Nathan Pavlos

Associate Professor, BSc PhD W.Aust.

  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1929 Citations
  • 27 h-Index
20002022
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Research Output 2000 2019

2019

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Ho, P. W. M., Chan, A. S., Pavlos, N. J., Sims, N. A. & Martin, T. J., Nov 2019, In : Biochemical Pharmacology. 169, 113627.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Endocytosis
Cyclic AMP
Parathyroid Hormone
Adenylyl Cyclases
1 Citation (Scopus)
Open Access
Osteitis Deformans
Osteoclasts
Quantitative Trait Loci
Genome-Wide Association Study
Genes
1 Citation (Scopus)

Membrane trafficking in osteoclasts and implications for osteoporosis

Ng, P. Y., Brigitte Patricia Ribet, A. & Pavlos, N. J., 30 Apr 2019, In : Biochemical Society Transactions. 47, 2, p. 639-650 12 p.

Research output: Contribution to journalReview article

Open Access
Osteoclasts
Osteoporosis
Membranes
Bone
Bone and Bones

Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly

Krauss, J. L., Roper, P. M., Ballard, A., Shih, C. C., Fitzpatrick, J. A. J., Cassat, J. E., Ng, P. Y., Pavlos, N. J. & Veis, D. J., 15 Oct 2019, In : mBio. 10, 5

Research output: Contribution to journalArticle

Open Access
Osteoclasts
Staphylococcus aureus
RANK Ligand
Osteomyelitis
Bone and Bones

Targeted sequencing of DCSTAMP in familial Paget's disease of bone

Sultana, M. A., Pavlos, N. J., Ward, L., Walsh, J. P. & Rea, S. L., 1 Jun 2019, In : Bone Reports. 10, 100198.

Research output: Contribution to journalArticle

Open Access
Osteitis Deformans
Genome-Wide Association Study
Osteoclasts
Causality
Exome
2018
18 Citations (Scopus)

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.

Research output: Contribution to journalArticle

Ovariectomy
Osteogenesis
Osteoporosis
Osteoclasts
Bone
429 Downloads (Pure)

Elucidating the role of sorting nexins in skeletal homeostasis

Chan, A. S., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Sorting Nexins
Parathyroid Hormone Receptor Type 1
Homeostasis
Endosomes
Bone Remodeling
4 Citations (Scopus)
170 Downloads (Pure)

Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts

Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G., Jun 2018, In : Journal of Bone & Mineral Research. 33, 6, p. 1044-1051

Research output: Contribution to journalArticle

Open Access
File
Quantitative Trait Loci
Genome-Wide Association Study
Osteoclasts
Bone Density
Single Nucleotide Polymorphism
109 Downloads (Pure)
File
Activator Appliances
RANK Ligand
Osteoclasts
Methionine
Homeostasis

Osteoclasts serve as an intracellular niche for replicating Staphylococcus aureus

Ballard, A., Krauss, J. L., Ng, P. Y., Cox, L., Goering, E., Pavlos, N. J. & Veis, D. J., Nov 2018, In : Journal of Bone and Mineral Research. 33, p. 192-192 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

5 Citations (Scopus)

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Johnson, R. W., Sun, Y., Ho, P. W. M., Chan, A. S. M., Johnson, J. A., Pavlos, N. J., Sims, N. A. & Martin, T. J., 16 May 2018, In : Frontiers in Endocrinology. 9, 9 p., 241.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)

Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies

Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J. & Xu, J., 1 Dec 2018, In : Bone Research. 6, 1, 16.

Research output: Contribution to journalReview article

Open Access
Rheumatoid Arthritis
Therapeutics
Joints
Antirheumatic Agents
Premature Mortality

Septins are critical regulators of osteoclastic bone resorption

Møller, A. M. J., Füchtbauer, E. M., Brüel, A., Andersen, T. L., Borggaard, X. G., Pavlos, N. J., Thomsen, J. S., Pedersen, F. S., Delaisse, J. M. & Søe, K., 1 Dec 2018, In : Scientific Reports. 8, 1, 13016.

Research output: Contribution to journalArticle

Open Access
Septins
Bone Resorption
Osteoclasts
Exocytosis
Thigh
2017
38 Citations (Scopus)
121 Downloads (Pure)

GPCR Signaling and Trafficking: The Long and Short of It

Pavlos, N. J. & Friedman, P. A., 1 Mar 2017, In : Trends in Endocrinology and Metabolism. 28, 3, p. 213-226 14 p.

Research output: Contribution to journalReview article

Open Access
File
G-Protein-Coupled Receptors
Parathyroid Hormone Receptor Type 1
Arrestins
Bone Development
Recycling

Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism.

