Prudence Hart

Adjunct Professor

  • The University of Western Australia (M560), 35 Stirling Highway,

    6009 Perth

    Australia

  • 6922 Citations
  • 45 h-Index
1976 …2019
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Research Output 1976 2019

2019

Exposure to solar UVR suppresses cell-mediated immunization responses in humans: The Australian Ultraviolet Radiation and Immunity Study

Swaminathan, A., Harrison, S. L., Ketheesan, N., van den Boogaard, C. H. A., Dear, K., Allen, M., Hart, P. H., Cook, M. & Lucas, R. M., Jul 2019, In : Journal of Investigative Dermatology. 139, 7, p. 1545–1553

Research output: Contribution to journalArticle

Open Access
Immunization
Ultraviolet radiation
Clothing
Immunity
Radiation
7 Citations (Scopus)

Exposure to Ultraviolet Radiation in the Modulation of Human Diseases

Hart, P. H., Norval, M., Byrne, S. N. & Rhodes, L. E., 1 Jan 2019, In : Annual Review of Pathology: Mechanisms of Disease. 14, p. 55-81 27 p.

Research output: Contribution to journalReview article

Radiation
Skin
Light
Vitiligo
Immunomodulation

Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome

Trend, S., Jones, A. P., Cha, L., Cooper, M. N., Geldenhuys, S., Fabis-Pedrini, M. J., Carroll, W. M., Cole, J. M., Booth, D. R., Lucas, R. M., French, M. A., Byrne, S. N., Kermode, A. G. & Hart, P. H., 28 May 2019, In : Scientific Reports. 9, 1, 13 p., 7980.

Research output: Contribution to journalArticle

Open Access

The case for greater vigilance in applying sunscreen during real-life sun exposure

Hart, P. H., 1 Mar 2019, In : British Journal of Dermatology. 180, 3, p. 462-463 2 p.

Research output: Contribution to journalComment/debate

Sunscreening Agents
Solar System
Saliva
Mastication
Assays
Blood
Flow rate
1 Citation (Scopus)
Cholecalciferol
Vitamin D
Skin
Irradiation
Ultraviolet radiation

Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission

Haifer, C., Lawrance, I. C., Center, J. R., Clarke, M. W., Hart, P. H., Eisman, J. A., Lucas, R. & Ghaly, S., 26 Jul 2019, In : Therapeutic Advances in Gastroenterology. 12, 12 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D
Crohn Disease
Vitamin D-Binding Protein
Inflammation
Vitamin D Deficiency
2018

A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study

Hart, P. H., Jones, A. P., Trend, S., Cha, L., Fabis-Pedrini, M. J., Cooper, M. N., d'Este, C., Geldenhuys, S., Carroll, W. M., Byrne, S. N., Booth, D. R., Cole, J. M., Lucas, R. M. & Kermode, A. G., 22 May 2018, In : Multiple Sclerosis Journal - Experimental, Translational and Clinical. 4, 2, 6 p.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Multiple Sclerosis
Randomized Controlled Trials
Radiation
Calcifediol
2 Citations (Scopus)

Cellular and molecular mechanisms of vitamin D in food allergy

Poole, A., Song, Y., Brown, H., Hart, P. H. & Zhang, G. B., 1 Jul 2018, In : Journal of Cellular and Molecular Medicine. 22, 7, p. 3270-3277 8 p.

Research output: Contribution to journalReview article

Open Access
Food Hypersensitivity
Vitamin D
Microbiota
Sunlight
DNA Methylation
201 Downloads (Pure)

Divisions of labour in dendritic cell immune-surveillance and epigenetic mechanisms of immune evasion

Wylie, B. C., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Immune Evasion
Epigenomics
Dendritic Cells
Immunity
Neoplasms
6 Citations (Scopus)

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

Research output: Contribution to journalArticle

Open Access
Microbiota
Colitis
Vitamin D
Dextran Sulfate
Inflammatory Bowel Diseases
1 Citation (Scopus)

Higher serum immunoglobulin G3 levels may predict the development of multiple sclerosis in individuals with clinically isolated syndrome

Trend, S., Jones, A. P., Cha, L., Byrne, S. N., Geldenhuys, S., Fabis-Pedrini, M. J., Carroll, W. M., Cole, J. M., Booth, D. R., Lucas, R. M., Kermode, A. G., French, M. A. & Hart, P. H., 13 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1590.

Research output: Contribution to journalArticle

Open Access
Multiple Sclerosis
Immunoglobulins
Immunoglobulin G
Serum
Immunoglobulin M

Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D

Gorman, S., Geldenhuys, S., Weeden, C., Grimbaldeston, M. A. & Hart, P., 1 Apr 2018, In : Archives of Dermatological Research. 310, 3, p. 221-230 10 p.

