Prudence Hart

Adjunct Professor

  • The University of Western Australia (M560), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2268 Citations
  • 26 h-Index
20032018
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Research Output 2004 2018

2018

Cellular and molecular mechanisms of vitamin D in food allergy

Poole, A., Song, Y., Brown, H., Hart, P. H. & Zhang, G. B., 1 Jul 2018, In : Journal of Cellular and Molecular Medicine. 22, 7, p. 3270-3277 8 p.

Research output: Contribution to journalReview article

Open Access
Food Hypersensitivity
Vitamin D
Microbiota
Sunlight
DNA Methylation

Divisions of labour in dendritic cell immune-surveillance and epigenetic mechanisms of immune evasion

Wylie, B. C., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Immune Evasion
Epigenomics
Dendritic Cells
Immunity
Neoplasms
1 Citations

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

Research output: Contribution to journalArticle

Open Access
Microbiota
Colitis
Vitamin D
Dextran Sulfate
Inflammatory Bowel Diseases

Higher serum immunoglobulin G3 levels may predict the development of multiple sclerosis in individuals with clinically isolated syndrome

Trend, S., Jones, A. P., Cha, L., Byrne, S. N., Geldenhuys, S., Fabis-Pedrini, M. J., Carroll, W. M., Cole, J. M., Booth, D. R., Lucas, R. M., Kermode, A. G., French, M. A. & Hart, P. H., 13 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1590.

Research output: Contribution to journalArticle

Open Access
Multiple Sclerosis
Immunoglobulins
Immunoglobulin G
Serum
Immunoglobulin M

Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D

Gorman, S., Geldenhuys, S., Weeden, C., Grimbaldeston, M. A. & Hart, P., 1 Apr 2018, In : Archives of Dermatological Research. 310, 3, p. 221-230 10 p.

Research output: Contribution to journalArticle

Interleukin-9
Regulatory T-Lymphocytes
Mast Cells
Vitamin D
Inflammation
1 Citations

Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., Newsholme, P., Goodridge, H. S., Pixley, F. J. & Hart, P. H., 1 Jan 2018, In : Journal of Immunology. 200, 1, p. 260-270

Research output: Contribution to journalArticle

Chemotactic Factors
Bone Marrow
Macrophages
Macrophage Colony-Stimulating Factor
Inflammation

Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis

Cha, L., Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Carroll, W. M., Lucas, R. M., Cole, J. M., Booth, D. R., Kermode, A. G. & Hart, P. H., 1 Jan 2018, In : Clinical and Translational Immunology. 7, 8, e1037.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
Arginase
Multiple Sclerosis
Arginine

Ultraviolet irradiation of skin alters the faecal microbiome independently of vitamin D in mice

Ghaly, S., Kaakoush, N. O., Lloyd, F., Gordon, L., Forest, C., Lawrance, I. C. & Hart, P. H., 11 Aug 2018, In : Nutrients. 10, 8, 1069.

Research output: Contribution to journalArticle

Open Access
Microbiota
vitamin D
Vitamin D
irradiation
colitis
Cholecalciferol
Vitamin D
Skin
Irradiation
Ultraviolet radiation
2017

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., May 2017, In : Clinical & Translational Immunology. 6, 5, e143.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Multiple Sclerosis
Blood Cells
Therapeutics

Altered regulatory T-cell fractions and Helios expression in Clinically Isolated Syndrome

Jones, A., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP7-NP7 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations

Are low sun exposure and/or vitamin D risk factors for type 1 diabetes?

Miller, K. M., Hart, P. H., de Klerk, N. H., Davis, E. A. & Lucas, R. M., 1 Mar 2017, In : PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. 16, 3, p. 381-398 18 p.

Research output: Contribution to journalReview article

Open Access
14 Citations

Circulating immune cells in multiple sclerosis

Jones, A. P., Kermode, A. G., Lucas, R. M., Carroll, W. M., Nolan, D. & Hart, P. H., 1 Feb 2017, In : Clinical and Experimental Immunology. 187, 2, p. 193-203 11 p.

