Photo of Michael Nutt
  • Source: Scopus
  • Calculated using citation counts from Scopus for publications in the UWA Profiles and Research Repository
20202020

Research output per year

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Personal profile

Research interests

  1. Thalidomide derivatives as potential agents for treating liver cancer
  2. Synthesis of heterocycles using a novel rhodiumII-catalysed tandem/domino approach
  3. Application of these methodologies to the total synthesis of natural products

Current projects

Thalidomide and its commercially available derivatives possess anti-cancer properties and are already used as effective treatments for hematological cancers like multiple myeloma. Using modern transition metal catalyzed cross-coupling reactions, we are able to rapidly generate a library of structurally diverse thalidomide analogues, which can then be assessed for their ability to selectively inhibit liver cancer proliferation. Some of these compounds have demonstrated remarkable activity in in vitro model assays of liver cancer growth/survival and metastasis. Importantly we are now also working to better understand the mode of action of these lead compounds at the molecular level to further fine tune their structure-activity profile.

Globally liver cancer is the 5th most common cancer, and the 3rd most common cause of cancer-related deaths. Treatment options are limited and often ineffective – currently only one chemotherapeutic is available, and it is associated with considerable off-target toxicity. We hope that by making drug selectivity a priority in our screening process, we may identify agents that could lead to the development of safer, more effective drugs for liver cancer with less adverse side-effects.

Education/Academic qualification

Chemistry, Bsc. (Hons), The University of Western Australia

Feb 2017Nov 2017

Award Date: 1 Dec 2017

Research expertise keywords

  • Medicinal Chemistry
  • Drug development
  • Catalysis
  • Total synthesis
  • transition metal organometallic chemistry
  • Organic chemistry

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