Research output per year
Research output per year
The University of Western Australia (M310), 35 Stirling Highway,
6009 Perth
Australia
Thalidomide and its commercially available derivatives possess anti-cancer properties and are already used as effective treatments for hematological cancers like multiple myeloma. Using modern transition metal catalyzed cross-coupling reactions, we are able to rapidly generate a library of structurally diverse thalidomide analogues, which can then be assessed for their ability to selectively inhibit liver cancer proliferation. Some of these compounds have demonstrated remarkable activity in in vitro model assays of liver cancer growth/survival and metastasis. Importantly we are now also working to better understand the mode of action of these lead compounds at the molecular level to further fine tune their structure-activity profile.
Globally liver cancer is the 5th most common cancer, and the 3rd most common cause of cancer-related deaths. Treatment options are limited and often ineffective – currently only one chemotherapeutic is available, and it is associated with considerable off-target toxicity. We hope that by making drug selectivity a priority in our screening process, we may identify agents that could lead to the development of safer, more effective drugs for liver cancer with less adverse side-effects.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Chemistry, Bsc. (Hons), The Design and Synthesis of Thalidomide Analogues as Potential Therapeutics for the Treatment of Liver Cancer, The University of Western Australia
Feb 2017 → Nov 2017
Award Date: 1 Dec 2017
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Stewart, S. (Investigator 01) & Nutt, M. (Investigator 02)
1/07/22 → 30/06/27
Project: Research
Nutt, M. (Recipient), 5 Feb 2018
Prize: Postgraduate Scholarship