Melinda Fitzgerald

Dr, Professor, BSc PhD W.Aust.

  • The University of Western Australia (M317), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1202 Citations
  • 20 h-Index
20062019
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Research Output 2007 2019

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Article
2019

Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

Toomey, L. M., Bartlett, C. A., Gavriel, N., McGonigle, T., Majimbi, M., Gopalasingam, G., Rodger, J. & Fitzgerald, M., 1 Dec 2019, In : Scientific Reports. 9, 1, 15297.

Research output: Contribution to journalArticle

Open Access
Optic Nerve Injuries
Myelin Sheath
Ion Channels
Wounds and Injuries
Purinergic P2X7 Receptors
1 Citation (Scopus)
76 Downloads (Pure)

Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection

Toomey, L. M., Bartlett, C. A., Majimbi, M., Gopalasingam, G., Rodger, J. & Fitzgerald, M., Jan 2019, In : Experimental Brain Research. 237, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)

Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed-head injury model

Fehily, B., Bartlett, C. A., Lydiard, S., Archer, M., Milbourn, H., Majimbi, M., Hemmi, J. M., Dunlop, S. A., Yates, N. J. & Fitzgerald, M., Jun 2019, In : Journal of Neurochemistry. 149, 5, p. 660-678

Research output: Contribution to journalArticle

Brain Concussion
Closed Head Injuries
Rodentia
Brain
Corpus Callosum

Elucidating the inability of functionalized nanoparticles to cross the blood-brain barrier and target specific cells in vivo

Naidu, P. S. R., Gavriel, N., Gray, C. G. G., Bartlett, C. A., Toomey, L. M., Kretzmann, J. A., Patalwala, D., McGonigle, T., Denham, E., Hee, C., Ho, D., Taylor, N. L., Norret, M., Smith, N. M., Dunlop, S. A., Iyer, K. S. & Fitzgerald, M., 26 Jun 2019, In : ACS APPLIED MATERIALS & INTERFACES. 11, 25, p. 22085-22095 11 p.

Research output: Contribution to journalArticle

Open Access
Doxorubicin
Copolymers
Nanoparticles
Water
Drug delivery

The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease

Gopalasingam, G., Bartlett, C. A., McGonigle, T., Majimbi, M., Warnock, A., Ford, A., Gough, A., Toomey, L. M. & Fitzgerald, M., 1 Sep 2019, In : Multiple Sclerosis and Related Disorders. 34, p. 1-8 8 p.

Research output: Contribution to journalArticle

Oligodendroglia
Demyelinating Diseases
Ion Channels
Ranvier's Nodes
Cuprizone
2018
8 Citations (Scopus)

Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma

Smith, N., Giacci, M., Gough, A., Bailey, C., McGonigle, T., Black, A., Clarke, T., Bartlett, C., Swaminatha Iyer, K., Dunlop, S. & Fitzgerald, M., 2018, In : Journal of Neuroinflammation. 15, p. 201

Research output: Contribution to journalArticle

Open Access
Blood-Brain Barrier
Inflammation
Wounds and Injuries
Optic Nerve Injuries
Cytokines
4 Citations (Scopus)

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D., Kretzmann, J., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M. A., Chawla, R., Evans, C., Clemons, T., Nguyen, M., Kretzmann, A., Blythe, A., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J., Bond, C., Kilburn, M. & 3 othersHurley, L., Smith, N. & Swaminatha Iyer, K., Dec 2018, In : Nature Nanotechnology. 13, 2

Research output: Contribution to journalArticle

Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid
9 Citations (Scopus)
10 Downloads (Pure)

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo

Giacci, M. K., Bartlett, C. A., Smith, N. M., Iyer, K. S., Toomey, L. M., Jiang, H., Guagliardo, P., Kilburn, M. R. & Fitzgerald, M., 18 Jul 2018, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 38, 29, p. 6491-6504 14 p.

Research output: Contribution to journalArticle

Open Access
File
Oligodendroglia
Wounds and Injuries
Cellular Structures
Secondary Ion Mass Spectrometry
Lipid Peroxidation

Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System

Bartlett, C. A. & Fitzgerald, M., 20 Dec 2018, In : Bio-Protocol. 8, 24, 14 p., 3118.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury

Chiha, W., LeVaillant, C. J., Bartlett, C. A., Hewitt, A. W., Melton, P. E., Fitzgerald, M. & Harvey, A. R., 1 Feb 2018, In : PLoS One. 13, 2, e0192348.

