• The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 7267 Citations
  • 42 h-Index
19992024
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Research Output 1999 2019

2019

Brief Report: Real-World Performance and Interobserver Agreement of Urine Lipoarabinomannan in Diagnosing HIV-Associated Tuberculosis in an Emergency Center

Van Hoving, D. J., Lahri, S., Lategan, H. J., Nicol, M. P., Maartens, G. & Meintjes, G., 1 May 2019, In : Journal of acquired immune deficiency syndromes (1999). 81, 1, p. e10-e14

Research output: Contribution to journalArticle

Point-of-Care Systems
Tuberculosis
Emergencies
HIV
Urine
1 Citation (Scopus)

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study

Schutz, C., Barr, D., Andrade, B. B., Shey, M., Ward, A., Janssen, S., Burton, R., Wilkinson, K. A., Sossen, B., Fukutani, K. F., Nicol, M., Maartens, G., Wilkinson, R. J. & Meintjes, G., Jul 2019, In : PLoS Medicine. 16, 7, p. e1002840

Research output: Contribution to journalArticle

Open Access
Tuberculosis
Cohort Studies
HIV
Prospective Studies
Mortality
Zimbabwe
HIV Infections
HIV
CD4 Lymphocyte Count
Therapeutics
4 Citations (Scopus)

Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis

Di Tanna, G. L., Raza Khaki, A., Theron, G., McCarthy, K., Cox, H., Mupfumi, L., Trajman, A., Sodai Zijenah, L., Mason, P., Bandason, T., Durovni, B., Bara, W., Hoelscher, M., Clowes, P., Mangu, C., Chanda, D., Pym, A., Mwaba, P., Cobelens, F., Nicol, M. P. & 4 othersDheda, K., Churchyard, G., Fielding, K. & Metcalfe, J. Z., 1 Feb 2019, In : The Lancet Global Health. 7, 2, p. e191-e199

Research output: Contribution to journalArticle

Open Access
Meta-Analysis
Tuberculosis
Sputum
HIV
Mortality
Multiplex Polymerase Chain Reaction
Sputum
Pneumocystis carinii
Inpatients
Real-Time Polymerase Chain Reaction

False rifampicin resistant results using Xpert MTB/RIF on urine samples in hospitalised HIV-infected patients

Schutz, C., Ward, A., Burton, R., Nicol, M. P., Blumenthal, U., Meintjes, G. & Kerkhoff, A. D., 28 Aug 2019, In : Southern African Journal of HIV Medicine. 20, 1, 10 p., 978.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

RSV Global Epidemiology Network & RESCEU Investigators, Aug 2019, In : The Lancet Global Health. 7, 8, p. E1031-E1045 15 p.

Research output: Contribution to journalArticle

Open Access

Guidance for Studies Evaluating the Accuracy of Sputum-Based Tests to Diagnose Tuberculosis

Schumacher, S. G., Wells, W. A., Nicol, M. P., Steingart, K. R., Theron, G., Dorman, S. E., Pai, M., Churchyard, G., Scott, L., Stevens, W., Nabeta, P., Alland, D., Weyer, K., Denkinger, C. M. & Gilpin, C., 8 Oct 2019, In : The Journal of infectious diseases. 220, S3, p. S99-S107

Research output: Contribution to journalArticle

Sputum
Tuberculosis
Routine Diagnostic Tests
Microscopy
Health Services Needs and Demand

Indoor air pollution and tobacco smoke exposure: impact on nasopharyngeal bacterial carriage in mothers and infants in an African birth cohort study

Vanker, A., Nduru, P. M., Barnett, W., Dube, F. S., Sly, P. D., Gie, R. P., Nicol, M. P. & Zar, H. J., Feb 2019, In : ERJ Open Research. 5, 1

Research output: Contribution to journalArticle

Open Access
Indoor Air Pollution
Smoke
Tobacco
Cohort Studies
Mothers

Influence of Socio-Economic and Psychosocial Profiles on the Human Breast Milk Bacteriome of South African Women

Ojo-Okunola, A., Claassen-Weitz, S., Mwaikono, K. S., Gardner-Lubbe, S., Stein, D. J., Zar, H. J., Nicol, M. P. & du Toit, E., 20 Jun 2019, In : Nutrients. 11, 6

Research output: Contribution to journalArticle

Open Access
Human Milk
breast milk
socioeconomics
Economics
Streptococcus

Longitudinal Population Dynamics of Staphylococcus aureus in the Nasopharynx During the First Year of Life

Abdulgader, S. M., Robberts, L., Ramjith, J., Nduru, P. M., Dube, F., Gardner-Lubbe, S., Zar, H. J. & Nicol, M. P., 15 Mar 2019, In : Frontiers in Genetics. 10, 10 p., 198.

