• The University of Western Australia (M310), 35 Stirling Highway, Room 3.42, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 643 Citations
  • 13 h-Index
20032019
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Personal profile

Biography

Michael Clarke's career initially involved 12 years working in clinical biochemistry in PathWest, culminating with a PhD studying antioxidants and health outcomes at UWA. In 2011 Michael joined UWA as a senior scientist in the Metabolomics Australia national network. Michael currently manages the Biological and Molecular Mass Spectrometry Facility (BMMSF) which also incorporates Metabolomics Australia within CMCA at UWA. Michaels' interests include hormone analysis using LCMS and drug pharmacokinetics in humans and animal models of disease.
In 2012 Michael established a reference assay for the analysis of Vitamin D in serum. The BMMSF is involved in several national projects studying Vitamin D and its effects on health outcomes in humans. The facility is recognised by the CDC for the analysis of Vitamin D in human serum and has recently passed certification for accuracy and precision for the 5th year in a row.

Roles and responsibilities

Technique group leader in Mass Spectrometry and Metabolomics
WA Node Leader (Metabolomics Australia)

Funding overview

Rural Industries Research & Development Corporation, 2016, $130,500
Development of honeybee products from a biodiversity hotspot
Katherine Hammer, Connie Locher, Michael Clarke (CI)

MS Research Australia, 2014, $180,000
Project Title: Vitamin D metabolites and risk of multiple sclerosis in the Ausimmune Study
Investigators: Robyn Lucas, Anne-Louise Ponsonby, Bruce Taylor, Lucinda Black, Michael Clarke(CI)

Telethon-Perth Children’s Hospital Research Fund 2014, $ $200,000
Project title: Improving gut biodiversity with soluble fibre in early life to prevent inflammatory disease – a pilot study to study effects on early immune development
Investigators: Susan Prescott, Desiree De Silva, Charles Mackay, Michael Clarke (CI), Rae-Chi Huang

National collaborative research infrastructure grant (NCRIS 2) 2013-14, $650,000
Bioplatforms Australia CRIS funding for Metabolomics
Investigators: Steven Smith, Michael Clarke (CI)

Bioplatforms Australia ex Education Investment Fund (EIF) 2011, $800,000
Investigators: Steven Smith, Michael Clarke (CI)

Royal Perth Hospital Medical Research Foundation Grant 2008, A$10K
Project Title: Correlation between Skin Conductance Monitoring, Surgical Stress Index and stress hormone plasma levels for assessment of intraoperative depth of analgesia
Investigators: Thomas Ledowski, Kevin Croft, Michael Clarke (CI)

Previous positions

Research Development Advisor
Faculty of Medicine, Dentistry and Health Sciences
University of Western Australia

Senior Medical Scientist
Core Chemical Pathology and Biochemistry
HPLC and Mass Spectrometry Laboratory
PathWest, Royal Perth Hospital

Current projects

D-Light project, see http://telethonkids.org.au/d-light/

Teaching overview

Semester 2,2009
Curtin University of Technology
Teaching second year Clinical Biochemistry students with emphasis on laboratory techniques

Research

Metabolomics in multiple sample types
Vitamin D metabolism in humans
Drug pharmacokinetics in a sheep model of human disease
Vitamin E metabolism in humans
Antioxidants in health and disease
Method development in Mass Spectrometry

Languages

English

Keywords

  • Mass spectrometry
  • Biochemistry service
  • Antioxidants
  • Cardiovascular nutrition
  • Vitamin D
  • Steroids
  • GCMS
  • LCMS
  • Metabolomics

Fingerprint Dive into the research topics where Michael Clarke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Vitamin D Medicine & Life Sciences
Tocopherols Medicine & Life Sciences
Vitamin E Medicine & Life Sciences
gamma-Tocopherol Medicine & Life Sciences
Mothers Medicine & Life Sciences
Sheep Medicine & Life Sciences
dexamethasone 21-phosphate Medicine & Life Sciences
Serum Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2019

An external quality assurance trial to assess mass spectrometry protein testing facilities for identifying multiple human peptides

Horan, M. P., Hoffmann, P., Briggs, M. T., Condina, M., Herbert, S., Ito, J., Rodger, A., McKay, M., Maltby, D., Crossett, B., Abudulai, L. N., Clarke, M. W. & Badrick, T., 5 Aug 2019, In : Analytical and Bioanalytical Chemistry. p. 1-7

Research output: Contribution to journalArticle

Quality assurance
Mass spectrometry
Mass Spectrometry
Peptides
Testing

Characterization of polyphenols in Australian sweet lupin (Lupinus angustifolius) seed coat by HPLC-DAD-ESI-MS/MS

Zhong, L., Wu, G., Fang, Z., Wahlqvist, M. L., Hodgson, J. M., Clarke, M. W., Junaldi, E. & Johnson, S. K., Feb 2019, In : Food Research International. 116, p. 1153-1162 10 p.

Research output: Contribution to journalArticle

Lupinus
Lupinus angustifolius
Polyphenols
detectors
Seeds

Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans

Ahmed Nasef, N., Loveday, S. M., Golding, M., Martins, R. N., Shah, T. M., Clarke, M., Coad, J., Moughan, P. J., Garg, M. L. & Singh, H., 2019, In : Food & function. 10, 8, p. 4584-4592

Research output: Contribution to journalArticle

Curcuma
turmeric
food matrix
meals (menu)
Biological Availability
Vitamin D Deficiency
Glucocorticoids
Mothers
Phenotype
Pregnancy

Datasets

No relationship between autistic traits and salivary testosterone concentrations in men from the general population

Tan, D. (Creator), Maybery, M. (Creator), Clarke, M. (Creator), Di Lorenzo, R. (Creator), Evans, M. (Creator), Mancinone, M. (Creator), Panos, C. (Creator), Whitehouse, A. (Creator), The University of Western Australia, 26 Mar 2018

Dataset

File

Projects 2011 2019