Paul Attwood

Professor, BSc PhD Brist.

  • The University of Western Australia (M310), 35 Stirling Highway, Room 369, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 2228 Citations
  • 26 h-Index
1980 …2018
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Personal profile

Biography

Associate Professor Paul Attwood completed his Bachelor of Science and PhD at the University of Bristol in the UK. From 1980 until 1984 he was a Senior Teaching Fellow in Biochemistry at the University of Adelaide. He then worked as a Research Associate in the Department of Biochemistry at the University of Wisconsin until 1986 when he moved to the Merrell Research Institute in Strasbourg, France, as a Senior Research Scientist. In 1988 A/Prof Paul Attwood moved to UWA.

Funding overview

2011 P. G. Arthur, M. Ludwig and P. V. Attwood Restructuring undergraduate laboratory classes in Biochemistry and Molecular Biology, ALTC Seeding Grant - $5,000

2011 P.V. Attwood MHRIF Infrastructure Grant $13,990

2010 P.V. Attwood MHRIF Infrastructure Grant $9,340

2009-2013 W.W. Cleland , P.V. Attwood, J.C. Wallace and M. St. Maurice Structure and function of pyruvate carboxylase NIH $1,888,388 ($683,731 to UWA).

2009 J.C. Wallace and P.V. Attwood New insights into the structure and function of pyruvate carboxylase. ARC Discovery Grant DP0988153 $110,000 ($91,000 to UWA).

2008 P.V. Attwood, Identification and characterisation of thymus histone H4 histidine kinase(s) and analysis of phosphorylated histone, UWA Small Grant - $14,321.

2007 Prof Andrew Harvey Millar, Prof Steven Michael Smith, Prof Colin Llewellyn Raston, Prof Ralph Nigel Martins, Prof Leigh William Simmons, Prof John Kevin Olynyk, Prof Geoffrey A Stewart, Prof Peter Jeffrey Leedman, Prof Lynda Dent Beazley, Prof James Michael Whelan, A/Prof Paul Vincent Attwood, Dr Alice Vrielink, Prof Charles Simon Bond, Prof Sarah Alison Dunlop, Dr Anthony John Bakker, Dr Peter Graeme Arthur, Prof George Cheng Yeoh, Dr Joshua Lucas Heazlewood, Dr Boris Claude Baer, Dr Holger Eubel, Dr Nicolas Lyndon Taylor, Dr Giuseppe Verdile, Dr Paul Geoffrey Besant, Dr Killugudi L Swaminatha-Iyer, Dr Patrick Michael Finnegan, Dr Martha Ludwig, MALDI Imaging and Protein Analysis Facility for WA, ARC LIEF - $470,000

2005-2009 W.W. Cleland , P.V. Attwood and J.C. Wallace Structure and function of pyruvate carboxylase NIH $1,690,000 ($567,000 to UWA).

2005 A.H. Millar, D.A. Day, J.M. Whelan, S.B. Powles, C.A. Atkins, P.G. Arthur, P.V. Attwood, T.R. Martin, G.A. Stewart, R. Oliver, G. E Wilcox 2005, 'LE0560987 - Robust High Resolution Gene and Protein Expression Analysis Facilities in WA', ARC LIEF - $156,697.00.

2005 P.V. Attwood, P.G. Arthur, P.G. Besant, M.A. Bogoyevitch, M.D. Cregan, P.E. Hartmann, M. Ludwig, T.R. Martin, R.C. Tuckey, J.M. Whelan, G.C. Yeoh, L.J. Abraham, A.H. Millar, Chemiluminesence Documentation System', NHMRC Equipment Grants - $51,115

2005 M.A. Bogoyevitch, L.J. Abraham, P.V. Attwood, P.G. Arthur, P.G. Besant, M.D. Cregan, P.E. Hartmann, M. Ludwig, T. Martin, R.C. Tuckey, J.M. Whelan, G.C. Yeoh, A.H. Millar, Olympus Fluorescence Microscope IX71, NHMRC Equipment Grants - $55,019.00.

