Prudence Hart

Adjunct Professor

  • The University of Western Australia (M560), 35 Stirling Highway,

    6009 Perth

    Australia

  • 6864 Citations
  • 45 h-Index
1976 …2019
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Research Output 1976 2019

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Article
2019

Exposure to solar UVR suppresses cell-mediated immunization responses in humans: The Australian Ultraviolet Radiation and Immunity Study

Swaminathan, A., Harrison, S. L., Ketheesan, N., van den Boogaard, C. H. A., Dear, K., Allen, M., Hart, P. H., Cook, M. & Lucas, R. M., Jul 2019, In : Journal of Investigative Dermatology. 139, 7, p. 1545–1553

Research output: Contribution to journalArticle

Open Access
Immunization
Ultraviolet radiation
Clothing
Immunity
Radiation

Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome

Trend, S., Jones, A. P., Cha, L., Cooper, M. N., Geldenhuys, S., Fabis-Pedrini, M. J., Carroll, W. M., Cole, J. M., Booth, D. R., Lucas, R. M., French, M. A., Byrne, S. N., Kermode, A. G. & Hart, P. H., 28 May 2019, In : Scientific Reports. 9, 1, 13 p., 7980.

Research output: Contribution to journalArticle

Open Access
Saliva
Mastication
Assays
Blood
Flow rate
1 Citation (Scopus)
Cholecalciferol
Vitamin D
Skin
Irradiation
Ultraviolet radiation

Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission

Haifer, C., Lawrance, I. C., Center, J. R., Clarke, M. W., Hart, P. H., Eisman, J. A., Lucas, R. & Ghaly, S., 26 Jul 2019, In : Therapeutic Advances in Gastroenterology. 12, 12 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D
Crohn Disease
Vitamin D-Binding Protein
Inflammation
Vitamin D Deficiency
2018

A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study

Hart, P. H., Jones, A. P., Trend, S., Cha, L., Fabis-Pedrini, M. J., Cooper, M. N., d'Este, C., Geldenhuys, S., Carroll, W. M., Byrne, S. N., Booth, D. R., Cole, J. M., Lucas, R. M. & Kermode, A. G., 22 May 2018, In : Multiple Sclerosis Journal - Experimental, Translational and Clinical. 4, 2, 6 p.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Multiple Sclerosis
Randomized Controlled Trials
Radiation
Calcifediol
6 Citations (Scopus)

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

Research output: Contribution to journalArticle

Open Access
Microbiota
Colitis
Vitamin D
Dextran Sulfate
Inflammatory Bowel Diseases
1 Citation (Scopus)

Higher serum immunoglobulin G3 levels may predict the development of multiple sclerosis in individuals with clinically isolated syndrome

Trend, S., Jones, A. P., Cha, L., Byrne, S. N., Geldenhuys, S., Fabis-Pedrini, M. J., Carroll, W. M., Cole, J. M., Booth, D. R., Lucas, R. M., Kermode, A. G., French, M. A. & Hart, P. H., 13 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1590.

Research output: Contribution to journalArticle

Open Access
Multiple Sclerosis
Immunoglobulins
Immunoglobulin G
Serum
Immunoglobulin M

Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D

Gorman, S., Geldenhuys, S., Weeden, C., Grimbaldeston, M. A. & Hart, P., 1 Apr 2018, In : Archives of Dermatological Research. 310, 3, p. 221-230 10 p.

Research output: Contribution to journalArticle

Interleukin-9
Regulatory T-Lymphocytes
Mast Cells
Vitamin D
Inflammation
3 Citations (Scopus)

Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., Newsholme, P., Goodridge, H. S., Pixley, F. J. & Hart, P. H., 1 Jan 2018, In : Journal of Immunology. 200, 1, p. 260-270

Research output: Contribution to journalArticle

Chemotactic Factors
Bone Marrow
Macrophages
Macrophage Colony-Stimulating Factor
Inflammation
2 Citations (Scopus)

Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis

Cha, L., Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Carroll, W. M., Lucas, R. M., Cole, J. M., Booth, D. R., Kermode, A. G. & Hart, P. H., 1 Jan 2018, In : Clinical and Translational Immunology. 7, 8, e1037.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
Arginase
Multiple Sclerosis
Arginine
1 Citation (Scopus)

Ultraviolet irradiation of skin alters the faecal microbiome independently of vitamin D in mice

Ghaly, S., Kaakoush, N. O., Lloyd, F., Gordon, L., Forest, C., Lawrance, I. C. & Hart, P. H., 11 Aug 2018, In : Nutrients. 10, 8, 1069.

