Personal profile
Biography
A/Prof Endersby is a world-renowned childhood brain cancer scientist with a track record of exceptional scientific leadership. A/Prof Endersby is the scientific head and co-leader of the Brain Tumour Research Team at Telethon Kids Institute, bringing together a scientifically diverse team of multi-national preclinical and clinical researchers to achieve demonstrated improved clinical outcomes for childhood brain cancer.
Funding overview
A/Prof Endersby has attracted more than $11 million in competitive funding from the NHMRC, MRFF, ARC and Cancer Australia, among others.
Industrial relevance
A/Prof 's international standing is recognised by her active role within the Collaborative Network for Neuro-Oncology Clinical Trials (CONNECT) Preclinical Steering Committee (USA, Europe & Aus) and the CNS Tumours Group of the Australian / New Zealand Children's Haematology & Oncology Group (ANZCHOG) where she interrogates preclinical studies of new therapies to decide which clinical trials should be made available within Australia. Her national recognition is evidenced by positions on committees such as the Brain Tumour Expert Group of the ZERO Childhood Cancer Program (Australia's largest childhood cancer personalised medicine program), Joint leader of the national ZERO2 Preclinical Research Strategy Working Group working towards enhanced support for basic and translational childhood cancer research in Australia and she is an invited member to the organising committee for Australia's premier Lorne Cancer Conference.
Teaching overview
A/Prof currently supervises 6 postdocs, 3 PhD students, 6 research assistants and 1 honours student.
Completions include 4 PhD, 3 Masters, 11 Honours, 5 MD/MBBS research students, 6 Cancer Council WA Vacation Scholars. A/Prof Endersby has hosted 19 high school students, 2 of whom won gold medals at international science competitions.
Engagement
A/Prof Endersby has made over 76 oral presentations, with 60 of those being invited, 14 at international conferences and 4 as a Keynote speaker. In addition to roles on prestigious international brain cancer committees, A/Prof Endersby was invited to Chair the Commonwealth Government's Australian Brain Cancer Mission Evaluation Advisory Panel (2022 - 2023). She also has roles on the Brain Perioperative Clinical Trial Program (BrainPOP) Assessment Committee, Cooperative Trials Group for Neuro-Oncology and Brain Cancer Biobank Australia.
Community engagement
A/Prof Endersby established the Telethon Kids Institute Cancer Centre Consumer Reference Group in 2016 and has well-developed and ongoing consumer input into her preclinical and clinical research. She promotes cancer research through community conversations, lab tours, donor meetings and social media and encourages her team to participate in community engagement.
Education/Academic qualification
Acute myeloid leukaemia, PhD, Madm, a novel adaptor protein that associates with Myeloid Leukaemia Factor 1., Curtin University
Award Date: 3 Dec 2003
Prostate cancer, Honours, Regulation of homeobox genes in prostate cancer cells by all-trans retinoic acid., Curtin University
Award Date: 1 Dec 1998
Molecular Genetics, BSc, Curtin University
Award Date: 1 Dec 1997
External positions
Head, Brain Tumour Research, The Kids Research Institute Australia (Telethon Kids Institute)
2011 → …
Industry keywords
- Clinical Trials
- Not for Profit
- Medicine and Pharma
Research expertise keywords
- Brain tumours
- Cancer biology
- Mouse models
- Signal transduction
- Cancer genetics
- Radiation oncology
- Neurobiology
- Oncoproteins and tumour suppressor proteins
- Preclinical models of disease (specifically murine models)
- Targeted therapy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 16 Peace, Justice and Strong Institutions
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Collaborations and top research areas from the last five years
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Current gaps in knowledge and future research directions for Aboriginal and Torres Strait Islander children with cancer
Truong, A., Williams-Tucker, K., Narkle, A., Slicer, E., Chapman, J. E., Lawler, J., Kotecha, R. S., Dholaria, H., Clark, J. R., Brown, A., Endersby, R., Gottardo, N. G. & Buck, J., 2 Jun 2025, In: Medical Journal of Australia. 222, 10, p. 524-528 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses
Lertsumitkul, L., Iliopoulos, M., Wang, S. S., McArthur, S. J., Ebert, L. M., Davenport, A. J., Endersby, R., Hansford, J. R., Drummond, K. J., Cross, R. & Jenkins, M. R., 7 Aug 2024, In: Journal for immunotherapy of cancer. 12, 8, 14 p., e009486.Research output: Contribution to journal › Article › peer-review
Open Access17 Link opens in a new tab Citations (Web of Science) -
Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastoma
