Matthew Piggott

Dr, BSc PhD W.Aust.

  • The University of Western Australia (M310), 35 Stirling Highway, Room 329, Bayliss Building, Perth campus

    6009 Perth

    Australia

19972020
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Research Output 1997 2019

Article
2 Citations (Scopus)
86 Downloads (Pure)
Open Access
File
Bearings (structural)
Acylation
Sodium Hydroxide
acetyl chloride
3 Citations (Scopus)
Benzene
Biological Products
Anthraquinones
Enantiomers
Bioactivity
17 Citations (Scopus)

A four-step total synthesis of radermachol

Buccini, M. & Piggott, M., 2014, In : Organic Letters. 16, 9, p. 2490-2493

Research output: Contribution to journalArticle

Ytterbium
acylation
Acylation
ytterbium
synthesis
1 Citation (Scopus)

Analysis of trimethyl carboxyphosphate by gas chromatography-mass spectrometry

Mcildowie, M., Attwood, P., Reeder, A. & Piggott, M., 2008, In : Analytical Biochemistry. 376, 2, p. 283-285

Research output: Contribution to journalArticle

Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Injections
Spectrometry
11 Citations (Scopus)

An Expeditious Synthesis of Iminosugars

Gandy, M., Piggott, M. & Stubbs, K., 2010, In : Australian Journal of Chemistry: an international journal for chemical science. 63, p. 1409-1412

Research output: Contribution to journalArticle

15 Citations (Scopus)

A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates

Johnston, T. H., Millar, Z., Huot, P., Wagg, K., Thiele, S., Salomonczyk, D., Yong-Kee, C. J., Gandy, M., Mcildowie, M., Lewis, K., Gomez-Ramirez, J., Lee, J., Fox, S. H., Martin-Iverson, M., Nash, J. E., Piggott, M. & Brotchie, J. M., 2012, In : FASEB Journal. 26, p. 2154-2163

Research output: Contribution to journalArticle

N-Methyl-3,4-methylenedioxyamphetamine
Cytotoxicity
Primates
Parkinson Disease
Street Drugs
1 Citation (Scopus)
Antrodia
Biological Products
Fungi
Cell Line
Growth
5 Citations (Scopus)

Bisannulation of 2,3-Dichloro-1,4-naphthoquinone with o-Nitrophenylacetic Acid Derivatives: A Succinct Synthesis of the ABCD Ring System of Alpkinidine

Buccini, M., Jeow, S. Y., Byrne, L., Skelton, B., Nguyen, T. M., Chai, C. L. L. & Piggott, M., 2013, In : European Journal of Organic Chemistry. 2013, p. 3232-3240

Research output: Contribution to journalArticle

60 Citations (Scopus)

Burning vegetation produces cyanohydrins that liberate cyanide and stimulate seed germination

Flematti, G., Merritt, D., Piggott, M., Trengove, R. D., Smith, S., Dixon, K. & Ghisalberti, E., 2011, In : Nature Communications. 2, p. 6pp

Research output: Contribution to journalArticle

germination
Cyanides
cyanides
Germination
vegetation

Carbon-Rich Trinuclear Octamethylferrocenophanes

Roemer, M., Wild, D. A., Sobolev, A. N., Skelton, B. W., Nealon, G. L., Piggott, M. J. & Koutsantonis, G. A., 18 Mar 2019, In : Inorganic Chemistry. 56, 6, p. 3789–3799

Research output: Contribution to journalArticle

Carbon
Friedel-Craft reaction
Metals
Friedel-Crafts reaction
ferrocenes
45 Citations (Scopus)

Characterization of 3,4-Methylenedioxymethamphetamine (MDMA) Enantiomers In Vitro and in the MPTP-Lesioned Primate: R-MDMA Reduces Severity of Dyskinesia, Whereas S-MDMA Extends Duration of ON-Time

Huot, P., Johnston, T. H., Lewis, K., Koprich, J. B., Reyes, M. G., Fox, S. H., Piggott, M. & Brotchie, J. M., 2011, In : Journal of Neuroscience. 31, p. 7190-7198

Research output: Contribution to journalArticle

N-Methyl-3,4-methylenedioxyamphetamine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dyskinesias
Primates
Levodopa

Confirmation of the Revised Structure of Samoquasine A and a Proposed Structural Revision of Cherimoline

Dhoro, F., Parkin-Gibbs, J., McIldowie, M., Skelton, B. W. & Piggott, M. J., 27 Jul 2018, In : Journal of Natural Products. 81, 7, p. 1658-1665 8 p.

