• The University of Western Australia (M318), 35 Stirling Highway,

    6009 Perth

    Australia

  • 555 Citations
  • 14 h-Index
20092020

Research output per year

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Personal profile

Research

The Burn Injury Research Unit covers all aspects of burn injury, from improving injury assessment through the use of novel technologies, to advanced wound biomaterials, understanding the biology of scar formation and rehabilitation after injury
A primary research focus is the response and integration of the bone marrow, nervous system and immune response to burn injury and how this impacts on the outcome. We are particularly interested in these systemic responses and how they influence healing, and have evidence now for cortical plasticity after burn injury, bone marrow responses affecting scar formation and systemic changes in peripheral nerves potentially caused by an immune mediator. Whilst most research on burn injury has, understandably, focused on topical intervention and the site of injury, a key aspect of our research is the hypothesis that these systemic responses are key to changing the healing process and improving the patient outcome. This has so far been borne out by our data showing long-term changes in these systems in response to burn injury that appear never to return to pre-injury states.

Research expertise keywords

  • Reinnervation and injury
  • Scar formation and maintenance
  • Tissue regeneration
  • Epigenetic changes in dermal cells after injury

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Research Output

Identification of Differentially Methylated CpG Sites in Fibroblasts from Keloid Scars

Alghamdi, M. A., Wallace, H. J., Melton, P. E., Moses, E. K., Stevenson, A., Al-Eitan, L. N., Rea, S., Duke, J. M., Danielsen, P. L., Prêle, C. M., Wood, F. M. & Fear, M. W., 28 Jun 2020, In : Biomedicines. 8, 7, 16 p., 181.

Research output: Contribution to journalArticle

Open Access
  • Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response

    Johnson, B., McAlister, S., McGuire, H., Thirthar Palanivelu, V., Stevenson, A., Richmond, P., Palmer, D., Metcalfe, J., Prescott, S., Wood, F., Fazekas de St Groth, B., Linden, M., Fear, M. & Fear, V., 21 Jul 2020, In : Frontiers in Immunology. 11, 15 p., 1481.

    Research output: Contribution to journalArticle

    Open Access
  • The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis

    Miles, T., Hoyne, G. F., Knight, D. A., Fear, M. W., Mutsaers, S. E. & Prêle, C. M., 1 Jan 2020, In : Clinical & Translational Immunology. 9, 7, p. e1153 e1153.

    Research output: Contribution to journalReview article

    Open Access
  • The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

    Johnson, B. Z., Stevenson, A. W., Prêle, C. M., Fear, M. W. & Wood, F. M., 30 Apr 2020, In : Biomedicines. 8, 5

    Research output: Contribution to journalReview article

    Open Access
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