Research output: Contribution to journalArticle

Open Access
Optic Nerve Injuries
optics
retina
Retina
Optics

The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury

Mao, Y., Black, A. M. B., Milbourn, H. R., Krakonja, S., Nesbit, M., Bartlett, C. A., Fehily, B., Takechi, R., Yates, N. J. & Fitzgerald, M., Nov 2018, In : International Journal of Molecular Sciences. 19, 11, 18 p., 3408.

Research output: Contribution to journalArticle

Open Access
Brain Concussion
brain damage
Ion Channels
Ranvier's Nodes
inhibitors
4 Citations (Scopus)

Three dimensional electron microscopy reveals changing axonal and myelin morphology along normal and partially injured optic nerves

Giacci, M. K., Bartlett, C. A., Huynh, M., Kilburn, M. R., Dunlop, S. A. & Fitzgerald, M., 1 Dec 2018, In : Scientific Reports. 8, 1, 3979.

Research output: Contribution to journalArticle

Open Access
Optic Nerve
Myelin Sheath
Axons
Electron Microscopy
Optic Nerve Injuries
2017
1 Citation (Scopus)

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M. K., O'Hare Doig, R. L., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M., 1 Feb 2017, In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Open Access
Optic Nerve Injuries
Ion Channels
Seroma
Purinergic P2X7 Receptors
Ranvier's Nodes
7 Citations (Scopus)
276 Downloads (Pure)

Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury

Halstrom, A., MacDonald, E., Neil, C., Arendts, G., Fatovich, D. & Fitzgerald, M., 1 Jan 2017, In : Journal of Clinical Neuroscience. 35, 1, p. 104-108 5 p.

Research output: Contribution to journalArticle

Open Access
File
Oxidative Stress
Myelin Basic Protein
Biomarkers
Lysine
Deoxyguanosine
3 Citations (Scopus)

Limiting oxidative stress following neurotrauma with a combination of ion channel inhibitors

Milbourn, H. R. & Fitzgerald, M., 1 Jun 2017, In : Discovery Medicine. 23, 129, p. 361-369 3.

Research output: Contribution to journalArticle

Open Access
Ion Channels
Oxidative Stress
Myelin Sheath
Oligodendroglia
Wounds and Injuries
8 Citations (Scopus)

Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons

Yates, N. J., Lydiard, S., Fehily, B., Weir, G., Chin, A., Bartlett, C. A., Alderson, J. & Fitzgerald, M., 1 Jul 2017, In : Experimental Brain Research. 235, 7, p. 2133-2149 17 p.

Research output: Contribution to journalArticle

Open Access
Brain Concussion
Lipid Peroxidation
Neurons
Head
Skull Fractures
3 Citations (Scopus)
Sarcopenia
Sciatic Nerve
Axons
Skeletal Muscle
S100 Proteins
11 Citations (Scopus)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Doig, R. L. OH., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In : BMC Neuroscience. 18, 16 p., 62.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
153 Downloads (Pure)
Open Access
File
serums
coronas
Blood Proteins
Nanoparticles
proteins
2016
13 Citations (Scopus)
191 Downloads (Pure)

A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice

Krishnan, V. S., White, Z., Mcmahon, C. D., Hodgetts, S., Fitzgerald, M., Shavlakadze, T., Harvey, A. & Grounds, M., 1 May 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 5, p. 464-478

Research output: Contribution to journalArticle

Open Access
File
Sarcopenia
Sciatic Nerve
Axons
Choline O-Acetyltransferase
Peripheral Nerves
7 Citations (Scopus)

A new perspective on delivery of red-near-infrared light therapy for disorders of the brain

Hart, N. S. & Fitzgerald, M., 19 Sep 2016, In : Discovery Medicine. 22, 120, 1 p.

Research output: Contribution to journalArticle

Open Access
Phototherapy
Brain Diseases
Light
Sunlight
Penetrance
16 Citations (Scopus)
Open Access
Blood-Brain Barrier
Nanoparticles
Optic Nerve Injuries
Cerebrovascular Disorders
Brain
1 Citation (Scopus)

Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system

Lozić, I., Hartz, R. V., Bartlett, C. A., Shaw, J. A., Archer, M., Sarapna Rajoo Naidu, P., Smith, N. M., Dunlop, S. A., Swaminatha Iyer, K., Kilburn, M. R. & Fitzgerald, M., 2016, In : Data in Brief. 7, p. 152-156 5 p.

