Personal profile
Biography
Professor Mark Nicol is a medical microbiologist in the Division of Infection and Immunity in the School of Biomedical Sciences. He also holds an honorary appointment at the University of Cape Town, South Africa. He has a passion for using modern molecular tools to understand complex microbial communities, investigating how imbalances in these communities cause illness and to develop and test better diagnostics for infections, particularly for diseases relating to poverty.
Specific focus areas of Dr Nicol’s research are the pathogenesis and diagnosis of respiratory infection and asthma in children, development, evaluation and implementation of novel diagnostic tests for tuberculosis, the cascade of care for patients with drug-resistant tuberculosis and the role of the microbiome in early childhood development and illness. Professor Nicol has done seminal work on diagnostics for tuberculosis in children and adults, which has provided an evidence base for the new molecular tuberculosis tests used worldwide, and has contributed to many WHO policy recommendations and guidelines.
Professor Nicol has successfully competed for grants from major national and international funders, including funding from the Australian NHMRC (Investigator Award, L2), National Institutes of Health, the Bill and Melinda Gates Foundation and Wellcome Trust. He is a member of the advisory board for several large biotech companies and grant consortia, and a member of the International Interview Panel for the Wellcome Trust.
He is chairperson of the World Health Organization Advisory Group for Tuberculosis Diagnostics and Laboratory Strengthening, a member of the WHO Tuberculosis Guideline Development Group and serves as a Consultant to the Antimicrobial Resistance Division of WHO.
External positions
Honorary Professor of Microbiology, University of Cape Town
1 Jan 2019 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 8 Decent Work and Economic Growth
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Corrigendum: Corynebacterium drakensteinense sp. nov., isolated from the nasopharynx of a healthy South African infant (Int. J. Syst. Evol. Microbiol., (2026), 76, 007068, 10.1099/IJSEM.0.007068)
Haines, R. R., Basuki, A., Tenaglia, V. P., Zar, H. J., Nicol, M. P. & Bahal, R. K., Mar 2026, In: International Journal of Systematic and Evolutionary Microbiology. 76, 3, 007118.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Corynebacterium drakensteinense sp. nov., isolated from the nasopharynx of a healthy South African infant
Haines, R., Basuki, A., Tenaglia, V., Zar, H., Nicol, M. & Kar Bahal, R., 6 Feb 2026, In: International Journal of Systematic and Evolutionary Microbiology. 76, 2, 9 p., 007068.Research output: Contribution to journal › Article › peer-review
Open Access -
Lung function trajectories and determinants from birth to 6-years in an African birth cohort: extending trajectories through infancy using oscillometry
Gray, D. M., Ullah, A., Chaya, S., Jacobs, C., Botha, M., Hantos, Z., Marozva, N., Stein, D. J., Nicol, M. P., Custovic, A. & Zar, H. J., Mar 2026, In: The European Respiratory Journal. 67, 3, 15 p.Research output: Contribution to journal › Article › peer-review
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Stool Processing Methods for Xpert Ultra Testing in Childhood Tuberculosis: A Prospective, Multicountry Accuracy Study
Stool H2H Study Team & Nicol, M. P., 15 Mar 2026, In: Clinical Infectious Diseases. 82, 3, p. 526-534 9 p.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Web of Science) -
Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study
TB-Speed Stool Study Group & Nicol, M. P., Aug 2025, In: The Lancet Microbe. 6, 8, 10 p., 101055.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)
Datasets
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Correction to: Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research
Allali, I. (Creator), Abotsi, R. E. (Creator), Tow, L. A. (Creator), Thabane, L. (Creator), Zar, H. J. (Creator), Mulder, N. M. (Creator) & Nicol, M. P. (Creator), Figshare, 20 Jan 2022
DOI: 10.6084/m9.figshare.c.5800963
Dataset
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Additional file 1 of Sputum bacterial load and bacterial composition correlate with lung function and are altered by long-term azithromycin treatment in children with HIV-associated chronic lung disease
Abotsi, R. E. (Creator), Dube, F. S. (Creator), Rehman, A. M. (Creator), Claassen-Weitz, S. (Creator), Xia, Y. (Creator), Simms, V. (Creator), Mwaikono, K. S. (Creator), Gardner-Lubbe, S. (Creator), McHugh, G. (Creator), Ngwira, L. G. (Creator), Kwambana-Adams, B. (Creator), Heyderman, R. S. (Creator), Odland, J. Ø. (Creator), Ferrand, R. A. (Creator) & Nicol, M. P. (Creator), Figshare, 20 Feb 2023
DOI: 10.6084/m9.figshare.22601284, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Sputum_bacterial_load_and_bacterial_composition_correlate_with_lung_function_and_are_altered_by_long-term_azithromycin_treatment_in_children_with_HIV-associated_chronic_lung_disease/22601284
Dataset
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Testing novel strategies for patients hospitalised with HIV-associated disseminated tuberculosis (NewStrat-TB): protocol for a randomised controlled trial
