Louise Winteringham

Personal profile

Biography

Louise Winteringham leads the Translational Cancer Research Program at the Perkins. Shas an extensive background in immunology and haematology focusing on the molecular and cellular biology of cancer, in particular haematological cancers. She completed her MSc in the Department of Clinical Immunology at Royal Perth Hospital investigating the impact of non-coding regions within the Major Histocompatibility Complex. Following three years working at St Bartholomew's Hospital in London, Louise was awarded the Richard Walter Gibbon Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at UWA to undertake her PhD so she returned to Perth where she joined the Leukemia Laboratory at WAIMR, headed by Professor Peter Klinken. Louise continued her work in cancer research focusing on the biochemical and cellular mechanisms that drive oncogenesis. She has identified several novel genes associated with the development and progression of cancer. In 2017 she initiated the Translational Cancer Research Program at The Perkins, developing collaborations with pathologists and surgeons to provide a co-ordinated approach to quickly move laboratory discoveries into cancer treatments. As part of this program, she has established pre-clinical models able to accurately evaluate new cancer treatments that modulate our own immune systems to fight cancer. These models are currently being used to develop precision oncology medicine in combination with several omics technologies.

Funding overview

2018-2023 CI A Forrest, 41 AIs including L Winteringham. The CRT Collaborative Cancer Research Grant: Enabling advanced single cell cancer genomics in Western Australia. Requested AUD 6.5M.

2013–2015 Development of a Murine Cell Model of Diamond Blackfan Anaemia
Klinken, P. & Winteringham, L. Captain Courageous Foundation AUD 259,927

2013-2015 Leukemia transcriptomics. Winteringham, L., Klinlen, S.P. McCusker Foundation AUD 600,000

2015 Illumina NeoPrep Library System. Morahan, G., Winteringham, L., Forrest, A., Lister, R., Heng, J., Fox, A. National Health & Medical Research Council NHMRC AUD 39,136

2014 Targeting Acute Myeloid Leukemia with micro RNAs
LWinteringham, L., Klinken, S.P. Rachael Doherty Foundation AUD 92,000

2010-2012 Characterization of Haemopoietic Lineage Determining Genes. Klinken, P, Bond, C., Winteringham, L., National Health & Medical Research Council NHMRC AUD 608,500

Industry keywords

Biotechnology
Health
Drug Discovery
Medicine and Pharma
Diagnostics

Research expertise keywords

Cancer
Novel cancer genes
Red blood cells
Cancer - translation
Personalised medicine
Humanised mice
Pre-clinical models
Leukemia

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Research Output

3607 Citations
22 h-Index
34 Article
3 Conference paper

Expression Levels of Therapeutic Targets as Indicators of Sensitivity to Targeted Therapeutics

Roy, R., Winteringham, L. N., Lassmann, T. & Forrest, A. R. R., Dec 2019, In : Molecular Cancer Therapeutics. 18, 12, p. 2480-2489 10 p.

Research output: Contribution to journal › Article

An integrated expression atlas of miRNAs and their promoters in human and mouse

de Rie, D., Abugessaisa, I., Alam, T., Arner, E., Arner, P., Ashoor, H., Astrom, G., Babina, M., Bertin, N., Burroughs, A. M., Carlisle, A. J., Daub, C. O., Detmar, M., Deviatiiarov, R., Fort, A., Gebhard, C., Goldowitz, D., Guhl, S., Ha, T. J., Harshbarger, J. & 50 others, Hasegawa, A., Hashimoto, K., Herlyn, M., Heutink, P., Hitchens, K. J., Hon, C. C., Huang, E., Ishizu, Y., Kai, C., Kasukawa, T., Klinken, P., Lassmann, T., Lecellier, C-H., Lee, W., Lizio, M., Makeev, V., Mathelier, A., Medvedeva, Y. A., Mejhert, N., Mungall, C. J., Noma, S., Ohshima, M., Okada-Hatakeyama, M., Persson, H., Rizzu, P., Roudnicky, F., Saetrom, P., Sato, H., Severin, J., Shin, J. W., Swoboda, R. K., Tarui, H., Toyoda, H., Vitting-Seerup, K., Winteringham, L., Yamaguchi, Y., Yasuzawa, K., Yoneda, M., Yumoto, N., Zabierowski, S., Zhang, P. G., Wells, C. A., Summers, K. M., Kawaji, H., Sandelin, A., Rehli, M., Hayashizaki, Y., Carninci, P., Forrest, A. R. R. & de Hoon, M. J. L., Sep 2017, In : Nature Biotechnology. 35, 9, p. 872–878