Research output: Contribution to journalArticle

Biological Products
hydrazine
Cyclization
Malus
perlolidine
1 Citation (Scopus)
Open Access
Sodium Hydroxide
Cyclization
Discrete Fourier transforms
Electrons
3 Citations (Scopus)
Biological Products
Crystal structure
X rays
Crystals
furan
8 Citations (Scopus)
121 Downloads (Pure)

Enhanced bi-stability in a ruthenium alkynyl spiropyran complex

Walkey, M. C., Byrne, L., Piggott, M., Low, P. & Koutsantonis, G., 21 May 2015, In : Dalton Transactions. 44, 19, p. 8812-8815

Research output: Contribution to journalArticle

Open Access
File
Ruthenium
Benzopyrans
Coordination Complexes
Electrodes
spiropyran
6 Citations (Scopus)

Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative chemical redesign: mechanisms and pathways to cell death

Wasik, A. M., Gandy, M., Mcildowie, M., Holder, M. J., Chamba, A., Challa, A., Lewis, K., Young, S. P., Scheel-Toellner, D., Dyer, M. J., Barnes, N. M., Piggott, M. & Gordon, J., 2012, In : Investigational New Drugs. 30, p. 1471-1483

Research output: Contribution to journalArticle

N-Methyl-3,4-methylenedioxyamphetamine
Lymphoma
Cell Death
Burkitt Lymphoma
Designer Drugs
11 Citations (Scopus)

Ethynylbenzenoid metabolites of Antrodia camphorata: Synthesis and inhibition of TNF expression

Buccini, M., Punch, K. A., Kaskow, B., Flematti, G., Skelton, B., Abraham, L. & Piggott, M., 2014, In : Organic and Biomolecular Chemistry. 12, 7, p. 1100-1113

Research output: Contribution to journalArticle

Open Access
Antrodia
necrosis
metabolites
Metabolites
Anti-Inflammatory Agents
14 Citations (Scopus)
113 Downloads (Pure)

Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides

Russell, S., Rahmani, R., Jones, A. J., Newson, H., Neilde, K., Cotillo, I., Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G., Ryan, E., Tanghe, S. & 6 othersRodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M., Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Neglected Diseases
African Trypanosomiasis
Trypanosoma brucei brucei
Chagas Disease
13 Citations (Scopus)

Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme

Adina-Zada, A., Jitrapakdee, S., Surinya, K. H., Mcildowie, MJ., Piggott, M., Cleland, W. W., Wallace, J. C. & Attwood, P., 2008, In : The International Journal of Biochemistry & Cell Biology. 40, 9, p. 1743-1752

Research output: Contribution to journalArticle

Pyruvate Carboxylase
Bacilli
Biotin
Bacillus
Carboxylation
5 Citations (Scopus)

Is 2,3,4,5-Tetramethoxybenzoyl Chloride a Natural Product?

Punch, K., Ghisalberti, E. & Piggott, M., 2011, In : Journal of Natural Products. 74, p. 1348–1350

Research output: Contribution to journalArticle

2 Citations (Scopus)

Limiting the Hydrolysis and Oxidation of Maleimide-Peptide Adducts Improves Detection of Protein Thiol Oxidation

Boyatzis, A. E., Bringans, S. D., Piggott, M. J., Duong, M. N., Lipscombe, R. J. & Arthur, P. G., May 2017, In : Journal of Proteome Research. 16, 5, p. 2004-2015 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Making Mixtures to Solve Structures: Structural Elucidation via Combinatorial Synthesis

Lengkeek, N., Greenwood, P., Nguyen, B., Koutsantonis, G. & Piggott, M., 2010, In : Journal of Combinatoral Chemistry. 12, p. 141-150

Research output: Contribution to journalArticle

3 Citations (Scopus)

Occurrence and significance of phytanyl arenes across the Permian-Triassic boundary interval

Grotheer, H., Le Métayer, P., Piggott, M. J., Lindeboom, E. J., Holman, A. I., Twitchett, R. J. & Grice, K., 1 Feb 2017, In : Organic Geochemistry. 104, p. 42-52 11 p.

