Michael Millward

Professor, MB BS W.Aust., MA Melb., FRACP

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 9440 Citations
  • 41 h-Index
20022024
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Research Output 2002 2020

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Article
2020

Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib monotherapy: Analysis from phase 2 and 3 clinical trials

Hauschild, A., Ascierto, P. A., Schadendorf, D., Grob, J. J., Ribas, A., Kiecker, F., Dutriaux, C., Demidov, L. V., Lebbé, C., Rutkowski, P., Blank, C. U., Gutzmer, R., Millward, M., Kefford, R., Haas, T., D'Amelio, A., Gasal, E., Mookerjee, B. & Chapman, P. B., Jan 2020, In : European Journal of Cancer. 125, p. 114-120 7 p.

Research output: Contribution to journalArticle

Phase III Clinical Trials
Melanoma
Dacarbazine
Disease-Free Survival
dabrafenib
2019

A panel of circulating MicroRNAs detects uveal melanoma with high precision

Stark, M. S., Gray, E. S., Isaacs, T., Chen, F. K., Millward, M., McEvoy, A., Zaenker, P., Ziman, M., Soyer, H. P., Glasson, W. J., Warrier, S. K., Stark, A. L., Rolfe, O. J., Palmer, J. M. & Hayward, N. K., Nov 2019, In : Translational Vision Science and Technology. 8, 6, 12.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Nevus
Blood
Biopsy
Real time systems

Circulating tumour DNA (ctDNA) as a biomarker in metachronous melanoma and colorectal cancer- a case report

Calapre, L., Warburton, L., Millward, M. & Gray, E. S., 14 Nov 2019, In : BMC Cancer. 19, 1, 1109.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Melanoma
Biomarkers
DNA
Neoplasms
1 Citation (Scopus)

Combined ipilimumab and nivolumab first-line and after BRAF-targeted therapy in advanced melanoma

Mason, R., Dearden, H. C., Nguyen, B., Oon, J. S., Smith, J. L., Randhawa, M., Mant, A., Warburton, L., Lo, S., Meniawy, T., Guminski, A., Parente, P., Ali, S., Haydon, A., Long, G. V., Carlino, M. S., Millward, M., Atkinson, V. G. & Menzies, A. M., 6 Oct 2019, In : Pigment Cell and Melanoma Research.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Proto-Oncogene Proteins c-akt
Protein-Serine-Threonine Kinases
Therapeutics
1 Citation (Scopus)

Effectiveness of dabrafenib in the treatment of patients with BRAF V600-mutated metastatic melanoma in a Named Patient Program

Martin-Algarra, S., Hinshelwood, R., Mesnage, S., Cebon, J., Ferrucci, P. F., Aglietta, M., Neyns, B., Chiarion-Sileni, V., Lindsay, C. R., Del Vecchio, M., Linardou, H., Merelli, B., Tonini, G., Atkinson, V., Freivogel, K., Stein, D., Dalland, L., Lau, M., Legenne, P., Queirolo, P. & 1 othersMillward, M., Oct 2019, In : Melanoma Research. 29, 5, p. 527-532 6 p.

Research output: Contribution to journalArticle

Melanoma
Confidence Intervals
Therapeutics
Disease-Free Survival
Fever
3 Citations (Scopus)

First-in-Human Phase I Study of the Selective MET Inhibitor, Savolitinib, in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Antitumor Activity

Gan, H. K., Millward, M., Hua, Y., Qi, C., Sai, Y., Su, W., Wang, J., Zhang, L., Frigault, M. M., Morgan, S., Yang, L. & Lickliter, J. D., 15 Aug 2019, In : Clinical Cancer Research. 25, 16, p. 4924-4932 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel

Gray, E. S., Witkowski, T., Pereira, M., Calapre, L., Herron, K., Irwin, D., Chapman, B., Khattak, M. A., Raleigh, J., Hatzimihalis, A., Cebon, J., Sandhu, S., McArthur, G. A., Millward, M., Ziman, M., Dobrovic, A. & Wong, S. Q., May 2019, In : JOURNAL OF MOLECULAR DIAGNOSTICS. 21, 3, p. 418-426 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Immunomagnetic-enriched subpopulations of melanoma circulating tumour cells (CTCs) exhibit distinct transcriptome profiles