Research output: Contribution to journal › Article

Open Access

113 Citations (Scopus)

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., Kawashima, T., Kojima, M., Kubosaki, A., Manabe, R. I., Murata, M., Nagao-Sato, S., Nakazato, K., Ninomiya, N., Nishiyori-Sueki, H., Noma, S. & 158 others, Saijyo, E., Saka, A., Sakai, M., Simon, C., Suzuki, N., Tagami, M., Watanabe, S., Yoshida, S., Arner, P., Axton, R. A., Babina, M., Kenneth Baillie, J., Barnett, T. C., Beckhouse, A. G., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Carlisle, A. J., Clevers, H. C., Davis, C. A., Detmar, M., Dohi, T., Edge, B. A. S., Edinger, M., Ehrlund, A., Ekwall, K., Endoh, M., Enomoto, H., Eslami, A., Fagiolini, M., Fairbairn, L., Farach-Carson, M. C., Faulkner, G. J., Ferrai, C., Fisher, M. E., Forrester, L. M., Fujita, R., Furusawa, J. I., Geijtenbeek, T. B., Gingeras, T., Goldowitz, D., Guhl, S., Guler, R., Gustincich, S., Ha, T. J., Hamaguchi, M., Hara, M., Hasegawa, Y., Herlyn, M., Heutink, P., Hitchens, K. J., Hume, D. A., Ikawa, T., Ishizu, Y., Kai, C., Kawamoto, H., Kawamura, Y. I., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L. M., Kitamura, T., Klein, S., Peter Klinken, S., Knox, A. J., Kojima, S., Koseki, H., Koyasu, S., Lee, W., Lennartsson, A., MacKay-Sim, A., Mejhert, N., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Morris, K. J., Motohashi, H., Mummery, C. L., Nakachi, Y., Nakahara, F., Nakamura, T., Nakamura, Y., Nozaki, T., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D. A., Passier, R., Patrikakis, M., Pombo, A., Pradhan-Bhatt, S., Qin, X. Y., Rehli, M., Rizzu, P., Roy, S., Sajantila, A., Sakaguchi, S., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schmidl, C., Schneider, C., Schulze-Tanzil, G. G., Schwegmann, A., Sheng, G., Shin, J. W., Sugiyama, D., Sugiyama, T., Summers, K. M., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Tomoiu, A., Toyoda, H., Wetering, M., Berg, L. M. V. D., Verardo, R., Vijayan, DI., Wells, C. A., Winteringham, L. N., Wolvetang, E., Yamaguchi, Y., Yamamoto, M., Yanagi-Mizuochi, C., Yoneda, M., Yonekura, Y., Zhang, P. G., Zucchelli, S., Abugessaisa, I., Arner, E., Harshbarger, J., Kondo, A., Lassmann, T., Lizio, M., Sahin, S., Sengstag, T., Severin, J., Shimoji, H., Suzuki, M., Suzuki, H., Kawai, J., Kondo, N., Itoh, M., Daub, C. O., Kasukawa, T., Kawaji, H., Carninci, P., Forrest, A. R. R. & Hayashizaki, Y., 29 Aug 2017, In : Scientific Data. 4, 170112.