Research output: Contribution to journalArticle

Permian-Triassic boundary
paleolatitude
Carbonates
Toluene
Benzene
3 Citations (Scopus)

Physical and Crystallographic Characterisation of the mGlu5 Antagonist MTEP and Its Monohydrochloride

Mcildowie, M., Gandy, M., Skelton, B., Brotchie, J. M., Koutsantonis, G., Spackman, M. & Piggott, M., 2010, In : Journal of Pharmaceutical Sciences. 99, p. 234-245

Research output: Contribution to journalArticle

112 Citations (Scopus)

Progress toward a Rationally Designed, Chemically Powered Rotary Molecular Motor

Kelly, T. R., Cai, XL., Damkaci, F., Panicker, S. B., Tu, B., Bushell, S. M., Cornella, I., Piggott, M., Salives, R., Cavero, M., Zhao, YJ. & Jasmin, S., 2007, In : Journal of American Chemical Society. 129, 2, p. 376-386

Research output: Contribution to journalArticle

Phosgene
Pyridine
Urethane
Stilbenes
Anthracene
11 Citations (Scopus)

Redesigning the designer drug ecstasy: non-psychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity

Gandy, M., Mcildowie, M., Lewis, K., Wasik, A. M., Salomonczyk, D., Wagg, K., Millar, Z. A., Tindiglia, D., Huot, P., Johnston, T., Thiele, S., Nguyen, B., Barnes, N. M., Brotchie, J. M., Martin-Iverson, M., Nash, J., Gordon, J. & Piggott, M., 2010, In : MedChemComm. 1, 4, p. 287-293

Research output: Contribution to journalArticle

5 Citations (Scopus)
Cycloaddition
Methyl Ethers
Methylation
Ether
furan
14 Citations (Scopus)

Stable triazolylphosphonate analogues of phosphohistidine

Mukai, S., Flematti, G., Byrne, L., Besant, P., Attwood, P. & Piggott, M., 2012, In : Amino Acids. 22 November 2011, p. 18pp

Research output: Contribution to journalArticle

3 Citations (Scopus)
Alkanes
Polypropylenes
alkane
Sediments
gas chromatography
8 Citations (Scopus)

Synthesis of 5,8-dimethoxynaphtho[2,3-c]furan-4(9H)-one

Piggott, M. & Wege, D., 2006, In : Tetrahedron. 62, 15, p. 3550-3556

Research output: Contribution to journalArticle

Acylation
Alkynes
Cycloaddition Reaction
Biological Products
Skeleton
20 Citations (Scopus)

Synthesis of Kalasinamide, a Putative Plant Defense Phototoxin

Gandy, M. & Piggott, M., 2008, In : Journal of Natural Products. 71, 5, p. 866-868

Research output: Contribution to journalArticle

Anthraquinones
Singlet Oxygen
Photooxidation
Poisons
Biosynthesis
30 Citations (Scopus)

The a2 Adrenergic Antagonist Fipamezole Improves Quality of Levodopa Action in Parkinsonian Primates

Johnston, T. H., Fox, S. H., Piggott, M., Savola, J. & Brotchie, J. M., 2010, In : Movement Disorders. 25, 13, p. 2084-2093

Research output: Contribution to journalArticle

15 Citations (Scopus)

The Monoamine Re-Uptake Inhibitor UWA-101 Improves Motor Fluctuations in the MPTP-Lesioned Common Marmoset