Research output: Contribution to journalReview article

Open Access
File
Multiple Sclerosis
B-Lymphocyte Subsets
T-Lymphocyte Subsets
B-Lymphocytes
T-Lymphocytes
3 Citations

Evolving identification of blood cells associated with clinically isolated syndrome: Importance of time since clinical presentation and diagnostic MRI

Trend, S., Jones, A. P., Geldenhuys, S., Byrne, S. N., Fabis-Pedrini, M. J., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., 15 Jun 2017, In : International Journal of Molecular Sciences. 18, 6, 1277.

Research output: Contribution to journalArticle

Open Access
blood cells
Magnetic resonance
magnetic resonance
Blood Cells
Blood

Expression of MS risk genes in whole blood of CIS patients treated with narrow band UVB phototherapy

Gatt, P., Lucas, R. M., Carroll, W. M., Nolan, D., Cole, J. M., Jones, A. P., Trend, S., Cha, L., Kermode, A. G., Hart, P. H. & Booth, D. R., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP14-NP14 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citations
8 Citations

Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of vitamin D and other UVB-induced molecules

Hart, P. H., Lucas, R. M., Booth, D. R., Carroll, W. M., Nolan, D., Cole, J. M., Jones, A. P. & Kermode, A. G., 24 Jan 2017, In : Frontiers in Immunology. 8, January, 3.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Vitamin D
Multiple Sclerosis
Solar System
Sunlight

Narrowband UVB phototherapy for Clinically Isolated Syndrome: Delivering the benefits of all UVB-induced molecules to early MS patients

Hart, P., Kermode, A. G., Lucas, R. M., Booth, D. R., Carroll, W. M., Nolan, D., Cole, J. M., Byrne, S. N., Jones, A. P., Trend, S. & Cha, L., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP7-NP7 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., Goodridge, H. S., Zon, L. I., Pixley, F. J. & Hart, P. H., Dec 2017, In : Experimental Hematology. 56, p. 64-68

Research output: Contribution to journalArticle

Open Access
File
16,16-Dimethylprostaglandin E2
Dinoprostone
Bone Marrow Cells
Cell Movement
Monocytes

Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

Fleury, N., Feelisch, M., Hart, P. H., Weller, R. B., Smoothy, J., Matthews, V. B. & Gorman, S., 1 Apr 2017, In : Journal of Endocrinology. 233, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Radiation
High Fat Diet
Nitric Oxide
Sunlight
Adiposity
8 Citations

The bioenergetics of inflammation: insights into obesity and type 2 diabetes

Keane, K. N., Calton, E. K., Carlessi, R., Hart, P. H. & Newsholme, P., 2017, In : European Journal of Clinical Nutrition. 71, 7, p. 904–912

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Energy Metabolism
Obesity
Inflammation
Leukocytes
7 Citations

Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

Zhu, K., Oddy, W. H., Holt, P., Ping-Delfos, W. C. S., Mountain, J., Lye, S., Pennell, C., Hart, P. H. & Walsh, J. P., 1 Jul 2017, In : American Journal of Clinical Nutrition. 106, 1, p. 276-283 8 p.

Research output: Contribution to journalArticle

Open Access
File
Vitamin D
Bone Density
Bone and Bones
Serum
Photon Absorptiometry

UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D., Scott, N. M., Goodridge, H. S., Dwyer, A., Greenland, E., Pixley, F. J., Newsholme, P. & Hart, P. H., 1 Sep 2017, In : American Journal of Pathology. 187, 9, p. 2046-2059 14 p.