Research output: Contribution to journalArticle

Open Access
Microbiota
vitamin D
Vitamin D
irradiation
colitis
2017

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., May 2017, In : Clinical & Translational Immunology. 6, 5, e143.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Multiple Sclerosis
Blood Cells
Therapeutics
3 Citations (Scopus)

Are low sun exposure and/or vitamin D risk factors for type 1 diabetes?

Miller, K. M., Hart, P. H., de Klerk, N. H., Davis, E. A. & Lucas, R. M., 1 Mar 2017, In : PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. 16, 3, p. 381-398 18 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Evolving identification of blood cells associated with clinically isolated syndrome: Importance of time since clinical presentation and diagnostic MRI

Trend, S., Jones, A. P., Geldenhuys, S., Byrne, S. N., Fabis-Pedrini, M. J., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., 15 Jun 2017, In : International Journal of Molecular Sciences. 18, 6, 1277.

Research output: Contribution to journalArticle

Open Access
blood cells
Magnetic resonance
magnetic resonance
Blood Cells
Blood
11 Citations (Scopus)

Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of vitamin D and other UVB-induced molecules

Hart, P. H., Lucas, R. M., Booth, D. R., Carroll, W. M., Nolan, D., Cole, J. M., Jones, A. P. & Kermode, A. G., 24 Jan 2017, In : Frontiers in Immunology. 8, January, 3.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Vitamin D
Multiple Sclerosis
Solar System
Sunlight
2 Citations (Scopus)
43 Downloads (Pure)

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., Goodridge, H. S., Zon, L. I., Pixley, F. J. & Hart, P. H., Dec 2017, In : Experimental Hematology. 56, p. 64-68

Research output: Contribution to journalArticle

Open Access
File
16,16-Dimethylprostaglandin E2
Dinoprostone
Bone Marrow Cells
Cell Movement
Monocytes
3 Citations (Scopus)

Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

Fleury, N., Feelisch, M., Hart, P. H., Weller, R. B., Smoothy, J., Matthews, V. B. & Gorman, S., 1 Apr 2017, In : Journal of Endocrinology. 233, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Radiation
High Fat Diet
Nitric Oxide
Sunlight
Adiposity
14 Citations (Scopus)
65 Downloads (Pure)

Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

Zhu, K., Oddy, W. H., Holt, P., Ping-Delfos, W. C. S., Mountain, J., Lye, S., Pennell, C., Hart, P. H. & Walsh, J. P., 1 Jul 2017, In : American Journal of Clinical Nutrition. 106, 1, p. 276-283 8 p.

Research output: Contribution to journalArticle

Open Access
File
Vitamin D
Bone Density
Bone and Bones
Serum
Photon Absorptiometry
2 Citations (Scopus)

UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D., Scott, N. M., Goodridge, H. S., Dwyer, A., Greenland, E., Pixley, F. J., Newsholme, P. & Hart, P. H., 1 Sep 2017, In : American Journal of Pathology. 187, 9, p. 2046-2059 14 p.

Research output: Contribution to journalArticle

Dendritic Cells
Bone and Bones
Skin
Bone Marrow
3-Hydroxyanthranilate 3,4-Dioxygenase
29 Citations (Scopus)

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

Hollams, E. M., Teo, S. M., Kusel, M., Holt, B. J., Holt, K. E., Inouye, M., De Klerk, N. H., Zhang, G., Sly, P. D., Hart, P. H. & Holt, P. G., Feb 2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 472-481.e9

Research output: Contribution to journalArticle

Vitamin D
Hypersensitivity
Asthma
Eczema
Parturition
3 Citations (Scopus)

Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

Gorman, S., Buckley, A. G., Ling, K. M., Berry, L. J., Fear, V. S., Stick, S. M., Larcombe, A. N., Kicic, A. & Hart, P. H., 1 Aug 2017, In : Physiological Reports. 5, 15, p. 1-12 e13371.

Research output: Contribution to journalArticle

Open Access
Vitamin D
Pneumonia
Cholecalciferol
Lung
Diet
2016
4 Citations (Scopus)
Open Access
Regulatory T-Lymphocytes
Vitamin D
Lymph Nodes
Inflammation
Cholecalciferol
6 Citations (Scopus)

Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo

Calapre, L., Gray, E. S., Kurdykowski, S., David, A., Hart, P., Descargues, P. & Ziman, M., 2016, In : BMC Dermatology. 16, 1, p. 6 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Hot Temperature
Apoptosis
Skin
DNA Damage
6 Citations (Scopus)