Research output: Contribution to journalArticle

Open Access
Nanoparticles
Secondary Ion Mass Spectrometry
Central Nervous System
Wounds and Injuries
Optic Nerve
2 Citations (Scopus)

Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration

Ashworth, B., Stephens, E., Bartlett, C., Serghiou, S., Giacci, M., Williams, A., Hart, N. & Fitzgerald, M., 18 May 2016, In : BMC Neuroscience. 17, 1

Research output: Contribution to journalArticle

Open Access
Phototherapy
Spinal Cord
Oxidative Stress
Central Nervous System
Nervous System Trauma
13 Citations (Scopus)
258 Downloads (Pure)

Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system

Lozić, I., Hartz, R. V., Bartlett, C., Shaw, J., Archer, M., Sarapna Rajoo Naidu, P., Smith, N., Dunlop, S., Swaminatha Iyer, K., Kilburn, M. & Fitzgerald, M., Jan 2016, In : Biomaterials. 74, p. 200-216 17 p.

Research output: Contribution to journalArticle

Open Access
File
Neurology
Nanoparticles
Aquaporin 4
Central Nervous System
Optic Nerve Injuries
2 Citations (Scopus)
275 Downloads (Pure)
Open Access
File
Brushes
Polymers
Polyetherimides
Nanoparticles
Proteins
3 Citations (Scopus)
198 Downloads (Pure)
Open Access
File
Nanoparticles
Imaging techniques
Lanthanoid Series Elements
Magnetic resonance
Rare earth elements
7 Citations (Scopus)
144 Downloads (Pure)
Open Access
File
Neuroglia
Cell Survival
Oxidative Stress
Purinergic P2X7 Receptors
Memantine
2015
2 Citations (Scopus)
Oxidative stress
Phototherapy
Oxidative Stress
Infrared radiation
Light
33 Citations (Scopus)

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Meloni, B., Milani, D., Edwards, A. B., Anderton, R. S., O'Hare Doig, R. L., Fitzgerald, M., Palmer, N. & Knuckey, N., 2015, In : Pharmacology and Therapeutics. 153, p. 36-54

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Arginine
Peptides
Endocytosis
Nervous System Diseases
8 Citations (Scopus)

Novel combinations of ion channel inhibitors for treatment of neurotrauma

O'Hare Doig, R. L. & Fitzgerald, M., 2015, In : Discovery Medicine. 19, 102, p. 41-47

Research output: Contribution to journalArticle

Oligodendroglia
Calcium Channels
Ion Channels
Purinergic P2X7 Receptors
Calcium
5 Citations (Scopus)
227 Downloads (Pure)

Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro

Challenor, M., Doig, R., Fuller-Carter, P., Giacci, M., Bartlett, C., Wale, C., Cozens, G., Hool, L., Dunlop, S., Swaminathan Iyer, K., Rodger, J. & Fitzgerald, M., May 2015, In : Biochimie. 112, p. 160-171

Research output: Contribution to journalArticle

Open Access
File
Retina
Rats
Glutamic Acid
AMPA Receptors
Messenger RNA
12 Citations (Scopus)

Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity

Stephens, E., Tauran, Y., Coleman, A. W. & Fitzgerald, M., 2015, In : Chemical Communications. 51, 5, p. 851-854

Research output: Contribution to journalArticle

Calixarenes
Oxidants
Alkanesulfonates
Bacteria
Bearings (structural)
2014
7 Citations (Scopus)
332 Downloads (Pure)

Changes in subtypes of Ca microdomains following partial injury to the central nervous system

Lozić, I., Bartlett, C., Shaw, J., Iyer, K., Dunlop, S., Kilburn, M. & Fitzgerald, M., Mar 2014, In : Metallomics. 6, 3, p. 455-464

Research output: Contribution to journalArticle

Open Access
File
Neurology
Optics
Central Nervous System
Tissue
Optic Nerve
20 Citations (Scopus)

Differential effects of 670 and 830 nm Red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury

Giacci, M., Wheeler, L., Lovett, S., Dishington, E., Majda, B., Bartlett, C., Thornton, E., Harford-Wright, E., Leonard, A., Vink, R., Harvey, A., Provis, J., Dunlop, S., Hart, N., Hodgetts, S., Natoli, R., Van Den Heuvel, C. & Fitzgerald, M., 2014, In : PLoS One. 9, 8, p. e104565 1-15

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration

O'Hare Doig, R. L., Bartlett, C., Maghzal, G. J., Lam, M., Archer, M., Stocker, R. & Fitzgerald, M., Nov 2014, In : Experimental Neurology. 261, p. 136-146 11 p.