Research output: Contribution to journalArticle

Dendritic Cells
Bone Marrow
Skin
3-Hydroxyanthranilate 3,4-Dioxygenase
CC Chemokines
23 Citations

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

Hollams, E. M., Teo, S. M., Kusel, M., Holt, B. J., Holt, K. E., Inouye, M., De Klerk, N. H., Zhang, G., Sly, P. D., Hart, P. H. & Holt, P. G., Feb 2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 472-481.e9

Research output: Contribution to journalArticle

Vitamin D
Hypersensitivity
Asthma
Eczema
Parturition
2 Citations
Open Access
Vitamin D
Pneumonia
Cholecalciferol
Lung
Diet
2016
4 Citations
Open Access
Regulatory T-Lymphocytes
Vitamin D
Lymph Nodes
Inflammation
Cholecalciferol
4 Citations

Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo

Calapre, L., Gray, E. S., Kurdykowski, S., David, A., Hart, P., Descargues, P. & Ziman, M., 2016, In : BMC Dermatology. 16, 1, p. 6 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Hot Temperature
Apoptosis
Skin
DNA Damage
2 Citations

High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Ghaly, S., Murray, K., Baird, A., Martin, K., Prosser, R., Mill, J., Simms, L. A., Hart, P. H., Radford-Smith, G., Bampton, P. A. & Lawrance, I. C., Oct 2016, In : Inflammatory Bowel Diseases. 22, 10, p. 2456-2464 9 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Crohn Disease
Albumins
Sunlight
Recurrence
6 Citations
Vitamin D Deficiency
Pyroglyphidae
Pneumonia
Genes
Smooth Muscle
5 Citations

Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Black, L., Burrows, S., Lucas, R. M., Marshall, C., Huang, R-C., Chan She Ping-Delfos, W., Beilin, L., Holt, P., Hart, P., Oddy, W. & Mori, T., Jun 2016, In : British Journal of Nutrition. 115, 11, p. 1994-2002

Research output: Contribution to journalArticle

Open Access
File
Young Adult
Serum
Insulin Resistance
Homeostasis
Blood Pressure
8 Citations

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

Roggenbuck, M., Anderson, D., Barfod, K. K., Feelisch, M., Geldenhuys, S., Sørensen, S. J., Weeden, C. E., Hart, P. H. & Gorman, S., 2016, In : Respiratory Research. 17, 1, p. 116 116 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Vitamin D
Lung
Diet
Ovalbumin
2015
4 Citations

Can skin exposure to sunlight prevent liver inflammation?

Gorman, S., Black, L., Feelisch, M., Hart, P. & Weller, R., 5 May 2015, In : Nutrients. 7, 5, p. 3219-3239

Research output: Contribution to journalReview article

Open Access
dermal exposure
Sunlight
fatty liver
vitamin D
Vitamin D
6 Citations

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: The Sun Exposure and Vitamin D Supplementation (SEDS) Study

Hartley, M., Hoare, S., Lithander, F. E., Neale, R. E., Hart, P., Gorman, S., Gies, P. H. F., Sherriff, J. L., Swaminathan, A., Beilin, L., Mori, T., King, L., Black, L., Marshall, K., Xiang, F., Wyatt, C., King, K., Slevin, T. J., Pandeya, N. & Lucas, R., 2015, In : BMC Public Health. 15, 1, p. 1-9

Research output: Contribution to journalArticle

Open Access
Solar System
Vitamin D
Vitamin D Deficiency
Skin Neoplasms
Serum
7 Citations

Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103 and XCR1+CD103+ dendritic cells

Wylie, B., Seppanen, E., Xiao, K., Zemek, R., Zanker, D., Prato, S., Foley, B., Hart, P., Kroczek, R. A., Chen, W. & Waithman, J., 2015, In : OncoImmunology. 4, 8, p. 1-11

Research output: Contribution to journalArticle

Cross-Priming
Melanoma-Specific Antigens
Dendritic Cells
Neoplasm Antigens
Skin

Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation

Scott, N. M., Ng, R. L. X., McGonigle, T. A., Gorman, S. & Hart, P., Nov 2015, In : Inflammation Research. 64, 11, p. 861-873 13 p.

