Minghao Zheng

Professor, MB BS Shantou, DM PhD W.Aust., FRCP, ARCPA

  • The University of Western Australia (M508), 35 Stirling Highway,

    6009 Perth

    Australia

  • The University of Western Australia (M501), 35 Stirling Highway,

    6009 Perth

    Australia

  • 5423 Citations
  • 44 h-Index
1992 …2022
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Personal profile

Biography

Prof. Ming-Hao Zheng is the Winthrop Professor and Director of Research at the Translational Orthopaedic Research Centre, Sir Charles Gairdner Hospital, Perth and the Associate Dean (International) of the Faculty of Medicine, Dentistry and Health Sciences, the University of Western Australia. He is also the Chung Kong Scholar Lecturing Professor and the Deputy Director of Australia-China Cooperative Research Centre for Biotherapeutics and Regenerative Medicine at the Zhejiang University, China, Director for UWA-Nanjing Bone and Joint Research Centre at Nanjing University. He has served on the editorial board member for numbers of Orthopaedics, stem cell and Pathology journals.
He has focused on the development of an academic career in bone and joint research and regenerative medicine. His productivity is evidenced by the quality of publications and patents, and his ability to transform laboratory research into clinical practice. He has published over 140 peer-reviewed papers in journals including Nature Medicine, Annals of Internal Medicine, Journal of Clinical Investigation, Molecular Cellular Biology, Journal of Biological Chemistry, American Journal of Pathology and Journal of Bone and Mineral Research.
His major achievements include studies in the molecular and cellular biology of the osteoclast, clinical and laboratory evaluation of cellular therapies, human bone allograft, development of cell-scaffold technology for cartilage, tendon and bone regeneration and regulatory framework in human tissue and cellular products. His work on Giant Cell Tumour of bone (GCT) has been used by WHO for classification of bone tumours and has been recorded in the textbook “Ackermans Surgical Pathology”.
He has 7 patents in the field of Orthopaedics and has introduced the concept and technology of autologous biotherapy in orthopaedics. His research results in the development of autologous stem cell and progenitor cell therapy in bone, cartilage and tendon. He has transformed the benchwork of Matrix-induced Autologous Chondrocyte Implantation (MACI) and Autologous Tencoyte Therapy (ATT) into clinical practices. In 2009, he received an honour from by Genzyme in Boston for his leadership, commitment and dedication to the advancement of MACI. To date, more than 120 hospitals across Australia and over 8000 patients in the world have used MACI for the treatment of cartilage defects.
Prof. Zheng has actively supervised and nursed quality postgraduate students and postdoctoral fellows with 24 PhD and 15 Master of Medical sciences students completing their degree in the last 15 years. Many of them have won awards at the national and international meetings for their research work and become high profile independent researchers.

Research

Molecular and cellular biology of the osteoclast, with focus on interacellular vesicle trafficking and V-ATPase;
Clinical trials and laboratory evaluation of cellular therapies in orthopaedics;
Human bone allograft –validation and process characterisation;
Development of cell-scaffold technology for cartilage, tendon and bone regeneration
Development of bioreactors for mechanical sense tissues

Keywords

  • Biotherapeutics
  • Bone cell biology
  • Tissue engineering
  • Bone tumour pathology
  • Cell therapy
  • Regenerative medicine

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Osteoclasts Medicine & Life Sciences
Chondrocytes Medicine & Life Sciences
Cartilage Medicine & Life Sciences
Bone Resorption Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Bone Chemical Compounds
Tendons Medicine & Life Sciences
Osteogenesis Medicine & Life Sciences

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Projects 1996 2022

Research Output 1992 2018

1 Citations

3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon-derived stem cells through a PI3K/AKT signaling pathway

Wang, T., Thien, C., Wang, C., Ni, M., Gao, J., Wang, A., Jiang, Q., Tuan, R. S., Zheng, Q. & Zheng, M. H., 29 Mar 2018, In : FASEB Journal. 32, 9, p. 4804-4814

Research output: Contribution to journalArticle

Tendons
Stem cells
Phosphatidylinositol 3-Kinases
Stem Cells
Tissue

Arthroscopic autologous chondrocyte implantation in the glenohumeral joint: a case report

Ebert, J. R., Fallon, M., Zheng, M. H. & Tay, A., 1 Oct 2018, In : Journal of Shoulder and Elbow Surgery. 27, 10, p. e300-e307

Research output: Contribution to journalArticle

1 Citations

Bi-directional regulation of cartilage metabolism by inhibiting BET proteins-analysis of the effect of I-BET151 on human chondrocytes and murine joints

Dai, J., Zhou, S., Ge, Q., Qin, J., Chen, D., Xu, Z., Shi, D., Li, J., Ju, H., Cao, Y., Zheng, M., Li, C. J., Gao, X., Teng, H. & Jiang, Q., 21 May 2018, In : Journal of Orthopaedic Surgery and Research. 13, 1, 118.

Research output: Contribution to journalArticle

Open Access
Chondrocytes
Cartilage
Joints
Anatomic Models
Osteoarthritis

Elucidating the role of sorting nexins in skeletal homeostasis

Chan, A. S., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Sorting Nexins
Parathyroid Hormone Receptor Type 1
Homeostasis
Endosomes
Bone Remodeling

Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration

Chen, P., Wu, Z., Leung, A., Chen, X., Landao-Bassonga, E., Gao, J., Chen, L., Zheng, M., Yao, F., Yang, H., Lidgren, L., Allan, B., Liu, Y., Wang, T. & Zheng, M., Nov 2018, In : Biomedical Materials. 13, 6, 11 p., 065014.

Research output: Contribution to journalArticle

Open Access