth Factor beta1
206 Citations (Scopus)

Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1(+), F4/80(+), CD11b(+) macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis

Schledzewski, K., Falkowski, M., Moldenhauer, G., Metharom, P., Kzhyshkowska, J., Ganss, R., Demory, A., Falkowska-Hansen, B., Kurzen, H., Ugurel, S., Geginat, G., Arnold, B. & Goerdt, S., 2006, In : Journal of Pathology. 209, 1, p. 67-77

Research output: Contribution to journalArticle

Lymphatic Endothelium
CD44 Antigens
Lymphangiogenesis
Wound Healing
Bone Marrow
67 Citations (Scopus)

Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma

Ryschich, E., Lizdenis, P., Ittrich, C., Benner, A., Stahl, S., Hamann, A., Schmitd, J., Knolle, P., Arnold, B., Hammerling, G. J. & Ganss, R., 2006, In : Cancer Research. 66, 1, p. 198-211

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Endothelial Cells
Blood Vessels
Growth
cathepsin S
40 Citations (Scopus)

Tumor growth or regression : powered by inflammation

Nelson, D. & Ganss, R., 2006, In : Journal of Leukocyte Biology. 80, 4, p. 685-690

Research output: Contribution to journalArticle

Inflammation
Growth
Neoplasms
Adaptive Immunity
Immunosuppressive Agents
33 Citations (Scopus)
Stem Cells
Stromal Cells
Neoplasms
Blood Vessels
Carcinogenesis
2005
192 Citations (Scopus)

Chemokines direct endothelial progenitors into tumor neovessels

Spring, H., Schuler, T., Arnold, B., Hammerling, G. J. & Ganss, R., 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, p. 18111-18116

Research output: Contribution to journalArticle

Chemokines
Neoplasms
Endothelial Cells
Bone Marrow Cells
Carcinogenesis
129 Citations (Scopus)

Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization

Berger, M., Bergers, G., Arnold, B., Hammerling, G. J. & Ganss, R., 2005, In : Blood. 105, 3, p. 1094-1101

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Pericytes
Tumors
Islets of Langerhans
Neoplasms
2 Citations (Scopus)

Stimulation of autoimmunity by toll-like receptor ligands

Limmer, A., Ganss, R., Garbi, N., Arnold, B. & Hammerling, G. J., 2005, In : Annals of the Rheumatic Diseases. 64, supp. 4, p. 15-17

Research output: Contribution to journalArticle

2004
103 Citations (Scopus)

CpG Motifs as Proinflammatroy Factors Render Autochthonous Tumors Permissive for Infiltration and Destruction

Garbi, N., Arnold, B., Gordon, S., Hammerling, G. J. & Ganss, R., 2004, In : The Journal of Immunology. 172, 10, p. 5861-5869

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Neoplasms
Vaccination
Islet Cell Carcinoma
T-Lymphocytes
2002
242 Citations (Scopus)

Combination of T-Cell Therapy and Trigger of Inflammation Induces Remodeling of the Vasculature and Tumor Eradication

Ganss, R., Ryschich, E., Klar, E., Arnold, B. & Hammerling, G. J., 2002, In : Cancer Research. 62, p. 1462-1470

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Inflammation
T-Lymphocytes
Adoptive Transfer
Neoplasms
75 Citations (Scopus)

Transformation of the microvascular system during multistage tumorigenesis

Ryschich, E., Schmidt, J., Hammerling, G. J., Klar, E. & Ganss, R., 2002, In : International Journal of Cancer. 97, p. 719-725

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasms
Leukocytes
Blood Vessels
Polyomavirus Transforming Antigens
2001
174 Citations (Scopus)

NK- and CD8+ T Cell-Mediated Eradication of Established Tumors by Peritumoral Injection of CpG-Containing Oligodeoxynucleotides

Kawarada, Y., Ganss, R., Garbi, N., Sacher, T., Arnold, B. & Hammerling, G. J., 2001, In : The Journal of Immunology. 167, p. 5247-5253

Research output: Contribution to journalArticle