Research output per year
Research output per year
Personal profile
Research
Dr. Pilar Blancafort research has focused on two areas; one is the manipulation of the epigenome in several cancer models, such as breast cancer. This includes the development of DNA binding proteins to reactivate dormant tumour suppressors , and the stable repression of oncogenic drivers. More recently Dr. Blancafort has harnessed CRISPR/Cas9 models to reactivate the immune response in breast cancer. In collaboration with several investigators, she has implemented targeted delivered systems for CRISPR in primary solid tumors. More recently Dr. Blancafort has studied the role of novel oncogenes in activating the PI3K-AKT-mTOR pathway in breast and ovarian cancers. In sum, her research outcomes are the development of new agents to target specific patways as specialised medicine tools in the field of womens cancers.
Research expertise keywords
- genome engineering, women's cancers, cancer epigenetics
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Research output
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A peptide-functionalised dendronised polymer for selective transfection in human liver cancer cells
Chopra, M., Sgro, A., Norret, M., Blancafort, P., Iyer, K. S. & Evans, C. W., 7 Nov 2021, In: New Journal of Chemistry. 45, 41, p. 19315-19320 6 p.Research output: Contribution to journal › Article › peer-review
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Design and characterization of a cell-penetrating peptide derived from the sox2 transcription factor
Gandhi, N. S., Wang, E., Sorolla, A., Kan, Y. J., Malik, A., Batra, J., Young, K. A., Tie, W. J., Blancafort, P. & Mancera, R. L., 1 Sep 2021, In: International Journal of Molecular Sciences. 22, 17, 9354.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity
Alves, E., McLeish, E., Blancafort, P., Coudert, J. D. & Gaudieri, S., 12 Aug 2021, In: Frontiers in Immunology. 12, 712722.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing
Alves, E., Taifour, S., Dolcetti, R., Chee, J., Nowak, A. K., Gaudieri, S. & Blancafort, P., 11 Jun 2021, In: Molecular Therapy - Methods and Clinical Development. 21, p. 592-606 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Citations (Scopus) -
SP94-Targeted Nanoparticles Enhance the Efficacy of Sorafenib and Improve Liver Cancer Cell Discrimination
Chopra, M., Sgro, A., Norret, M., Blancafort, P., Iyer, K. S. & Evans, C. W., 18 Jan 2021, In: ACS Applied Bio Materials. 4, 1, p. 1023-1029 7 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
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NHMRC Equipment Grant qPCR
Pflueger, C., Lister, R., Laing, N., Ravenscroft, G., Morahan, G., Leedman, P., Blancafort, P., Forrest, A., Nilsson, J., Waryah, C., Chee, J., Nowak, A. & Gaudieri, S.
National Health & Medical Research Council NHMRC
14/02/22 → 10/02/23
Project: Research
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iXon Life Camera with SRFF-Stream for High-Speed Live-Cell Single Molecule Imaging
Swaminatha Iyer, K., Lister, R., Fox, A., Smith, N., Choi, Y. S., Stubbs, K., Lesterhuis, W., Blancafort, P., Bond, C., Jiang, H., Geddes, D., Chooi, H., Sarkar-Tyson, M., Evans, C., Chen, K., Rassell, A., Waryah, C., Golden, E. & Woodward, E.
National Health & Medical Research Council NHMRC
3/01/22 → 6/06/22
Project: Research
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Targeting oncogenic fusions in childhood sarcomas by locus-specific epigenetic editing
Blancafort, P., Houighton, P., Swaminatha Iyer, K. & foroutan, M.
Cancer Council of Western Australia
1/04/21 → 30/10/22
Project: Research
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Targeted Epigenetic Modification to Improve Mesothelioma Responses to Immunotherapy
30/09/20 → 29/09/22
Project: Research