Research output: Contribution to journalArticle

Open Access
File
Bone Marrow Cells
Inflammation
Bone Marrow
Dendritic Cells
Allergens
21 Citations
Open Access
Vitamin D Deficiency
Vitamin D
Smooth Muscle
Muscle
Lung

UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis

Geldenhuys, S., Mohammad, M. G., Hui, L., Hassanpour, M., Ng, R., Scott, N. M., Lucas, R., Brown, D. A. & Hart, P., 2015, In : Journal of Multiple Sclerosis. 2, 3, p. 1-5

Research output: Contribution to journalArticle

39 Citations

Vitamin D in fetal development: Findings from a birth cohort study

Hart, P., Lucas, R., Walsh, J., Zosky, G., Whitehouse, A., Zhu, K., Allen, K., Kusel, M. M., Anderson, D. & Mountain, J., 2015, In : Pediatrics. 135, 1, p. e167-e173

Research output: Contribution to journalArticle

2014
18 Citations
Genome-Wide Association Study
Vitamin D
Single Nucleotide Polymorphism
Cohort Studies
Chromosomes
56 Citations

Immune cell trafficking from the brain maintains CNS immune tolerance

Mohammad, M. G., Tsai, V. W. W., Ruitenberg, M., Hassanpour, M., Li, H., Hart, P., Breit, S. N., Sawchenko, P. E. & Brownl, D. A., 3 Mar 2014, In : The Journal of clinical investigation. 124, 3, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
40 Citations

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

Robinson, M., Whitehouse, A., Newnham, J., Gorman, S., Jacoby, P., Holt, B. J., Serralha, M., Tearne, J., Holt, P., Hart, P. & Kusel, M., 1 Jun 2014, In : Archives of Women's Mental Health. 17, 3, p. 213-219

Research output: Contribution to journalArticle

Open Access
File
Postpartum Depression
Vitamin D
Mothers
Pregnancy
Serum
24 Citations
Open Access
File
Adiposity
Serum
Insulin Resistance
Vitamin D Deficiency
Odds Ratio
23 Citations
Open Access
File
Vitamin D
Young Adult
Depression
Anxiety
Serum
50 Citations

Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: A prospective cohort study

Zhu, K., Whitehouse, A., Hart, P., Kusel, M., Mountain, J., Lye, S., Pennell, C. & Walsh, J., May 2014, In : Journal of Bone and Mineral Research. 29, 5, p. 1088-1095

Research output: Contribution to journalArticle

Open Access
Vitamin D
Bone Density
Cohort Studies
Mothers
Prospective Studies
18 Citations

Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrow

Scott, N. M., Ng, R. L., Gorman, S., Norval, M., Waithman, J. & Hart, P., Feb 2014, In : Journal of Leukocyte Biology. 95, 2, p. 225-232

Research output: Contribution to journalArticle

Open Access
Dinoprostone
Dendritic Cells
Bone Marrow
Bone Marrow Cells
Myeloid Progenitor Cells
1 Citations

Reply

Zosky, G. R., Hart, P., Whitehouse, A. & Hall, G., 2014, In : Annals of the American Thoracic Society. 11, 8, p. 1337-1338

Research output: Contribution to journalLetter

35 Citations

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet

Geldenhuys, S., Hart, P., Endersby, R., Jacoby, P., Feelisch, M., Weller, R. B. J. B., Matthews, V. & Gorman, S., 2014, In : Diabetes. 63, 11, p. 3759-3769

Research output: Contribution to journalArticle

High Fat Diet
Vitamin D
Obesity
Radiation
Sunlight

UVR-induced immunosupression

Norval, M. & Hart, P., 2014, Handbook of Photomedicine. Hamblin, MR. & Huang, YY. (eds.). United States: Taylor & Francis, p. 111-122

Research output: Chapter in Book/Conference paperChapter

26 Citations

Vitamin D and immunity

Lucas, R., Gorman, S., Geldenhuys, S. & Hart, P., 2014, In : F1000Prime Reports. 6, p. 1-11

Research output: Contribution to journalArticle

Vitamin D
Immunity
Vitamin D Deficiency
Physiologic Calcification
Microbiota
57 Citations

Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

Zosky, G., Hart, P., Whitehouse, A., Kusel, M., Ang, W., Foong, R., Chen, L., Holt, P., Sly, P. D. L. & Hall, G., 2014, In : Annals of the American Thoracic Society. 11, 4, p. 571-577

Research output: Contribution to journalArticle

Vitamin D Deficiency
Asthma
Pregnancy
Lung
Mothers