McDonald, M., Ng, P. Y., Butt, D., Pathmanandavel, K., Biro, M., Terry, R., Khoo, W. H., Mohanty, S., Simic, M., Chai, R., Quinn, J., Pettitt, J., Abi-Hanna, D., Jain, R., Weninger, W., Baldock, P., Rogers, M., Brink, R., Pavlos, N., Croucher, P. & 1 othersPhan, T., Dec 2017, In : Journal of Bone & Mineral Research. 32, p. S37-S37 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2016
15 Citations (Scopus)

A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration

Roohani-Esfahani, S. I., No, Y. J., Lu, Z., Ng, P. Y., Chen, Y., Shi, J., Pavlos, N. & Zreiqat, H., 10 Jun 2016, In : Biomedical Materials (Bristol). 11, 3

Research output: Contribution to journalArticle

Bioceramics
Tissue regeneration
Bone
Osteoblasts
Biocompatibility
13 Citations (Scopus)

Alexidine dihydrochloride attenuates osteoclast formation and bone resorption and protects against LPS-induced osteolysis

Zhu, X., Gao, J., Ng, P. Y., Qin, A., Steer, J., Pavlos, N., Zheng, M., Dong, Y. & Cheng, T. S., 16 Mar 2016, In : Journal of Bone & Mineral Research. 31, 3, p. 560-572 13 p.

Research output: Contribution to journalArticle

Osteolysis
Osteoclasts
Bone Resorption
Arthroplasty
Contact Lens Solutions
38 Citations (Scopus)
171 Downloads (Pure)

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

Clairfeuille, T., Mas, C., Chan, A., Yang, Z., Tello-Lafoz, M., Chandra, M., Widagdo, J., Kerr, M. C., Paul, B., Mérida, I., Teasdale, R. D., Pavlos, N., Anggono, V. & Collins, B. M., Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 921-932

Research output: Contribution to journalArticle

Open Access
File
Sorting Nexins
Recycling
Protein Transport
Ligands
Acidic Amino Acids
2 Citations (Scopus)
Acidification
Osteoclasts
Adenosine Triphosphatases
Proton Pumps
Proteins
3 Citations (Scopus)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
Calmodulin
Bone Resorption
Osteoclasts
Calcium
calmidazolium
26 Citations (Scopus)

Glucocorticoid impairs cell-cell communication by autophagymediated degradation of connexin 43 in osteocytes

Gao, J., Cheng, T. S., Qin, A., Pavlos, N., Wang, T., Song, K., Wang, Y., Chen, L., Zhou, L., Jiang, Q., Takayanagi, H., Yan, S. & Zheng, M., 10 May 2016, In : Oncotarget. 7, 19, p. 26966-26978

Research output: Contribution to journalArticle

Open Access
Osteocytes
Connexin 43
Autophagy
Cell Communication
Glucocorticoids
11 Citations (Scopus)

Mutations of vasopressin receptor 2 including novel L312S have differential effects on trafficking

Tiulpakov, A., White, C., Abhayawardana, R., See, H. B., Chan, A., Seeber, R., Heng, J., Dedov, I., Pavlos, N. & Pfleger, K., 1 Aug 2016, In : Molecular Endocrinology. 30, 8, p. 889-904

Research output: Contribution to journalArticle

Open Access
Vasopressin Receptors
Mutation
Hyponatremia
Nephrogenic Diabetes Insipidus
Natriuresis

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis

Fujiwara, T., Ye, S., Castro-Gomes, T., Winchell, C., Andrews, N., Voth, D., Varughese, K., Mackintosh, S., Feng, Y., Pavlos, N., Nakamura, T., Manolagas, S. & Zhao, H., 20 Oct 2016, In : JCI Insight. 1, 17, e86330.

Research output: Contribution to journalArticle

Open Access
Lysosomes
Homeostasis
Bone and Bones
Osteoclasts
Bone Resorption
21 Citations (Scopus)

Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth

Chan, A., Clairfeuille, T., Landao-Bassonga, E., Kinna, G., Ng, P. Y., Loo, L. S., Cheng, T. S., Zheng, M., Hong, W., Teasdale, R. D., Collins, B. M. & Pavlos, N., 15 Apr 2016, In : Molecular Biology of the Cell. 27, 8, p. 1367-1382 16 p.

