Peter Le Souef

Professor, MD W.Aust., MRCP(UK), FRACP

  • The University of Western Australia (M561), 35 Stirling Highway,

    6009 Perth

    Australia

  • 8146 Citations
  • 49 h-Index
1993 …2023
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Personal profile

Biography

Education and training
• MBBS (UWA) 1966-71, MRCP(UK) 1976, FRACP 1980, MD 1984
• paediatrics: University College Hospital, London 1974-75, neonatal research fellow 1976-77
• respiratory physiology research fellow: Hospital for Sick Children, Toronto 1981-82
• respiratory research fellow: Royal Children’s Hospital, Melbourne 1983-84
• molecular genetics sabbatical: University of Oxford, UK 1991

Employment
• Winthrop Professor of Paediatrics, University of Western Australia (UWA); 1998-present.
• Head, School of Paediatrics and Child Health (SPACH), UWA: 1998-2001, 2004 to present
• Head, Immunogenetics Research Group, SPACH, UWA
• Respiratory Physician, Founding Head, Department of Respiratory Medicine, PMH, Perth, WA

Roles and responsibilities

• Head, School of Paediatrics and Child Health (SPACH), UWA: 1998-2001, 2004 to present
• Head, Immunogenetics Research Group, SPACH, UWA

Future research

Mechanisms of acute viral respiratory infections in children
Immunogenetics of HIV infections in adults and children
Predictions of population growth of health in children

Funding overview

Current NHMRC funding:
• 51. Sly PD, Holt PG, Le Souëf PN, Tang M “Winter-only treatment with omalizumab to prevent asthma exacerbations in children” NHMRC #APP1021316
$738,329 NHMRC project grant 2012-14
• 52. Le Souëf PN, Goldblatt J, Currie A, Landau L, Hayden C. “Longitudinal characterization of respiratory and immune development from birth to adulthood” NHMRC # APP1031635 $510,373 NHMRC project grant 2012-14
• 54. Le Souëf PN, Currie A, Bizzintino J, Smith D, Cookson W, Gern J, Geelhoed G, Hales B, Khoo S-K. “Investigation into host susceptibility and immune responses in young children with acute wheezing due to human rhinovirus group C infection” NHMRC # APP1045760
$658,890 NHMRC project grant 2013-15

Current non-NHMRC funding: includes:
• 55. Naniche D, Blanco J,…. Le Souëf P. ‘Development of novel biomarkers distinguishing early HIV infection from longstanding infection in Sub-Saharan Africa”
Bill & Melinda Gates: total: $US1,013,466 Le Souëf component $US 191,452 2013-15

Previous positions

EMPLOYMENT RECORD:
1972 Resident Medical Officer - intern year
1973 Senior Resident Medical Officer - ICU, anaesthetics
QUEEN ELIZABETH MEDICAL CENTRE, PERTH, WA

1973 Senior Resident Medical Office - paediatrics
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1974 - 1975 House Physician - paediatrics (Prof LB Strang)
1975 Senior House Officer - neonatology (Prof EOR Reynolds)
1976 - 1977 Research Registrar - neonatology (Prof EOR Reynolds)
UNIVERSITY COLLEGE HOSPITAL, LONDON, UK

1978 Senior Registrar - neonatology
KING EDWARD MEMORIAL HOSPITAL FOR WOMEN, PERTH, WA

1979 Medical Registrar - paediatrics
1979 - 1980 Senior Registrar - emergency, developmental, neonatology
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1981 - 1983 Research Fellow - respiratory physiology (Prof AC Bryan)
THE HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA

1983 - 1984 Research Fellow - paediatric respiratory medicine (Prof PD Phelan)
ROYAL CHILDREN'S HOSPITAL, MELBOURNE, VICTORIA

1984 - 1998 Founding Head of Department
Department of Respiratory Medicine
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1984 - present Consultant Respiratory Physician
Department of Respiratory Medicine
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1985 - 1992 Senior Lecturer
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1987 - 1990 Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1991 Visiting Research Fellow, Asthma Genetics Group
OXFORD UNIVERSITY, UK

1992 - 1993 Acting Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1992 - 1998 Associate Professor
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1993 - present Honorary Research Fellow
INSTITUTE OF CHILD HEALTH RESEARCH, PERTH, WA

1998 - 2001 Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1998 - 2009 Professor of Paediatrics
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA

2004 - present Head of School
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA

2009 - present Winthrop Professor of Paediatrics
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA

Current projects

Mechanisms of acute viral respiratory infections in children
Immunogenetics of HIV infections in adults and children
Longitudinal assessment of the Perth Infant Asthma Follow-up Cohort - 24 yrs

Industrial relevance

Has held 34 industry grants

Research

Previous research profile and leadership include establishing several new research initiatives:
• infant respiratory function: designed/implemented innovative techniques: single breath technique in neonates and raised volume forced expiratory method for measuring infant lung function
• Perth Children’s Aerosol Research Group: founded this group which has made the greatest international contribution to outlining the science of aerosol drug delivery in children.
• Immunogenetics Research Group: from 1992 with Prof Jack Goldblatt - all aspects of asthma genetics research; this expertise has led to vaccine, measles, malaria and HIV research in Africa
• human evolution: defined effect of geoclimatic factors on human immune system evolution
• raised > $15 million in competitive research grants and grants from industry

Current research profile and leadership
• current studies focus on mechanisms involved in acute respiratory virus infections in early life, and how these affect the immune system, airway microbiome and the later development of asthma
• asthma in children: viruses, immunology and microbiome – team has discovered that human rhinovirus group C is: main cause of severe children’s asthma; causes majority of acute attacks; most common cause of wheeze in <2yr olds; only respiratory virus related to atopy
• immunogenetics: asthma, allergy, HIV (Gates grant - Africa), early respiratory infections (Africa)
• epigenetics: Finland/Russia, Greenland/Denmark Inuits, maternal in utero contribution to infant

Languages

English

Keywords

  • Paediatric respiratory medicine

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Projects 1996 2023

Research Output 1993 2018

1 Citations

Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood

Owens, L., Laing, I. A., Zhang, G., Turner, S. & Le Souëf, P. N., 1 Aug 2018, In : Pediatric Pulmonology. 53, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

Pulmonary Ventilation
Lung
Spirometry
Asthma
Growth
2 Citations

Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma

Poulsen, N. N., Bjerregaard, A., Khoo, S. K., Laing, I. A., Le Souëf, P., Backer, V., Rapley, L., Cohen, S. E., Barrett, L., Thompson, P., Baltic, S. & Porsbjerg, C., 1 Jul 2018, In : Respiratory Medicine. 140, p. 50-56 7 p.

Research output: Contribution to journalArticle

Interleukin-2
Asthma
Cytokines
Interleukin-13
Inflammation
1 Citations

A marked shift in innate and adaptive immune response in Chinese immigrants living in a Western environment

Saiganesh, A., Hales, B. J., Li, Y., Holt, P. G., Le Souëf, P. N. & Zhang, G., Oct 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2092-2094

Research output: Contribution to journalLetter

2 Citations

Association between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescents

Laurence, C., van der Merwe, L., Zhang, G., Le Souëf, P. & Levin, M., 1 May 2018, In : Pediatric Allergy and Immunology. 29, 3, p. 311-317 7 p.

Research output: Contribution to journalArticle

Interleukin-10
Alleles
Phenotype
Interleukin-4
Immunoglobulin E