2005 P.V. Attwood Investigation of the role of inosine monophosphate dehydrogenase as a histone H4 histidine kinase and possible oncodevelopmental marker. UWA Small Grant - $5,000.

2004 P.G. Besant and P.V. Attwood. Mammalian histidine kinases. Ada Bartholomew Medical Research Trust - $25,000

2003 Q. Cui, L.J. Abraham, P.V. Attwood, D.A. Day, A.M. Dharmarajan, A.R. Harvey, S.I. Hodgetts, P.J. Mark, G.W. Plant, T.G. Redgrave, R.C. Tuckey, B.J. Waddell, J.M. Whelan 'Beckman Coulter Optima L-80 XP Ultracentrifuge', NHMRC Equipment Grants - $90,000.

2003 P.V. Attwood Structure-function relationships in biotin-dependent enzymes, using pyruvate carboxylase as a model, as determined by X-ray crystallography and protein engineering. UWA Small Grant - $15,000

2002-2004 P.V. Attwood, G.C. Yeoh, M.A. Bogoyevitch and C.W. Turck Mammalian histidine kinase: its characterisation and role in hepatic cellular proliferation ARC Discovery Project grant - $150,000

2001 P.G. Arthur, C.A. Atkins, P.V. Attwood, S.J. Barker, G. Begley, K.D. Croft, D.A. Day, KF Illett, J.T. Lambers, R.J. Lipscombe, A.H. Millar, G.A. Stewart, J.M Whelan, J.A. Wilce, M.C. Wilce, Mass Spectrometry Facility for Protein Analysis, NHMRC: Equipment Grants - $100,376.

2000-2001 P.V. Attwood, P.G. Arthur, C.A. Atkins, S.J. Barker, G. Begley, K.D. Croft, D.A. Day, KF Illett, J.T. Lambers, R.J. Lipscombe, A.H. Millar, G.A. Stewart, J.M Whelan, J.A. Wilce, M.C. Wilce for purchase of LC/ESI/TOF mass spectrometer for protein analysis. ARC RIEF - $510,000

2000 P.V. Attwood, G.C. Yeoh and M. Bogoyevitch. Purification, characterisation, cloning and sequencing of a novel mammalian nuclear histidine kinase found in proliferating tissue. UWA Small Grant - $6,390.

1999-2001 P.V. Attwood and J.C. Wallace. Molecular dissection of the catalytic mechanism of pyruvate carboxylase by site-directed mutagenesis and kinetic - $196,900 (98,000 to UWA).

1999-2000 P.V. Attwood and P.G. Arthur. Cellular protein analysis in the study of the roles of histidine kinase and hypoxia in the regulation of cellular function. Lotteries Commission of W.A. - $52,175

1998-2000 P.V. Attwood. Purification, characterisation, cloning and sequencing of a novel mammalian nuclear histidine kinase found in proliferating tissue. ARC Small Grant - $46,220.

1997-1998 P.V. Attwood. Protein Chemistry Facility. Ada Bartholomew Medical Research Trust - $134,000.

1997 P.V. Attwood. Enzymic biotin carboxylation: mechanism and regulation in pyruvate carboxylase. ARC Small Grant - $20,000.

1996-97 P.V. Attwood. The role of basic amino acid protein kinases in cellular signalling leading to proliferation. Cancer Foundation of Western Australia - $52,000.

1996 P.V. Attwood. Enzymic biotin carboxylation: mechanism of action in pyruvate carboxylase. ARC Small Grant - $11,651

1995 P.V. Attwood. Grant to purchase Silicon Graphics computer and Biosym molecular modelling software for Protein Facility and CO2 environment incubator for Confocal Microscopy Facility of CCMB. Lotteries Commission of WA - $68,081.

