Projects per year
Personal profile
Biography
Dr Nathan Pavlos is an Associate Professor and Head of the Cellular Orthopaedics Laboratory, School of Biomedical Sciences at the University of Western Australia. He completed his undergraduate (1999) and PhD studies in Bone Cell Biology (2005) at UWA. In 2007 Dr Pavlos was awarded a NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany, from 2007-2009 with Prof Reinhard Jahn where he worked on the molecular regulation of synaptic vesicle exo-endocytosis in neurons. In 2010 Dr Pavlos returned to UWA to start up his own laboratory with a focus on intracellular trafficking and transport in bone cells.
Roles and responsibilities
Dr Pavlos is Treasurer for the Australian & and New Zealand Society for Orthopaedic Research and Treasurer for The Australian & New Zealand Orthopaedic Research Society. He is also an active reviewer for the National Health & Medical Research Council (NHMRC), Editorial Board Member for the Journal of Orthopaedic Translation and reviewer for several scientific journals
Funding overview
NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme
Previous positions
2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)
Current projects
Sorting-Out the Skeleton: The role of intracellular trafficking in bone homeostasis and disease.
Teaching overview
Path2210: Fundamentals of Pathology and Laboratory Medicine
Path 3308-Pathology and Laboratory Medicine II
Unit Coordinator (2010-2015)
SMED4221 Research Foundations Unit (MD Scholarly Activity)
Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.
Path 3308-Pathology and Laboratory Medicine II
Unit Coordinator (2010-2015)
SMED4221 Research Foundations Unit (MD Scholarly Activity)
Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.
Research
Dr Pavlos’s current research interests focus on the molecular mechanisms of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating musculoskeletal diseases including osteoporosis, osteoarthritis, Paget's disease and tumour-mediated bone loss. To achieve this, he combines innovative microscopy-based platforms together with high-through-put screens including integrative genomic, quantitative proteomics and phenomics to systematically decipher the core molecular machinery underlying bone resorption. Along with his focus on osteoclasts and bone biology, he also has a long-standing interest in the molecular regulation and dynamics of intracellular trafficking, a process essential for normal cellular function and is often perturbed in many different diseases including skeletal disorders, neurological disease, cancer, inflammation and pathogen invasion.
Keywords
- Bone cell biology
- Tissue engineering
- Pathogenesis of bone disease
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Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2005 2022
Slc37a2 as a therapeutic target for osteolytic diseases
Arthritis Foundation of Australia
1/01/19 → 31/12/19
Project: Research
‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/22
Project: Research
The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
Pavlos, N., Xu, J. & Teasdale, R.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/21
Project: Research
Gene mining for novel molecular determinants of the skeleton
Xu, J., Pavlos, N., Tickner, J., Wilson, S. & Walsh, J.
National Health & Medical Research Council NHMRC
1/01/17 → 31/12/19
Project: Research
Furin: Carving-up vital substrates for bone remodelling and homeostasis
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/16 → 31/12/19
Project: Research
Research Output 2000 2019
Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone
Mullin, B. H., Zhu, K., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Xu, J., Walsh, J. P. & Wilson, S. G., 1 Dec 2019, In : Scientific Reports. 9, 1, 1052.Research output: Contribution to journal › Article
Open Access
Osteitis Deformans
Osteoclasts
Quantitative Trait Loci
Genome-Wide Association Study
Genes
Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways
Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.Research output: Contribution to journal › Article
Ovariectomy
Osteogenesis
Osteoporosis
Osteoclasts
Bone
Elucidating the role of sorting nexins in skeletal homeostasis
Chan, A. S., 2018, (Unpublished)Research output: Thesis › Doctoral Thesis
File
Sorting Nexins
Parathyroid Hormone Receptor Type 1
Homeostasis
Endosomes
Bone Remodeling
Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts
Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G., Jun 2018, In : Journal of Bone & Mineral Research. 33, 6, p. 1044-1051Research output: Contribution to journal › Article
Open Access
File
Quantitative Trait Loci
Genome-Wide Association Study
Osteoclasts
Bone Density
Single Nucleotide Polymorphism
New insights into the role of Methionine 199 in the function of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and bone homeostasis
Qiu, H., 2018Research output: Thesis › Master's Thesis
File
Activator Appliances
RANK Ligand
Osteoclasts
Methionine
Homeostasis