Philip Burcham

Associate Professor, BSc PhD W.Aust.

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1149 Citations
  • 18 h-Index
20012018
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Research Output 2001 2018

12 Citations (Scopus)

UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes

Ghaoui, R., Sallustio, B. C., Burcham, P. & Fontaine, F. R., 2003, In : Chemico-Biological Interactions. 145, 2, p. 201-211

Research output: Contribution to journalArticle

Clofibric Acid
Glucuronosyltransferase
Glucuronides
Hepatocytes
DNA

Toxicology down under - A different perspective - Response

Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1498-1498

Research output: Contribution to journalLetter

Toxicology down under - A Different Perspective

Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1497-1498

Research output: Contribution to journalLetter

4 Citations (Scopus)
24 Citations (Scopus)

Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers

Burcham, P., Raso, A. & Thompson, C., 2010, In : Chemico-Biological Interactions. 183, p. 416-424

Research output: Contribution to journalArticle

Taking Pharmaceutical Innovation to the Masses

Burcham, P. C., 13 Jul 2017, In : ACS Medicinal Chemistry Letters. 8, 7, p. 686-689 4 p.

Research output: Contribution to journalReview article

Innovation
Western Australia
Pharmaceutical Preparations
Students
Literacy
58 Citations (Scopus)
Acrolein
Hydralazine
Liver
Proteins
Glutathione
1 Citation (Scopus)

Science in Two Minds: Reflections on the Missional Disunity Within Contemporary Medicine

Burcham, P., 2014, In : Christian Bioethics. 20, 3, p. 359-375

Research output: Contribution to journalArticle

12 Citations (Scopus)

Reactivity with Tris(hydroxymethyl) aminomethane Confounds Immunodetection of Acrolein-Adducted Proteins

Burcham, P., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2003, In : Chemical Research in Toxicology. 16, 10, p. 1196-1201

Research output: Contribution to journalArticle

Acrolein
Tromethamine
Proteins
Lysine
Buffers
39 Citations (Scopus)

Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde

Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2004, In : Organic and Biomolecular Chemistry. 2, 18, p. 2578-2584

Research output: Contribution to journalArticle

20 Citations (Scopus)
161 Downloads (Pure)
File
Acrolein
Alkylation
Cytochromes c
Toxicity
Culture Media
51 Citations (Scopus)

Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity

Burcham, P., Fontaine, F. R., Kaminskas, L. M., Petersen, D. R. & Pyke, S. M., 2004, In : Molecular Pharmacology. 65, 3, p. 655-664

Research output: Contribution to journalArticle

Acrolein
Hydralazine
Cytoprotection
Pharmaceutical Preparations
Proteins
10 Citations (Scopus)

Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice

Ong, F. H. C., Henry, P. & Burcham, P., 2012, In : Toxicology Letters. 212, 3, p. 241-251

Research output: Contribution to journalArticle

12 Citations (Scopus)
Pharmacology
Pharmaceutical Preparations
Spinal Cord Injuries
Pyridoxal
Nucleophiles
17 Citations (Scopus)
2-butenal
Protein Carbonylation
Carbonylation
Poisons
Aldehydes
6 Citations (Scopus)

Optimisation of the comet genotoxicity assay in freshly isolated murine hepatocytes: detection of strong in vitro DNA damaging properties for styrene

Fontaine, F. R., Degraaf, Y. C., Ghaoui, R., Sallustio, B. C., Edwards, J. & Burcham, P., 2004, In : Toxicology in Vitro. 18, 3, p. 343-350

Research output: Contribution to journalArticle

Styrene
Comet Assay
Hepatocytes
Assays
DNA Damage
8 Citations (Scopus)

Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity

Burcham, P., 2006, In : Toxicological Sciences. 89, 2, p. 349-351

Research output: Contribution to journalArticle

30 Citations (Scopus)
Wine
DNA Damage
Alcohols
Radiation
Catechin
22 Citations (Scopus)
Acrolein
HSP90 Heat-Shock Proteins
Toxicity
Proteins
Hydralazine
4 Citations (Scopus)

Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein

Cheah, E., Mann, T., Burcham, P. & Henry, P., 15 Feb 2015, In : Biochemical Pharmacology. 93, 4, p. 519–526 8 p.

Research output: Contribution to journalArticle

Acrolein
Human Influenza
Smooth Muscle
Muscle
Infection
52 Citations (Scopus)

Inactivation of Glutathione Peroxidase Activity Contributes to UV-Induced Squamous Cell Carcinoma Formation

Walshe, J., Serewko-Auret, M. M., Teakle, N., Cameron, S., Minto, K., Smith, L., Burcham, P., Russell, T., Strutton, G., Griffin, A., Chu, F. F., Esworthy, S., Reeve, V. & Saunders, N. A., 2007, In : Cancer Research. 67, 10, p. 4751-4758

Research output: Contribution to journalArticle

Glutathione Peroxidase
Squamous Cell Carcinoma
Skin
Peroxides
Radiation
60 Citations (Scopus)
Acrolein
Hydralazine
Cytoprotection
Aldehydes
Proteins
52 Citations (Scopus)