High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Ghaly, S., Murray, K., Baird, A., Martin, K., Prosser, R., Mill, J., Simms, L. A., Hart, P. H., Radford-Smith, G., Bampton, P. A. & Lawrance, I. C., Oct 2016, In : Inflammatory Bowel Diseases. 22, 10, p. 2456-2464 9 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Crohn Disease
Albumins
Sunlight
Recurrence
6 Citations (Scopus)
Vitamin D Deficiency
Pyroglyphidae
Pneumonia
Genes
Smooth Muscle
8 Citations (Scopus)
144 Downloads (Pure)

Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Black, L., Burrows, S., Lucas, R. M., Marshall, C., Huang, R-C., Chan She Ping-Delfos, W., Beilin, L., Holt, P., Hart, P., Oddy, W. & Mori, T., Jun 2016, In : British Journal of Nutrition. 115, 11, p. 1994-2002

Research output: Contribution to journalArticle

Open Access
File
Young Adult
Serum
Insulin Resistance
Homeostasis
Blood Pressure
10 Citations (Scopus)

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

Roggenbuck, M., Anderson, D., Barfod, K. K., Feelisch, M., Geldenhuys, S., Sørensen, S. J., Weeden, C. E., Hart, P. H. & Gorman, S., 2016, In : Respiratory Research. 17, 1, p. 116 116 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Vitamin D
Lung
Diet
Ovalbumin
2015
9 Citations (Scopus)

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: The Sun Exposure and Vitamin D Supplementation (SEDS) Study

Hartley, M., Hoare, S., Lithander, F. E., Neale, R. E., Hart, P., Gorman, S., Gies, P. H. F., Sherriff, J. L., Swaminathan, A., Beilin, L., Mori, T., King, L., Black, L., Marshall, K., Xiang, F., Wyatt, C., King, K., Slevin, T. J., Pandeya, N. & Lucas, R., 2015, In : BMC Public Health. 15, 1, p. 1-9

Research output: Contribution to journalArticle

Open Access
Solar System
Vitamin D
Vitamin D Deficiency
Skin Neoplasms
Serum
13 Citations (Scopus)

Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103 and XCR1+CD103+ dendritic cells

Wylie, B., Seppanen, E., Xiao, K., Zemek, R., Zanker, D., Prato, S., Foley, B., Hart, P., Kroczek, R. A., Chen, W. & Waithman, J., 2015, In : OncoImmunology. 4, 8, p. 1-11

Research output: Contribution to journalArticle

Cross-Priming
Melanoma-Specific Antigens
Dendritic Cells
Neoplasm Antigens
Skin
115 Downloads (Pure)

Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation

Scott, N. M., Ng, R. L. X., McGonigle, T. A., Gorman, S. & Hart, P., Nov 2015, In : Inflammation Research. 64, 11, p. 861-873 13 p.

Research output: Contribution to journalArticle

Open Access
File
Bone Marrow Cells
Inflammation
Bone Marrow
Dendritic Cells
Allergens
24 Citations (Scopus)

The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

Foong, R., Bosco, A., Jones, A., Gout, A., Gorman, S., Hart, P. & Zosky, G. R., 1 Nov 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 664-675 12 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D Deficiency
Vitamin D
Smooth Muscle
Muscle
Lung

UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis

Geldenhuys, S., Mohammad, M. G., Hui, L., Hassanpour, M., Ng, R., Scott, N. M., Lucas, R., Brown, D. A. & Hart, P., 2015, In : Journal of Multiple Sclerosis. 2, 3, p. 1-5

Research output: Contribution to journalArticle

Open Access
49 Citations (Scopus)

Vitamin D in fetal development: Findings from a birth cohort study

Hart, P., Lucas, R., Walsh, J., Zosky, G., Whitehouse, A., Zhu, K., Allen, K., Kusel, M. M., Anderson, D. & Mountain, J., 2015, In : Pediatrics. 135, 1, p. e167-e173

Research output: Contribution to journalArticle

2014
23 Citations (Scopus)
Genome-Wide Association Study
Vitamin D
Cohort Studies
Chromosomes
Pregnancy
59 Citations (Scopus)

Immune cell trafficking from the brain maintains CNS immune tolerance

Mohammad, M. G., Tsai, V. W. W., Ruitenberg, M., Hassanpour, M., Li, H., Hart, P., Breit, S. N., Sawchenko, P. E. & Brownl, D. A., 3 Mar 2014, In : The Journal of clinical investigation. 124, 3, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)
217 Downloads (Pure)

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

Robinson, M., Whitehouse, A., Newnham, J., Gorman, S., Jacoby, P., Holt, B. J., Serralha, M., Tearne, J., Holt, P., Hart, P. & Kusel, M., 1 Jun 2014, In : Archives of Women's Mental Health. 17, 3, p. 213-219