Aya-Bonilla, C., Gray, E. S., Manikandan, J., Freeman, J. B., Zaenker, P., Reid, A. L., Khattak, M. A., Frank, M. H., Millward, M. & Ziman, M., 1 Feb 2019, In : Cancers. 11, 2, 157.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Transcriptome
Melanoma
Gene Expression
Epithelial-Mesenchymal Transition
3 Citations (Scopus)

Incidence, features and management of radionecrosis in melanoma patients treated with cerebral radiotherapy and anti-PD-1 antibodies

da Silva, I. P., Glitza, I. C., Haydu, L. E., Johnpulle, R., Banks, P. D., Grass, G. D., Goldinger, S. M. A., Smith, J. L., Everett, A. S., Koelblinger, P., Roberts-Thomson, R., Millward, M., Atkinson, V. G., Guminski, A., Kapoor, R., Conry, R. M., Carlino, M. S., Wang, W., Shackleton, M. J., Eroglu, Z. & 5 othersLo, S., Hong, A. M., Long, G. V., Johnson, D. B. & Menzies, A. M., Jul 2019, In : PIGMENT CELL & MELANOMA RESEARCH. 32, 4, p. 553-563 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Locus-specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma

Calapre, L., Giardina, T., Robinson, C., Reid, A. L., Al-Ogaili, Z., Pereira, M. R., McEvoy, A. C., Warburton, L., Hayward, N. K., Khattak, M. A., Meniawy, T. M., Millward, M., Amanuel, B., Ziman, M. & Gray, E. S., Feb 2019, In : Molecular Oncology. p. 171-184 14 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
DNA
Mutation
Neoplasms
Biopsy
1 Citation (Scopus)

Monitoring melanoma recurrence with circulating tumor DNA: A proof of concept from three case studies

McEvoy, A. C., Pereira, M. R., Reid, A., Pearce, R., Cowell, L., Al-Ogaili, Z., Khattak, M. A., Millward, M., Meniawy, T. M., Gray, E. S. & Ziman, M., 4 Jan 2019, In : Oncotarget. 10, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Recurrence
DNA
Neoplasms
Physiologic Monitoring
3 Citations (Scopus)

Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial

Friedlander, M., Meniawy, T., Markman, B., Mileshkin, L., Harnett, P., Millward, M., Lundy, J., Freimund, A., Norris, C., Mu, S., Wu, J., Paton, V. & Gao, B., Sep 2019, In : The Lancet Oncology. 20, 9, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Neoplasms
Nausea
Safety
Hepatitis
Vomiting

PD-L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study

Khattak, M. A., Reid, A., Freeman, J., Pereira, M., McEvoy, A., Lo, J., Frank, M. H., Meniawy, T., Didan, A., Spencer, I., Amanuel, B., Millward, M., Ziman, M. & Gray, E., 5 Dec 2019, In : The Oncologist.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Melanoma
Disease-Free Survival
Biomarkers
pembrolizumab
3 Citations (Scopus)

Programmed death ligand-1 expression in non-small cell lung cancer in a Western Australian population and correlation with clinicopathologic features

Ye, L., Leslie, C., Jacques, A., Ardakani, N. M., Amanuel, B. & Millward, M., Apr 2019, In : Modern Pathology. 32, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
414 Downloads (Pure)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R., de Jong, E., Chin, M., Schuster, I., Fear, V., Casey, T., Forbes, C., Dart, S., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., O Muiri, D., Degli-Esposti, M., Millward, M., Nowak, A., Lassmann, T., Bosco, A., Lake, R. & 1 othersLesterhuis, W., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 14 p., eaav7816.

Research output: Contribution to journalArticle

Open Access
File
STAT1 Transcription Factor
Tumor Microenvironment
Neoplasms
Toll-Like Receptor 3
Transcriptome
2018
24 Citations (Scopus)

Anti-PD-1/PD-L1 immunotherapy in patients with solid organ transplant, HIV or hepatitis B/C infection

Tio, M., Rai, R., Ezeoke, O. M., McQuade, J. L., Zimmer, L., Khoo, C., Park, J. J., Spain, L., Turajlic, S., Ardolino, L., Yip, D., Goldinger, S. M., Cohen, J. V., Millward, M., Atkinson, V., Kane, A. Y., Ascierto, P. A., Garbe, C., Gutzmer, R., Johnson, D. B. & 5 othersRizvi, H. A., Joshua, A. M., Hellmann, M. D., Long, G. V. & Menzies, A. M., Nov 2018, In : European Journal of Cancer. 104, p. 137-144 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

A Phase i study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours

Dredge, K., Brennan, T. V., Hammond, E., Lickliter, J. D., Lin, L., Bampton, D., Handley, P., Lankesheer, F., Morrish, G., Yang, Y., Brown, M. P. & Millward, M., 1 Apr 2018, In : British Journal of Cancer. 118, 8, p. 1035-1041 7 p.