Research output: Contribution to journalArticle

Interleukin-9
Regulatory T-Lymphocytes
Mast Cells
Vitamin D
Inflammation
3 Citations (Scopus)

Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., Newsholme, P., Goodridge, H. S., Pixley, F. J. & Hart, P. H., 1 Jan 2018, In : Journal of Immunology. 200, 1, p. 260-270

Research output: Contribution to journalArticle

Chemotactic Factors
Bone Marrow
Macrophages
Macrophage Colony-Stimulating Factor
Inflammation
2 Citations (Scopus)

Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis

Cha, L., Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Carroll, W. M., Lucas, R. M., Cole, J. M., Booth, D. R., Kermode, A. G. & Hart, P. H., 1 Jan 2018, In : Clinical and Translational Immunology. 7, 8, e1037.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
Arginase
Multiple Sclerosis
Arginine
2 Citations (Scopus)

Ultraviolet irradiation of skin alters the faecal microbiome independently of vitamin D in mice

Ghaly, S., Kaakoush, N. O., Lloyd, F., Gordon, L., Forest, C., Lawrance, I. C. & Hart, P. H., 11 Aug 2018, In : Nutrients. 10, 8, 1069.

Research output: Contribution to journalArticle

Open Access
Microbiota
vitamin D
Vitamin D
irradiation
colitis
10 Citations (Scopus)

Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis

Hart, P. H. & Norval, M., 1 Jan 2018, In : Photochemical and Photobiological Sciences. 17, 12, p. 1872-1884 13 p.

Research output: Contribution to journalReview article

immunosuppression
Ultraviolet radiation
ultraviolet radiation
Skin
immune systems
2017

Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Jones, A. P., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., May 2017, In : Clinical & Translational Immunology. 6, 5, e143.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Multiple Sclerosis
Blood Cells
Therapeutics

Altered regulatory T-cell fractions and Helios expression in Clinically Isolated Syndrome

Jones, A., Trend, S., Byrne, S. N., Fabis-Pedrini, M. J., Geldenhuys, S., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP7-NP7 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

3 Citations (Scopus)

Are low sun exposure and/or vitamin D risk factors for type 1 diabetes?

Miller, K. M., Hart, P. H., de Klerk, N. H., Davis, E. A. & Lucas, R. M., 1 Mar 2017, In : PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. 16, 3, p. 381-398 18 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)
120 Downloads (Pure)

Circulating immune cells in multiple sclerosis

Jones, A. P., Kermode, A. G., Lucas, R. M., Carroll, W. M., Nolan, D. & Hart, P. H., 1 Feb 2017, In : Clinical and Experimental Immunology. 187, 2, p. 193-203 11 p.

Research output: Contribution to journalReview article

Open Access
File
Multiple Sclerosis
B-Lymphocyte Subsets
T-Lymphocyte Subsets
B-Lymphocytes
T-Lymphocytes
3 Citations (Scopus)

Evolving identification of blood cells associated with clinically isolated syndrome: Importance of time since clinical presentation and diagnostic MRI

Trend, S., Jones, A. P., Geldenhuys, S., Byrne, S. N., Fabis-Pedrini, M. J., Nolan, D., Booth, D. R., Carroll, W. M., Lucas, R. M., Kermode, A. G. & Hart, P. H., 15 Jun 2017, In : International Journal of Molecular Sciences. 18, 6, 1277.

Research output: Contribution to journalArticle

Open Access
blood cells
Magnetic resonance
magnetic resonance
Blood Cells
Blood

Expression of MS risk genes in whole blood of CIS patients treated with narrow band UVB phototherapy

Gatt, P., Lucas, R. M., Carroll, W. M., Nolan, D., Cole, J. M., Jones, A. P., Trend, S., Cha, L., Kermode, A. G., Hart, P. H. & Booth, D. R., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP14-NP14 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citation (Scopus)
11 Citations (Scopus)

Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of vitamin D and other UVB-induced molecules

Hart, P. H., Lucas, R. M., Booth, D. R., Carroll, W. M., Nolan, D., Cole, J. M., Jones, A. P. & Kermode, A. G., 24 Jan 2017, In : Frontiers in Immunology. 8, January, 3.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Vitamin D
Multiple Sclerosis
Solar System
Sunlight

Narrowband UVB phototherapy for Clinically Isolated Syndrome: Delivering the benefits of all UVB-induced molecules to early MS patients

