Personal profile
Biography
Michael is the former Node Leader for Metabolomics Australia (MA), based at the Harry Perkins Institute (North) building. MA is an NCRIS flagship capability managed by the Centre for Microscopy, Characterisation and Analysis at UWA. Michaels' interests include hormone analysis using LCMS and drug pharmacokinetics in humans and animal models of disease. In 2012 Michael established a reference assay for the analysis of Vitamin D in serum. The MA node is involved in several national projects studying Vitamin D and its effects on health outcomes in humans. The facility is recognised by the CDC for the analysis of Vitamin D in human serum and has recently passed certification for accuracy and precision for the 5th year in a row. The MA node also supports multi-disciplinary research in plant, oceans and natural product discovery applications using GCMS, LCMS and high resolution mass spectrometry.
Roles and responsibilities
Clinical Biochemist (Toxicology), PathWest Laboratory Medicine
Senior Adjunct Research Fellow, School of Biomedical Sciences (UWA)
Funding overview
National Collaborative Research Infrastructure Strategy, 2019-23, $2.5M
Bioplatforms Australia and WA State government funding for Metabolomics
Investigator:Michael Clarke (CI)
Rural Industries Research & Development Corporation, 2016, $130,500
Development of honeybee products from a biodiversity hotspot
Katherine Hammer, Connie Locher, Michael Clarke (CI)
MS Research Australia, 2014, $180,000
Project Title: Vitamin D metabolites and risk of multiple sclerosis in the Ausimmune Study
Investigators: Robyn Lucas, Anne-Louise Ponsonby, Bruce Taylor, Lucinda Black, Michael Clarke(CI)
Telethon-Perth Children’s Hospital Research Fund 2014, $ $200,000
Project title: Improving gut biodiversity with soluble fibre in early life to prevent inflammatory disease – a pilot study to study effects on early immune development
Investigators: Susan Prescott, Desiree De Silva, Charles Mackay, Michael Clarke (CI), Rae-Chi Huang
National Collaborative Research Infrastructure Strategy (NCRIS 2) 2013-14, $650,000
Bioplatforms Australia CRIS funding for Metabolomics
Investigators: Steven Smith, Michael Clarke (CI)
Bioplatforms Australia ex Education Investment Fund (EIF) 2011, $800,000
Investigators: Steven Smith, Michael Clarke (CI)
Royal Perth Hospital Medical Research Foundation Grant 2008, A$10K
Project Title: Correlation between Skin Conductance Monitoring, Surgical Stress Index and stress hormone plasma levels for assessment of intraoperative depth of analgesia
Investigators: Thomas Ledowski, Kevin Croft, Michael Clarke (CI)
Previous positions
Director Scientific Services, ChemCentre, Western Australia
Node Leader, Metabolomics Australia, University of Western Australia
Research Development Advisor
Faculty of Medicine, Dentistry and Health Sciences
University of Western Australia
Senior Medical Scientist
Core Chemical Pathology and Biochemistry
HPLC and Mass Spectrometry Laboratory
PathWest, Royal Perth Hospital
Current projects
Teaching overview
Curtin University of Technology
Teaching second year Clinical Biochemistry students with emphasis on laboratory techniques
Research
Vitamin D metabolism in humans
Drug pharmacokinetics in a sheep model of human disease
Vitamin E metabolism in humans
Antioxidants in health and disease
Method development in Mass Spectrometry
Languages
Research expertise keywords
- Mass spectrometry
- Biochemistry service
- Antioxidants
- Cardiovascular nutrition
- Vitamin D
- Steroids
- GCMS
- LCMS
- Metabolomics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Effect of daily sunscreen application on vitamin D: Findings from the open-label randomized controlled Sun-D Trial
Tran, V., Duarte Romero, B. L., Andersen, H., Clarke, M., Collins, L. G., Dawson, T., Hartel, G., Lefevre, J. G., Lucas, R. M., McLeod, D. S. A., Milne, R. L., Sinclair, C., Whiteman, D. C., Waterhouse, M. & Neale, R. E., Dec 2025, In: British Journal of Dermatology. 193, 6, p. 1128-1137 11 p.Research output: Contribution to journal › Article › peer-review
