Richard Lake

Adjunct Professor

  • The University of Western Australia (M505), 35 Stirling Highway,

    6009 Perth

    Australia

  • 6110 Citations
  • 33 h-Index
1996 …2022
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Research Output 1996 2019

6 Citations (Scopus)
431 Downloads (Pure)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R., de Jong, E., Chin, M., Schuster, I., Fear, V., Casey, T., Forbes, C., Dart, S., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., O Muiri, D., Degli-Esposti, M., Millward, M., Nowak, A., Lassmann, T., Bosco, A., Lake, R. & 1 othersLesterhuis, W., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 14 p., eaav7816.

Research output: Contribution to journalArticle

Open Access
File
STAT1 Transcription Factor
Tumor Microenvironment
Neoplasms
Toll-Like Receptor 3
Transcriptome
2018
5 Citations (Scopus)

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Fear, V., Tilsed, C. M., Chee, H. E. J., Forbes, C., Casey, T., Solin, J., Lansley, S., Lesterhuis, W., Dick, I., Nowak, A., Robinson, B., Lake, R. & Fisher, S., 30 Jul 2018, In : Oncolmmunology. 14 p., e1494111.

Research output: Contribution to journalArticle

Open Access
Mesothelioma
Neoplasms
Therapeutics
Asbestos
Regulatory T-Lymphocytes
1 Citation (Scopus)
Open Access
Lymphocytes
Mesothelioma
Pleural Effusion
Tumors
Blood
2017
21 Citations (Scopus)
Open Access
Maximum Tolerated Dose
Drug Therapy
Inbred C57BL Mouse
Dexamethasone
Weight Loss
56 Citations (Scopus)
618 Downloads (Pure)
Open Access
File
Tumor Biomarkers
Biomarkers
Mathematics
Drug Industry
Therapeutics
14 Citations (Scopus)
345 Downloads (Pure)

Transient Treg depletion enhances therapeutic anti-cancer vaccination

Fisher, S., Aston, W., Chee, H. E. J., Khong, A., Cleaver, A., Solin, J., Ma, S., Lesterhuis, W., Dick, I., Holt, R., Creaney, J., Boon, L., Robinson, B. & Lake, R., Mar 2017, In : Immunity Inflammation and Disease.. 5, 1, p. 16-28 12 p., 10.1002/iid3.136.

Research output: Contribution to journalArticle

Open Access
File
Vaccination
Neoplasms
Diphtheria Toxin
Therapeutics
Immunity
9 Citations (Scopus)
Open Access
Chemoradiotherapy
Regulatory T-Lymphocytes
Rectal Neoplasms
Cell Count
Neoplasms
2016
33 Citations (Scopus)

A novel clinical prediction model for prognosis in malignant pleural mesothelioma using decision tree analysis

Brims, F., Meniawy, T., Duffus, I., De Fonseka, D., Segal, A., Creaney, J., Maskell, N., Lake, R., De Klerk, N. & Nowak, A., 2016, In : Journal of Thoracic Oncology. 11, 4, p. 573-582

Research output: Contribution to journalArticle

Open Access
Decision Trees
Decision Support Techniques
Survival
Weight Loss
Regression Analysis
1 Citation (Scopus)
158 Downloads (Pure)

A subset of malignant mesothelioma tumors retain osteogenic potential

Lansley, S. M., Pedersen, B., Robinson, C., Searles, R. G., Sterrett, G., Van Bruggen, I., Lake, R. A., Mutsaers, S. E. & Prele, C., 25 Nov 2016, In : Scientific Reports. 6, 36349.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Osteoblasts
Osteogenesis
Malignant Mesothelioma
Osteonectin
42 Citations (Scopus)

Chemotherapy and immunotherapy: Mapping the road ahead

Cook, A. M., Lesterhuis, W. J., Nowak, A. K. & Lake, R. A., 2016, In : Current Opinion in Immunology. 39, p. 23-29 7 p.

Research output: Contribution to journalReview article

Immunotherapy
Drug Therapy
Neoplasms
Pharmaceutical Preparations
Weapons
20 Citations (Scopus)
Open Access
Immunotherapy
Dexamethasone
Drug Therapy
Regulatory T-Lymphocytes
Neoplasms
14 Citations (Scopus)
Non-Small Cell Lung Carcinoma
T-Lymphocytes
Protein-Tyrosine Kinases
Immunotherapy
Biomarkers
2015
31 Citations (Scopus)
Open Access
Pemetrexed
Cisplatin
Clinical Trials
Antibodies
B-Lymphocytes
3 Citations (Scopus)
212 Downloads (Pure)

Consistent gene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma

Robinson, C., Dick, I., Wise, M., Holloway, A., Diyagama, D., Robinson, B., Creaney, J. & Lake, R., 18 Dec 2015, In : BMC Cancer. 15, 14 p., 983.

