Research Output per year
Research Output 2001 2018
UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes
Ghaoui, R., Sallustio, B. C., Burcham, P. & Fontaine, F. R., 2003, In : Chemico-Biological Interactions. 145, 2, p. 201-211Research output: Contribution to journal › Article
Clofibric Acid
Glucuronosyltransferase
Glucuronides
Hepatocytes
DNA
Toxicology down under - A different perspective - Response
Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1498-1498Research output: Contribution to journal › Letter
Toxicology down under - A Different Perspective
Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1497-1498Research output: Contribution to journal › Letter
Toxicology down under: Past achievements, present realities, and future prospects
Burcham, P., 2008, In : Chemical Research in Toxicology. 21, 5, p. 967-970Research output: Contribution to journal › Letter
Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers
Burcham, P., Raso, A. & Thompson, C., 2010, In : Chemico-Biological Interactions. 183, p. 416-424Research output: Contribution to journal › Article
Taking Pharmaceutical Innovation to the Masses
Burcham, P. C., 13 Jul 2017, In : ACS Medicinal Chemistry Letters. 8, 7, p. 686-689 4 p.Research output: Contribution to journal › Review article
Innovation
Western Australia
Pharmaceutical Preparations
Students
Literacy
Strong Protein Adduct Trapping Accompanies Abolition of Acrolein-Mediated Hepatotoxicity by Hydralazine in Mice
Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2004, In : The Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1003-1010Research output: Contribution to journal › Article
Acrolein
Hydralazine
Liver
Proteins
Glutathione
Science in Two Minds: Reflections on the Missional Disunity Within Contemporary Medicine
Burcham, P., 2014, In : Christian Bioethics. 20, 3, p. 359-375Research output: Contribution to journal › Article
Reactivity with Tris(hydroxymethyl) aminomethane Confounds Immunodetection of Acrolein-Adducted Proteins
Burcham, P., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2003, In : Chemical Research in Toxicology. 16, 10, p. 1196-1201Research output: Contribution to journal › Article
Acrolein
Tromethamine
Proteins
Lysine
Buffers
Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde
Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2004, In : Organic and Biomolecular Chemistry. 2, 18, p. 2578-2584Research output: Contribution to journal › Article
Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: Influence of nucleophilic culture media constituents
Thompson, C. & Burcham, P., 2008, In : Toxicology in Vitro. 22, 4, p. 844-853Research output: Contribution to journal › Article
File
Acrolein
Alkylation
Cytochromes c
Toxicity
Culture Media
Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity
Burcham, P., Fontaine, F. R., Kaminskas, L. M., Petersen, D. R. & Pyke, S. M., 2004, In : Molecular Pharmacology. 65, 3, p. 655-664Research output: Contribution to journal › Article
Acrolein
Hydralazine
Cytoprotection
Pharmaceutical Preparations
Proteins
Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice
Ong, F. H. C., Henry, P. & Burcham, P., 2012, In : Toxicology Letters. 212, 3, p. 241-251Research output: Contribution to journal › Article
Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress
Burcham, P., 2008, In : Chemical Research in Toxicology. 21, 4, p. 779-786Research output: Contribution to journal › Article
Pharmacology
Pharmaceutical Preparations
Spinal Cord Injuries
Pyridoxal
Nucleophiles
Oxidative Bioactivation of Crotyl Alcohol to the Toxic Endogenous Aldehyde Crotonaldehyde: Association of Protein Carbonylation with Toxicity in Mouse Hepatocytes
Fontaine, F. R., Dunlop, R. A., Petersen, D. R. & Burcham, P., 2002, In : Chemical Research in Toxicology. 15, p. 1051-1058Research output: Contribution to journal › Article
2-butenal
Protein Carbonylation
Carbonylation
Poisons
Aldehydes
Optimisation of the comet genotoxicity assay in freshly isolated murine hepatocytes: detection of strong in vitro DNA damaging properties for styrene
Fontaine, F. R., Degraaf, Y. C., Ghaoui, R., Sallustio, B. C., Edwards, J. & Burcham, P., 2004, In : Toxicology in Vitro. 18, 3, p. 343-350Research output: Contribution to journal › Article