5 Link opens in a new tab Citations (Web of Science) -
Perturbation of the ovine placental transcriptome occurs at sub-therapeutic exposures to antenatal steroid therapy
Johnson, E. L., Usuda, H., Carter, S. W. D., Ikeda, H., Kumagai, Y., Takahashi, T., Takahashi, Y., Saito, Y., Watson, H. R. S., Clarke, M. W., Ireland, D. J., Newnham, J. P., Saito, M., Illanes, S. E., Sesurajan, B. P., Choolani, M. A., Jobe, A. H. & Kemp, M. W., Nov 2025, In: Placenta. 171, 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy
Fee, E. L., Usuda, H., Carter, S. W. D., Ikeda, H., Takahashi, T., Takahashi, Y., Kumagai, Y., Clarke, M. W., Ireland, D. J., Newnham, J. P., Saito, M., Illanes, S. E., Sesurajan, B. P., Shen, L., Choolani, M. A., Oguz, G., Ramasamy, A., Ritchie, S., Ritchie, A. & Jobe, A. H. & 1 others, , 4 Feb 2025, In: BMC Medicine. 23, 17 p., 65.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Association of serum vitamin D with diagnosis and growth of abdominal aortic aneurysm
Thanigaimani, S., Neale, R. E., Waterhouse, M., Moxon, J. V., Yeap, B. B., Norman, P. E., Flicker, L., Hankey, G. J., Jenkins, J., Quigley, F., Clarke, M. W. & Golledge, J., 19 Jun 2024, In: JVS-Vascular Science. 5, 11 p., 100208.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Characterisation of common hypothetical surface peptides between protozoan parasites (Perkinsus olseni) originating from different geographical locations
Hanrio, E., Bogema, D., Davern, K., Batley, J., Clarke, M., Abudulai, L., Severn-Ellis, A. & Dang, C., 2024, In: Diseases of Aquatic Organisms. 158, p. 143-155 13 p.Research output: Contribution to journal › Article › peer-review
Datasets
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No relationship between autistic traits and salivary testosterone concentrations in men from the general population
Tan, D. (Creator), Maybery, M. T. (Creator), Clarke, M. W. (Creator), Di Lorenzo, R. (Creator), Evans, M. (Creator), Mancinone, M. (Creator), Panos, C. (Creator) & Whitehouse, A. J. (Creator), The University of Western Australia, 26 Mar 2018
Dataset
File
Projects
- 4 Finished
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Development of honeybee products from a biodiversity hotspot
Hammer, K. (Investigator 01), Locher, C. (Investigator 02) & Clarke, M. (Investigator 03)
1/07/16 → 15/05/20
Project: Research
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Vitamin D metabolites and risk of multiple sclerosis in the Ausimmune Study
Lucas, R. (Investigator 01), Ponsonby, A. L. (Investigator 02), Taylor, B. (Investigator 03), Black, L. (Investigator 04) & Clarke, M. (Investigator 05)
Multiple Sclerosis Research Australia
1/01/15 → 31/12/15
Project: Research
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Metabolomics Australia Informatics 2013/2014
Smith, S. (Investigator 01) & Clarke, M. (Investigator 02)
National Collaborative Research Infrastructure Strategy
1/01/13 → 30/06/19
Project: Research
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Metabolomics Australia Informatics
Smith, S. (Investigator 01) & Clarke, M. (Investigator 02)
1/01/11 → 31/12/13
Project: Research
Equipment
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Agilent 6340 Ion Trap with 1290 UPLC
Centre for Microscopy, Characterisation & AnalysisFacility/equipment: Equipment
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Agilent 6460 QQQ with 2D 1290 UPLC
Centre for Microscopy, Characterisation & AnalysisFacility/equipment: Equipment
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Agilent 7890 Series GC with 5975 MSD (X2)
Centre for Microscopy, Characterisation & AnalysisFacility/equipment: Equipment
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Biological and molecular mass spectrometry (BMMS)
Clarke, M. (Manager)
Centre for Microscopy, Characterisation & AnalysisFacility/equipment: Facility
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