Nicole Smith

Dr, PhD W.Aust.

  • The University of Western Australia (M313), 35 Stirling Highway,

    6009 Perth

    Australia

  • 515 Citations
  • 14 h-Index
20072021
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Research Output 2007 2020

2020
1 Citation (Scopus)

Epigenetic modification of cytosines fine tunes the stability of i-motif DNA

Wright, E. P., Abdelhamid, M. A. S., Ehiabor, M. O., Grigg, M., Irving, K., Smith, N. & Waller, Z. A. E., 10 Jan 2020, In : Nucleic Acids Research. 48, 1, 8 p.

Research output: Contribution to journalArticle

Open Access
Nucleotide Motifs
Cytosine
Epigenomics
5-Methylcytosine
Nanotechnology
2019
1 Citation (Scopus)

Elucidating the inability of functionalized nanoparticles to cross the blood-brain barrier and target specific cells in vivo

Naidu, P. S. R., Gavriel, N., Gray, C. G. G., Bartlett, C. A., Toomey, L. M., Kretzmann, J. A., Patalwala, D., McGonigle, T., Denham, E., Hee, C., Ho, D., Taylor, N. L., Norret, M., Smith, N. M., Dunlop, S. A., Iyer, K. S. & Fitzgerald, M., 26 Jun 2019, In : ACS APPLIED MATERIALS & INTERFACES. 11, 25, p. 22085-22095 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

TGF‐β‐induced fibrotic stress increases G‐quadruplex formation in human fibroblasts

Toshniwal, P., Nguyen, M., Guédin, A., Viola, H., Ho, D., Kim, Y., Bhatt, U., Bond, C., Hool, L., Hurley, L., Mergny, J-L., Fear, M., Wood, F., Swaminatha Iyer, K. & Smith, N., Nov 2019, In : FEBS Letters. 593, 22, p. 3149-3161 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Wound Healing
Cicatrix
Collagen
Medical problems
1 Citation (Scopus)

Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers

Kretzmann, J. A., Evans, C. W., Moses, C., Sorolla, A., Kretzmann, A. L., Wang, E., Ho, D., Hackett, M. J., Dessauvagie, B. F., Smith, N. M., Redfern, A. D., Waryah, C., Norret, M., Iyer, K. S. & Blancafort, P., 7 Sep 2019, In : Chemical Science. 10, 33, p. 7718-7727 10 p.

Research output: Contribution to journalArticle

Open Access
2018
9 Citations (Scopus)

Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma

Smith, N., Giacci, M., Gough, A., Bailey, C., McGonigle, T., Black, A., Clarke, T., Bartlett, C., Swaminatha Iyer, K., Dunlop, S. & Fitzgerald, M., 2018, In : Journal of Neuroinflammation. 15, p. 201

Research output: Contribution to journalArticle

Open Access
Blood-Brain Barrier
Inflammation
Wounds and Injuries
Optic Nerve Injuries
Cytokines
4 Citations (Scopus)

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D., Kretzmann, J., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M. A., Chawla, R., Evans, C., Clemons, T., Nguyen, M., Kretzmann, A., Blythe, A., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J., Bond, C., Kilburn, M. & 3 othersHurley, L., Smith, N. & Swaminatha Iyer, K., Dec 2018, In : Nature Nanotechnology. 13, 2

Research output: Contribution to journalArticle

Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid
5 Citations (Scopus)

Multicarbazole scaffolds for selective G-quadruplex binding

Ou, A., Guédin, A., Skelton, B., Amrane, S., Evans, C., Norret, M., Swaminatha Iyer, K., Mergny, J-L. & Smith, N., 2018, In : ChemComm. 54, 69, p. 9647-9650

Research output: Contribution to journalArticle

Scaffolds
DNA
Ligands
Chain length
pyrrolidine
12 Citations (Scopus)
40 Downloads (Pure)

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo

Giacci, M. K., Bartlett, C. A., Smith, N. M., Iyer, K. S., Toomey, L. M., Jiang, H., Guagliardo, P., Kilburn, M. R. & Fitzgerald, M., 18 Jul 2018, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 38, 29, p. 6491-6504 14 p.

