Appointed Brian Metcalf Chair in Biological Chemistry in the School of Molecular Sciences at the University of Western Australia (Perth) in June 2026, I have had the privilege to start my career as a trained chemist/chemical engineer from ESCOM in France, and pursue a research career with a PhD in organic synthetic chemistry from Michigan State University, and postdoc positions at the School of Pharmacy at Bath University and the Dyson Perrins laboratory in Oxford in the UK, before taking my first academic position at Queen's University Belfast as a junior lecturer and then as a reader in the School of Chemistry and Chemical Engineering to then be appointed full professor after joining the School of Pharmacy. More recently and for almost a decade, my lab has been immersed within a more clinical and translational setting within the College of Medicine and the Mitchell Cancer Institute at the University of South Alabama.

From this varied training and acquired expertise, I have been able to develop research programs that span across the physical and life sciences and medical research. My lab embeds synthetic methodology development using mechanochemistry to access nucleosides, nucleotides, and nucleic acid building blocks, and generates non-radioactive isotopologues for organism and cell-based metabolic and flux tracing in the context of canonical nucleotides and B3-vitamin metabolism. This work provides insights into how complex intracellular metabolic and signalling networks control the biosynthetic pathways of B-vitamins' metabolism, the nucleotide pools, and the total and relative abundance of functional redox cofactors. Aspects of our work also seek to reveal how some NAD catabolites have regulatory functions beyond signalling and redox bioenergetics, while other catabolites are endogenous pathogenic entities affecting cells, tissues, and organisms' cellular bioenergetics and homeostasis, especially in the context of aging, cancer, and chronic inflammatory diseases.

•  Professor and Director (Pharmacology), University of South Alabama: Nov 2016-May 2026
•  Professor (Pharmacy), Queen's University Belfast: Jan 2010-Oct 2016
•  Levitt Research Visiting Professor (Biochemistry), University of Iowa: Nov 2015-Oct 2016
• Associate Professor (Chemistry and Chemical Engineering), Queen's University Belfast: Jan 2000-May 2010