• The University of Western Australia (M519), 35 Stirling Highway, Room 3.42, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 745 Citations
  • 15 h-Index
20032020

Research output per year

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Personal profile

Biography

Michael is the Node Leader for Metabolomics Australia (MA), based at the Harry Perkins Institute (North) building.  MA is an NCRIS flagship capability managed by the Centre for Microscopy, Characterisation and Analysis at UWA.   Michaels' interests include hormone analysis using LCMS and drug pharmacokinetics in humans and animal models of disease. In 2012 Michael established a reference assay for the analysis of Vitamin D in serum. The MA node is involved in several national projects studying Vitamin D and its effects on health outcomes in humans. The facility is recognised by the CDC for the analysis of Vitamin D in human serum and has recently passed certification for accuracy and precision for the 5th year in a row.  The MA node also supports multi-disciplinary research in plant, oceans and natural product discovery applications using GCMS, LCMS and high resolution mass spectrometry.

Roles and responsibilities

Technique group leader in Mass Spectrometry and Metabolomics
WA Node Leader (Metabolomics Australia)

Funding overview

Rural Industries Research & Development Corporation, 2016, $130,500
Development of honeybee products from a biodiversity hotspot
Katherine Hammer, Connie Locher, Michael Clarke (CI)

MS Research Australia, 2014, $180,000
Project Title: Vitamin D metabolites and risk of multiple sclerosis in the Ausimmune Study
Investigators: Robyn Lucas, Anne-Louise Ponsonby, Bruce Taylor, Lucinda Black, Michael Clarke(CI)

Telethon-Perth Children’s Hospital Research Fund 2014, $ $200,000
Project title: Improving gut biodiversity with soluble fibre in early life to prevent inflammatory disease – a pilot study to study effects on early immune development
Investigators: Susan Prescott, Desiree De Silva, Charles Mackay, Michael Clarke (CI), Rae-Chi Huang

National collaborative research infrastructure grant (NCRIS 2) 2013-14, $650,000
Bioplatforms Australia CRIS funding for Metabolomics
Investigators: Steven Smith, Michael Clarke (CI)

Bioplatforms Australia ex Education Investment Fund (EIF) 2011, $800,000
Investigators: Steven Smith, Michael Clarke (CI)

Royal Perth Hospital Medical Research Foundation Grant 2008, A$10K
Project Title: Correlation between Skin Conductance Monitoring, Surgical Stress Index and stress hormone plasma levels for assessment of intraoperative depth of analgesia
Investigators: Thomas Ledowski, Kevin Croft, Michael Clarke (CI)

Previous positions

Research Development Advisor
Faculty of Medicine, Dentistry and Health Sciences
University of Western Australia

Senior Medical Scientist
Core Chemical Pathology and Biochemistry
HPLC and Mass Spectrometry Laboratory
PathWest, Royal Perth Hospital

Current projects

D-Light project, see http://telethonkids.org.au/d-light/

Teaching overview

Semester 2,2009
Curtin University of Technology
Teaching second year Clinical Biochemistry students with emphasis on laboratory techniques

Research

Metabolomics in multiple sample types
Vitamin D metabolism in humans
Drug pharmacokinetics in a sheep model of human disease
Vitamin E metabolism in humans
Antioxidants in health and disease
Method development in Mass Spectrometry

Languages

English

Research expertise keywords

  • Mass spectrometry
  • Biochemistry service
  • Antioxidants
  • Cardiovascular nutrition
  • Vitamin D
  • Steroids
  • GCMS
  • LCMS
  • Metabolomics

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Research Output

Open Access
  • Dose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs

    Hillman, N. H., Abugisisa, L., Royse, E., Fee, E., Kemp, M. W., Kramer, B. W., Schmidt, A. F., Salomone, F., Clarke, M. W., Musk, G. C. & Jobe, A. H., 17 Feb 2020, In : Pediatric Research.

    Research output: Contribution to journalArticle

  • Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep

    Hillman, N. H., Kothe, T. B., Schmidt, A. F., Kemp, M. W., Royse, E., Fee, E., Salomone, F., Clarke, M. W., Musk, G. C. & Jobe, A. H., 1 Jan 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 1, p. L41-L48

    Research output: Contribution to journalArticle

  • The Pharmacokinetics of Medetomidine Administered Subcutaneously during Isoflurane Anaesthesia in Sprague-Dawley Rats

    Kint, L. T., Seewoo, B. J., Hyndman, T. H., Clarke, M. W., Edwards, S. H., Rodger, J., Feindel, K. W. & Musk, G. C., Jun 2020, In : Animals. 10, 6, 14 p., 1050.

    Research output: Contribution to journalArticle

    Open Access
  • Datasets

    No relationship between autistic traits and salivary testosterone concentrations in men from the general population

    Tan, D. (Creator), Maybery, M. (Creator), Clarke, M. (Creator), Di Lorenzo, R. (Creator), Evans, M. (Creator), Mancinone, M. (Creator), Panos, C. (Creator) & Whitehouse, A. (Creator), The University of Western Australia, 26 Mar 2018

    Dataset

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    Projects

    Equipment