Nathan Pavlos

Associate Professor, BSc PhD W.Aust.

  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2111 Citations
  • 28 h-Index
20002022

Research output per year

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Personal profile

Biography

Dr Nathan Pavlos is an Associate Professor and Head of the Bone Biology & Disease Laboratory, School of Biomedical Sciences at the University of Western Australia. He completed his undergraduate (1999) and PhD studies in Bone Cell Biology (2005) at UWA. In 2007 Dr Pavlos was awarded a NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany, from 2007-2009 with Prof Reinhard Jahn where he worked on the molecular regulation of synaptic vesicle exo-endocytosis in neurons. In 2010 Dr Pavlos returned to UWA to start up his own laboratory with a focus on intracellular trafficking and transport in bone cells.

Roles and responsibilities

Dr Pavlos is Treasurer for the Australian & and New Zealand Society for Orthopaedic Research and Treasurer for The Australian & New Zealand Orthopaedic Research Society. He is also an active reviewer for the National Health & Medical Research Council (NHMRC), Editorial Board Member for the Journal of Orthopaedic Translation and reviewer for several scientific journals

Funding overview

NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme

Previous positions

2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)

Current projects

Sorting-Out the Skeleton: The role of intracellular trafficking in bone homeostasis and disease.

Orphan transporters in bone homeostasis and disease

Teaching overview

IMED3003: Body Systems & Disease III (Unit Coordinator)

SURG5850: Masters of Surgery (Research Coorinator)

Path2210: Fundamentals of Pathology and Laboratory Medicine

Path 3308-Pathology and Laboratory Medicine II
Unit Coordinator (2010-2015)

SMED4221 Research Foundations Unit (MD Scholarly Activity)


Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.

Research

Dr Pavlos’s current research interests focus on the molecular mechanisms of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating musculoskeletal diseases including osteoporosis, osteoarthritis, Paget's disease and tumour-mediated bone loss. To achieve this, he combines innovative microscopy-based platforms together with high-through-put screens including integrative genomic, quantitative proteomics and phenomics to systematically decipher the core molecular machinery underlying bone resorption. Along with his focus on osteoclasts and bone biology, he also has a long-standing interest in the molecular regulation and dynamics of intracellular trafficking, a process essential for normal cellular function and is often perturbed in many different diseases including skeletal disorders, neurological disease, cancer, inflammation and pathogen invasion.

Dr Pavlos is also a Graduate Research Coordinator for the Faculty of Health and Medical Sciences

Keywords

  • Bone cell biology
  • Tissue engineering
  • Pathogenesis of bone disease

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Research Output

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 80.

Research output: Contribution to journalArticle

Open Access
  • Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

    Ho, P. W. M., Chan, A. S., Pavlos, N. J., Sims, N. A. & Martin, T. J., Nov 2019, In : Biochemical Pharmacology. 169, 113627.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
    Open Access
  • 2 Citations (Scopus)

    Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal

    McDonald, M., Khoo, W. H., Mohanty, S., Terry, R., Chai, R., Quinn, J., Pettitt, J., Xiao, Y., Baldock, P., Rogers, M., Croucher, P., Tri Phan, Ng, P. Y., Pavlos, N. & Biro, M., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 44-45 2 p.

    Research output: Contribution to journalAbstract/Meeting Abstract

    Membrane trafficking in osteoclasts and implications for osteoporosis

    Ng, P. Y., Brigitte Patricia Ribet, A. & Pavlos, N. J., 30 Apr 2019, In : Biochemical Society Transactions. 47, 2, p. 639-650 12 p.

    Research output: Contribution to journalReview article

    Open Access
  • 4 Citations (Scopus)

    Projects