Research output: Contribution to journalArticle

Open Access
File
Asbestos
Mesothelioma
Transcriptome
Transgenic Mice
Viral Tumor Antigens
27 Citations (Scopus)
Open Access
Chemoradiotherapy
Regulatory T-Lymphocytes
Rectal Neoplasms
Cell Count
Stromal Cells
21 Citations (Scopus)

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Lesterhuis, W., Rinaldi, C., Jones, A., Rozali, E., Dick, I., Khong, A., Boon, L., Robinson, B., Nowak, A., Bosco, A. & Lake, R., 21 Jul 2015, In : Scientific Reports. 5, p. 1-11 11 p., 12298 .

Research output: Contribution to journalArticle

Open Access
Drug Combinations
Immunotherapy
Drug Repositioning
Neoplasms
Chromosome Mapping

Novel insights into the pathophysiology and treatment of malignant pleural mesothelioma

Cook, A., Khong, A., Nowak, A. K. & Lake, R. A., 2015, In : Lung Cancer Management. 4, 5, p. 249-259 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Restoration of defective cross-presentation in tumors by gemcitabine

Mcdonnell, A., Lesterhuis, W., Khong, A., Nowak, A., Lake, R., Currie, A. & Robinson, B., 2015, In : OncoImmunology. 4, 5, p. e1005501

Research output: Contribution to journalArticle

Open Access
gemcitabine
Cross-Priming
Antigen Presentation
Cytotoxic T-Lymphocytes
Neoplasm Antigens
18 Citations (Scopus)

Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen

Creaney, J., Ma, S., Sneddon, S. A., Tourigny, M., Dick, I., Leon, J., Khong, A., Fisher, S., Lake, R., Lesterhuis, W., Nowak, A., Leary, S., Watson, M. W. & Robinson, B., 2015, In : OncoImmunology. 4, 7, p. 1-7

Research output: Contribution to journalArticle

Carcinogens
Enzyme-Linked Immunospot Assay
Peptides
Neoplasms
Nucleotides
31 Citations (Scopus)
Open Access
Cross-Priming
Neoplasm Antigens
Dendritic Cells
Drug Therapy
Neoplasms
2014
12 Citations (Scopus)

Chemotherapy enhances cross-presentation of nuclear tumor antigens

Anyaegbu, C., Lake, R., Heel, K., Robinson, B. & Fisher, S., 22 Sep 2014, In : PLoS One. 9, 9, p. e107894

Research output: Contribution to journalArticle

Open Access
Cross-Priming
Nuclear Antigens
Chemotherapy
Neoplasm Antigens
drug therapy

Combining chemotherapy and checkpoint blockade in thoracic cancer: how to proceed?

Aston, W., Fisher, S., Khong, A., Mok, C., Nowak, A., Lake, R. & Lesterhuis, W., 2014, In : Lung Cancer Management. 3, 6, p. 443-457

Research output: Contribution to journalReview article

5 Citations (Scopus)

Comment on "Drug discovery: Turning the titanic"

Lesterhuis, W., Bosco, A. & Lake, R., 2014, In : Science Translational Medicine. 6, 229, p. 229le2

Research output: Contribution to journalLetter

Drug Discovery
Research
4 Citations (Scopus)
Asbestos
Mesothelioma
Vitamin D
Incidence
Diet
9 Citations (Scopus)
Cyclooxygenase 2 Inhibitors
Asbestos
Non-Steroidal Anti-Inflammatory Agents
Mesothelioma
Animal Models
12 Citations (Scopus)

Long-term exposure of mesothelial cells to SV40 and asbestos leads to malignant transformation and chemotherapy resistance

Cleaver, A., Bhamidipaty, K., Wylie, B., Connor, T., Robinson, C., Robinson, B., Mutsaers, S. & Lake, R., 2014, In : Carcinogenesis. 35, 2, p. 407-414

Research output: Contribution to journalArticle

Simian virus 40
Asbestos
Drug Therapy
Mesothelioma
Crocidolite Asbestos
2 Citations (Scopus)

Mouse models of mesothelioma: strengths, limitations and clinical translation

Robinson, C., Solin, J., Lee, G., Lake, R. & Lesterhuis, W., 2014, In : Lung Cancer Management. 3, 5, p. 397-410

Research output: Contribution to journalArticle

5 Citations (Scopus)

Neoadjuvant anti-tumor vaccination prior to surgery enhances survival

Fisher, S., Cleaver, A., Lakhiani, D., Khong, A., Connor, T., Wylie, B., Lesterhuis, W., Robinson, B. & Lake, R., 4 Sep 2014, In : Journal of Translational Medicine. 12, 1, p. 1-10

Research output: Contribution to journalArticle

Open Access
Surgery
Tumors
Vaccination
T-cells
Neoplasms
3 Citations (Scopus)
139 Downloads (Pure)

Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans

Robinson, C., Alfonso, H. S., Woo, S., Walsh, A., Olsen, N., Musk, A., Robinson, B., Nowak, A. & Lake, R., 5 Aug 2014, In : PLoS One. 9, 8, e103025.

