Minghao Zheng

Professor, MB BS Shantou, DM PhD W.Aust., FRCP, ARCPA

  • The University of Western Australia (M501), 35 Stirling Highway,

    6009 Perth


  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth


  • 7392 Citations
  • 49 h-Index
1992 …2020

Research output per year

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Personal profile


Prof. Ming-Hao Zheng is the Winthrop Professor and Director of Research at the Translational Orthopaedic Research Centre, Sir Charles Gairdner Hospital, Perth and the Associate Dean (International) of the Faculty of Medicine, Dentistry and Health Sciences, the University of Western Australia. He is also the Chung Kong Scholar Lecturing Professor and the Deputy Director of Australia-China Cooperative Research Centre for Biotherapeutics and Regenerative Medicine at the Zhejiang University, China, Director for UWA-Nanjing Bone and Joint Research Centre at Nanjing University. He has served on the editorial board member for numbers of Orthopaedics, stem cell and Pathology journals.
He has focused on the development of an academic career in bone and joint research and regenerative medicine. His productivity is evidenced by the quality of publications and patents, and his ability to transform laboratory research into clinical practice. He has published over 140 peer-reviewed papers in journals including Nature Medicine, Annals of Internal Medicine, Journal of Clinical Investigation, Molecular Cellular Biology, Journal of Biological Chemistry, American Journal of Pathology and Journal of Bone and Mineral Research.
His major achievements include studies in the molecular and cellular biology of the osteoclast, clinical and laboratory evaluation of cellular therapies, human bone allograft, development of cell-scaffold technology for cartilage, tendon and bone regeneration and regulatory framework in human tissue and cellular products. His work on Giant Cell Tumour of bone (GCT) has been used by WHO for classification of bone tumours and has been recorded in the textbook “Ackermans Surgical Pathology”.
He has 7 patents in the field of Orthopaedics and has introduced the concept and technology of autologous biotherapy in orthopaedics. His research results in the development of autologous stem cell and progenitor cell therapy in bone, cartilage and tendon. He has transformed the benchwork of Matrix-induced Autologous Chondrocyte Implantation (MACI) and Autologous Tencoyte Therapy (ATT) into clinical practices. In 2009, he received an honour from by Genzyme in Boston for his leadership, commitment and dedication to the advancement of MACI. To date, more than 120 hospitals across Australia and over 8000 patients in the world have used MACI for the treatment of cartilage defects.
Prof. Zheng has actively supervised and nursed quality postgraduate students and postdoctoral fellows with 24 PhD and 15 Master of Medical sciences students completing their degree in the last 15 years. Many of them have won awards at the national and international meetings for their research work and become high profile independent researchers.


Molecular and cellular biology of the osteoclast, with focus on interacellular vesicle trafficking and V-ATPase;
Clinical trials and laboratory evaluation of cellular therapies in orthopaedics;
Human bone allograft –validation and process characterisation;
Development of cell-scaffold technology for cartilage, tendon and bone regeneration
Development of bioreactors for mechanical sense tissues

Research expertise keywords

  • Biotherapeutics
  • Bone cell biology
  • Tissue engineering
  • Bone tumour pathology
  • Cell therapy
  • Regenerative medicine

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Research Output

Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis

Chen, L., Yao, F., Wang, T., Li, G., Chen, P., Bulsara, M., Zheng, J. J. Y., Landao-Bassonga, E., Firth, M., Vasantharao, P., Huang, Y., Lorimer, M., Graves, S., Gao, J., Carey-Smith, R., Papadimitriou, J., Zhang, C., Wood, D., Jones, C. & Zheng, M., 8 Apr 2020, In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Open Access
  • miR-136-3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol-induced osteopenia

    Chen, Y., Yu, H., Zhu, D., Liu, P., Yin, J., Liu, D., Zheng, M., Gao, J., Zhang, C. & Gao, Y., 1 Apr 2020, In : FASEB Journal. 34, 4, p. 5348-5362 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)

    Surgical applications of intracorporal tissue adhesive agents: current evidence and future development

    Gillman, N., Lloyd, D., Bindra, R., Ruan, R. & Zheng, M., 3 May 2020, In : Expert Review of Medical Devices. 17, 5, p. 443-460 18 p.

    Research output: Contribution to journalReview article

  • Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques

    Gao, Y., Gao, J., Li, H., Du, D., Jin, D., Zheng, M. & Zhang, C., 23 Sep 2019, In : Therapeutic Advances in Musculoskeletal Disease. 11

    Research output: Contribution to journalReview article

    Open Access
  • Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network

    Gao, J., Qin, A., Liu, D., Ruan, R., Wang, Q., Yuan, J., Cheng, T. S., Filipovska, A., Papadimitriou, J. M., Dai, K., Jiang, Q., Gao, X., Feng, J. Q., Takayanagi, H., Zhang, C. & Zheng, M. H., 20 Nov 2019, In : Science Advances. 5, 11, eaaw7215.

    Research output: Contribution to journalArticle

    Open Access
  • Projects