Personal profile
Biography
Louise Winteringham leads the Translational Cancer Research Program at the Perkins. Shas an extensive background in immunology and haematology focusing on the molecular and cellular biology of cancer, in particular haematological cancers. She completed her MSc in the Department of Clinical Immunology at Royal Perth Hospital investigating the impact of non-coding regions within the Major Histocompatibility Complex. Following three years working at St Bartholomew's Hospital in London, Louise was awarded the Richard Walter Gibbon Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at UWA to undertake her PhD so she returned to Perth where she joined the Leukemia Laboratory at WAIMR, headed by Professor Peter Klinken. Louise continued her work in cancer research focusing on the biochemical and cellular mechanisms that drive oncogenesis. She has identified several novel genes associated with the development and progression of cancer. In 2017 she initiated the Translational Cancer Research Program at The Perkins, developing collaborations with pathologists and surgeons to provide a co-ordinated approach to quickly move laboratory discoveries into cancer treatments. As part of this program, she has established pre-clinical models able to accurately evaluate new cancer treatments that modulate our own immune systems to fight cancer. These models are currently being used to develop precision oncology medicine in combination with several omics technologies.
Funding overview
2013–2015 Development of a Murine Cell Model of Diamond Blackfan Anaemia
Klinken, P. & Winteringham, L. Captain Courageous Foundation AUD 259,927
2013-2015 Leukemia transcriptomics. Winteringham, L., Klinlen, S.P. McCusker Foundation AUD 600,000
2015 Illumina NeoPrep Library System. Morahan, G., Winteringham, L., Forrest, A., Lister, R., Heng, J., Fox, A. National Health & Medical Research Council NHMRC AUD 39,136
2014 Targeting Acute Myeloid Leukemia with micro RNAs
LWinteringham, L., Klinken, S.P. Rachael Doherty Foundation AUD 92,000
2010-2012 Characterization of Haemopoietic Lineage Determining Genes. Klinken, P, Bond, C., Winteringham, L., National Health & Medical Research Council NHMRC AUD 608,500
Industry keywords
- Biotechnology
- Health
- Drug Discovery
- Medicine and Pharma
- Diagnostics
Research expertise keywords
- Cancer
- Novel cancer genes
- Red blood cells
- Cancer - translation
- Personalised medicine
- Humanised mice
- Pre-clinical models
- Leukemia
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Complementarity and integration of animal and in vitro non-animal pre-clinical model systems– an Australian perspective
Arkell, R. M., Wolvetang, E. J., Gulati, T., Hennessy, J. E., Hill, A. P., Jardé, T., Kueh, A. J., Thomas, P. Q., Winteringham, L. N. & Dobbie, M. S., Jun 2025, In: Mammalian Genome. 36, 2, p. 482-487 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
FBP1 controls liver cancer evolution from senescent MASH hepatocytes
The Liver Cancer Collaborative, 9 Jan 2025, In: Nature. 637, 8045, p. 461-469 9 p., 15691.Research output: Contribution to journal › Article › peer-review
36 Link opens in a new tab Citations (Scopus) -
Systematic Review and Meta-Analysis of microRNA-7-5p Expression and Biological Significance in Head and Neck Squamous Cell Carcinoma
Brown, R. A. M., Phillips, M., Woo, A. J., Kujan, O., Flukes, S., Winteringham, L. N., Dymond, L. C., Wheeler, F., Pollock, B., Beveridge, D. J., Denisenko, E. & Leedman, P. J., 1 Oct 2025, In: Cancers. 17, 19, 32 p., 3232.Research output: Contribution to journal › Review article › peer-review
Open Access2 Link opens in a new tab Citations (Web of Science) -
Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor
He, B., Dymond, L., Wood, K. H., Bastow, E. R., Satiaputra, J., Li, J., Johansson-Percival, A., Hamzah, J., Kumarasinghe, M. P., Ballal, M., Foo, J., Johansson, M., Ee, H. C., White, S. W., Winteringham, L. & Ganss, R., 22 Sept 2024, In: OncoImmunology. 13, 1, 13 p., 2406576.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Citations (Web of Science) -
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)
FANTOM Consortium, 1 Dec 2022, In: Nature Communications. 13, 1, 1200.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
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Understanding and targeting cholesterol and fat metabolism to combat pancreatic cancer
Hamzah, J. (Investigator 01), Kirla, H. (Investigator 02), Johansson, M. (Investigator 03) & Winteringham, L. (Investigator 04)
5/01/26 → 4/01/27
Project: Research
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Defeating Primary Liver Cancer
Leedman, P. (Investigator 01), Tirnitz-Parker, N. (Investigator 02), Winteringham, L. (Investigator 03), Wallace, M. (Investigator 04), Carlessi, R. (Investigator 05), Dwyer, B. (Investigator 06), Gupta, S. (Investigator 07) & Currenti, J. (Investigator 08)
1/01/26 → 31/12/29
Project: Research
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REPROGRAMMING STRESS-INDUCED CELLULAR SIGNALING TO IMPROVE THERAPY RESPONSES IN OVARIAN CANCER
Blancafort, P. (Investigator 01), Golden, E. (Investigator 02), Redfern, A. (Investigator 03), Cheasley, D. (Investigator 04), Curtis, C. (Investigator 05) & Winteringham, L. (Investigator 06)
NHMRC National Health and Medical Research Council
1/01/25 → 1/01/29
Project: Research
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Building a clinical tool to deliver a precision medicine approach for liver cancer
Winteringham, L. (Investigator 01), Donnellan, A. (Investigator 02), Wallace, M. (Investigator 03), Dwyer, B. (Investigator 04), Tirnitz-Parker, N. (Investigator 05), Leedman, P. (Investigator 06) & Carter, K. (Investigator 07)
Department of Health (Western Australia)
29/11/24 → 29/11/26
Project: Research
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Epigenome engineering for the therapeutic reprogramming of the mesenchymal to epithelial states in breast cancer
Blancafort, P. (Investigator 01), Waryah, C. (Investigator 02), Redfern, A. (Investigator 03), Winteringham, L. (Investigator 04) & Woo, A. (Investigator 05)
NHMRC National Health and Medical Research Council
1/02/24 → 31/12/28
Project: Research
Press/Media
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$15 million in funding to support health and medical research
Green, D., Ingley, E., Miller, K., Hool, L., Coffin, J., Dickinson, J., Richmond, P., Fuller, K., Erber, W., Fatovich, D., Winteringham, L., Naylor, L., Milroy, H., Wittek, A., Viola, H., Ganss, R., Zhu, K., Mullin, B., Johansson-Percival, A., Satiaputra, J., Chakera, A., Cabrera Serrano, M., Haynes, A., McCutcheon, D., Richards, T., Cross, D., Hui, H., McVeigh, J., Parizel, P. M. & Mulroney, K.
15/12/20 → 16/12/20
3 items of Media coverage
Press/Media: Press / Media