Huot, P., Johnston, T. H., Gandy, M., Reyes, M. G., Fox, S. H., Piggott, M. & Brotchie, J. M., 2012, In : PLoS One. 7, 9, p. 1-7

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
Acylation
Metabolites
Dehydration
Anions
furan
19 Citations (Scopus)

The Synthesis of Ventilone A

Piggott, M. & Wege, D., 2000, In : Australian Journal of Chemistry. 53, 2000, p. 749-754

Research output: Contribution to journalArticle

Isatin
Naphthols
Boron
Acids
dimethyl ether
5 Citations (Scopus)

Total synthesis of monosporascone and dihydromonosporascone

Punch, K. A. & Piggott, M., 2014, In : Organic and Biomolecular Chemistry. 12, 17, p. 2801-2810

Research output: Contribution to journalArticle

Open Access
Acylation
Cycloaddition Reaction
Biological Products
Silver
Chlorides

Total synthesis of the antimalarial ascidian natural product albopunctatone

Pullella, G. A., Wdowiak, A. P., Sykes, M. L., Lucantoni, L., Sukhoverkov, K. V., Zulfiqar, B., Sobolev, A. N., West, N. P., Mylne, J. S., Avery, V. M. & Piggott, M. J., 9 Jul 2019, In : Organic Letters.

Research output: Contribution to journalArticle

Urochordata
anthraquinones
Antimalarials
Biological Products
Anthraquinones
22 Citations (Scopus)

UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances l-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset

Huot, P., Johnston, T. H., Lewis, K. D., Koprich, J. B., Reyes, M. G., Fox, S. H., Piggott, M. & Brotchie, J. M., 2014, In : Neuropharmacology. 82, p. 76-87

Research output: Contribution to journalArticle

Callithrix
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dyskinesias
Serotonin Uptake Inhibitors
Levodopa
30 Citations (Scopus)
4 Citations (Scopus)

What Is the Structure of the Antitubercular Natural Product Eucapsitrione?

Pullella, G. A., Wild, D. A., Nealon, G. L., Elyashberg, M. & Piggott, M. J., 21 Jul 2017, In : Journal of Organic Chemistry. 82, 14, p. 7287-7299 13 p.

Research output: Contribution to journalArticle

Biological Products
Cyclization
eucapsitrione
anthracene
Letter
2 Citations (Scopus)

Post-translational modifications: Panning for phosphohistidine

Piggott, M. & Attwood, P., 2013, In : Nature Chemical Biology. 9, 7, p. 411-412

Research output: Contribution to journalLetter

Patent

Heterocyclic compounds and use of same

Baell, J., Piggott, M., Russell, S., Toynton, A., Rahmani, R., Ferrins, L. & Nguyen, N., 2015, Patent No. WO 2015172196 A1 20151119

Research output: Patent

Review article
2 Citations (Scopus)

Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine

Piggott, M. J. & Attwood, P. V., 1 Aug 2017, In : Amino Acids. 49, 8, p. 1309-1323 15 p.

Research output: Contribution to journalReview article

Phosphoamino Acids
Protein Tyrosine Phosphatases
Phosphoprotein Phosphatases
Post Translational Protein Processing
Catalysis
50 Citations (Scopus)

Focus on phosphoarginine and phospholysine

Besant, P., Attwood, P. & Piggott, M., 2009, In : Current Protein and Peptide Science. 10, 6, p. 536-550

Research output: Contribution to journalReview article

Phosphorylation
Phosphoamino Acids
Biochemistry
Phosphocreatine
Biological systems
19 Citations (Scopus)

Focus on phosphoaspartate and phosphoglutamate

Attwood, P., Besant, P. & Piggott, M., 2011, In : Amino Acids. 40, p. 1035-1051

Research output: Contribution to journalReview article

102 Citations (Scopus)

Focus on phosphohistidine

Attwood, P., Piggott, M., Zu, X. L. & Besant, P., 2007, In : Amino Acids. 32, 1, p. 145-156

Research output: Contribution to journalReview article

Phosphorylation
Histidine
Phosphothreonine
Cell signaling
Phosphoserine
31 Citations (Scopus)