Research output: Contribution to journalArticle

Open Access
Respiratory Tract Infections
Parturition
Mothers
Low Birth Weight Infant
Incidence

Microbiological diagnosis of pulmonary tuberculosis in children by oral swab polymerase chain reaction

Nicol, M. P., Wood, R. C., Workman, L., Prins, M., Whitman, C., Ghebrekristos, Y., Mbhele, S., Olson, A., Jones-Engel, L. E., Zar, H. J. & Cangelosi, G. A., 25 Jul 2019, In : Scientific Reports. 9, 1, p. 10789

Research output: Contribution to journalArticle

Open Access
Sputum
Pulmonary Tuberculosis
Tuberculosis
Polymerase Chain Reaction
Pediatrics

Multicenter Study of the Accuracy of the BD MAX™ MDR-TB Assay for Detection of Mycobacterium tuberculosis Complex and Mutations Associated with Resistance to Rifampin and Isoniazid

Shah, M., Paradis, S., Betz, J., Beylis, N., Bharadwaj, R., Caceres, T., Gotuzzo, E., Joloba, M., Mave, V., Nakiyingi, L., Nicol, M. P., Pradhan, N., King, B., Armstrong, D., Knecht, D., Maus, C. E., Cooper, C. K., Dorman, S. E. & Manabe, Y. C., 27 Sep 2019, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Isoniazid
Rifampin
Sputum
Mycobacterium tuberculosis

Nasopharyngeal carriage of antimicrobial-resistant pneumococci in an intensively sampled South African birth cohort

Manenzhe, R., Moodley, C., Abdulgader, S. M., Robberts, F. J. L., Zar, H. J., Nicol, M. P. & Dube, F. S., 27 Mar 2019, In : Frontiers in Microbiology. 10, 10 p., 610.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study

Broger, T., Sossen, B., du Toit, E., Kerkhoff, A. D., Schutz, C., Ivanova Reipold, E., Ward, A., Barr, D. A., Macé, A., Trollip, A., Burton, R., Ongarello, S., Pinter, A., Lowary, T. L., Boehme, C., Nicol, M. P., Meintjes, G. & Denkinger, C. M., 30 May 2019, In : The Lancet Infectious Diseases. 10 p.

Research output: Contribution to journalArticle

Open Access
Point-of-Care Systems
Tuberculosis
HIV
Inpatients
Chronic Disease Hospitals

Recent developments in the diagnosis of drug-resistant tuberculosis

Nicol, M. P. & Cox, H., 1 Jan 2019, In : Microbiology Australia. 40, 2, p. 82-86 5 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Drug Resistance
Mutation
Secondary Prevention
Coinfection

Tuberculosis Diagnosis in Children Using Xpert Ultra on Different Respiratory Specimens

Zar, H. J., Workman, L. J., Prins, M., Bateman, L. J., Mbhele, S. P., Whitman, C. B., Denkinger, C. M. & Nicol, M. P., 5 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Sputum
Tuberculosis
Pulmonary Tuberculosis
HIV
Sensitivity and Specificity

What causes symptoms suggestive of tuberculosis in HIV-positive people with negative initial investigations?

Hanifa, Y., Toro Silva, S., Karstaedt, A., Sahid, F., Charalambous, S., Chihota, V. N., Churchyard, G. J., von Gottberg, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Stevens, W., Fielding, K. L. & Grant, A. D., 1 Feb 2019, In : International Journal of Tuberculosis & Lung Disease. 23, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

Tuberculosis
HIV
Weight Loss
Food Supply
Cough
2018
18 Citations (Scopus)

Accuracy of Xpert Mtb/Rif Ultra for the Diagnosis of Pulmonary Tuberculosis in Children

Nicol, M. P., Workman, L., Prins, M., Bateman, L., Ghebrekristos, Y., Mbhele, S., Denkinger, C. M. & Zar, H. J., Oct 2018, In : Pediatric Infectious Disease Journal. 37, 10, p. E261-E263 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries

Whittaker, E., Nicol, M. P., Zar, H. J., Tena-Coki, N. G. & Kampmann, B., 1 Dec 2018, In : Scientific Reports. 8, 1, 15309.

