Nathan Pavlos

FASBMR, Associate Professor

  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth

    Australia

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Personal profile

Biography

Dr Nathan Pavlos is an Associate Professor, Head of the Bone Biology & Disease Laboratory and Head of the Tissue Repair and Regenerative Biology Research Cluster within the School of Biomedical Sciences at the University of Western Australia. He completed his undergraduate (1999) and PhD studies in Bone Cell Biology (2005) at UWA. In 2007 Dr Pavlos was awarded a NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany, from 2007-2009 with Prof Reinhard Jahn where he worked on the molecular regulation of synaptic vesicle exo-endocytosis in neurons. In 2010 Dr Pavlos returned to UWA to start up his own laboratory with a focus on intracellular trafficking and transport in bone cells.

Roles and responsibilities

Dr Pavlos is President-Elect for the Australian & and New Zealand Society for Orthopaedic Research,  Treasurer for The Australian & New Zealand Orthopaedic Research Society and Secretary for The Australian and New Zealand Society for Cell & Developmental Biology. He is also an active reviewer for the National Health & Medical Research Council (NHMRC), Associate Editor for Frontiers in Translational Pharmacology and Founding Editorial Board Member for Osteology and the Journal of Orthopaedic Translation and reviewer for several scientific journals.

Funding overview

NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme

Previous positions

2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)

Treasurer, Australian and New Zealand Orthopaedic Research Society (ANZORS) (2012-2018)

Current projects

Sorting-Out the Skeleton: The role of intracellular trafficking in bone homeostasis and disease.

Orphan transporters in bone homeostasis and disease

Teaching overview

IMED3003: Body Systems & Disease III (Unit Coordinator)

Path 3308-Pathology and Laboratory Medicine II (Unit Co-Coordinator) 

SURG5850: Masters of Surgery (Research Coordinator)

Path2210: Fundamentals of Pathology and Laboratory Medicine


SMED4221 Research Foundations Unit (MD Scholarly Activity)


Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.

Research

Dr Pavlos’s current research interests focus on the molecular mechanisms of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating musculoskeletal diseases including osteoporosis, osteoarthritis, Paget's disease and tumour-mediated bone loss. To achieve this, he combines innovative microscopy-based platforms together with high-through-put screens including integrative genomic, quantitative proteomics and phenomics to systematically decipher the core molecular machinery underlying bone resorption. Along with his focus on osteoclasts and bone biology, he also has a long-standing interest in the molecular regulation and dynamics of intracellular trafficking, a process essential for normal cellular function and is often perturbed in many different diseases including skeletal disorders, neurological disease, cancer, inflammation and pathogen invasion.

Dr Pavlos is also a Graduate Research Coordinator for the Faculty of Health and Medical Sciences

External positions

President-Elect, Australian & New Zealand Orthopaedic Research Society

2020 → …

Secretary, Australian & New Zealand Society for Cell and Developmental Biology

2019 → …

Treasurer, Australian & New Zealand Bone and Mineral Society

2013 → …

Treasurer, Australian & New Zealand Orthopaedic Research Society

20122018

Research expertise keywords

  • Bone cell biology
  • Osteoclasts
  • Pathogenesis of bone disease
  • Membrane transport
  • Osteoporosis
  • Tissue engineering
  • Microscopy

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