Research output: Contribution to journalArticle

Open Access
Safety
Neoplasms
Epistaxis
Maximum Tolerated Dose
Plasma Cells

Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma

Beasley, A., Isaacs, T., Khattak, M. A., Freeman, A. B., Allcock, R., Chen, F. K., Pereira, M. R., Yau, K., Bentel, J., Vermeulen, T., Calapre, L., Millward, M., Ziman, M. R. & Gray, E. S., 17 May 2018, In : JCO precision oncology. 2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

McEvoy, A. C., Warburton, L., Al-Ogaili, Z., Celliers, L., Calapre, L., Pereira, M. R., Khattak, M. A., Meniawy, T. M., Millward, M., Ziman, M. & Gray, E. S., 9 Jul 2018, In : BMC Cancer. 18, 1, 726.

Research output: Contribution to journalArticle

Open Access
Tumor Burden
Melanoma
DNA
Neoplasms
Polymerase Chain Reaction
8 Citations (Scopus)

Implementation of next generation sequencing technology for somatic mutation detection in routine laboratory practice

Giardina, T., Robinson, C., Grieu-Iacopetta, F., Millward, M., Iacopetta, B., Spagnolo, D. & Amanuel, B., 1 Jun 2018, In : Pathology. 50, 4, p. 389-401 13 p.

Research output: Contribution to journalArticle

Technology
Mutation
Neoplasms
Gene Frequency
Non-Small Cell Lung Carcinoma
6 Citations (Scopus)

Medical Oncology Group of Australia position statement and membership survey on voluntary assisted dying

Karapetis, C. S., Stein, B., Koczwara, B., Harrup, R., Milleshkin, L., Parente, P., Millward, M., Haines, I., Blinman, P. & Olver, I., 1 Jul 2018, In : Internal Medicine Journal. 48, 7, p. 774-779 6 p.

Research output: Contribution to journalArticle

Open Access
Medical Oncology
Physicians
State Government
Surveys and Questionnaires
Palliative Care
13 Citations (Scopus)

Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC

McKeage, M. J., Kotasek, D., Markman, B., Hidalgo, M., Millward, M. J., Jameson, M. B., Harris, D. L., Stagg, R. J., Kapoun, A. M., Xu, L. & Hughes, B. G. M., Feb 2018, In : Targeted Oncology. 13, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma

Dunkel, Y., Reid, A. L., Ear, J., Aznar, N., Millward, M., Gray, E., Pearce, R., Ziman, M. & Ghosh, P., 1 Dec 2018, In : Scientific Reports. 8, 1, 18036.

Research output: Contribution to journalArticle

Open Access
Melanoma
Protein Isoforms
Skin
GTP-Binding Proteins
Circulating Neoplastic Cells
2 Citations (Scopus)

Real-world efficacy and toxicity of combined nivolumab and ipilimumab in patients with metastatic melanoma

Parakh, S., Randhawa, M., Nguyen, B., Warburton, L., Hussain, M. A., Cebon, J., Millward, M., Yip, D. & Ali, S., 13 Nov 2018, In : Asia–Pacific Journal of Clinical Oncology.