Styrene
Comet Assay
Hepatocytes
Assays
DNA Damage
Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity
Burcham, P., 2006, In : Toxicological Sciences. 89, 2, p. 349-351Research output: Contribution to journal › Article
Moderate acute intake of de-alcoholised red wine, but not alcohol, is protective against radiation-induced DNA damage ex vivo - Results of a comparative in vivo intervention study in younger men
Greenrod, W., Stockley, C. S., Burcham, P., Abbey, M. & Fenech, M., 2005, In : Mutation Research. 591, 1/2, p. 290-301Research output: Contribution to journal › Article
Wine
DNA Damage
Alcohols
Radiation
Catechin
Intermolecular Protein Cross-Linking During Acrolein Toxicity : Efficacy of Carbonyl Scavengers as Inhibitors of Heat Shock Protein-90 Cross-Linking in A549 Cells
Burcham, P., Raso, A., Thompson, C. & Tan, D., 2007, In : Chemical Research in Toxicology. 20, 11, p. 1629-1637Research output: Contribution to journal › Article
Acrolein
HSP90 Heat-Shock Proteins
Toxicity
Proteins
Hydralazine
Intermediate Filament Carbonylation During Acute Acrolein Toxicity in A549 Lung Cells: Functional Consequences, Chaperone Redistribution, and Protection by Bisulfite
Burcham, P., Raso, A. & Thompson, C., 2010, In : Antioxidants & Redox Signaling. 12, p. 337-347Research output: Contribution to journal › Article
Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein
Cheah, E., Mann, T., Burcham, P. & Henry, P., 15 Feb 2015, In : Biochemical Pharmacology. 93, 4, p. 519–526 8 p.Research output: Contribution to journal › Article
Acrolein
Human Influenza
Smooth Muscle
Muscle
Infection
Inactivation of Glutathione Peroxidase Activity Contributes to UV-Induced Squamous Cell Carcinoma Formation
Walshe, J., Serewko-Auret, M. M., Teakle, N., Cameron, S., Minto, K., Smith, L., Burcham, P., Russell, T., Strutton, G., Griffin, A., Chu, F. F., Esworthy, S., Reeve, V. & Saunders, N. A., 2007, In : Cancer Research. 67, 10, p. 4751-4758Research output: Contribution to journal › Article
Glutathione Peroxidase
Squamous Cell Carcinoma
Skin
Peroxides
Radiation
Hydralazine Inhibits Rapid Acrolein-Induced Protein Oligomerization: Role of Aldehyde Scavenging and Adduct Trapping in Cross-Link Blocking and Cytoprotection
Burcham, P. & Pyke, S. M., 2006, In : Molecular Pharmacology. 69, 3, p. 1056-1065Research output: Contribution to journal › Article
Acrolein
Hydralazine
Cytoprotection
Aldehydes
Proteins
Genome-Wide Transcriptional Responses to Acrolein
Thompson, C. & Burcham, P., 2008, In : Chemical Research in Toxicology. 21, 12, p. 2245-2256Research output: Contribution to journal › Article
Acrolein
Genes
Genome
Transcription
Microarrays
2
Citations
(Scopus)
Functional characterisation and application of an ex vivo perfusion-superfusion system in murine airways
Cheah, E. Y., Mann, T. S., Burcham, P. C. & Henry, P. J., 1 Mar 2017, In : Journal of Pharmacological and Toxicological Methods. 84, p. 66-77 12 p.Research output: Contribution to journal › Article
Acrolein
Mucins
Perfusion
Ventilation
Periodic Acid
Extensive Protein Carbonylation Precedes Acrolein-Mediated Cell Death in Mouse Hepatocytes
Burcham, P. & Fontaine, F., 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 6, p. 309-316Research output: Contribution to journal › Article
Effect of N-acetylcysteine supplementation on oxidative stress status and alveolar inflammation in people exposed to asbestos: A double-blind, randomized clinical trial
Alfonso, H., Franklin, P., Ching, S., Croft, K., Burcham, P., Olsen, N., Reid, A., Joyce, D., De Klerk, N. & Musk, A., 2015, In : Respirology. 20, 7, p. 1102-1107Research output: Contribution to journal › Article
Asbestos
Acetylcysteine
Oxidative Stress
Randomized Controlled Trials
Inflammation
Differences in Lysine Adduction by Acrolein and Methyl Vinyl Ketone : Implications for Cytotoxicity in Cultured Hepatocytes
Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2005, In : Chemical Research in Toxicology. 18, 11, p. 1627-1633Research output: Contribution to journal › Article
Acrolein
Cytotoxicity
Lysine
Hepatocytes
Proteins
Cylindrospermopsin-Induced Protein Synthesis Inhibition and its Dissociation from Acute Toxicity in Mouse Hepatocytes
Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2003, In : Environmental Toxicology. 18, 4, p. 243-251Research output: Contribution to journal › Article
Toxicity
Hepatocytes
toxicity
protein
Cytochrome P-450 Enzyme System
Cylindrospermopsin genotoxicity and cytotoxicity: Role of cytochrome P-450 and oxidative stress
Humpage, A. R., Fontaine, F., Froscio, S., Burcham, P. & Falconer, I. E., 2005, In : Journal of Toxicology and Environmental Health. Part A: Current Issues. 68, 9, p. 739-753Research output: Contribution to journal › Article
Oxidative stress
Cytotoxicity
Cytochrome P-450 Enzyme System
Oxidative Stress
Cytochromes
Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress
Burcham, P., Raso, A. & Kaminskas, L. M., Nov 2012, In : Molecular Pharmacology. 82, 5, p. 876-886Research output: Contribution to journal › Article
Acrolein
HSP90 Heat-Shock Proteins
Hydralazine
Cytoprotection
Intermediate Filaments
Cell-free Protein Synthesis Inhibition Assay for the Cyanobacterial Toxin Cylindrospermopsin
Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2001, In : Environmental Toxicology. 16, p. 408-412Research output: Contribution to journal › Article
toxin
Assays
assay
protein
High performance liquid chromatography
Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP_Glucuronosyltransferases : Role of Acyl Glucuronide Metabolites and Glycation Pathways
Southwood, H. T., Degraaf, Y. C., Mackenzie, P. I., Miners, J. O., Burcham, P. & Sallustio, B. C., 2007, In : Chemical Research in Toxicology. 20, 10, p. 1520-1527Research output: Contribution to journal › Article
Glucuronosyltransferase
HEK293 Cells
Glucuronides
Metabolites
Carboxylic Acids
Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury
Burcham, P., Kaminskas, L. M., Tan, D. & Pyke, S. M., 2008, In : Mini-Reviews in Medicinal Chemistry. 8, p. 319-330Research output: Contribution to journal › Literature review
2
Citations
(Scopus)
39
Downloads
(Pure)
Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation
Burcham, P. C., 1 Aug 2018, In : Biochemical Pharmacology. 154, p. 397-406 10 p.Research output: Contribution to journal › Review article
Open Access
File
Drug therapy
Hydralazine
Lipids
Drug Therapy
Alcoholic Liver Diseases
Bioactivation of Carboxylic Acid Compounds by UDP-Glucuronosyltransferases to DNA-Damaging Intermediates : Role of Glycoxidation and Oxidative Stress Genotoxicity
Sallustio, B. C., Degraff, Y. C., Weekley, J. S. & Burcham, P., 2006, In : Chemical Research in Toxicology. 19, 5, p. 683-691Research output: Contribution to journal › Article
Clofibric Acid
Glucuronosyltransferase
Oxidative stress
Carboxylic Acids
DNA Damage
9
Citations
(Scopus)
An Introduction to Toxicology
Burcham, P., 2014, Not available. London: Springer, p. 327Research output: Chapter in Book/Conference paper › Other chapter contribution
Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products
Burcham, P., Kaminskas, L. M., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2002, In : Toxicology. 181-182, p. 229-236Research output: Contribution to journal › Article
Acrolein
Aldehydes
Lipid Peroxidation
Lipids
Pharmaceutical Preparations
Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers
Burcham, P., Raso, A. & Henry, P., 7 May 2014, In : Toxicology. 319, 1, p. 44-52Research output: Contribution to journal › Article
Keratin-8
Acrolein
Intermediate Filaments
Ubiquitination
Monolayers
Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism
Cheah, E., Burcham, P., Mann, T. & Henry, P., 1 May 2014, In : Biochemical Pharmacology. 89, 1, p. 148-156Research output: Contribution to journal › Article
Open Access
File
Acrolein
Smooth Muscle
Muscle
Unmyelinated Nerve Fibers
Dinoprostone
Acrolein and the Lung: Chemical, Molecular, and Pathological Aspects
Burcham, P., Henry, P. & Thompson, C., 2010, Advances in Molecular Toxicology. Fishbein, J. C. (ed.). Great Britain: Elsevier, p. 1-36Research output: Chapter in Book/Conference paper › Chapter
17
Citations
(Scopus)
215
Downloads
(Pure)
Acrolein and human disease: untangling the knotty exposure scenarios accompanying several diverse disorders
Burcham, P. C., 17 Jan 2017, In : Chemical Research in Toxicology. 30, 1, p. 145-161 17 p.Research output: Contribution to journal › Article
Open Access
File
Acrolein
Poisons
Xenobiotics
Chemical Phenomena
Health