Personal profile
Biography
Professor Nathan Pavlos is Head of the Bone Biology & Disease Laboratory and Chair of the Research Commitee within the School of Biomedical Sciences.
He completed his undergraduate and PhD studies at the University of Western Australia. He was awarded a prestigious NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany (Reinhard Jahn Lab). In 2010, Dr Pavlos returned to UWA as an NHMRC Research Fellow to establish his own research laboratory.
His research has been published in leading international journals including Cell, Nature Structural & Molecular Biology, Nature Comunications and the Journal of Bone & Mineral Research. His award-winning research regularly receives national and international attention and he has attracted more than $11 million in competitive funding as a chief investigator.
Roles and responsibilities
• Head, Bone Biology & Disease Laboratory, School of Biomedical Sciences
• Chair, School of Biomedical Sciences Research Committee
• Head, Tissue Repair and Regenerative Biology Research Cluster
• Graduate Research Coordinator (SBMS, SMED)
• Immediate Past President, Australian and New Zealand Society for Orthopaedic Research (ANZORS)
Funding overview
NHMRC-Ideas Grants
NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
ARC-Linkage and LIEF Grants
Arthritis Australia
ANZBMS-Bone Health Foundation
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme
Previous positions
2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)
Tresurer and Executive Council, Australian & New Zealand Bone and Mineral Society (ANZBMS) (2013-2019)
Treasurer and Executive Council, Australian & New Zealand Orthopaedic Research Society (ANZORS) (2012-2018)
Secretary, Australian & New Zealand Society for Cell and Developmental Biology (ANZSCDB) (2019-2021)
Member (WG4), The GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork (GEMSTONE) (2019-2022)
President, Australian & New Zealand Orthopaedic Research Society (ANZORS) (2021-2024)
Current projects
Sorting-Out the Skeleton: The role of intracellular trafficking in bone homeostasis and disease.
Orphan transporters in bone homeostasis and disease
Teaching overview
IMED3003: Body Systems & Disease III (Unit Coordinator)
PATH3308-Pathology and Laboratory Medicine II (Unit Co-Coordinator)
SURG5853: Masters of Surgery (Unit Coordinator)
PATH2210: Fundamentals of Pathology and Laboratory Medicine
IMED4121: Integrated Medical Sciences
IMED4444: Integrated Medical Sciences
DENT3002: Body Systems
PODI3115: Body Systems
SMED4221 Research Foundations Unit (MD Scholarly Activity)
Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.
Research
Dr Pavlos’s current research interests focus on the molecular mechanisms of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating musculoskeletal diseases including osteoporosis, osteoarthritis, Paget's disease and tumour-mediated bone loss. To achieve this, he combines innovative microscopy-based platforms together with high-through-put screens including integrative genomic, quantitative proteomics and phenomics to systematically decipher the core molecular machinery underlying bone resorption. Along with his focus on osteoclasts and bone biology, he also has a long-standing interest in the molecular regulation and dynamics of intracellular trafficking, a process essential for normal cellular function and is often perturbed in many different diseases including skeletal disorders, neurological disease, cancer, inflammation and pathogen invasion.