Research output: Contribution to journalArticle

Open Access
File
mesothelioma
asbestos
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Asbestos
Mesothelioma
12 Citations (Scopus)

The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40

Khong, A., Cleaver, A., Alatas, M. F., Wylie, B., O'Connor, T., Fisher, S., Broomfield, S., Lesterhuis, W., Currie, A., Lake, R. & Robinson, B., 2014, In : BMC Cancer. 14, p. 1-9

Research output: Contribution to journalArticle

Open Access
2013

Activation of Immune-Mediated Tumor Cell Death by Chemotherapy

Mccoy, M., Nowak, A. & Lake, R., 2013, Cell Death in Biology and Diseases. Johnson, D. E. (ed.). New York: Springer, p. 373-399 (Cell Death Signaling in Cancer Biology and Treatment).

Research output: Chapter in Book/Conference paperChapter

Effects of Chemothrapy on the tumor Microenvironment and Anti-tumor Immunity

Meniawy, T., Nowak, A. & Lake, R., 2013, Tumor Ablation. Keisari, Y. (ed.). Dordrecht: Springer, p. 1-28 (The Tumor Microenvironment 5).

Research output: Chapter in Book/Conference paperChapter

32 Citations (Scopus)
Open Access
3 Citations (Scopus)

Immune Stimulatory Features of Classical Chemotherapy

Lesterhuis, W., Nowak, A. & Lake, R., 2013, Cancer Immunotherapy. Predergast, G. C. & Jaffee, E. M. (eds.). Second Edition ed. UNITED KINGDOM: Elsevier, Vol. n/a. p. 395-414 (Immune Supression and Tumor Growth).

Research output: Chapter in Book/Conference paperChapter

15 Citations (Scopus)
227 Downloads (Pure)
Open Access
File
76 Citations (Scopus)
146 Downloads (Pure)

Synergistic Effect of CTLA-4 Blockade and Cancer Chemotherapy in the Induction of Anti-Tumor Immunity

Lesterhuis, W., Salmons, J., Nowak, A., Rozali, E., Khong, A., Dick, I., Harken, J., Robinson, B. & Lake, R., 2013, In : PLoS One. 8, 4, p. 8pp

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Induction Chemotherapy
Chemotherapy
drug therapy
Tumors
2012

Heat-Shocking of Murine Malignant Mesothelioma Cells Enhances Their Effectiveness as an Autologous Anti-Tumour Vaccine

Fisher, S., Broomfield, S., van der Most, R., Lake, R., Robinson, B. & Currie, A., Feb 2012, In : Journal of Cancer Therapy. 3, 1, p. 47-56

Research output: Contribution to journalArticle

Open Access
Cancer Vaccines
Hot Temperature
Shock
Vaccines
Neoplasms
10 Citations (Scopus)

Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8+ T-cell immunity

Brown, M. D., Van Der Most, R., Vivian, J., Lake, R., Larma, I., Robinson, B. & Currie, A., 2012, In : OncoImmunology. 1, 7, p. 1084-1094

Research output: Contribution to journalArticle

34 Citations (Scopus)
Open Access
Thorax
T-Lymphocytes
Drug Therapy
Survival
T-Lymphocyte Subsets
157 Citations (Scopus)

Programmed death ligand 2 in cancer-induced immune suppression

Rozali, E., Hato, S. V., Robinson, B., Lake, R. & Lesterhuis, W., 2012, In : Clinical and Developmental Immunology. 2012, p. 8 pp

Research output: Contribution to journalArticle

Open Access
49 Citations (Scopus)

The use of agonistic anti-CD40 therapy in treatments for cancer

Khong, A., Nelson, D. J., Nowak, A., Lake, R. & Robinson, B., 2012, In : International Reviews of Immunology. 31, p. 246-266

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation

McDonnell, A., Currie, A., Brown, M., Kania, K., Wylie, B., Cleaver, A., Lake, R. & Robinson, B., 2012, In : Oncolmmunology. 1, 6, p. 840-846

Research output: Contribution to journalArticle

Open Access