Research output: Contribution to journalArticle

Melanoma
Immunotherapy
Disease-Free Survival
Therapeutics
nivolumab
2017
8 Citations (Scopus)

Clinical and therapeutic implications of BRAF mutation heterogeneity in metastatic melanoma

Mesbah Ardakani, N., Leslie, C., Grieu-Iacopetta, F., Lam, W. S., Budgeon, C., Millward, M. & Amanuel, B., 1 Mar 2017, In : Pigment Cell and Melanoma Research. 30, 2, p. 233-242

Research output: Contribution to journalArticle

Gene Frequency
Melanoma
Mutation
Therapeutics
Survival
166 Citations (Scopus)

Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/ K-mutant melanoma: Long-term survival and safety analysis of a phase 3 study

Long, G. V., Flaherty, K. T., Stroyakovskiy, D., Gogas, H., Levchenko, E., de Braud, F., Larkin, J., Garbe, C., Jouary, T., Hauschild, A., Chiarion-Sileni, V., Lebbe, C., Mandalà, M., Millward, M., Arance, A., Bondarenko, I., Haanen, J. B. A. G., Hansson, J., Utikal, J., Ferraresi, V. & 11 othersMohr, P., Probachai, V., Schadendorf, D., Nathan, P. D., Robert, C., Ribas, A., Davies, M. A., Lane, S. R., Legos, J. J., Mookerjee, B. & Grob, J. J., Jul 2017, In : Annals of Oncology. 28, 7, p. 1631-1639 9 p.

Research output: Contribution to journalArticle

Survival Analysis
Melanoma
Safety
Survival
Disease-Free Survival
56 Citations (Scopus)
617 Downloads (Pure)
Open Access
File
Tumor Biomarkers
Biomarkers
Mathematics
Drug Industry
Therapeutics

Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device

Aya-Bonilla, C. A., Marsavela, G., Freeman, J. B., Lomma, C., Frank, M. H., Khattak, M. A., Meniawy, T. M., Millward, M., Warkiani, M. E., Gray, E. S. & Ziman, M., 15 Sep 2017, In : Oncotarget. 8, 40, p. 67355-67368 14 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Sensitive droplet digital PCR method for detection of TERT promoter mutations in cell free DNA from patients with metastatic melanoma

McEvoy, A. C., Calapre, L., Pereira, M. R., Giardina, T., Robinson, C., Khattak, M. A., Meniawy, T. M., Pritchard, A. L., Hayward, N. K., Amanuel, B., Millward, M., Ziman, M. & Gray, E. S., 3 Oct 2017, In : Oncotarget. 8, 45, p. 78890-78900 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Survey of practices around pharmaceutical company funding for continuing professional development among medical oncologists and trainees in Australia

Lee, Y. C., Kroon, R., Koczwara, B., Haines, I., Francis, K., Millward, M., Kefford, R., Olver, I. & Mileshkin, L., 1 Aug 2017, In : Internal Medicine Journal. 47, 8, p. 888-893 6 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Conflict of Interest
Organizational Policy
Financial Management
Education
2 Citations (Scopus)

Treatment of ALK-rearranged non-small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context

Itchins, M., Chia, P. L., Hayes, S. A., Howell, V. M., Gill, A. J., Cooper, W. A., John, T., Mitchell, P., Millward, M., Clarke, S. J., Solomon, B. & Pavlakis, N., 1 Aug 2017, In : Asia-Pacific Journal of Clinical Oncology. 13, p. 3-13 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Therapeutics
Gene Rearrangement
Drug Resistance
Protein-Tyrosine Kinases
2016
38 Citations (Scopus)

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

Soria, J-C., Gan, H. K., Blagden, S. P., Plummer, R. E., Arkenau, H. T., Ranson, M., Evans, T. R. J., Zalcman, G., Bahleda, R., Hollebecque, A., Lemech, C. R., Dean, E., Brown, J. L., Gibson, D., Peddareddigari, V. G. R., Murray, S., Nebot, N., Mazumdar, J., Swartz, L., Auger, K. R. & 3 othersFleming, R. A., Singh, R. P. & Millward, M., Dec 2016, In : Annals of Oncology. 27, 12, p. 2268-2274 7 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Pharmacokinetics
Neurofibromin 2
Maximum Tolerated Dose
Neoplasms
3 Citations (Scopus)

Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

Harvey, N., Millward, M., Macgregor, K., Bucat, R. P. & Wood, B., 2016, In : American Journal of Dermatopathology. 38, 12, p. e159-e162

Research output: Contribution to journalArticle

Halo Nevi
Melanoma
Antibodies, Monoclonal, Humanized
Skin
Neoplasm Metastasis
49 Citations (Scopus)

Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy

Bowyer, S., Prithviraj, P., Lorigan, P., Larkin, J., Mcarthur, G., Atkinson, V., Millward, M., Khou, M., Diem, S., Ramanujam, S., Kong, B., Liniker, E., Guminski, A., Parente, P., Andrews, M. C., Parakh, S., Cebon, J., Long, G. V., Carlino, M. S. & Klein, O., 2016, In : British Journal of Cancer. 114, 10, p. 1084-1089