Research output: Contribution to journalArticle

Mycobacterium bovis
T-Lymphocytes
CD4 Antigens
Cytokines
Population
1 Citation (Scopus)

Blood and virus detection on barber clippers

Spengane, Z., Korsman, S., Mkentane, K., Davids, L. M., Zemanay, W., Africa, M., Mbhele, S., Nicol, M., Gumedze, F., Ngwanya, D. & Khumalo, N. P., 1 Apr 2018, In : South African Medical Journal. 108, 4, p. 278-282 5 p.

Research output: Contribution to journalArticle

Open Access
Hepatitis B virus
South Africa
HIV
Viruses
Hair
1 Citation (Scopus)

Characterisation of STEC and other diarrheic E. coli isolated on CHROMagar™STEC at a tertiary referral hospital, Cape Town

Kalule, J. B., Keddy, K. H. & Nicol, M. P., 8 Jun 2018, In : BMC Microbiology. 18, 1, 55.

Research output: Contribution to journalArticle

Open Access
Shiga Toxin
Tertiary Care Centers
Escherichia coli
Enteropathogenic Escherichia coli
Microbiology

Development of a clinical prediction rule to diagnose Pneumocystis jirovecii pneumonia in the World Health Organization's algorithm for seriously ill HIV-infected patients

Maartens, G., Stewart, A., Griesel, R., Kengne, A. P., Dube, F., Nicol, M., Rangaka, M. X. & Mendelson, M., 2018, In : Southern African Journal of HIV Medicine. 19, 1, p. 851

Research output: Contribution to journalArticle

Open Access
Pneumocystis carinii
Pneumocystis Pneumonia
Decision Support Techniques
HIV
Respiratory Rate
6 Citations (Scopus)

Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes

Breen, M. S., Wingo, A. P., Koen, N., Donald, K. A., Nicol, M., Zar, H. J., Ressler, K. J., Buxbaum, J. D. & Stein, D. J., 1 Oct 2018, In : Brain, Behavior, and Immunity. 73, p. 320-330 11 p.

Research output: Contribution to journalArticle

Open Access
Fetal Blood
Mothers
Post-Traumatic Stress Disorders
Psychology
Gene Expression
2 Citations (Scopus)

HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort

Claassen-Weitz, S., Gardner-Lubbe, S., Nicol, P., Botha, G., Mounaud, S., Shankar, J., Nierman, W. C., Mulder, N., Budree, S., Zar, H. J., Nicol, M. P. & Kaba, M., 1 Dec 2018, In : Scientific Reports. 8, 1, 5078.

Research output: Contribution to journalArticle

Open Access
HIV
Parturition
Mothers
Meconium
Actinobacteria
7 Citations (Scopus)

Human breast milk bacteriome in health and disease

Ojo-Okunola, A., Nicol, M. & du Toit, E., 3 Nov 2018, In : Nutrients. 10, 11, 1643.

Research output: Contribution to journalReview article

Open Access
Human Milk
breast milk
Health
bacteriome
microorganisms
4 Citations (Scopus)

Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation

Dube, F. S., Ramjith, J., Gardner-Lubbe, S., Nduru, P., Robberts, F. J. L., Wolter, N., Zar, H. J. & Nicol, M. P., 1 Dec 2018, In : Scientific Reports. 8, 1, 12497.

Research output: Contribution to journalArticle

Open Access
Conjugate Vaccines
Streptococcus pneumoniae
Parturition
Serogroup
13-valent pneumococcal vaccine

Lymphadenopathy in a TB-Endemic Region: Employing Focused Techniques in a Rapid Access Lymph Node Biopsy Clinic

Antel, K. R., Verburgh, E., Louw, V. J., Oosthuizen, J., Malherbe, F., Gary, M. & Nicol, M., 29 Nov 2018, In : Blood. 132, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

14 Citations (Scopus)

Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible?