Research output: Contribution to journalArticle

Open Access
File
Postpartum Depression
Vitamin D
Mothers
Pregnancy
Serum
28 Citations (Scopus)
154 Downloads (Pure)

Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity

Black, L., Jacoby, P., Chan She Ping-Delfos, W., Mori, T., Beilin, L., Olynyk, J., Ayonrinde, O. T., Huang, R-C., Holt, P., Hart, P., Oddy, W. & Adams, L., Jun 2014, In : Journal of Gastroenterology and Hepatology (Australia). 29, 6, p. 1215-1222

Research output: Contribution to journalArticle

Open Access
File
Adiposity
Serum
Insulin Resistance
Vitamin D Deficiency
Odds Ratio
29 Citations (Scopus)
299 Downloads (Pure)

Low vitamin D levels are associated with symptoms of depression in young adult males

Black, L., Jacoby, P., Allen, K., Trapp, G., Hart, P., Byrne, S., Mori, T., Beilin, L. & Oddy, W., May 2014, In : Australian & New Zealand Journal of Psychiatry. 48, 5, p. 464-471

Research output: Contribution to journalArticle

Open Access
File
Vitamin D
Young Adult
Depression
Anxiety
Serum
62 Citations (Scopus)

Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: A prospective cohort study

Zhu, K., Whitehouse, A., Hart, P., Kusel, M., Mountain, J., Lye, S., Pennell, C. & Walsh, J., May 2014, In : Journal of Bone and Mineral Research. 29, 5, p. 1088-1095

Research output: Contribution to journalArticle

Open Access
Vitamin D
Bone Density
Cohort Studies
Mothers
Prospective Studies
20 Citations (Scopus)

Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrow

Scott, N. M., Ng, R. L., Gorman, S., Norval, M., Waithman, J. & Hart, P., Feb 2014, In : Journal of Leukocyte Biology. 95, 2, p. 225-232

Research output: Contribution to journalArticle

Open Access
Dinoprostone
Dendritic Cells
Bone Marrow
Bone Marrow Cells
Myeloid Progenitor Cells
45 Citations (Scopus)

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet

Geldenhuys, S., Hart, P., Endersby, R., Jacoby, P., Feelisch, M., Weller, R. B. J. B., Matthews, V. & Gorman, S., 2014, In : Diabetes. 63, 11, p. 3759-3769

Research output: Contribution to journalArticle

High Fat Diet
Vitamin D
Obesity
Radiation
Sunlight
31 Citations (Scopus)

Vitamin D and immunity

Lucas, R., Gorman, S., Geldenhuys, S. & Hart, P., 2014, In : F1000Prime Reports. 6, p. 1-11

Research output: Contribution to journalArticle

Vitamin D
Immunity
Vitamin D Deficiency
Physiologic Calcification
Microbiota
62 Citations (Scopus)

Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

Zosky, G., Hart, P., Whitehouse, A., Kusel, M., Ang, W., Foong, R., Chen, L., Holt, P., Sly, P. D. L. & Hall, G., 2014, In : Annals of the American Thoracic Society. 11, 4, p. 571-577

Research output: Contribution to journalArticle

Vitamin D Deficiency
Asthma
Pregnancy
Lung
Mothers
24 Citations (Scopus)
Open Access
15 Citations (Scopus)
216 Downloads (Pure)

Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

Black, L., Burrows, S., Jacoby, P., Oddy, W., Beilin, L., Chan She Ping-Delfos, W., Marshall, C. E., Holt, P., Hart, P. & Mori, T., Oct 2014, In : British Journal of Nutrition. 112, 7, p. 1154-1162

Research output: Contribution to journalArticle

Open Access
File
Vitamin D
Serum
25-hydroxyvitamin D
Linear Models
Consensus
2013
31 Citations (Scopus)

Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice

Ng, R. L. X., Scott, N. M., Strickland, D., Gorman, S., Grimbaldeston, M. A., Norval, M., Waithman, J. & Hart, P., 2013, In : Journal of Immunology. 190, p. 5471-5484

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice

Ng, R. L. X., Scott, N. M., Bisley, J. L., Lambert, M. J., Gorman, S., Norval, M. & Hart, P., Dec 2013, In : Immunology. 140, 4, p. 399-412

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Bone Marrow
Immunity
Radiation
Gene Expression
49 Citations (Scopus)

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

Whitehouse, A., Holt, B. J., Serralha, M., Holt, P., Hart, P. & Kusel, M., 2013, In : Journal of Autism and Developmental Disorders. Online, p. 1-10

Research output: Contribution to journalArticle

16 Citations (Scopus)
206 Downloads (Pure)
Open Access
File
Vitamin D
Mothers
Pregnancy
Logistic Models
Feeding and Eating Disorders