Research output: Contribution to journalArticle

Optic Nerve
Oxidative Stress
Wounds and Injuries
Antioxidants
Mitochondrial Degradation
4 Citations (Scopus)

Strategies to limit dysmyelination during secondary degeneration following neurotrauma

Fitzgerald, M., Jun 2014, In : Neural Regeneration Research. 9, 11, p. 1096-1099

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
Photons
Nanoparticles
Magnetic properties
Composite materials
Laser spectroscopy
2013
1 Citation (Scopus)
698 Downloads (Pure)
Open Access
File
16 Citations (Scopus)

Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

James, E., Eggers, P., Harvey, A., Dunlop, S., Fitzgerald, M., Stubbs, K. & Raston, C. L., 2013, In : Organic and Biomolecular Chemistry. 11, 36, p. 6108-6112

Research output: Contribution to journalArticle

12 Citations (Scopus)

Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm

Cummins, N., Bartlett, C., Archer, M., Bartlett, E., Hemmi, J., Harvey, A., Dunlop, S. & Fitzgerald, M., 2013, In : BMC Neuroscience. 14, 98, p. 14pp

Research output: Contribution to journalArticle

Open Access
Optic Nerve
Aconitate Hydratase
Citrate (si)-Synthase
Central Nervous System
Wounds and Injuries
21 Citations (Scopus)
Open Access
Oligodendroglia
Neurology
central nervous system
stem cells
Stem Cells
30 Citations (Scopus)
Iron oxides
Thermal effects
Nanocrystals
Nanoparticles
Lasers
25 Citations (Scopus)

Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment

Szymanski, C. R., Chiha, W., Morellini, N., Cummins, N., Bartlett, C., O'Hare Doig, R. L., Savigni, D., Payne, S., Harvey, A., Dunlop, S. & Fitzgerald, M., 2013, In : PLoS One. 8, 6, p. 14pp

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Optic Nerve
optics
Oligodendroglia
Optics
42 Citations (Scopus)

Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders

Fitzgerald, M., Hodgetts, S., Van Den Heuvel, C., Natoli, R. C., Hart, N., Valter, K., Harvey, A., Vink, R., Provis, J. M. & Dunlop, S., 2013, In : Reviews in the Neurosciences. 24, 2, p. 205-226

Research output: Contribution to journalArticle

Nervous System Trauma
Central Nervous System Diseases
Central Nervous System
Stroke
Nerve Tissue
27 Citations (Scopus)

Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma

Savigni, D., O'Hare Doig, R. L., Szymanski, C. R., Bartlett, C., Lozić, I., Smith, N. & Fitzgerald, M., 2013, In : Neuropharmacology. 75, p. 380-390

Research output: Contribution to journalArticle

Myelin Sheath
Reflex
Purinergic P2X Receptors
Optic Nerve Injuries
Optokinetic Nystagmus
2012
17 Citations (Scopus)

Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

Eggers, P., Becker, T., Melvin, M., Boulos, R., James, E., Morellini, N., Harvey, A., Dunlop, S., Fitzgerald, M., Stubbs, K. & Raston, C., 2012, In : RSC Advances. 2, p. 6250-6257

Research output: Contribution to journalArticle

33 Citations (Scopus)

In vivo Imaging and Biodistribution of Multimodal Polymeric Nanoparticles Delivered to the Optic Nerve

Harrison, J., Bartlett, C., Cowin, G., Nicholls, PK., Evans, C., Clemons, T., Zdyrko, B., Luzinov, IA., Harvey, A., Swaminatha Iyer, K., Dunlop, S. & Fitzgerald, M., 2012, In : Small. 8, 10, p. 1579-1589

Research output: Contribution to journalArticle