External positions
Immediate Past President, Australian & New Zealand Orthopaedic Research Society
2025 → …
Member (Big Data Committee), International Federation of Musculoskeletal Research Societies (IFMRS)
2024 → …
Member (Program Advisory Group), American Society for Bone and Mineral Research (ASBMR)
2023 → …
Chair (Sponsorship), International Combined Orthopaedic Research Societies (ICORS) 2025 World Congress of Orthopaedic Research
2023 → …
Chair, The Hunter Cell Biology Meeting
2023 → …
Member (Subspeciality Presidents Committee), Australian Orthopaedic Association (AOA)
2021 → …
Consultant, Australian Institute of Robotic Orthopaedics
2020 → …
Research expertise keywords
- Bone cell biology
- Osteoclasts
- Pathogenesis of bone disease
- Membrane transport
- Osteoporosis
- Tissue engineering
- Microscopy
- Membrane transport of ions—electrophysiology and microscopy
- Organelle gene expression
- Big data (Omics)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
-
SDG 9 Industry, Innovation, and Infrastructure
-
SDG 13 Climate Action
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts
Ng, P. Y., Ribet, A. B. P., Guo, Q., Mullin, B. H., Tan, J. W. Y., Landao-Bassonga, E., Stephens, S., Chen, K., Yuan, J., Abudulai, L., Bollen, M., Nguyen, E. T. T. T., Kular, J., Papadimitriou, J. M., Søe, K., Teasdale, R. D., Xu, J., Parton, R. G., Takayanagi, H. & Pavlos, N. J., Dec 2023, In: Nature Communications. 14, 1, 23 p., 906.Research output: Contribution to journal › Article › peer-review
Open Access27 Link opens in a new tab Citations (Scopus) -
Moesin controls cell-cell fusion and osteoclast function
Dufrançais, O., Plozza, M., Juzans, M., Métais, A., Monard, S. C., Bordignon, P. J., Verdys, P., Sanchez, T., Bergert, M., Halper, J., Panebianco, C. J., Mascarau, R., Gence, R., Arnaud, G., Ben Neji, M., Maridonneau-Parini, I., Le Cabec, V., Boerckel, J. D., Pavlos, N. J. & Diz-Muñoz, A. & 7 others, , 3 Nov 2025, In: The Journal of Cell Biology. 224, 11, 28 p., e202409169.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Citations (Web of Science) -
Bone Trans-omics: Integrating Omics to Unveil Mechanistic Molecular Networks Regulating Bone Biology and Disease
Mullin, B. H., Ribet, A. B. P. & Pavlos, N. J., Oct 2023, In: Current Osteoporosis Reports. 21, 5, p. 493-502 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access14 Link opens in a new tab Citations (Scopus) -
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
McDonald, M. M., Khoo, W. H., Ng, P. Y., Xiao, Y., Zamerli, J., Thatcher, P., Kyaw, W., Pathmanandavel, K., Grootveld, A. K., Moran, I., Butt, D., Nguyen, A., Warren, S., Biro, M., Butterfield, N. C., Guilfoyle, S. E., Komla-Ebri, D., Dack, M. R. G., Dewhurst, H. F. & Logan, J. G. & 26 others, , 4 Mar 2021, In: Cell. 184, 5, p. 1330-1347.e13Research output: Contribution to journal › Article › peer-review
Open Access355 Link opens in a new tab Citations (Scopus) -
Genome topology analysis and transcriptomics of human osteoclasts reveals enhancer-promoter interactions at loci for bone traits and diseases
Wilson, S. G., Campbell, P. J., Sooraj, D., Leatherbarrow, K., Mullin, B. H., Brown, S. J., Zhu, K., Mullin, S., Ward, B. K., Zhang, J., Torchia, J., Dudbridge, F., Xu, J., Pavlos, N. J., Chandler, D. & Walsh, J. P., 4 Sept 2025, In: JBMR Plus. 9, 10, p. ziaf120 ziaf120.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
-
Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes
Kenny, J. (Contributor), Mullin, B. H. (Contributor), Tomlinson, W. (Contributor), Robertson, B. (Contributor), Yuan, J. (Contributor), Chen, W. (Contributor), Zhao, J. (Contributor), Pavlos, N. J. (Contributor), Walsh, J. P. (Contributor), Wilson, S. G. (Contributor), Tickner, J. (Contributor), Morahan, G. (Contributor) & Xu, J. (Contributor), Figshare, 16 Aug 2024
DOI: 10.6084/m9.figshare.c.6962026
Dataset
-
Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