Cox, H., Hughes, J., Black, J. & Nicol, M. P., 1 Sep 2018, In : The Lancet Infectious Diseases. 18, 9, p. e282-e287

Research output: Contribution to journalReview article

Multidrug-Resistant Tuberculosis
Precision Medicine
Standard of Care
Tuberculosis
Therapeutics

Preventing tuberculosis-related death in children with HIV

Tootla, H. D. & Nicol, M. P., 1 Feb 2018, In : The lancet. HIV. 5, 2, p. e62-e64

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, J. B., Fortuin, S., Calder, B., Robberts, L., Keddy, K. H., Nel, A. J. M., Garnett, S., Nicol, M., Warner, D. F., Soares, N. C. & Blackburn, J. M., 30 May 2018, In : Journal of Proteomics. 180, p. 25-35 11 p.

Research output: Contribution to journalArticle

Shiga-Toxigenic Escherichia coli
Proteomics
Escherichia coli
Enteropathogenic Escherichia coli
Virulence
1 Citation (Scopus)

Serologic Responses in Childhood Pulmonary Tuberculosis

Nonyane, B. A. S., Nicol, M. P., Andreas, N. J., Rimmele, S., Schneiderhan-Marra, N., Workman, L. J., Perkins, M. D., Joos, T., Broger, T., Ellner, J. J., Alland, D., Kampmann, B., Dorman, S. E. & Zar, H. J., 1 Jan 2018, In : Pediatric Infectious Disease Journal. 37, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Pulmonary Tuberculosis
Tuberculosis
Antigens
Area Under Curve
Immunoglobulin G

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar, H. J. & Nicol, M. P., 6 Oct 2018, In : The Lancet. 392, 10154, p. 1169-1170 2 p.

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South Africa

Martinez, L., le Roux, D. M., Barnett, W., Stadler, A., Nicol, M. P. & Zar, H. J., 1 Jan 2018, In : The Lancet Child & Adolescent Health. 2, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Open Access
Tuberculin Test
South Africa
Skin Tests
Tuberculosis
Cohort Studies
3 Citations (Scopus)

Tuberculosis eradication: renewed commitment and global investment required

Cox, H. & Nicol, M. P., 1 Mar 2018, In : The Lancet Infectious Diseases. 18, 3, p. 228-229 2 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis?

Khonga, M. & Nicol, M. P., 1 Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 6-8 3 p.

Research output: Contribution to journalComment/debate

95 Citations (Scopus)

Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

Dorman, S. E., Schumacher, S. G., Alland, D., Nabeta, P., Armstrong, D. T., King, B., Hall, S. L., Chakravorty, S., Cirillo, D. M., Tukvadze, N., Bablishvili, N., Stevens, W., Scott, L., Rodrigues, C., Kazi, M. I., Joloba, M., Nakiyingi, L., Nicol, M. P., Ghebrekristos, Y., Anyango, I. & 12 othersMurithi, W., Dietze, R., Lyrio Peres, R., Skrahina, A., Auchynka, V., Chopra, K. K., Hanif, M., Liu, X., Yuan, X., Boehme, C. C., Ellner, J. J. & Denkinger, C. M., 1 Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

Open Access
Rifampin
Mycobacterium tuberculosis
Sputum
Tuberculosis
Multiple Drug Resistance
2017
3 Citations (Scopus)

A clinical scoring system to prioritise investigation for tuberculosis among adults attending HIV clinics in South Africa

Hanifa, Y., Fielding, K. L., Chihota, V. N., Adonis, L., Charalambous, S., Foster, N., Karstaedt, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Sinanovic, E., Sahid, F., Stevens, W., Vassall, A., Churchyard, G. J. & Grant, A. D., 1 Aug 2017, In : PLoS One. 12, 8, e0181519.

Research output: Contribution to journalArticle

Open Access
South Africa
tuberculosis
Screening
Tuberculosis
Health
11 Citations (Scopus)

Advances in the diagnosis of pneumonia in children

Zar, H. J., Andronikou, S. & Nicol, M. P., 26 Jul 2017, In : BMJ (Online). 358, j2739.