Hart, P., Kermode, A. G., Lucas, R. M., Booth, D. R., Carroll, W. M., Nolan, D., Cole, J. M., Byrne, S. N., Jones, A. P., Trend, S. & Cha, L., Nov 2017, In : Multiple Sclerosis. 23, 13, p. NP7-NP7 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations (Scopus)
48 Downloads (Pure)

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., Goodridge, H. S., Zon, L. I., Pixley, F. J. & Hart, P. H., Dec 2017, In : Experimental Hematology. 56, p. 64-68

Research output: Contribution to journalArticle

Open Access
File
16,16-Dimethylprostaglandin E2
Dinoprostone
Bone Marrow Cells
Cell Movement
Monocytes
4 Citations (Scopus)

Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

Fleury, N., Feelisch, M., Hart, P. H., Weller, R. B., Smoothy, J., Matthews, V. B. & Gorman, S., 1 Apr 2017, In : Journal of Endocrinology. 233, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Radiation
High Fat Diet
Nitric Oxide
Sunlight
Adiposity
14 Citations (Scopus)

The bioenergetics of inflammation: insights into obesity and type 2 diabetes

Keane, K. N., Calton, E. K., Carlessi, R., Hart, P. H. & Newsholme, P., 2017, In : European Journal of Clinical Nutrition. 71, 7, p. 904–912

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Energy Metabolism
Obesity
Inflammation
Leukocytes
14 Citations (Scopus)
73 Downloads (Pure)

Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

Zhu, K., Oddy, W. H., Holt, P., Ping-Delfos, W. C. S., Mountain, J., Lye, S., Pennell, C., Hart, P. H. & Walsh, J. P., 1 Jul 2017, In : American Journal of Clinical Nutrition. 106, 1, p. 276-283 8 p.

Research output: Contribution to journalArticle

Open Access
File
Vitamin D
Bone Density
Bone and Bones
Serum
Photon Absorptiometry
2 Citations (Scopus)

UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D., Scott, N. M., Goodridge, H. S., Dwyer, A., Greenland, E., Pixley, F. J., Newsholme, P. & Hart, P. H., 1 Sep 2017, In : American Journal of Pathology. 187, 9, p. 2046-2059 14 p.

Research output: Contribution to journalArticle

Dendritic Cells
Bone and Bones
Skin
Bone Marrow
3-Hydroxyanthranilate 3,4-Dioxygenase
29 Citations (Scopus)

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

Hollams, E. M., Teo, S. M., Kusel, M., Holt, B. J., Holt, K. E., Inouye, M., De Klerk, N. H., Zhang, G., Sly, P. D., Hart, P. H. & Holt, P. G., Feb 2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 472-481.e9

Research output: Contribution to journalArticle

Vitamin D
Hypersensitivity
Asthma
Eczema
Parturition
3 Citations (Scopus)

Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

Gorman, S., Buckley, A. G., Ling, K. M., Berry, L. J., Fear, V. S., Stick, S. M., Larcombe, A. N., Kicic, A. & Hart, P. H., 1 Aug 2017, In : Physiological Reports. 5, 15, p. 1-12 e13371.

Research output: Contribution to journalArticle

Open Access
Vitamin D
Pneumonia
Cholecalciferol
Lung
Diet
2016
4 Citations (Scopus)
Open Access
Regulatory T-Lymphocytes
Vitamin D
Lymph Nodes
Inflammation
Cholecalciferol
6 Citations (Scopus)

Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo

Calapre, L., Gray, E. S., Kurdykowski, S., David, A., Hart, P., Descargues, P. & Ziman, M., 2016, In : BMC Dermatology. 16, 1, p. 6 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Hot Temperature
Apoptosis
Skin
DNA Damage
7 Citations (Scopus)

High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Ghaly, S., Murray, K., Baird, A., Martin, K., Prosser, R., Mill, J., Simms, L. A., Hart, P. H., Radford-Smith, G., Bampton, P. A. & Lawrance, I. C., Oct 2016, In : Inflammatory Bowel Diseases. 22, 10, p. 2456-2464 9 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Crohn Disease
Albumins
Sunlight
Recurrence
6 Citations (Scopus)
Vitamin D Deficiency
Pyroglyphidae
Pneumonia
Genes
Smooth Muscle
8 Citations (Scopus)
197 Downloads (Pure)

Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Black, L., Burrows, S., Lucas, R. M., Marshall, C., Huang, R-C., Chan She Ping-Delfos, W., Beilin, L., Holt, P., Hart, P., Oddy, W. & Mori, T., Jun 2016, In : British Journal of Nutrition. 115, 11, p. 1994-2002

Research output: Contribution to journalArticle

Open Access
File
Young Adult
Serum
Insulin Resistance
Homeostasis
Blood Pressure
10 Citations (Scopus)

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

Roggenbuck, M., Anderson, D., Barfod, K. K., Feelisch, M., Geldenhuys, S., Sørensen, S. J., Weeden, C. E., Hart, P. H. & Gorman, S., 2016, In : Respiratory Research. 17, 1, p. 116 116 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Vitamin D
Lung
Diet
Ovalbumin
2015
7 Citations (Scopus)

Can skin exposure to sunlight prevent liver inflammation?

