No photo of Richard Lake

View Scopus Profile

Richard Lake

Adjunct Professor

  • 5993 Citations
  • 33 h-Index
1996 …2022
If you made any changes in Pure these will be visible here soon.

Personal profile

Research

NK cells as the missing link between anti-cancer chemotherapy and CD8 T cell responses
Immunotherapy Plus Chemotherapy Boosts Mesothelioma Treatment Effectiveness

Keywords

  • Cancer
  • Immunology
  • Molecular biology

Fingerprint Dive into the research topics where Richard Lake is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 41 Similar Profiles
Neoplasms Medicine & Life Sciences
Mesothelioma Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Drug Therapy Medicine & Life Sciences
Asbestos Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences
Cross-Priming Medicine & Life Sciences
Neoplasm Antigens Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Aston, W. J., Hope, D. E., Cook, A. M., Boon, L., Dick, I., Nowak, A. K., Lake, R. A. & Lesterhuis, W. J., Jul 2019, In : OncoImmunology. 8 p.

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)
218 Downloads (Pure)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R., de Jong, E., Chin, M., Schuster, I., Fear, V., Casey, T., Forbes, C., Dart, S., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., O Muiri, D., Degli-Esposti, M., Millward, M., Nowak, A., Lassmann, T., Bosco, A., Lake, R. & 1 othersLesterhuis, W., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 14 p., eaav7816.

Research output: Contribution to journal › Article

Open Access
File
STAT1 Transcription Factor
Tumor Microenvironment
Neoplasms
Toll-Like Receptor 3
Transcriptome
4 Citations (Scopus)

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Fear, V., Tilsed, C. M., Chee, H. E. J., Forbes, C., Casey, T., Solin, J., Lansley, S., Lesterhuis, W., Dick, I., Nowak, A., Robinson, B., Lake, R. & Fisher, S., 30 Jul 2018, In : Oncolmmunology. 14 p., e1494111.

Research output: Contribution to journal › Article

Open Access
Mesothelioma
Neoplasms
Therapeutics
Asbestos
Regulatory T-Lymphocytes

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

Chee, J., Watson, M. W., Chopra, A., Nguyen, B., Cook, A. M., Creaney, J., Lesterhuis, W. J., Robinson, B. W., Gary Lee, Y. C., Nowak, A. K., Lake, R. A. & McDonnell, A. M., 5 Dec 2018, In : BMC Research Notes. 11, 1, 6 p., 864.

Research output: Contribution to journal › Article

Open Access
Lymphocytes
Mesothelioma
Pleural Effusion
Tumors
Blood
18 Citations (Scopus)

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

Aston, W. J., Hope, D. E., Nowak, A. K., Robinson, B. W., Lake, R. A. & Lesterhuis, W. J., 16 Oct 2017, In : BMC Cancer. 17, 1, 684.

Research output: Contribution to journal › Article

Open Access
Maximum Tolerated Dose
Drug Therapy
Inbred C57BL Mouse
Dexamethasone
Weight Loss

Projects 1997 2022

How genetic background influences the development of mesothelioma (in asbestos exposed populations)

Lake, R., Morahan, G. & Fisher, S.

National Health & Medical Research Council NHMRC

1/01/19 → 31/12/22

Project: Research

ACRF Centre for Advanced Cancer Genomics (NovaSeq)

Forrest, A., Leedman, P., Lister, R., Lassmann, T., Saunders, C., Farah, C., Robinson, B., Nowak, A., Kees, U., Johns, T., Ganss, R., Erber, W., Lake, R., Millward, M., Ziman, M. & Amanuel, B.

Australian Cancer Research Foundation

30/10/18 → 29/10/21

Project: Research

The MexTAg Collaborative Cross: understanding genetic modifiers in mesothelioma

Lake, R., Fisher, S., Morahan, G., Ram, R., Lesterhuis, W. & Nowak, A.

US Department of Defense

15/07/18 → 14/07/20

Project: Research

Identifying immune biomarkers of response to chemotherapy in malignant mesothelioma

McDonnell, A., Nowak, A., Lake, R., Robinson, B. & Cook, A.

Insurance & Care NSW (icare)

1/04/18 → 31/03/20

Project: Research

Analysis of T cell receptor diversity in animal models of mesothelioma

Lake, R., Chee, J., Lesterhuis, W., Robinson, B., Fisher, S., Watson, M., Chopra, A. & Holt, R.

Insurance & Care NSW (icare)

1/04/18 → 31/03/21

Project: Research