Mullin, B. H. (Creator), Tickner, J. (Creator), Zhu, K. (Creator), Kenny, J. (Creator), Mullin, S. (Creator), Brown, S. J. (Creator), Dudbridge, F. (Creator), Pavlos, N. J. (Creator), Mocarski, E. S. (Creator), Walsh, J. (Creator), Xu, J. (Creator) & Wilson, S. G. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.4909641.v1, https://springernature.figshare.com/collections/Characterisation_of_genetic_regulatory_effects_for_osteoporosis_risk_variants_in_human_osteoclasts/4909641/1
Dataset
-
Optimising lasers for ablation of structurally complex solid non-metals
Clode, P. (Investigator 01) & Pavlos, N. (Investigator 02)
ARC Australian Research Council
6/09/23 → 31/07/27
Project: Research
-
Unlocking the Therapeutic Potential of a New ‘Dual-Action’ Target for Bone and Joint Diseases
Pavlos, N. (Investigator 01), Takayanagi, H. (Investigator 02), Ng, P. Y. (Investigator 03), Mullin, B. (Investigator 04), Collins, B. (Investigator 05), Passioura, T. (Investigator 06) & Rackham, O. (Investigator 07)
NHMRC National Health and Medical Research Council
1/01/23 → 31/12/26
Project: Research
-
TARGETING A NEW SUBTYPE OF ESTROGEN RECEPTOR POSITIVE BREAST CANCER
Blancafort, P. (Investigator 01), Redfern, A. (Investigator 02), Golden, E. (Investigator 03), Johnstone, L. (Investigator 04), Pavlos, N. (Investigator 05) & Sharma, A. (Investigator 06)
National Breast Cancer Foundation
31/05/22 → 31/12/26
Project: Research
-
Lionheart FX Automated High-Content Microscope for the QEII Biomedical Research Precinct
Pavlos, N. (Chief Investigator), Barnett, T. (CoPI), Blancafort, P. (CoPI), Chen, K. (CoPI), Chooi, H. (CoPI), Hamzah, J. (CoPI), Hirvonen, L. (CoPI), Ingley, E. (CoPI), Johnstone, L. (CoPI), Kahler, C. (CoPI), Keelan, J. (CoPI), Kular, J. (CoPI), Mullin, B. (CoPI), Nicol, M. (CoPI), Pixley, F. (CoPI), Swaminatha Iyer, I. (CoPI), Waithman, J. (CoPI), Wilson, S. (CoPI) & Woodward, E. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
-
Defining the nutrient substrates for bone remodelling
Chen, K. (Investigator 01), Jiang, H. (Investigator 02), Swaminatha Iyer, I. (Investigator 03), Xu, J. (Investigator 04), Greenblatt, M. (Investigator 05) & Pavlos, N. (Investigator 06)
1/01/23 → 31/12/25
Project: Research
Prizes
-
-
-
Fellow of the American Society of Bone and Mineral Research (FASBMR)
Pavlos, N. (Recipient), 2020
Prize: Fellowship
-
Finalist - Excellence in Teaching Awards – Individual Teaching
Pavlos, N. (Recipient), 2020
Prize: Award
-
Activities
-
53rd Congress of the European Calcified Tissue Society
Pavlos, N. (Keynote speaker/Invited speaker)
2026Activity: Conferences and workshops › Contribution or participation in a conference
-
10th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
Pavlos, N. (Keynote speaker/Invited speaker)
2026Activity: Conferences and workshops › Participation in workshop, seminar or course
-
Community Conservation "Living with Bone and Joint Conditions"
Pavlos, N. (Organiser)
25 Mar 2026Activity: Conferences and workshops › Participation in workshop, seminar or course
-
Neuronal Cell Biology Symposium- Max Planck Institute for Multidisciplinary Sciences
Pavlos, N. (Keynote speaker/Invited speaker)
2025Activity: Conferences and workshops › Participation in workshop, seminar or course
-
The 11th International Symposium on Autophagy
Pavlos, N. (Keynote speaker/Invited speaker)
2025Activity: Conferences and workshops › Contribution or participation in a conference
Courses
Press/Media
-
What the doctorate ordered: programs link industry with PhD candidates
23/05/24
1 item of Media coverage
Press/Media: Press / Media
-
UWA researchers awarded major share of competitive national grants
15/12/23
1 item of Media coverage
Press/Media: Press / Media
-
-
UWA medical research benefits from national health grants
16/12/22
1 item of Media coverage
Press/Media: Press / Media
-
AIRO partners with UWA bone and regenerative biology experts
8/12/22
1 item of Media coverage
Press/Media: Press / Media