Dewdney, B., Miranda, P. J., Kuchibhotla, M., Palanisamy, R., Richworth, C., Milligan, C. J., Ng, Z. Y., Ursich, L., Petrou, S., Fletcher, E., Daly, R. J., Lim Kam Sian, T. C. C., Valvi, S., Endersby, R. & Johns, T. G., 1 Jan 2024, In: Neuro-Oncology Advances. 6, 1, 14 p., vdae187.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers
Buck, J., Hii, H. & Endersby, R., 2024, Patient-Derived Xenografts: Methods and Protocols. Saad, M. I. (ed.). 1 ed. Humana Press Inc., p. 41-53 13 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Conference paper › Chapter › peer-review
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“If you build it, they will come”: the convergence of funding, research and collaboration in paediatric brain cancer clinical trials
Hansford, J., Valvi, S., de Boer, J., McCowage, G., Govender, D., Kirby, M., Ziegler, D., Manoharan, N., Hassall, T., Wainwright, B., Alvaro, F., Wood, P. J., Eisenstat, D., Quang, D. A. K., Jenkins, M., Dun, M., Laughton, S. J., Endersby, R., Dodgshun, A. & Gottardo, N., Nov 2024, In: Medical Journal of Australia. 221, 10, p. 520-523 4 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)
Datasets
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Hierarchical synergy of Pten, p53 and Rb pathways in high-grade astrocytoma induced in adult brain
Chow, L. M. L. (Creator), Endersby, R. (Creator), Zhu, X. (Creator), Rankin, S. (Creator), Qu, C. (Creator), Zhang, J. (Creator), Broniscer, A. (Creator), Ellison, D. W. (Creator) & Baker, S. J. (Creator), Gene Expression Omnibus (NCBI), 23 Mar 2011
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22927
Dataset
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Bridging the Gap: Advancing Brain Tumour Research and Diagnostic Services for Adolescents and Young Adults in Western Australia
Dholaria, H. (Investigator 01) & Endersby, R. (Investigator 02)
1/01/26 → 31/12/27
Project: Research
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Developing more effective and less toxic treatments for rare brain cancers in infants
Endersby, R. (Investigator 01), Gottardo, N. (Investigator 02), Short, A. (Investigator 03), Dholaria, H. (Investigator 04), Starobova, H. (Investigator 05), Hansford, J. (Investigator 06) & Buck, J. (Investigator 07)
MRFF Medical Research Future Fund
1/01/26 → 31/12/28
Project: Research
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Replacement of laboratory sterilisation equipment for paediatric health and medical research and innovation.
Hales, B. (Investigator 01), Samuels, A. (Investigator 02), Kirkham, L.-A. (Investigator 03) & Endersby, R. (Investigator 04)
Department of Health (Western Australia)
25/06/25 → 25/06/28
Project: Research
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Building translational capacity in WA; Establishing the tools needed to develop treatments for Australian children with muscle disease.
Taylor, R. (Investigator 01), Ravenscroft, G. (Investigator 02), Clayton, J. (Investigator 03), Kuznetsova, I. (Investigator 04), Elaskalani, O. (Investigator 05), Endersby, R. (Investigator 06) & Forrest, A. (Investigator 07)
Stan Perron Charitable Foundation
2/07/23 → 4/07/27
Project: Research
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Harnessing the immune system to fight high-risk, childhood brain cancers using DNA damage response inhibitors and radiation therapy.
Gottardo, N. (Investigator 01), Endersby, R. (Investigator 02), Ebert, M. (Investigator 03), Buck, J. (Investigator 04) & Howlett, M. (Investigator 05)
1/06/24 → 30/11/25
Project: Research
Prizes
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Highly Commended for the Dr Louisa Alessandri Memorial Fund Award for Excellence and Commitment to Research
Endersby, R. (Recipient), Jun 2013
Prize: Award
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Presenter of the Year Award - Child Health Research Seminar Series
Endersby, R. (Recipient), Dec 2012
Prize: Award
Activities
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ZERO Childhood Cancer National Scientific Symposium
Endersby, R. (Participant)
2024Activity: Conferences and workshops › Contribution or participation in a conference
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Brain Perioperative Clinical Trial Program (BrainPOP) (External organisation)
Endersby, R. (Director)
2023 → …Activity: Memberships › Membership of committee
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National review (External organisation)
Endersby, R. (Director)
2023 → 2024Activity: Memberships › Membership of committee
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ZERO Childhood Cancer Program (External organisation)
Endersby, R. (Director)
2022 → …Activity: Memberships › Membership of committee
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Australian Brain Cancer Mission Strategic Advisory Group (External organisation)
Endersby, R. (Director)
2022 → 2023Activity: Memberships › Membership of committee
Press/Media
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The Perth family fighting to save their baby boy from a rare and aggressive brain cancer
27/01/25
1 Media contribution
Press/Media: Press / Media