Matthew Linden

Dr, PhD W.Aust.

  • The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1536 Citations
  • 20 h-Index
20012019
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Personal profile

Biography

After earning his PhD in haematology at The University of Western Australia in 2003, Matthew undertook a prestigious postdoctoral fellowship and then junior faculty research position at The Centre for Platelet Function Studies at The University of Massachusetts Medical School, which became The Centre for Platelet Research at Harvard Medical School. Matthew returned to Australia in 2007 as a senior academic at RMIT University's School of Medical Sciences. He returned to the University of Western Australia as Associate Professor and Head of Cytometry in the Centre for Microscopy, Chatacterisation and Analysis in 2012, before joining the School of Pathology and Laboratory Medicine (now the School of Biomedical Sciences) as Associate Professor of Haematology in 2015.

Roles and responsibilities

Matthew is Associate Professor of Haematology at The School Biomedical Sciences. He leads the development and delivery of haematology coursework in the Master of Clinical Pathology, supports undergraduate teaching in the Bachelor of Science (Biomedical Sciences Major), and forms part of the School's research program in haematology. Matthew also leads a program of research which focuses on the role of platelets and platelet interactions in health and disease.

Funding overview

2018 Ruby Red Foundation (CIC)15,000
2018 Perpetual Trustees IMPACT (IPAP2018/1802 CIC) $81,606
2017 UWA Research Collaboration Award (CID) $29,290
2016 NHMRC Project Grant (APP1129317 CIF) $1,113,385
2016 Australian Research Council Discovery Project (DP170104832 CIC) $372,500
2014 Australian Research Council LIEF (LE150100066 CIE) $440,000
2014 WA Department of Health (CIA) $75,000
2014 Ada Bartholomew Trust (CIA) $28,471
2013 Perpetual Trustees & Ronald Geoffrey Arnott Foundation (CIA) $65,000
2013 The Ian Potter Foundation (CIA) $25,000
2013 NHMRC Equipment Allocation (CIA) $50,000
2012 Diabetes Australia Research Trust (CIA) $58,407.
2011 Helen McPherson Research Trust (CIC) $24,700.
2011 RMIT University Scheme for Teaching and Learning Research (CIC) $6,924.
2010 Carlton Football Club (CIB) $25,255.
2009 Ian Potter Foundation (CIA) $100,000.

Previous positions

2012 - 2015 Associate Professor and Head (Cytometry), University of Western Australia
2008 - 2012 Senior Lecturer and Director of Flow Cytometry, RMIT University
2007 - 2008 Research Officer, RMIT University School of Medical Sciences
2005 - 2007 Research Instructor, University of Massachusetts Medical School Department of Emergency Medicine
2003 - 2007 Postdoctoral Fellow, University of Masscahusetts, Department of Pediatrics

Current projects

View my "Be Inspired" profile
President Elect, Australasian Cytometry Society - http://cytometry.org.au/
ISAC Marylou Ingram Scholar, International Society for the Advancement of Cytometry
Treasurer, CYTO Asia Organising Committee
Chair, "WA Flow" The Western Australian Flow Cytometry Interest Group.

Industrial relevance

Matthew works closely with biopharmaceutical industry partners in the development of new antiplatelet therapies with novel therapeutic targets, and to characterise the effect of other investigational agents on platelet function. He also works closely with industry partners in the development of new laboratory methods for the assessment of platelet function and monitoring the effectiveness of antiplatelet therapy.

Teaching overview

PATH5161 - Unit Coordinator
PATH5162 - Unit Coordinator
PATH5142 - Laboratory
PATH5122, IMED2002, PATH3307, MICR5831 - Lectures

Research

Matthew's research focus is in the study of blood platelets. His research has three key themes. His contribution to the understanding of mechanisms of underlying platelet hyper-reactivity and its relationship to antiplatelet therapy resistance has improved the diagnosis and management of this condition. Through broad collaborations, Matthew has led the development of new antiplatelet therapies with novel therapeutic targets. Finally, Matthew has begun to unravel the role of platelets in immunity and aging, particularly through their interactions with blood monocytes and neutrophils.

External positions

Adjunct Senior Lecturer, Monash University

2010 → …

Keywords

  • Drug Discovery
  • Clinical Trials
  • Medicine and Pharma
  • Flow cytometry analysis
  • Panel design for multiparameter flow cytometry
  • Cell sorting
  • Immunophenotyping
  • Standardisation, calibration, and control in flow cytometry
  • Optical filter sets for multiparameter flow cytometry
  • Compensation in flow cytometry
  • Titering antibodies
  • Conjugation of fluorochromes to monoclonal antibodies
  • Immunophenotypic analysis of platelets
  • Platelet function studies
  • Haematology
  • Whole blood analysis of leukocyte-platelet aggregates
  • DNA content measurement for DNA ploidy and cell cycle analysis by flow cytometry
  • Sperm chromatin structure assay (SCSA) for fertility assessment
  • Flow cytometry of apoptosis
  • Analysis of intracellular organelles and granules by flow cytometry
  • Intracellular cytokine measurement by flow cytometry
  • Multiplex cytometry bead assay
  • Flow cytometric analysis of calcium mobilisation in whole-blood platelets
  • Listmode data processing

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Blood Platelets Medicine & Life Sciences
Flow Cytometry Medicine & Life Sciences
Platelet Activation Medicine & Life Sciences
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Spermatozoa Medicine & Life Sciences
Polycystic Ovary Syndrome Medicine & Life Sciences
Exercise Medicine & Life Sciences

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Research Output 2001 2018

Blood Platelets
Exercise
Platelet Activation
Brachial Artery
Acute Coronary Syndrome
1 Citations
Walking
Blood Platelets
Monocytes
Atherosclerosis
Exercise

Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure

Haynes, A., Linden, M. D., Chasland, L. C., Nosaka, K., Maiorana, A., Dawson, E. A., Dembo, L. H., Naylor, L. H. & Green, D. J., 1 Jun 2017, In : Journal of Applied Physiology. 122, 6, p. 1418-1424 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Blood Platelets
Heart Failure
Dilatation
Exercise

Imaging flow cytometry in the assessment of leukocyte-platelet aggregates

Hui, H., Fuller, K. A., Erber, W. N. & Linden, M. D., 1 Jan 2017, In : Methods. 112, p. 46-54 9 p.

Research output: Contribution to journalArticle

Flow cytometry
Platelets
Flow Cytometry
Leukocytes
Blood Platelets
1 Citations
Open Access
Platelet Aggregation
Monocytes
Blood Platelets
Platelet Activation
Adenosine Diphosphate