Research output: Contribution to journalArticle

Open Access
File
Oligodendroglia
Wounds and Injuries
Cellular Structures
Secondary Ion Mass Spectrometry
Lipid Peroxidation
2017

Colloidal Crystals: Using Self-Assembly to Create Structures From Nanoparticle Building Blocks

Evans, C., Swaminatha Iyer, K. & Smith, N., 22 Jun 2017, Comprehensive Supramolecular Chemistry II. Atwood, J. (ed.). 2 ed. United States: Academic Press, Vol. 9. p. 109-128 20 p.

Research output: Chapter in Book/Conference paperChapter

Self assembly
Nanoparticles
Crystals
Intelligent materials
Functional materials
4 Citations (Scopus)

Direct correlation of PNIPAM thermal transition and magnetic resonance relaxation of iron oxide nanoparticles

Taib, N. I., Agarwal, V., Smith, N. M., Woodward, R. C., Pierre, T. G. S. & Iyer, K. S., 1 Nov 2017, In : Materials Chemistry Frontiers. 1, 11, p. 2335-2340 6 p.

Research output: Contribution to journalArticle

Interaction of gold nanorods with genomic DNA

Kretzmann, J., Ho, D., Toshniwal, P., Evans, C., Norret, M., Nguyen, M., Veder, J-P., Jiang, H., Munshi, A., Blythe, A., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J., Bond, C., Hurley, L., Kilburn, M., Smith, N. & Iyer, K. S., 20 Aug 2017, In : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 254, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

19 Citations (Scopus)

Magnetically recoverable Fe3O4@Au-coated nanoscale catalysts for the A3-coupling reaction

Munshi, A. M., Shi, M., Thomas, S. P., Saunders, M., Spackman, M. A., Iyer, K. S. & Smith, N. M., 2017, In : Dalton Transactions. 46, 16, p. 5133-5137 5 p.

Research output: Contribution to journalArticle

Open Access
Alkynes
Aldehydes
Discrete Fourier transforms
Amines
Electrostatics
13 Citations (Scopus)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Doig, R. L. OH., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In : BMC Neuroscience. 18, 16 p., 62.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
216 Downloads (Pure)
Open Access
File
serums
coronas
Blood Proteins
Nanoparticles
proteins
2016
16 Citations (Scopus)
Open Access
Blood-Brain Barrier
Nanoparticles
Optic Nerve Injuries
Cerebrovascular Disorders
Brain
1 Citation (Scopus)

Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system

Lozić, I., Hartz, R. V., Bartlett, C. A., Shaw, J. A., Archer, M., Sarapna Rajoo Naidu, P., Smith, N. M., Dunlop, S. A., Swaminatha Iyer, K., Kilburn, M. R. & Fitzgerald, M., 2016, In : Data in Brief. 7, p. 152-156 5 p.

Research output: Contribution to journalArticle

Open Access
Nanoparticles
Secondary Ion Mass Spectrometry
Central Nervous System
Wounds and Injuries
Optic Nerve
3 Citations (Scopus)

Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

Singh, R., Ho, D., Lim, L-Y., Swaminatha Iyer, K. & Smith, N. M., Dec 2016, In : ACS Omega. 1, 6, p. 1114-1120

Research output: Contribution to journalArticle

Open Access
Ligands
Nanoparticles
Biocompatibility
Folic Acid
Cells
27 Citations (Scopus)

Dose-Dependent Therapeutic Distinction between Active and Passive Targeting Revealed Using Transferrin-Coated PGMA Nanoparticles

Singh, R., Norret, M., House, M., Galabura, Y., Bradshaw, M., Ho, D., Woodward, R., St Pierre, T., Luzinov, I., Smith, N., Lim, L. Y. & Swaminatha Iyer, K., 20 Jan 2016, In : Small. 12, 3, p. 351-359

Research output: Contribution to journalArticle

Transferrin
Nanoparticles
Tumors
Neoplasms
Drug delivery
13 Citations (Scopus)
336 Downloads (Pure)

Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system

Lozić, I., Hartz, R. V., Bartlett, C., Shaw, J., Archer, M., Sarapna Rajoo Naidu, P., Smith, N., Dunlop, S., Swaminatha Iyer, K., Kilburn, M. & Fitzgerald, M., Jan 2016, In : Biomaterials. 74, p. 200-216 17 p.