Research output: Contribution to journalArticle

Open Access
Sorting Nexins
Parathyroid Hormone Receptor Type 1
Bone Development
Osteoblasts
Endosomes
12 Citations (Scopus)

Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo

Zhu, X., Gao, J., Landao-Bassonga, E., Pavlos, N., Qin, A., Steer, J., Zheng, M., Dong, Y. & Cheng, T. S., 15 Mar 2016, In : Biochemical Pharmacology. 104, p. 118-130 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Bromides
Bone
Bone and Bones
2015
7 Citations (Scopus)

A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

Ali, N., Jurczyluk, J., Shay, G., Tnimov, Z., Alexandrov, K., Munoz, M. A., Skinner, O. P., Pavlos, N. & Rogers, M. J., 2015, In : Small GTPases. 6, 4, p. 202-211

Research output: Contribution to journalArticle

14 Citations (Scopus)

Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass

Kular, J., Tickner, J., Pavlos, N., Viola, H., Abel, T., Lim, B., Yang, X., Chen, H., Cook, R., Hool, L., Zheng, M. & Xu, J., 16 Jan 2015, In : Journal of Biological Chemistry. 290, 3, p. 1729-1742

Research output: Contribution to journalArticle

Open Access
Choline Kinase
Phosphorylcholine
Osteoclasts
Bone
Bone and Bones
9 Citations (Scopus)

Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study

Lim, W., Wong, G., Lim, E. M., Byrnes, E., Zhu, K., Devine, A., Pavlos, N., Prince, R. & Lewis, J., 19 Oct 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2078-2085 8 p.

Research output: Contribution to journalArticle

Open Access
Hospitalization
Cohort Studies
Prospective Studies
Osteoporotic Fractures
Pelvic Bones
3 Citations (Scopus)

Disulfiram Attenuates Osteoclast Differentiation In Vitro: A Potential Antiresorptive Agent

Ying, H., Qin, A., Cheng, T. S., Pavlos, N., Rea, S., Dai, K. & Zheng, M., 30 Apr 2015, In : PLoS One. 10, 4, p. 1-17

Research output: Contribution to journalArticle

Open Access
disulfiram
Bone Density Conservation Agents
Disulfiram
osteoclasts
Osteoclasts
7 Citations (Scopus)

Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head

Li, G., Zheng, Q., Landao-Bassonga, E., Cheng, T. S., Pavlos, N., Ma, Y., Zhang, C. & Zheng, M., 2015, In : Bone. 77, p. 91-97

Research output: Contribution to journalArticle

Bone Remodeling
Thigh
Bone and Bones
Bone Cysts
Homeostasis
5 Citations (Scopus)
102 Downloads (Pure)

Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-B Activation, and IB Degradation

Qin, S., Ang, E., Dai, L., Yang, X., Ye, D., Chen, H., Zhou, L., Yang, M., Teguh, D. A., Tan, R., Xu, J., Tickner, J., Pavlos, N. & Xu, J., 5 Nov 2015, In : International Journal of Molecular Sciences. 16, 11, p. 26599–26607 9 p.

Research output: Contribution to journalArticle

Open Access
File
Germacrane Sesquiterpenes
osteogenesis
Osteoclasts
Bone Resorption
bones
17 Citations (Scopus)
233 Downloads (Pure)

Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-қB activation and titanium particle-induced osteolysis in a mouse model

Huang, J., Zhou, L., Wu, H., Pavlos, N., Chim, S., Liu, Q., Zhao, J., Xue, W., Tan, R., Ye, J., Ang, E., Feng, H. T., Tickner, J., Xu, J., Ding, Y. & Xu, J., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, p. 346-353

Research output: Contribution to journalArticle

Open Access
File
Osteolysis
Osteoclasts
Bone Resorption
Titanium
Bone
2014
8 Citations (Scopus)

Identical subchondral bone microarchitecture pattern with increasedbone resorption in rheumatoid arthritis as compared to osteoarthritis

Li, G., Ma, Y., Cheng, T. S., Landao-Bassonga, E., Qin, A., Pavlos, N., Zhang, C., Zheng, Q. & Zheng, M., 2014, In : Osteoarthritis and Cartilage. 22, 12, p. 2083-2092

Research output: Contribution to journalArticle

Open Access
Osteoarthritis
Rheumatoid Arthritis
Bone
Bone and Bones
Bone Remodeling
36 Citations (Scopus)

The GTPase RaB26 links synaptic vesicles to the autophagy pathway

Binotti, B., Pavlos, N., Riedel, D., Wenzel, D. L., Vorbrüggen, G., Schalk, A. M., Kühnel, K., Boyken, J., Erck, C., Martens, H. E., Chua, J. & Jahn, R., 2014, In : eLife. 2015, 4, p. 1-23

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Synaptic Vesicles
GTP Phosphohydrolases
Autophagy
Carisoprodol
2013
21 Citations (Scopus)

Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption

Ng, P. Y., Cheng, T. S., Zhao, H., Ye, S., Ang, E., Khor, E. C., Feng, H. T., Xu, J., Zheng, M. & Pavlos, N., 2013, In : Journal of Bone and Mineral Research. 28, 1, p. 119-134