Genome-Wide Transcriptional Responses to Acrolein

Thompson, C. & Burcham, P., 2008, In : Chemical Research in Toxicology. 21, 12, p. 2245-2256

Research output: Contribution to journalArticle

Acrolein
Genes
Genome
Transcription
Microarrays
2 Citations (Scopus)
Acrolein
Mucins
Perfusion
Ventilation
Periodic Acid
35 Citations (Scopus)
6 Citations (Scopus)
Asbestos
Acetylcysteine
Oxidative Stress
Randomized Controlled Trials
Inflammation
24 Citations (Scopus)

Differences in Lysine Adduction by Acrolein and Methyl Vinyl Ketone : Implications for Cytotoxicity in Cultured Hepatocytes

Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2005, In : Chemical Research in Toxicology. 18, 11, p. 1627-1633

Research output: Contribution to journalArticle

Acrolein
Cytotoxicity
Lysine
Hepatocytes
Proteins
150 Citations (Scopus)

Cylindrospermopsin-Induced Protein Synthesis Inhibition and its Dissociation from Acute Toxicity in Mouse Hepatocytes

Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2003, In : Environmental Toxicology. 18, 4, p. 243-251

Research output: Contribution to journalArticle

Toxicity
Hepatocytes
toxicity
protein
Cytochrome P-450 Enzyme System
133 Citations (Scopus)

Cylindrospermopsin genotoxicity and cytotoxicity: Role of cytochrome P-450 and oxidative stress

Humpage, A. R., Fontaine, F., Froscio, S., Burcham, P. & Falconer, I. E., 2005, In : Journal of Toxicology and Environmental Health. Part A: Current Issues. 68, 9, p. 739-753

Research output: Contribution to journalArticle

Oxidative stress
Cytotoxicity
Cytochrome P-450 Enzyme System
Oxidative Stress
Cytochromes
9 Citations (Scopus)

Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress

Burcham, P., Raso, A. & Kaminskas, L. M., Nov 2012, In : Molecular Pharmacology. 82, 5, p. 876-886

Research output: Contribution to journalArticle

Acrolein
HSP90 Heat-Shock Proteins
Hydralazine
Cytoprotection
Intermediate Filaments
74 Citations (Scopus)

Cell-free Protein Synthesis Inhibition Assay for the Cyanobacterial Toxin Cylindrospermopsin

Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2001, In : Environmental Toxicology. 16, p. 408-412

Research output: Contribution to journalArticle

toxin
Assays
assay
protein
High performance liquid chromatography
16 Citations (Scopus)

Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP_Glucuronosyltransferases : Role of Acyl Glucuronide Metabolites and Glycation Pathways

Southwood, H. T., Degraaf, Y. C., Mackenzie, P. I., Miners, J. O., Burcham, P. & Sallustio, B. C., 2007, In : Chemical Research in Toxicology. 20, 10, p. 1520-1527

Research output: Contribution to journalArticle

Glucuronosyltransferase
HEK293 Cells
Glucuronides
Metabolites
Carboxylic Acids
20 Citations (Scopus)

Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

Burcham, P., Kaminskas, L. M., Tan, D. & Pyke, S. M., 2008, In : Mini-Reviews in Medicinal Chemistry. 8, p. 319-330

Research output: Contribution to journalLiterature review

2 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
Drug therapy
Hydralazine
Lipids
Drug Therapy
Alcoholic Liver Diseases
27 Citations (Scopus)
Clofibric Acid
Glucuronosyltransferase
Oxidative stress
Carboxylic Acids
DNA Damage
9 Citations (Scopus)

An Introduction to Toxicology

Burcham, P., 2014, Not available. London: Springer, p. 327

Research output: Chapter in Book/Conference paperOther chapter contribution

87 Citations (Scopus)

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products

Burcham, P., Kaminskas, L. M., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2002, In : Toxicology. 181-182, p. 229-236

Research output: Contribution to journalArticle

Acrolein
Aldehydes
Lipid Peroxidation
Lipids
Pharmaceutical Preparations
5 Citations (Scopus)
Keratin-8
Acrolein
Intermediate Filaments
Ubiquitination
Monolayers
14 Citations (Scopus)
222 Downloads (Pure)

Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism

Cheah, E., Burcham, P., Mann, T. & Henry, P., 1 May 2014, In : Biochemical Pharmacology. 89, 1, p. 148-156

Research output: Contribution to journalArticle

Open Access
File
Acrolein
Smooth Muscle
Muscle
Unmyelinated Nerve Fibers
Dinoprostone
11 Citations (Scopus)

Acrolein and the Lung: Chemical, Molecular, and Pathological Aspects

Burcham, P., Henry, P. & Thompson, C., 2010, Advances in Molecular Toxicology. Fishbein, J. C. (ed.). Great Britain: Elsevier, p. 1-36

Research output: Chapter in Book/Conference paperChapter

17 Citations (Scopus)
215 Downloads (Pure)
Open Access
File
Acrolein
Poisons
Xenobiotics
Chemical Phenomena
Health