Research output: Contribution to journalArticle

Open Access
Melanoma
Antibodies
Therapeutics
Pneumonia
Phase III Clinical Trials
8 Citations (Scopus)

Optimizing combination dabrafenib and trametinib therapy in BRAF mutation-positive advanced melanoma patients: Guidelines from Australian melanoma medical oncologists

Atkinson, V., Long, G. V., Menzies, A. M., Mcarthur, G., Carlino, M. S., Millward, M., Roberts-Thomson, R., Brady, B., Kefford, R., Haydon, A. & Cebon, J., 2016, In : Asia-Pacific Journal of Clinical Oncology. 12, p. 5-12

Research output: Contribution to journalArticle

Melanoma
Mitogen-Activated Protein Kinase Kinases
Guidelines
Mutation
Proto-Oncogene Proteins B-raf
14 Citations (Scopus)
Non-Small Cell Lung Carcinoma
T-Lymphocytes
Protein-Tyrosine Kinases
Immunotherapy
Biomarkers
27 Citations (Scopus)

Phase i clinical trial of marizomib (NPI-0052) in patients with advanced malignancies including multiple myeloma: Study NPI-0052-102 final results

Harrison, S. J., Mainwaring, P., Price, T., Millward, M., Padrik, P., Underhill, C. R., Cannell, P. K., Reich, S. D., Trikha, M. & Spencer, A., 2016, In : Clinical Cancer Research. 22, 18, p. 4559-4566

Research output: Contribution to journalArticle

Multiple Myeloma
Appointments and Schedules
Clinical Trials
Neoplasms
Proteasome Inhibitors
2015
31 Citations (Scopus)
Open Access
Pemetrexed
Cisplatin
Clinical Trials
Antibodies
B-Lymphocytes
13 Citations (Scopus)

A phase III randomized trial of adding topical nitroglycerin to first-line chemotherapy for advanced nonsmall-cell lung cancer: The Australasian lung cancer trials group NITRO trial

Davidson, A., Veillard, A. S., Tognela, A., Chan, M. M. K., Hughes, B. G. M., Boyer, M., Briscoe, K., Begbie, S., Abdi, E., Crombie, C., Long, J., Boyce, A., Lewis, C. R., Varma, S., Broad, A., Muljadi, N., Chinchen, S., Espinoza, D., Coskinas, X., Pavlakis, N. & 2 othersMillward, M. & Stockler, M. R., Nov 2015, In : Annals of Oncology. 26, 11, p. 2280-2286 7 p.

Research output: Contribution to journalArticle

Nitroglycerin
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Carboplatin
Drug Therapy

Bleeding Small Intestine Pyogenic Granuloma on 18F-FDG PET/CT

Iravani, A., Law, A., Millward, M., Warner, M. & Sparrow, S., Nov 2015, In : Clinical Nuclear Medicine. 40, 11, p. 869-870 2 p.

Research output: Contribution to journalArticle

Pyogenic Granuloma
Fluorodeoxyglucose F18
Small Intestine
Melanoma
Hemorrhage
79 Citations (Scopus)

BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer

Falchook, G., Millward, M., Hong, D., Naing, A., Piha-Paul, S. A., Waguespack, S. G., Cabanillas, M. E., Sherman, S. I., Ma, B., Curtis, M., Goodman, V. L. & Kurzrock, R., 2015, In : Thyroid. 25, 1, p. 71-77

Research output: Contribution to journalArticle

Thyroid Neoplasms
Febrile Neutropenia
Skin
Time and Motion Studies
Alopecia
17 Citations (Scopus)

Characterization of hypoxia in malignant pleural mesothelioma with FMISO PET-CT

Francis, R., Segard, T., Morandeau, L., Lee, G., Millward, M., Segal, A. & Nowak, A., 2015, In : Lung Cancer. 90, 1, p. 55-60

Research output: Contribution to journalArticle

Neoplasms
Drug Therapy
Malignant Mesothelioma
Hypoxia
Positron Emission Tomography Computed Tomography
30 Citations (Scopus)

Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment

Gray, E. S., Reid, A. L., Bowyer, S., Calapre, L., Siew, K., Pearce, R., Cowell, L., Frank, M. H., Millward, M. & Ziman, M., Aug 2015, In : Journal of Investigative Dermatology. 135, 8, p. 2040-2048

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Tumors
Melanoma
CD146 Antigens
Therapeutics
138 Citations (Scopus)

Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma

Gray, E. S., Rizos, H., Reid, A. L., Boyd, S. C., Pereira, M. R., Lo, J., Tembe, V., Freeman, J., Lee, J. H. J., Scolyer, R. A., Siew, K., Lomma, C., Cooper, A., Khattak, M., Meniawy, T., Long, G. V., Carlino, M. S., Millward, M. & Ziman, M., 8 Dec 2015, In : Oncotarget. 6, 39, p. 42008-42018

Research output: Contribution to journalArticle

Open Access
Melanoma
DNA
Neoplasms
Therapeutics
Immunotherapy
605 Citations (Scopus)

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

Long, G. V., Stroyakovskiy, D., Gogas, H., Levchenko, E., De Braud, F., Larkin, J., Garbe, C., Jouary, T., Hauschild, A., Grob, J. J., Chiarion-Sileni, V., Lebbe, C., Mandalà, M., Millward, M., Arance, A., Bondarenko, I., Haanen, J. B. A. G., Hansson, J., Utikal, J., Ferraresi, V. & 14 othersKovalenko, N., Mohr, P., Probachai, V., Schadendorf, D., Nathan, P., Robert, C., Ribas, A., Demarini, D. J., Irani, J. G., Swann, S., Legos, J. J., Jin, F., Mookerjee, B. & Flaherty, K., 2015, In : The Lancet. 386, 9992, p. 444-451

Research output: Contribution to journalArticle

Melanoma
Randomized Controlled Trials
Placebos
Survival
dabrafenib
53 Citations (Scopus)

Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR

Reid, A. L., Freeman, J. B., Millward, M., Ziman, M. & Gray, E. S., Oct 2015, In : Clinical Biochemistry. 48, 15, p. 999-1002 4 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Melanoma
Cells
Polymerase Chain Reaction
11 Citations (Scopus)

Equivocal ALK fluorescence in-situ hybridization (FISH) cases may benefit from ancillary ALK FISH probe testing

Selinger, C., Cooper, W., Lum, T., Mcneil, C., Morey, A., Waring, P., Amanuel, B., Millward, M., Peverall, J., Van Vliet, C., Christie, M., Tran, Y., Diakos, C., Pavlakis, N., Gill, A. J. & O'Toole, S., 2015, In : Histopathology. 67, 5, p. 654-663

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
Immunohistochemistry
Molecular Probes
5 Citations (Scopus)

FOXP3+ T regulatory lymphocytes in primary melanoma are associated with BRAF mutation but not with response to BRAF inhibitor

Leslie, C., Bowyer, S. E., White, A., Grieu-Iacopetta, F., Trevenen, M., Iacopetta, B., Amanuel, B. & Millward, M., 2015, In : Pathology. 47, 6, p. 557-563

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Regulatory T-Lymphocytes
Melanoma
Mutation
Tumor-Infiltrating Lymphocytes
44 Citations (Scopus)

Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma

Schadendorf, D., Amonkar, M. M., Stroyakovskiy, D., Levchenko, E., Gogas, H., De Braud, F., Grob, J. J., Bondarenko, I., Garbe, C., Lebbe, C., Larkin, J., Chiarion-Sileni, V., Millward, M., Arance, A., Mandalà, M., Flaherty, K. T., Nathan, P., Ribas, A., Robert, C., Casey, M. & 4 othersDemarini, D. J., Irani, J. G., Aktan, G. & Long, G. V., 2015, In : European Journal of Cancer. 51, 7, p. 833-840

Research output: Contribution to journalArticle

Melanoma
Quality of Life
Pain
Constipation
Dyspnea
5 Citations (Scopus)

Mutational Analysis of BRAF Inhibitor-Associated Squamoproliferative Lesions

Clynick, B., Tabone, T., Fuller, K., Erber, W., Meehan, K., Millward, M., Wood, B. & Harvey, N., 2015, In : JOURNAL OF MOLECULAR DIAGNOSTICS. 17, 6, p. 644-651

Research output: Contribution to journalArticle