• The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

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Personal profile

Biography

I am a researcher, a teacher, and a leader.

My research focuses on enabling technologies to better understand how blood platelets work in health and disease. This approach yields knowledge and tools that are of use to scientists and doctors in diagnosis, monitoring and treatment of disease. It contributes to science and medical education and is valuable to patients and their families to better understand and monitor their health.

As a teacher, I train the next generation of hospital scientists with a bespoke, accredited, work integrated postgraduate curriculum that I developed.

My works are widely published. I am a sought-after speaker at international events in my field. I provide advice to the Australian government and I guide and enable scientific advancement in my field through a variety of national and global leadership roles.


Specialties: Cytometry, platelet biology, work integrated learning 

Roles and responsibilities

Matthew is Associate Professor of Haematology at The School Biomedical Sciences. He leads the development and delivery of haematology coursework in the Master of Clinical Pathology, supports undergraduate teaching in the Bachelor of Science (Biomedical Sciences Major), and forms part of the School's research program in haematology. Matthew also leads a program of research which focuses on the role of platelets and platelet interactions in health and disease.

Funding overview

2019 Perpetual Trustees IMACT (IPAP2019/0291 CIC) $300,000
2018 Ruby Red Foundation (CIC) $15,000
2018 Perpetual Trustees IMPACT (IPAP2018/1802 CIC) $81,606
2017 UWA Research Collaboration Award (CID) $29,290
2016 NHMRC Project Grant (APP1129317 CIF) $1,113,385
2016 Australian Research Council Discovery Project (DP170104832 CIC) $372,500
2014 Australian Research Council LIEF (LE150100066 CIE) $440,000
2014 WA Department of Health (CIA) $75,000
2014 Ada Bartholomew Trust (CIA) $28,471
2013 Perpetual Trustees & Ronald Geoffrey Arnott Foundation (CIA) $65,000
2013 The Ian Potter Foundation (CIA) $25,000
2013 NHMRC Equipment Allocation (CIA) $50,000
2012 Diabetes Australia Research Trust (CIA) $58,407.
2011 Helen McPherson Research Trust (CIC) $24,700.
2011 RMIT University Scheme for Teaching and Learning Research (CIC) $6,924.
2010 Carlton Football Club (CIB) $25,255.
2009 Ian Potter Foundation (CIA) $100,000.

Previous positions

2012 - 2015 Associate Professor and Head (Cytometry), University of Western Australia
2008 - 2012 Senior Lecturer and Director of Flow Cytometry, RMIT University
2007 - 2008 Research Officer, RMIT University School of Medical Sciences
2005 - 2007 Research Instructor, University of Massachusetts Medical School Department of Emergency Medicine
2003 - 2007 Postdoctoral Fellow, University of Masscahusetts, Department of Pediatrics

Current projects

View my "Be Inspired" profile
Councillor and Past President, Australasian Cytometry Society - http://cytometry.org.au/
Board of Directors, Australian Council for the Certification of the Medical Laboratory Scientific Workforce - http://accmlsw.org.au/

ISAC Marylou Ingram Scholar and Chairman of the Membership Serviced Committee, International Society for the Advancement of Cytometry - http://isac-net.org/

Editorial Board - Journal of Cardiovascular Pharmacology & Therapeutics
Reviews Editor - Frontiers in Cardiovascular Biology

Industrial relevance

Matthew works closely with biopharmaceutical industry partners in the development of new antiplatelet therapies with novel therapeutic targets, and to characterise the effect of other investigational agents on platelet function. He also works closely with industry partners in the development of new laboratory methods for the assessment of platelet function and monitoring the effectiveness of antiplatelet therapy.

Teaching overview

Deputy Convener, Master of Clinical Pathology
PATH5161 - Unit Coordinator
PATH5162 - Unit Coordinator
PATH5142 - Laboratory
PATH5122, IMED2002, PATH3307, MICR5831 - Lectures

Research

Matthew's research focus is in the study of blood platelets. His research has three key themes. His contribution to the understanding of mechanisms of underlying platelet hyper-reactivity and its relationship to antiplatelet therapy resistance has improved the diagnosis and management of this condition. Through broad collaborations, Matthew has led the development of new antiplatelet therapies with novel therapeutic targets. Finally, Matthew has begun to unravel the role of platelets in immunity and aging, particularly through their interactions with blood monocytes and neutrophils.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Honorary Senior Fellow, University of Melbourne

24 Jul 2019 → …

Adjunct Senior Lecturer, Monash University (Australia)

2010 → …

Industry keywords

  • Drug Discovery
  • Clinical Trials
  • Medicine and Pharma

Research expertise keywords

  • Flow cytometry analysis
  • Panel design for multiparameter flow cytometry
  • Cell sorting
  • Immunophenotyping
  • Standardisation, calibration, and control in flow cytometry
  • Optical filter sets for multiparameter flow cytometry
  • Compensation in flow cytometry
  • Titering antibodies
  • Conjugation of fluorochromes to monoclonal antibodies
  • Immunophenotypic analysis of platelets
  • Platelet function studies
  • Haematology
  • Whole blood analysis of leukocyte-platelet aggregates
  • DNA content measurement for DNA ploidy and cell cycle analysis by flow cytometry
  • Sperm chromatin structure assay (SCSA) for fertility assessment
  • Flow cytometry of apoptosis
  • Analysis of intracellular organelles and granules by flow cytometry
  • Intracellular cytokine measurement by flow cytometry
  • Multiplex cytometry bead assay
  • Flow cytometric analysis of calcium mobilisation in whole-blood platelets
  • Listmode data processing

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