Gorman, S., Black, L., Feelisch, M., Hart, P. & Weller, R., 5 May 2015, In : Nutrients. 7, 5, p. 3219-3239

Research output: Contribution to journalReview article

Open Access
dermal exposure
Sunlight
fatty liver
vitamin D
Vitamin D
9 Citations (Scopus)

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: The Sun Exposure and Vitamin D Supplementation (SEDS) Study

Hartley, M., Hoare, S., Lithander, F. E., Neale, R. E., Hart, P., Gorman, S., Gies, P. H. F., Sherriff, J. L., Swaminathan, A., Beilin, L., Mori, T., King, L., Black, L., Marshall, K., Xiang, F., Wyatt, C., King, K., Slevin, T. J., Pandeya, N. & Lucas, R., 2015, In : BMC Public Health. 15, 1, p. 1-9

Research output: Contribution to journalArticle

Open Access
Solar System
Vitamin D
Vitamin D Deficiency
Skin Neoplasms
Serum
14 Citations (Scopus)

Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103 and XCR1+CD103+ dendritic cells

Wylie, B., Seppanen, E., Xiao, K., Zemek, R., Zanker, D., Prato, S., Foley, B., Hart, P., Kroczek, R. A., Chen, W. & Waithman, J., 2015, In : OncoImmunology. 4, 8, p. 1-11

Research output: Contribution to journalArticle

Cross-Priming
Melanoma-Specific Antigens
Dendritic Cells
Neoplasm Antigens
Skin
135 Downloads (Pure)

Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation

Scott, N. M., Ng, R. L. X., McGonigle, T. A., Gorman, S. & Hart, P., Nov 2015, In : Inflammation Research. 64, 11, p. 861-873 13 p.

Research output: Contribution to journalArticle

Open Access
File
Bone Marrow Cells
Inflammation
Bone Marrow
Dendritic Cells
Allergens
25 Citations (Scopus)

The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

Foong, R., Bosco, A., Jones, A., Gout, A., Gorman, S., Hart, P. & Zosky, G. R., 1 Nov 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 664-675 12 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D Deficiency
Vitamin D
Smooth Muscle
Muscle
Lung
33 Citations (Scopus)

Ultraviolet radiation, vitamin D and multiple sclerosis

Lucas, R. M., Byrne, S. N., Correale, J., Ilschner, S. & Hart, P. H., 1 Oct 2015, In : Neurodegenerative Disease Management. 5, 5, p. 413-424 12 p.

Research output: Contribution to journalReview article

Open Access
Vitamin D
Multiple Sclerosis
Solar System
Radiation
Chemokines

UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis

Geldenhuys, S., Mohammad, M. G., Hui, L., Hassanpour, M., Ng, R., Scott, N. M., Lucas, R., Brown, D. A. & Hart, P., 2015, In : Journal of Multiple Sclerosis. 2, 3, p. 1-5

Research output: Contribution to journalArticle

Open Access
49 Citations (Scopus)

Vitamin D in fetal development: Findings from a birth cohort study

Hart, P., Lucas, R., Walsh, J., Zosky, G., Whitehouse, A., Zhu, K., Allen, K., Kusel, M. M., Anderson, D. & Mountain, J., 2015, In : Pediatrics. 135, 1, p. e167-e173

Research output: Contribution to journalArticle

2014
23 Citations (Scopus)
Genome-Wide Association Study
Vitamin D
Cohort Studies
Chromosomes
Pregnancy
59 Citations (Scopus)

Immune cell trafficking from the brain maintains CNS immune tolerance

Mohammad, M. G., Tsai, V. W. W., Ruitenberg, M., Hassanpour, M., Li, H., Hart, P., Breit, S. N., Sawchenko, P. E. & Brownl, D. A., 3 Mar 2014, In : The Journal of clinical investigation. 124, 3, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)
232 Downloads (Pure)

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

Robinson, M., Whitehouse, A., Newnham, J., Gorman, S., Jacoby, P., Holt, B. J., Serralha, M., Tearne, J., Holt, P., Hart, P. & Kusel, M., 1 Jun 2014, In : Archives of Women's Mental Health. 17, 3, p. 213-219

Research output: Contribution to journalArticle

Open Access
File
Postpartum Depression
Vitamin D
Mothers
Pregnancy
Serum