Research output per year
Research output per year
Personal profile
Research
Dr. Pilar Blancafort research has focused on two areas; one is the manipulation of the epigenome in several cancer models, such as breast cancer. This includes the development of DNA binding proteins to reactivate dormant tumour suppressors , and the stable repression of oncogenic drivers. More recently Dr. Blancafort has harnessed CRISPR/Cas9 models to reactivate the immune response in breast cancer. In collaboration with several investigators, she has implemented targeted delivered systems for CRISPR in primary solid tumors. More recently Dr. Blancafort has studied the role of novel oncogenes in activating the PI3K-AKT-mTOR pathway in breast and ovarian cancers. In sum, her research outcomes are the development of new agents to target specific patways as specialised medicine tools in the field of womens cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research expertise keywords
- genome engineering, women's cancers, cancer epigenetics
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Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
Sgro, A., Cursons, J., Waryah, C., Woodward, E. A., Foroutan, M., Lyu, R., Yeoh, G. C. T., Leedman, P. J. & Blancafort, P., Dec 2023, In: Clinical Epigenetics. 15, 1, 24 p., 73.Research output: Contribution to journal › Article › peer-review
Open Access -
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
Kim, M., Singh, M., Lee, B-K., Hibbs, M., Richardson, K., Ellies, L., Wintle, L., Stuart, L., Wang, J. Y., Voon, D. C., Blancafort, P., Wang, J., Kim, J., Leedman, P. & Woo, A., Dec 2022, In: Oncogenesis. 11, 1, 60.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
de Mendoza, A., Nguyen, T. V., Ford, E., Poppe, D., Buckberry, S., Pflueger, J., Grimmer, M. R., Stolzenburg, S., Bogdanovic, O., Oshlack, A., Farnham, P. J., Blancafort, P. & Lister, R., Dec 2022, In: Genome Biology. 23, 1, p. 1-31 32 p., 163.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
A peptide-functionalised dendronised polymer for selective transfection in human liver cancer cells
Chopra, M., Sgro, A., Norret, M., Blancafort, P., Iyer, K. S. & Evans, C. W., 7 Nov 2021, In: New Journal of Chemistry. 45, 41, p. 19315-19320 6 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Design and characterization of a cell-penetrating peptide derived from the sox2 transcription factor
Gandhi, N. S., Wang, E., Sorolla, A., Kan, Y. J., Malik, A., Batra, J., Young, K. A., Tie, W. J., Blancafort, P. & Mancera, R. L., 1 Sep 2021, In: International Journal of Molecular Sciences. 22, 17, 9354.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Datasets
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Additional file 2 of Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
de Mendoza Soler, A. (Creator), Nguyen, T. V. (Creator), Ford, E. (Creator), Poppe, D. (Creator), Buckberry, S. (Creator), Pflueger, J. (Creator), Grimmer, M. R. (Creator), Stolzenburg, S. (Creator), Bogdanovic, O. (Creator), Oshlack, A. (Creator), Farnham, P. J. (Creator), Blancafort, P. (Creator) & Lister, R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20381820.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Large-scale_manipulation_of_promoter_DNA_methylation_reveals_context-specific_transcriptional_responses_and_stability/20381820/1
Dataset
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Additional file 2 of Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
de Mendoza Soler, A. (Creator), Nguyen, T. V. (Creator), Ford, E. (Creator), Poppe, D. (Creator), Buckberry, S. (Creator), Pflueger, J. (Creator), Grimmer, M. R. (Creator), Stolzenburg, S. (Creator), Bogdanovic, O. (Creator), Oshlack, A. (Creator), Farnham, P. J. (Creator), Blancafort, P. (Creator) & Lister, R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20381820, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Large-scale_manipulation_of_promoter_DNA_methylation_reveals_context-specific_transcriptional_responses_and_stability/20381820
Dataset
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Identification and targeting of the oncogene AAMDC in ovarian cancer
Golden, E., Blancafort, P., Cohen, P., Yu, Y., Redfern, A. & Wang, E.
1/01/23 → 30/06/24
Project: Research
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Spatial analysis of tumour-immune cell interactions: implications for cancer immunotherapy design
Gaudieri, S., Blancafort, P. & Bosco, A.
1/01/23 → 31/12/23
Project: Research
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Zeiss Celldiscoverer7 for automated high resolution imaging of complex biomedical samples
Fox, A., Choi, Y. S., Rodger, J., Tang, A., Hool, L., Pillow, J., Lister, R., Bond, C., Hodgetts, S., Chen, K., Blancafort, P., Redfern, A., Swaminatha Iyer, K., Smith, N., Marshall, A., Fear, M., Wood, F., Evans, C., Chooi, H. & Rassell, A.
National Health & Medical Research Council NHMRC
1/07/22 → 31/10/23
Project: Research
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TARGETING A NEW SUBTYPE OF ESTROGEN RECEPTOR POSITIVE BREAST CANCER
Blancafort, P., Redfern, A., Golden, E., Johnstone, L., Pavlos, N. & Sharma, A.
National Breast Cancer Foundation
31/05/22 → 31/05/26
Project: Research