Research output: Contribution to journalReview article

Pneumonia
Virus Diseases
Respiratory System
Thorax
Biomarkers
2 Citations (Scopus)
Open Access
Azithromycin
Clinical Protocols
Lung Diseases
Chronic Disease
Randomized Controlled Trials
3 Citations (Scopus)

Carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in HIV-infected children in Zimbabwe

Wilmore, S. M. S., Kranzer, K., Williams, A., Makamure, B., Nhidza, A. F., Mayini, J., Bandason, T., Metcalfe, J., Nicol, M. P., Balakrishnan, I., Ellington, M. J., Woodford, N., Hopkins, S., McHugh, T. D. & Ferrand, R. A., 1 May 2017, In : Journal of Medical Microbiology. 66, 5, p. 609-615 7 p., 000474.

Research output: Contribution to journalArticle

Open Access
Zimbabwe
Enterobacteriaceae
beta-Lactamases
HIV
Clavulanic Acid
2 Citations (Scopus)

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function

Hemingway, C., Berk, M., Anderson, S. T., Wright, V. J., Hamilton, S., Eleftherohorinou, H., Kaforou, M., Goldgof, G. M., Hickman, K., Kampmann, B., Schoeman, J., Eley, B., Beatty, D., Pienaar, S., Nicol, M. P., Griffiths, M. J., Waddell, S. J., Newton, S. M., Coin, L. J., Relman, D. A. & 2 othersMontana, G. & Levin, M., 1 Nov 2017, In : PLoS One. 12, 11, e0185973.

Research output: Contribution to journalArticle

Open Access
Meningeal Tuberculosis
T-cells
meningitis
tuberculosis
childhood
31 Citations (Scopus)

Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study

Cox, H., Dickson-Hall, L., Ndjeka, N., van’t Hoog, A., Grant, A., Cobelens, F., Stevens, W. & Nicol, M., 1 Feb 2017, In : PLoS Medicine. 14, 2, e1002238.

Research output: Contribution to journalArticle

Open Access
Multidrug-Resistant Tuberculosis
South Africa
Cohort Studies
Retrospective Studies
Rifampin

Development of a real-time PCR assay and comparison to CHROMagar (TM) STEC to screen for Shiga toxin-producing Escherichia coli in stool, Cape Town, South Africa

Kalule, J. B., Keddy, K. H., Smith, A., Nicol, M. P. & Robberts, L., 14 Dec 2017, In : African journal of laboratory medicine. 6, 1, 8 p., 609.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: A prospective cohort

Lawn, S. D., Kerkhoff, A. D., Burton, R., Schutz, C., Boulle, A., Vogt, M., Gupta-Wright, A., Nicol, M. P. & Meintjes, G., 21 Mar 2017, In : BMC Medicine. 15, 1, 67.

Research output: Contribution to journalArticle

Open Access
South Africa
Tuberculosis
HIV
Urine
Sputum
4 Citations (Scopus)

Diagnostic accuracy of two multiplex real-Time polymerase chain reaction assays for the diagnosis of meningitis in children in a resource-limited setting

Khumalo, J., Nicol, M., Hardie, D., Muloiwa, R., Mteshana, P. & Bamford, C., 1 Mar 2017, In : PLoS One. 12, 3, e0173948.

Research output: Contribution to journalArticle

Open Access
meningitis
Multiplex Polymerase Chain Reaction
Polymerase chain reaction
Meningitis
Real-Time Polymerase Chain Reaction
16 Citations (Scopus)

Disseminated tuberculosis among hospitalised HIV patients in South Africa: A common condition that can be rapidly diagnosed using urine-based assays

Kerkhoff, A. D., Barr, D. A., Schutz, C., Burton, R., Nicol, M. P., Lawn, S. D. & Meintjes, G., 1 Dec 2017, In : Scientific Reports. 7, 1, 10931.

Research output: Contribution to journalArticle

Open Access
South Africa
Tuberculosis
HIV
Urine
Sputum
3 Citations (Scopus)

Genome sequence for shiga toxin- producing Escherichia coli O26: H11, associated with a cluster of hemolytic- uremic syndrome cases in South Africa, 2017

Smith, A. M., Bosco, K. J., Nicol, M. P., Kleynhans, J., McCulloch, M., Duze, S. T., Ismail, A., Allam, M., Tau, N. P. & Keddy, K. H., 1 Sep 2017, In : Genome Announcements. 5, 38, e00989-17.

Research output: Contribution to journalComment/debate

Shiga-Toxigenic Escherichia coli
Hemolytic-Uremic Syndrome
South Africa
Genome
Disease Outbreaks