Philip Burcham

Associate Professor, BSc PhD W.Aust.

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1133 Citations
  • 18 h-Index
20012018
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Research Output 2001 2018

2018
1 Citation (Scopus)
13 Downloads (Pure)
Open Access
File
Drug therapy
Hydralazine
Lipids
Drug Therapy
Alcoholic Liver Diseases
2017
14 Citations (Scopus)
167 Downloads (Pure)
Open Access
File
Acrolein
Poisons
Xenobiotics
Chemical Phenomena
Health
1 Citation (Scopus)
Acrolein
Mucins
Perfusion
Ventilation
Periodic Acid

Taking Pharmaceutical Innovation to the Masses

Burcham, P. C., 13 Jul 2017, In : ACS Medicinal Chemistry Letters. 8, 7, p. 686-689 4 p.

Research output: Contribution to journalReview article

Innovation
Western Australia
Pharmaceutical Preparations
Students
Literacy
2015
6 Citations (Scopus)
Asbestos
Acetylcysteine
Oxidative Stress
Randomized Controlled Trials
Inflammation
4 Citations (Scopus)

Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein

Cheah, E., Mann, T., Burcham, P. & Henry, P., 15 Feb 2015, In : Biochemical Pharmacology. 93, 4, p. 519–526 8 p.

Research output: Contribution to journalArticle

Acrolein
Human Influenza
Smooth Muscle
Muscle
Infection
2014
13 Citations (Scopus)
187 Downloads (Pure)

Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism

Cheah, E., Burcham, P., Mann, T. & Henry, P., 1 May 2014, In : Biochemical Pharmacology. 89, 1, p. 148-156

Research output: Contribution to journalArticle

Open Access
File
Acrolein
Smooth Muscle
Muscle
Unmyelinated Nerve Fibers
Dinoprostone
5 Citations (Scopus)
Keratin-8
Acrolein
Intermediate Filaments
Ubiquitination
Monolayers
9 Citations (Scopus)

An Introduction to Toxicology

Burcham, P., 2014, Not available. London: Springer, p. 327

Research output: Chapter in Book/Conference paperOther chapter contribution

1 Citation (Scopus)

Science in Two Minds: Reflections on the Missional Disunity Within Contemporary Medicine

Burcham, P., 2014, In : Christian Bioethics. 20, 3, p. 359-375

Research output: Contribution to journalArticle

2012
9 Citations (Scopus)

Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress

Burcham, P., Raso, A. & Kaminskas, L. M., Nov 2012, In : Molecular Pharmacology. 82, 5, p. 876-886

Research output: Contribution to journalArticle

Acrolein
HSP90 Heat-Shock Proteins
Hydralazine
Cytoprotection
Intermediate Filaments
9 Citations (Scopus)

Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice

Ong, F. H. C., Henry, P. & Burcham, P., 2012, In : Toxicology Letters. 212, 3, p. 241-251

Research output: Contribution to journalArticle

2010
11 Citations (Scopus)

Acrolein and the Lung: Chemical, Molecular, and Pathological Aspects

Burcham, P., Henry, P. & Thompson, C., 2010, Advances in Molecular Toxicology. Fishbein, J. C. (ed.). Great Britain: Elsevier, p. 1-36

Research output: Chapter in Book/Conference paperChapter

24 Citations (Scopus)

Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers

Burcham, P., Raso, A. & Thompson, C., 2010, In : Chemico-Biological Interactions. 183, p. 416-424

Research output: Contribution to journalArticle

2008
20 Citations (Scopus)

Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

Burcham, P., Kaminskas, L. M., Tan, D. & Pyke, S. M., 2008, In : Mini-Reviews in Medicinal Chemistry. 8, p. 319-330

Research output: Contribution to journalLiterature review

52 Citations (Scopus)

Genome-Wide Transcriptional Responses to Acrolein

Thompson, C. & Burcham, P., 2008, In : Chemical Research in Toxicology. 21, 12, p. 2245-2256

Research output: Contribution to journalArticle

Acrolein
Genes
Genome
Transcription
Microarrays
12 Citations (Scopus)
Pharmacology
Pharmaceutical Preparations
Spinal Cord Injuries
Pyridoxal
Nucleophiles
20 Citations (Scopus)
112 Downloads (Pure)
File
Acrolein
Alkylation
Cytochromes c
Toxicity
Culture Media
4 Citations (Scopus)

Toxicology down under - A Different Perspective

Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1497-1498

Research output: Contribution to journalLetter

Toxicology down under - A different perspective - Response

Burcham, P., 2008, In : Chemical Research in Toxicology. 21, p. 1498-1498

Research output: Contribution to journalLetter

2007
16 Citations (Scopus)

Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP_Glucuronosyltransferases : Role of Acyl Glucuronide Metabolites and Glycation Pathways

Southwood, H. T., Degraaf, Y. C., Mackenzie, P. I., Miners, J. O., Burcham, P. & Sallustio, B. C., 2007, In : Chemical Research in Toxicology. 20, 10, p. 1520-1527

Research output: Contribution to journalArticle

Glucuronosyltransferase
HEK293 Cells
Glucuronides
Metabolites
Carboxylic Acids
50 Citations (Scopus)

Inactivation of Glutathione Peroxidase Activity Contributes to UV-Induced Squamous Cell Carcinoma Formation