Research output: Contribution to journalArticle

Open Access
File
Neurology
Nanoparticles
Aquaporin 4
Central Nervous System
Optic Nerve Injuries
7 Citations (Scopus)

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Agarwal, V., Toshniwal, P., Smith, NE., Smith, N., Li, B., Clemons, T., Byrne, L., Kakulas, F., Wood, F., Fear, M., Corry, B. & Swaminathan Lyer, K., 2016, In : Chemical Communications. 52, 2, p. 327-330

Research output: Contribution to journalArticle

7 Citations (Scopus)

Functional Reactive Polymer Electrospun Matrix

Agarwal, V., Ho, D., Ho, D., Galabura, Y., Yasin, F., Gong, P., Ye, W., Singh, R., Munshi, A., Saunders, M., Woodward, R. C., St. Pierre, T., Wood, F. M., Fear, M., Lorenser, D., Sampson, D. D., Zdyrko, B., Luzinov, I., Smith, N. M. & Swaminatha Iyer, K., 24 Feb 2016, In : ACS Applied Materials and Interfaces. 8, 7, p. 4934-4939 6 p.

Research output: Contribution to journalArticle

Functional polymers
Polymer matrix
Functional materials
Hybrid materials
Substrates
8 Citations (Scopus)

Magnetically Directed Assembly of Nanocrystals for Catalytic Control of a Three-Component Coupling Reaction

Munshi, A. M., Agarwal, V., Ho, D., Raston, C. L., Saunders, M., Smith, N. M. & Iyer, K. S., 7 Sep 2016, In : Crystal Growth and Design. 16, 9, p. 4773-4776

Research output: Contribution to journalArticle

Nanocrystals
nanocrystals
assembly
Ferrosoferric Oxide
dipoles
2 Citations (Scopus)
323 Downloads (Pure)
Open Access
File
Brushes
Polymers
Polyetherimides
Nanoparticles
Proteins
3 Citations (Scopus)
240 Downloads (Pure)
Open Access
File
Nanoparticles
Imaging techniques
Lanthanoid Series Elements
Magnetic resonance
Rare earth elements
2 Citations (Scopus)

Regulation of collagen expression using nanoparticle mediated inhibition of TGF-β activation

Li, B., Clemons, T., Agarwal, V., Kretzmann, J., Bradshaw, M., Toshniwal, P., Smith, N., Li, S., Fear, M., Wood, F. & Swaminathan Iyer, K., 1 Feb 2016, In : New Journal of Chemistry. 40, 2, p. 1091-1095

Research output: Contribution to journalArticle

Fibroblasts
Collagen
Phosphates
Chemical activation
Nanoparticles
8 Citations (Scopus)
160 Downloads (Pure)
Open Access
File
Neuroglia
Cell Survival
Oxidative Stress
Purinergic P2X7 Receptors
Memantine
2015
19 Citations (Scopus)

Hierarchical patterning of multifunctional conducting polymer nanoparticles as a bionic platform for topographic contact guidance

Ho, D., Zou, J., Chen, X., Munshi, A., Smith, N., Agarwal, V., Hodgetts, S., Plant, G. W., Bakker, T., Harvey, A., Luzinov, I. A. & Iyer, K., 24 Feb 2015, In : ACS Nano. 9, 2, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

bionics
Bionics
Conducting polymers
conducting polymers
platforms
15 Citations (Scopus)
334 Downloads (Pure)
Open Access
File
ischemia
antioxidants
Antioxidants
Curcumin
Peptides
16 Citations (Scopus)

RNA interference using c-Myc-conjugated nanoparticles suppresses breast and colorectal cancer models

Tangudu, N. K., Verma, V. K., Clemons, T., Beevi, S. S., Hay, T., Mahidhara, G., Raja, M., Nair, R. A., Alexander, L. E., Patel, A. B., Jose, J., Smith, N. M., Zdyrko, B., Bourdoncle, A., Luzinov, I., Swaminatha Iyer, K., Clarke, A. R. & Dinesh Kumar, L., May 2015, In : Molecular Cancer Therapeutics. 14, 5, p. 1259-1269

Research output: Contribution to journalArticle

Open Access
RNA Interference
Nanoparticles
Colorectal Neoplasms
Breast Neoplasms
Neoplasms
20 Citations (Scopus)
359 Downloads (Pure)

The design and structural characterization of a synthetic pentatricopeptide repeat protein

Gully, B., Shah, K., Lee, M., Shearston, K., Smith, N., Sadowska, A., Blythe, A., Bernath-Levin, K., Stanley, W., Small, I. & Bond, C., Feb 2015, In : ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. 71, 2, p. 196-208

