Research output per year
Research output per year
Personal profile
Biography
I completed my Bachelor of Science in Biomedical Science with honours in Biochemistry and Molecular Biology at UWA in 2015. I then went on to complete my PhD under the supervision of Prof. Alice Vrielink in 2020. Here, my research focused on the structural and biophysical characterisation of a bacterial membrane protein complex involved in polysaccharide export. In 2020 I moved to Ireland to take up a postdoctoral position at Trinity College Dublin and was awarded an Irish Research Council Postdoctoral Fellowship. Here my research focused on membrane bound enzymes involved in bacterial lipoprotein processing as antibiotic targets. In 2022 I returned to Perth to take up a postdoctoral position focussing on structure-based drug design of cancer therapeutics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry and Molecular Biology, PhD, Structural and Biophysical Characterisation of the Neisserial capsular polysaccharide export complex, The University of Western Australia
Award Date: 27 Jul 2020
Biochemistry and Molecular Biology, BSc.Hons, Biophysical Characterisation of CtrC and CtrD from Neisseria meningitidis, The University of Western Australia
Award Date: 22 Mar 2016
External positions
Postdoctoral Fellow, Trinity College Dublin
24 Feb 2020 → 7 Dec 2022
Research expertise keywords
- Structural Biology
- Protein Chemistry
- Biophysics
- Enzymology
- Membrane Proteins
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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7.10 MAG. A Novel Host Monoacylglyceride for In Meso (Lipid Cubic Phase) Crystallization of Membrane Proteins
Krawinski, P., Smithers, L., van Dalsen, L., Boland, C., Ostrovitsa, N., Pérez, J. & Caffrey, M., 3 Apr 2024, In: Crystal Growth & Design. 24, 7, p. 2985-3001 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural analysis of the SAM domain of the Arabidopsis mitochondrial tRNA import receptor
Olasz, B., Smithers, L., Evans, G., Anandan, A., Murcha, M. & Vrielink, A., May 2024, In: The Journal of Biological Chemistry. 300, 5, p. 107258 107258.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural analysis of the Sterile alpha motif (SAM) domain of the Arabidopsis mitochondrial tRNA import receptor
Olasz, B., Smithers, L., Evans, G., Anandan, A., Murcha, M. & Vrielink, A., 2023, bioRxiv.Research output: Working paper
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Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase
Smithers, L., Degtjarik, O., Weichart, D., Huang, C.-Y., Boland, C., Bowan, K., Oluwole, A., Lutomski, C., Robinson, C., Scanlan, E., Wang, M., Olieric, V., Shalev-Benami, M. & Caffrey, M., 30 Jun 2023, In: Science Advances. 9, 26, p. eadf5799 17 p., eadf5799.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
9.8 MAG: A new host lipid for In Meso (lipid cubic phase) crystallization of integral membrane proteins
van Dalsen, L., Smithers, L., Boland, C., Weichart, D. & Caffrey, M., 6 Jan 2021, In: Crystal Growth & Design. 21, 1, p. 490-500 11 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Datasets
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Replication Data for: Exploring the interactions of cell-derived vesicles from eukaryotic and prokaryotic origin with homologous cells
Atienza Garriga, J. (Creator), Smithers, L. (Creator), Vrielink, A. (Creator) & Ferrer Miralles, N. (Creator), Consorci de Serveis Universitaris de Catalunya, 21 Oct 2024
DOI: 10.34810/data1795, https://dataverse.csuc.cat/citation?persistentId=doi:10.34810/data1795
Dataset
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AKTA Pure Liquid Chromatography System
Bond, C. (CoPI), Chooi, H. (CoPI), Fox, A. (CoPI), Kretzmann, J. (CoPI), Melville, K. (CoPI), Rudler, D. (CoPI), Sarkar-Tyson, M. (CoPI), Smith, N. (CoPI), Smithers, L. (CoPI), Stubbs, K. (CoPI), Swaminatha Iyer, I. (CoPI), Vrielink, A. (CoPI), Wang, T. (CoPI) & Waters, M. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
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Core infrastructure: high-throughput nanodrop spectrophotometer
Kretzmann, J. (Investigator 01), Evans, C. (Investigator 02), Choi, Y. S. (Investigator 03), Waryah, C. (Investigator 04), Sarkar-Tyson, M. (Investigator 05), Wang, T. (Investigator 06), Bond, C. (Investigator 07), Vrielink, A. (Investigator 08), Smith, N. (Investigator 09), Lesterhuis, W. (Investigator 10), Marshall, A. (Investigator 11), Stubbs, K. (Investigator 12), Breese, K. (Investigator 13), Chen, K. (Investigator 14), Smithers, L. (Investigator 15), Wylie, B. (Investigator 16), Wang, E. (Investigator 17) & Blancafort, P. (Investigator 18)
NHMRC National Health and Medical Research Council
15/03/24 → 31/12/24
Project: Research
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Avestin Emulsiflex C5 Cell Homogeniser for Protein Production
Bond, C. (Investigator 01), Vrielink, A. (Investigator 02), Fox, A. (Investigator 03), Stubbs, K. (Investigator 04), Kahler, C. (Investigator 05), Smith, N. (Investigator 06), Kretzmann, J. (Investigator 07), Marshall, A. (Investigator 08), Evans, C. (Investigator 09), Smithers, L. (Investigator 10), Debowski, A. (Investigator 11), Bzdyl, N. (Investigator 12), Chooi, H. (Investigator 13), Fritz, G. (Investigator 14), Small, I. (Investigator 15), Lesterhuis, W. (Investigator 16), Sarkar-Tyson, M. (Investigator 17) & Piggott, M. (Investigator 18)
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
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Multifuge X4R refrigerated centrifuge
Bond, C. (Investigator 01), Vrielink, A. (Investigator 02), Fox, A. (Investigator 03), Stubbs, K. (Investigator 04), Kahler, C. (Investigator 05), Smith, N. (Investigator 06), Kretzmann, J. (Investigator 07), Evans, C. (Investigator 08), Marshall, A. (Investigator 09), Smithers, L. (Investigator 10), Debowski, A. (Investigator 11), Bzdyl, N. (Investigator 12), Chooi, H. (Investigator 13), Fritz, G. (Investigator 14), Small, I. (Investigator 15), Lesterhuis, W. (Investigator 16), Piggott, M. (Investigator 17) & Sarkar-Tyson, M. (Investigator 18)
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
Prizes
Activities
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INSTRUCT CryoEM Workshop
Smithers, L. (Participant)
23 May 2022 → 25 May 2022Activity: Conferences and workshops › Participation in workshop, seminar or course
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British Biophysical Society Biennial Meeting
Smithers, L. (Participant)
29 Jun 2022 → 1 Jul 2022Activity: Conferences and workshops › Contribution or participation in a conference
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Instruct-ERIC Macromolecular X-ray, electron and neutron crystallography
Smithers, L. (Participant)
29 Jun 2021 → 6 Jul 2021Activity: Conferences and workshops › Participation in workshop, seminar or course
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43rd Lorne Conference on Protein Structure and Function
Smithers, L. (Participant)
4 Feb 2018 → 8 Feb 2018Activity: Conferences and workshops › Contribution or participation in a conference
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Crystal 31
Smithers, L. (Participant)
4 Dec 2017 → 6 Dec 2017Activity: Conferences and workshops › Contribution or participation in a conference