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption

Khor, E. C., Abel, T., Tickner, J., Chim, S., Wang, C., Cheng, T. S., Ng, B., Ng, P. Y., Teguh, D., Kenny, J., Yang, X., Chen, H., Nakayama, K. I., Nakayama, K., Pavlos, N., Zheng, M. & Xu, J., 2013, In : PLoS One. 8, 8, p. 16pp

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation

Liu, Q., Wu, H., Chim, S., Zhou, L., Zhao, J., Feng, H., Wei, Q., Wang, Q., Zheng, M., Tan, R. X., Gu, Q., Xu, J., Pavlos, N., Tickner, J. & Xu, J., 2013, In : Biochemical Pharmacology. 86, 12, p. 1775-1783

Research output: Contribution to journalArticle

158 Citations (Scopus)

Subchondral bone in osteoarthritis: Insight into risk factors and microstructural changes

Li, G., Yin, J., Gao, J., Cheng, T. S., Pavlos, N., Zhang, C. & Zheng, M., 2013, In : Arthritis Research and Therapy. 15, 6, p. 223

Research output: Contribution to journalReview article

Open Access
18 Citations (Scopus)

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter

Chua, J. J. E., Butkevich, E., Worseck, J. M., Kittelmann, M., Gronborg, M., Behrmann, E., Stelzel, U., Pavlos, N., Lalowski, M. M., Eimer, S., Wanker, E. E., Klopfenstein, D. R. & Jahn, R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 15, p. 5862–5867

Research output: Contribution to journalArticle

42 Citations (Scopus)

Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption

Qin, A., Cheng, T. S., Lin, Z., Cao, L., Chim, S., Pavlos, N., Xu, J., Zheng, M. & Dai, K. R., 2012, In : PLoS One. 7, 4, p. 1-11

Research output: Contribution to journalArticle

Open Access
71 Citations (Scopus)

V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption

Qin, A., Cheng, T. S., Pavlos, N., Lin, Z., Dai, K. R. & Zheng, M., 2012, In : International Journal of Biochemistry and Cell Biology. 44, 9, p. 1422-1435

Research output: Contribution to journalArticle

3 Citations (Scopus)

“Fusion and Fission” Unveils Remarkable Insights into Osteoclast Plasticity

Pavlos, N. & Ng, P. Y., 2012, In : Calcified Tissue International. 19, p. 157-158

Research output: Contribution to journalLetter

2011
51 Citations (Scopus)

Autologous tenocyte therapy for experimental achilles tendinopathy in a rabbit model

Chen, J., Yu, Q., Wu, B., Lin, Z., Pavlos, N., Xu, J., Ouyang, H., Wang, A. & Zheng, M., 2011, In : Tissue Engineering - Part A. 17, p. 2037-2049

Research output: Contribution to journalArticle

35 Citations (Scopus)

Distinct yet overlapping roles of Rab CTPases on synaptic vesicles

Pavlos, N. & Jahn, R., 2011, In : Small GTPases. 2, 2, p. 77-81

Research output: Contribution to journalArticle

50 Citations (Scopus)

EGFL6 promotes endothelial cell migration and angiogenesis through the activation of Extracellular Signal-regulated Kinase

Chim, S., Qin, A., Tickner, J., Pavlos, N., Davey, T. N., Wang, H., Guo, Y., Zheng, M. & Xu, J., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22035-22046

Research output: Contribution to journalArticle

48 Citations (Scopus)

In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering

Lin, Z., Solomon, K. L., Zhang, X., Pavlos, N., Abel, T., Willers, C., Dai, K., Xu, J., Zheng, Q. & Zheng, M., 2011, In : International Journal of Biological Sciences. 7, 7, p. 968-977

Research output: Contribution to journalArticle

27 Citations (Scopus)

LIS1 Regulates Osteoclast Formation and Function through its Interactions with Dynein/Dynactin and Plekhm1

Ye, S., Fowler, T. W., Pavlos, N., Ng, P. Y., Liang, K., Feng, Y., Zheng, M., Kurten, R., Manolagas, S. C. & Zhao, H., 2011, In : PLoS One. 6, 11, p. 1-14

Research output: Contribution to journalArticle

Open Access
39 Citations (Scopus)

M-CSF Potently Augments RANKL-Induced Resorption Activation in Mature Human Osteoclasts

Hodge, J. M., Collier, F. M., Pavlos, N., Kirkland, M. A. & Nicholson, G. C., 2011, In : PLoS One. 6, p. 1-8

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Tctex-1, A novel interaction partner of RAB3D is required for osteoclastic bone resorption

Pavlos, N., Cheng, T. S., Qin, Q., Ng, P. Y., Feng, H. T., Ang, E., Carrello, S., Sung, CH., Jahn, R., Zheng, M. & Xu, J., 2011, In : Molecular and Cellular Biology. 31, 7, p. 1551-1564

Research output: Contribution to journalArticle