1994 P.V. Attwood. The catalytic mechanism and molecular regulation of pyruvate carboxylase: a study using rapid reaction kinetics and analysis of enzyme intermediates. ARC Small Grant - $29,861.

1992-1993 P.V. Attwood and A. Johnson. Studies of pyruvate carboxylase relating molecular structure to function and regulation. A.R.C. - $70,000.

1989-1991 P.V. Attwood. An investigation of the mechanism of catalysis of pyruvate carboxylase and its regulation by the metabolic activator acetyl CoA. ARC - $95,400.

1989-1991 P.V. Attwood. A study on the early events of mitogenic stimulation in human macrophages and T-lymphocytes: the effects of glucocorticoids and correlations with steroid resistance in kidney transplant patients. U.W.A. Special Research Grant - $83,128.

1989 P.V. Attwood. A study on the early events of mitogenic stimulation in human macrophages and T-lymphocytes: the effects of glucocorticoids and correlations with steroid resistance in kidney transplant patients. U.W.A. Medical Faculty Grant - $7,500.

1988 P.V. Attwood. A kinetic investigation of the biotin-carboxylation reaction of pyruvate carboxylase and the regulatory role of acetyl CoA. U.W.A. Special Research Grant - $25,503.

Current projects

Collaborators

Prof W.W. Cleland, University of Wisconsin, Madison
Prof John Wallace, University of Adelaide
A/Prof Sarawut Jitrapakdee, University of Mahidol, Thailand
Prof M.A. Geeves, University of Kent, Canterbury, England
Prof Susanne Klumpp, University of Westphalia, Munster, Germany
Prof C.W. Turk, Max Plank Institute for Physics, Germany, Munich

Teaching overview

BIOC3351 Molecular and Structural Biochemistry
BIOC2201 Biochemistry of the Cell
BIOC2202 Metabolic and Cellular Biochemistry
PSB-BIOC3351 Molecular and Structural Biochemistry (Singapore Campus)
PSB-GENE3331/3332 Molecular Genetics
IMED1113/4; IDNT1131/2; PODI1131/2 Molecules, Genes and Cells
IMED1101/IMED2203 Medicine Bridging Units

Research

Enzymology, protein-histidine phosphorolation
Structure and function of pyruvate carboxylase
Investigation of histidine kinases and their role in mammalian cell biology

Keywords

  • Biotin-dependent enzymes
  • Enzymes
  • Histidine kinases
  • Protein structure and function
  • Structure and function of enzymes

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1996 2013

Research Output 1980 2018

2 Citations

Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection

Lao-On, U., Attwood, P. V. & Jitrapakdee, S., Apr 2018, In : Journal of Molecular Medicine. 96, 3-4, p. 237–247 11 p.

Research output: Contribution to journalReview article

Pyruvate Carboxylase
Infection
Neoplasms
Type 2 Diabetes Mellitus
Amino Acids
5 Citations

The actions of NME1/NDPK-A and NME2/NDPK-B as protein kinases

Attwood, P. V. & Muimo, R., 1 Mar 2018, In : Laboratory Investigation. 98, 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

File
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase
Histidine
Protein Kinases
Phosphoprotein Phosphatases
1 Citations

Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine

Piggott, M. J. & Attwood, P. V., 1 Aug 2017, In : Amino Acids. 49, 8, p. 1309-1323 15 p.

Research output: Contribution to journalReview article

Phosphoamino Acids
Protein Tyrosine Phosphatases
Phosphoprotein Phosphatases
Post Translational Protein Processing
Catalysis
Open Access
File
Teaching
Learning
Students
Aptitude
Data visualization
2 Citations
arginine glutamate
Rhizobium etli
Pyruvate Carboxylase
Acetyl Coenzyme A
Chemical activation

Activities 2017 2017

  • 1 Invited talk

Histidine Kinases

Paul Attwood (Speaker)
20 Sep 2017

Activity: Talk or presentation typesInvited talk