Personal profile
Biography
Rhonda completed her PhD in 2015 under the supervision of Dr Daniela Ulgiati. The focus of her doctoral studies was the identification and characterisation transcriptional regulatory mechanisms, and the role of non-coding single nucleotide polymorphisms in human health and autoimmune disease.
Rhonda is now applying her interest in regulation of gene expression to the field of muscle disease. Specifically her research has two main aims; 1) To improve rates of diagnosis by developing a pipeline for the routine screening of regulatory regions, and 2) to develop new treatments for early onset neuromuscular disorders. Areas of investigation include AAV-mediated gene therapy, CRISPR/Cas9 gene editing and manipulation of gene expression, oligonucleotide-based therapeutics, and induced pluripotent stem cell models of muscle disease.
Rhonda also has experience teaching and lecturing in the field of genetics as part of the school of biomedical sciences.
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Collaborations and top research areas from the last five years
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HMGCS1 variants cause rigid spine syndrome amenable to mevalonic acid treatment in an animal model
Dofash, L. N. H., Miles, L. B., Saito, Y., Rivas, E., Calcinotto, V., Oveissi, S., Serrano, R. J., Templin, R., Ramm, G., Rodger, A., Haywood, J., Ingley, E., Clayton, J. S., Taylor, R. L., Folland, C. L., Groth, D., Hock, D. H., Stroud, D. A., Gorokhova, S. & Donkervoort, S. & 21 others, , 1 May 2025, In: Brain. 148, 5, p. 1707-1722 16 p.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus) -
An Update on Reported Variants in the Skeletal Muscle α-Actin (ACTA1) Gene
Clayton, J. S., Johari, M., Taylor, R. L., Dofash, L., Allan, G., Monahan, G., Houweling, P. J., Ravenscroft, G. & Laing, N. G., 2024, In: Human Mutation. 2024, 1, 19 p., 6496088.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Citations (Scopus) -
Generation of a human ACTA1-tdTomato reporter iPSC line using CRISPR/Cas9 editing
Houweling, P. J., Crossman, V., Tiong, C. F., Coles, C. A., Taylor, R. L., Clayton, J. S., Graham, A., Vlahos, K., Howden, S. E. & North, K. N., Mar 2024, In: Stem Cell Research. 75, 7 p., 103313.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Generation of iPSC lines from three Laing distal myopathy patients with a recurrent MYH7 p.Lys1617del variant
Clayton, J. S., Vo, C., Crane, J., Scriba, C. K., Saker, S., Larmonier, T., Malfatti, E., Romero, N. B., Ravenscroft, G., Laing, N. G. & Taylor, R. L., Oct 2024, In: Stem Cell Research. 80, 6 p., 103491.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of two iPSC lines from adult central core disease patients with dominant missense variants in the RYR1 gene
Clayton, J. S., Vo, C., Crane, J., Scriba, C. K., Saker, S., Larmonier, T., Malfatti, E., Romero, N. B., Ravenscroft, G., Laing, N. G. & Taylor, R. L., Jun 2024, In: Stem Cell Research. 77, 103411.Research output: Contribution to journal › Article › peer-review
Open Access
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Building translational capacity in WA; Establishing the tools needed to develop treatments for Australian children with muscle disease.
Taylor, R. (Investigator 01), Ravenscroft, G. (Investigator 02), Clayton, J. (Investigator 03), Kuznetsova, I. (Investigator 04), Elaskalani, O. (Investigator 05), Endersby, R. (Investigator 06) & Forrest, A. (Investigator 07)
Stan Perron Charitable Foundation
2/07/23 → 4/07/27
Project: Research
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WA Near-miss Awards: Ideas Grants 2021
Taylor, R. (Investigator 01)
Department of Health (Western Australia)
1/07/22 → 30/06/23
Project: Research
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Testing novel genetic therapies for ACTA1 nemaline myopathy (NEM3) – harnessing patient cells
Laing, N. (Investigator 01), Nowak, K. (Investigator 02), Ravenscroft, G. (Investigator 03), Taylor, R. (Investigator 04) & Clayton, J. (Investigator 05)
A Foundation Building Strength Inc
5/08/20 → 4/08/22
Project: Research
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Evaluating an allele-specific genetic therapy for congenital myopathy caused by dominant mutations in the skeletal muscle actin (ACTA1) gene
Nowak, K. (Investigator 01), Laing, N. (Investigator 02) & Taylor, R. (Investigator 03)
Association Francaise contre les Myopathies (AFM)
30/05/18 → 30/11/19
Project: Research
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Evaluating gene therapy for McArdle's disease using a mouse model
Laing, N. (Investigator 01), Nowak, K. (Investigator 02) & Taylor, R. (Investigator 03)
Muscular Dystrophy Association of America
1/02/17 → 31/07/18
Project: Research