Research output: Contribution to journalArticle

Open Access
File
Proteins
RNA-Binding Proteins
Consensus Sequence
RNA
RNA Editing
2014
28 Citations (Scopus)

Controlling nanomaterial synthesis, chemical reactions and self assembly in dynamic thin films

Chen, X., Smith, N., Swaminatha Iyer, K. & Raston, C. L., 2014, In : Chemical Society Reviews. 43, 5, p. 1387-1399

Research output: Contribution to journalLiterature review

Nanostructured materials
Self assembly
Chemical reactions
Inorganic compounds
Thin films
13 Citations (Scopus)
Stereoselectivity
Regioselectivity
Diels-Alder reactions
Carbon Nanotubes
adducts
2013
12 Citations (Scopus)

In situ coating of diatom frustules with silver nanoparticles

Toster, J., Zhou, Q. L., Smith, N., Swaminatha Iyer, K., Rosei, F. & Raston, C. L., 2013, In : Green Chemistry. 15, 8, p. 2060-2063

Research output: Contribution to journalArticle

Reducing Agents
Reducing agents
Silver
Glucose
Cleaning
29 Citations (Scopus)

Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma

Savigni, D., O'Hare Doig, R. L., Szymanski, C. R., Bartlett, C., Lozić, I., Smith, N. & Fitzgerald, M., 2013, In : Neuropharmacology. 75, p. 380-390

Research output: Contribution to journalArticle

Myelin Sheath
Reflex
Purinergic P2X Receptors
Optic Nerve Injuries
Optokinetic Nystagmus

Three Ca2+ channel inhibitors in combination reduce chronic secondary degeneration following neurotrauma

Savigni, D., Doig, R. OH., Szymanski, C., Bartlett, C., Lozic, I., Smith, N. & Fitzgerald, M., Jul 2013, In : Glia. 61, Supplement 1, p. S197-S198 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2012
14 Citations (Scopus)

Mercury–thymine interaction with a chair type G-quadruplex architecture

Smith, N., Amrane, S., Rosu, F., Gabelica, V. & Mergny, J., 2012, In : Chemical Communications. 48, p. 11464-11466

Research output: Contribution to journalArticle

10 Citations (Scopus)

The role of thermodynamics and kinetics in ligand binding to G-quadruplex DNA

Corry, B. & Smith, N., 2012, In : Chemical Communications. 48, p. 8958-8960

Research output: Contribution to journalArticle

2011
45 Citations (Scopus)

DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Smith, N., 2011, In : ChemComm. 47, 17, p. 4992 4994 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)

Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands

Smith, N., Labrunie, G., Corry, B., Tran, P. L. T., Norret, M., Djavaheri-Mergny, M., Raston, C. & Mergny, J. L., 2011, In : Organic & Biomolecular Chemistry. 9, p. 6154-6162

Research output: Contribution to journalArticle

G-Quadruplexes
deoxyribonucleic acid
Stabilization
stabilization
Ligands
2009
16 Citations (Scopus)

A microfluidic platform to synthesise a G-quadruplex binding ligand

Smith, N., Corry, B., Swaminatha Iyer, K., Norret, M. & Raston, C., 2009, In : Lab on a Chip. 9, p. 2021-2025

Research output: Contribution to journalArticle

G-Quadruplexes
Chemical reactivity
Oncology
Microfluidics
Catalyst selectivity
236 Downloads (Pure)

High triarylpyridine affinity towards a parallel G-quadruplex in the c-kit promoter

Smith, N., 2009, (Unpublished)

Research output: ThesisDoctoral Thesis

File
DNA
Genes
Ligands
Pyridines
Chemical reactivity
3 Citations (Scopus)

Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells

Smith, N., Soh, P., Asokananthan, N., Norret, M., Stewart, G. & Raston, C., 2009, In : New Journal of Chemistry. 33, 9, p. 1793-1980

Research output: Contribution to journalArticle

Chalcones
Bioactivity
Polyethylene glycols
Carrier concentration
Cytokines
2007
36 Citations (Scopus)

PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Smith, NM., Raston, C., Smith, CB. & Sobolev, AN., 2007, In : Green Chemistry. 9, 11, p. 1185-1190 1190 p.

Research output: Contribution to journalArticle

Open Access
aldehyde
Aldehydes
Polyethylene glycols
acetate
ammonium