Walshe, J., Serewko-Auret, M. M., Teakle, N., Cameron, S., Minto, K., Smith, L., Burcham, P., Russell, T., Strutton, G., Griffin, A., Chu, F. F., Esworthy, S., Reeve, V. & Saunders, N. A., 2007, In : Cancer Research. 67, 10, p. 4751-4758

Research output: Contribution to journalArticle

Glutathione Peroxidase
Squamous Cell Carcinoma
Skin
Peroxides
Radiation
22 Citations (Scopus)
Acrolein
HSP90 Heat-Shock Proteins
Toxicity
Proteins
Hydralazine
2006
27 Citations (Scopus)
Clofibric Acid
Glucuronosyltransferase
Oxidative stress
Carboxylic Acids
DNA Damage
60 Citations (Scopus)
Acrolein
Hydralazine
Cytoprotection
Aldehydes
Proteins
8 Citations (Scopus)

Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity

Burcham, P., 2006, In : Toxicological Sciences. 89, 2, p. 349-351

Research output: Contribution to journalArticle

2005
128 Citations (Scopus)

Cylindrospermopsin genotoxicity and cytotoxicity: Role of cytochrome P-450 and oxidative stress

Humpage, A. R., Fontaine, F., Froscio, S., Burcham, P. & Falconer, I. E., 2005, In : Journal of Toxicology and Environmental Health. Part A: Current Issues. 68, 9, p. 739-753

Research output: Contribution to journalArticle

Oxidative stress
Cytotoxicity
Cytochrome P-450 Enzyme System
Oxidative Stress
Cytochromes
24 Citations (Scopus)

Differences in Lysine Adduction by Acrolein and Methyl Vinyl Ketone : Implications for Cytotoxicity in Cultured Hepatocytes

Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2005, In : Chemical Research in Toxicology. 18, 11, p. 1627-1633

Research output: Contribution to journalArticle

Acrolein
Cytotoxicity
Lysine
Hepatocytes
Proteins
29 Citations (Scopus)
Wine
DNA Damage
Alcohols
Radiation
Catechin
2004
6 Citations (Scopus)

Optimisation of the comet genotoxicity assay in freshly isolated murine hepatocytes: detection of strong in vitro DNA damaging properties for styrene

Fontaine, F. R., Degraaf, Y. C., Ghaoui, R., Sallustio, B. C., Edwards, J. & Burcham, P., 2004, In : Toxicology in Vitro. 18, 3, p. 343-350

Research output: Contribution to journalArticle

Styrene
Comet Assay
Hepatocytes
Assays
DNA Damage
51 Citations (Scopus)

Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity

Burcham, P., Fontaine, F. R., Kaminskas, L. M., Petersen, D. R. & Pyke, S. M., 2004, In : Molecular Pharmacology. 65, 3, p. 655-664

Research output: Contribution to journalArticle

Acrolein
Hydralazine
Cytoprotection
Pharmaceutical Preparations
Proteins
39 Citations (Scopus)

Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde

Kaminskas, L. M., Pyke, S. M. & Burcham, P., 2004, In : Organic and Biomolecular Chemistry. 2, 18, p. 2578-2584

Research output: Contribution to journalArticle

58 Citations (Scopus)
Acrolein
Hydralazine
Liver
Proteins
Glutathione
2003
150 Citations (Scopus)

Cylindrospermopsin-Induced Protein Synthesis Inhibition and its Dissociation from Acute Toxicity in Mouse Hepatocytes

Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2003, In : Environmental Toxicology. 18, 4, p. 243-251

Research output: Contribution to journalArticle

Toxicity
Hepatocytes
toxicity
protein
Cytochrome P-450 Enzyme System
12 Citations (Scopus)

Reactivity with Tris(hydroxymethyl) aminomethane Confounds Immunodetection of Acrolein-Adducted Proteins

Burcham, P., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2003, In : Chemical Research in Toxicology. 16, 10, p. 1196-1201

Research output: Contribution to journalArticle

Acrolein
Tromethamine
Proteins
Lysine
Buffers
12 Citations (Scopus)

UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes

Ghaoui, R., Sallustio, B. C., Burcham, P. & Fontaine, F. R., 2003, In : Chemico-Biological Interactions. 145, 2, p. 201-211

Research output: Contribution to journalArticle

Clofibric Acid
Glucuronosyltransferase
Glucuronides
Hepatocytes
DNA
2002
86 Citations (Scopus)

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products

Burcham, P., Kaminskas, L. M., Fontaine, F. R., Petersen, D. R. & Pyke, S. M., 2002, In : Toxicology. 181-182, p. 229-236

Research output: Contribution to journalArticle

Acrolein
Aldehydes
Lipid Peroxidation
Lipids
Pharmaceutical Preparations
17 Citations (Scopus)
2-butenal
Protein Carbonylation
Carbonylation
Poisons
Aldehydes
2001
74 Citations (Scopus)

Cell-free Protein Synthesis Inhibition Assay for the Cyanobacterial Toxin Cylindrospermopsin

Froscio, S. M., Humpage, A. R., Burcham, P. & Falconer, I. R., 2001, In : Environmental Toxicology. 16, p. 408-412

Research output: Contribution to journalArticle

toxin
Assays
assay
protein
High performance liquid chromatography
35 Citations (Scopus)