Namale, P. E. (Contributor), Boloko, L. (Contributor), Vermeulen, M. (Contributor), Haigh, K. A. (Contributor), Bagula, F. (Contributor), Maseko, A. (Contributor), Sossen, B. (Contributor), Lee-Jones, S. (Contributor), Msomi, Y. (Contributor), McIlleron, H. (Contributor), Mnguni, A. T. (Contributor), Crede, T. (Contributor), Szymanski, P. (Contributor), Naude, J. (Contributor), Ebrahim, S. (Contributor), Vallie, Y. (Contributor), Moosa, M. S. (Contributor), Bandeker, I. (Contributor), Hoosain, S. (Contributor), Nicol, M. P. (Contributor), Samodien, N. (Contributor), Centner, C. (Contributor), Dowling, W. (Contributor), Denti, P. (Contributor), Gumedze, F. (Contributor), Little, F. (Contributor), Parker, A. (Contributor), Price, B. (Contributor), Schietekat, D. (Contributor), Simmons, B. (Contributor), Hill, A. (Contributor), Wilkinson, R. J. (Contributor), Oliphant, I. (Contributor), Hlungulu, S. (Contributor), Apolisi, I. (Contributor), Toleni, M. (Contributor), Asare, Z. (Contributor), Mpalali, M. K. (Contributor), Boshoff, E. (Contributor), Prinsloo, D. (Contributor), Lakay, F. (Contributor), Bekiswa, A. (Contributor), Jackson, A. (Contributor), Barnes, A. (Contributor), Johnson, R. (Contributor), Wasserman, S. (Contributor), Maartens, G. (Contributor), Barr, D. (Contributor), Schutz, C. (Contributor) & Meintjes, G. (Contributor), Figshare, 9 May 2024
DOI: 10.6084/m9.figshare.c.7224457
Dataset
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Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research
Allali, I. (Creator), Abotsi, R. E. (Creator), Tow, L. A. (Creator), Thabane, L. (Creator), Zar, H. J. (Creator), Mulder, N. M. (Creator) & Nicol, M. P. (Creator), Figshare, 16 Dec 2021
DOI: 10.6084/m9.figshare.c.5753532
Dataset
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Additional file 1 of Succession and determinants of the early life nasopharyngeal microbiota in a South African birth cohort
Claassen-Weitz, S. (Creator), Gardner-Lubbe, S. (Creator), Xia, Y. (Creator), Mwaikono, K. S. (Creator), Mounaud, S. H. (Creator), Nierman, W. C. (Creator), Workman, L. (Creator), Zar, H. J. (Creator) & Nicol, M. P. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26594033.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Succession_and_determinants_of_the_early_life_nasopharyngeal_microbiota_in_a_South_African_birth_cohort/26594033/1
Dataset
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Comprehensive Targeted Profiling of Membrane Phospholipids
Moggach, F. (Chief Investigator), Chen, K. (CoPI), Geddes, D. (CoPI), Kar Bahal, R. (CoPI), Lozic, I. (CoPI), Nicol, M. (CoPI), Parthenay, J. (CoPI), Swaminatha Iyer, I. (CoPI) & Taylor, N. (CoPI)
The University of Western Australia
1/01/26 → 31/12/26
Project: Research
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Australian Bronchiectasis Centre of Research Excellence especially for Aboriginal and Torres Strait Islander Children -Development of a Bayesian Network to Quantify Contributions of Factors Predisposing to Chronic Wet Cough
Schultz, A. (Investigator 01), Mascaro, S. (Investigator 02), Chang, A. (Investigator 03), Versteegh, L. (Investigator 04), Richmond, P. (Investigator 05), Blyth, C. (Investigator 06), Iosifidis, T. (Investigator 07), Lassmann, T. (Investigator 08), Kicic, A. (Investigator 09), Nicol, M. (Investigator 10) & Ramsey, K. (Investigator 11)
NHMRC National Health and Medical Research Council
5/12/25 → 31/12/26
Project: Research
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WA Breast Milk Biobank
Palmer, D. (Investigator 02), Nicol, M. (Investigator 03), Sharp, M. (Investigator 04), Hassan, M. (Investigator 05), Perrella, S. (Investigator 06), Stinson, L. (Investigator 07) & Vokes, R. (Investigator 08)
Stan Perron Charitable Foundation
1/01/25 → 31/12/29
Project: Research
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Developing respiratory probiotics to prevent pneumonia and asthma in children
Nicol, M. (Investigator 01), Kar Bahal, R. (Investigator 02), Kicic, A. (Investigator 03) & Zar, H. (Investigator 04)
Stan Perron Charitable Foundation
1/01/25 → 31/12/29
Project: Research
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Systematic reviews for the development of diagnostic stewardship recommendations for bacteriology and mycology diagnostic tests
Nicol, M. (Investigator 01) & Kar Bahal, R. (Investigator 02)
31/07/24 → 30/03/27
Project: Research
Activities
- 4 Submissions to standard setting body
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Member, WHO external review group for the guidelines on the management of TB in children and adolescents
Nicol, M. (Consultant)
2021Activity: Industry and government engagement/consultancy › Submissions to standard setting body
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Member of the WHO Advisory Group on Tuberculosis Diagnostics and Laboratory Strengthening
Nicol, M. (Consultant)
2021 → …Activity: Industry and government engagement/consultancy › Submissions to standard setting body
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Member of WHO Guideline Development Group: TB Infection skin tests
Nicol, M. (Consultant)
2021Activity: Industry and government engagement/consultancy › Submissions to standard setting body
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Member of WHO Guideline Development Group: Nucleic acid amplification tests to detect TB and DR-TB
Nicol, M. (Consultant)
2020 → …Activity: Industry and government engagement/consultancy › Submissions to standard setting body
Press/Media
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University of Cape Town Faculty of Health Sciences Reports Findings in Tuberculosis (The Long-Term Impact of Early-Life Tuberculosis Disease on Child Health: A Prospective Birth Cohort Study)
17/02/23
1 item of Media coverage
Press/Media: Press / Media