Nathan Pavlos

Associate Professor, BSc PhD W.Aust.

  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1703 Citations
  • 24 h-Index
20002022
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Personal profile

Biography

Dr Nathan Pavlos is an Associate Professor and Head of the Cellular Orthopaedics Laboratory, School of Biomedical Sciences at the University of Western Australia. He completed his undergraduate (1999) and PhD studies in Bone Cell Biology (2005) at UWA. In 2007 Dr Pavlos was awarded a NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany, from 2007-2009 with Prof Reinhard Jahn where he worked on the molecular regulation of synaptic vesicle exo-endocytosis in neurons. In 2010 Dr Pavlos returned to UWA to start up his own laboratory with a focus on intracellular trafficking and transport in bone cells.

Roles and responsibilities

Dr Pavlos is Treasurer for the Australian & and New Zealand Society for Orthopaedic Research and Treasurer for The Australian & New Zealand Orthopaedic Research Society. He is also an active reviewer for the National Health & Medical Research Council (NHMRC), Editorial Board Member for the Journal of Orthopaedic Translation and reviewer for several scientific journals

Funding overview

NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme

Previous positions

2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
State Representative (WA), Australian and New Zealand Society for Cell and Developmental Biology (ANZSCDB)(2013-2015)

Current projects

Sorting-Out the Skeleton: The role of intracellular trafficking in bone homeostasis and disease.

Teaching overview

Path2210: Fundamentals of Pathology and Laboratory Medicine

Path 3308-Pathology and Laboratory Medicine II
Unit Coordinator (2010-2015)

SMED4221 Research Foundations Unit (MD Scholarly Activity)


Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.

Research

Dr Pavlos’s current research interests focus on the molecular mechanisms of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating musculoskeletal diseases including osteoporosis, osteoarthritis, Paget's disease and tumour-mediated bone loss. To achieve this, he combines innovative microscopy-based platforms together with high-through-put screens including integrative genomic, quantitative proteomics and phenomics to systematically decipher the core molecular machinery underlying bone resorption. Along with his focus on osteoclasts and bone biology, he also has a long-standing interest in the molecular regulation and dynamics of intracellular trafficking, a process essential for normal cellular function and is often perturbed in many different diseases including skeletal disorders, neurological disease, cancer, inflammation and pathogen invasion.

Keywords

  • Bone cell biology
  • Tissue engineering
  • Pathogenesis of bone disease

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2005 2022

Research Output 2000 2019

Open Access
Osteitis Deformans
Osteoclasts
Quantitative Trait Loci
Genome-Wide Association Study
Genes
12 Citations

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.

Research output: Contribution to journalArticle

Ovariectomy
Osteogenesis
Osteoporosis
Osteoclasts
Bone

Elucidating the role of sorting nexins in skeletal homeostasis

Chan, A. S., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Sorting Nexins
Parathyroid Hormone Receptor Type 1
Homeostasis
Endosomes
Bone Remodeling
2 Citations

Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts

Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G., Jun 2018, In : Journal of Bone & Mineral Research. 33, 6, p. 1044-1051

Research output: Contribution to journalArticle

Open Access
File
Quantitative Trait Loci
Genome-Wide Association Study
Osteoclasts
Bone Density
Single Nucleotide Polymorphism
File
Activator Appliances
RANK Ligand
Osteoclasts
Methionine
Homeostasis