Research output: Contribution to journal › Article

Open Access

30 Citations (Scopus)

Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium

Yu, N. Y-L., Hallström, B. M., Fagerberg, L., Ponten, F., Kawaji, H., Carninci, P., Forrest, A., Hayashizaki, Y., Uhlén, M., Daub, C. O., Alam, I., Albanese, D., Altschuler, G., Andersson, R., Arakawa, T., Archer, J., Arner, E., Arner, P., Babina, M., Baillie, K. & 244 others, Bajic, V., Baker, S., Balic, A., Balwierz, P., Beckhouse, A., Bertin, N., Blake, J. A., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Burroughs, M., Califano, A., Cannistraci, C., Carbajo, D., Chen, Y., Chierici, M., Ciani, Y., Clevers, H., Dalla, E., Davis, C., De Hoon, M., De Lima Morais, D., Detmar, M., Diehl, A., Dimont, E., Dohi, T., Drabros, F., Edge, A., Edinger, M., Ekwall, K., Endoh, M., Enomoto, H., Fagiolini, M., Fairbairn, L., Fang, H., Farach-Carson, M. C., Faulkner, G., Favorov, A., Fisher, M., Francescatto, M., Freeman, T., Frith, M., Fujita, R., Fukuda, S., Furlanello, C., Furuno, M., Furusawa, J-I., Geijtenbeek, T. B. H., Gibson, A., Gingeras, T., Goldowitz, D., Gough, J., Guhl, S., Guler, R., Gustincich, S., Ha, T., Haberle, V., Hamaguchi, M., Hara, M., Harbers, M., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, T., Herlyn, M., Heutink, P., Hide, W., Hitchens, K., Ho Sui, S., Hofmann, O., Hoof, I., Hori, F., Hume, D., Huminiecki, L., Ilda, K., Ikawa, T., Ishizu, Y., Itoh, M., Jankovic, B., Jia, H., Jorgensen, M., Joshi, A., Jurman, G., Kaczkowski, B., Kai, C., Kaida, K., Kaiho, A., Kajiyama, K., Kanamori-Katayama, M., Kasianov, A., Kasukawa, T., Katayama, S., Kato, S., Kawaguchi, S., Kawai, J., Kawamoto, H., Kawamura, Y., Kwashima, T., Kempfle, J., Kenna, T., Kere, J., Khachigian, L., Kitamura, T., Klinken, P., Knox, A., Kojima, M., Kojima, S., Kondo, N., Koseki, H., Koyasu, S., Krampitz, S., Kubosaki, A., Kulalovskiy, I., Kwon, A. T. J., Laros, J., Lassmann, T., Lenhard, B., Lennartsson, A., Li, K., Lilje, B., Lipovich, L., Lizio, M., Mackay-Sim, A., Makeev, V., Manabe, R., Mar, J., Marchand, B., Mathelier, A., Medvedeva, Y., Meehan, T. F., Mejhert, N., Meynert, A., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Motakis, E., Motohashi, H., Mummery, C., Mungall, C. J., Murata, M., Nagao, S., Nakachi, Y., Nakahara, F., Nakamura, Y., Nakazato, K., Ninomiya, N., Nishiyori, H., Noma, S., Nozaki, T., Ogishima, S., Ohkura, N., Ohmiya, H., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D., Pain, A., Passier, R., Persson, H., Piazza, S., Plessy, C., Pradhan-Bhatt, S., Prendergast, J., Rackham, O., Ramilowski, J., Rashid, M., Ravasi, T., Rehli, M., Rizzu, P., Roncador, M., Roy, S., Rye, M., Saijyo, E., Sajantila, A., Saka, A., Sakaguchi, S., Sakai, M., Sandelin, A., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schaefer, U., Schmeier, S., Schmidl, C., Schneider, C., Schultes, E. A., Schulze-Tanzil, G., Schwegmann, A., Semple, C., Sengstag, T., Severin, J., Sheng, G., Shimoji, H., Shimoni, Y., Shin, J., Simon, C., Sugiyama, D., Sugiyama, T., Summers, K., Suzuki, H., Suzuki, M., Suzuki, N., Swoboda, R., T Hoen, P., Tagami, M., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Tatum, Z., Taylor, M., Thompson, M., Toyoda, H., Toyoda, T., Valen, E., Van De Wetering, M., Van Den Berg, L., Van Nimwegen, E., Verardo, R., Vijayan, D., Vitezic, M., Vorontzov, I., Wasserman, W., Watanabe, S., Wells, C., Winteringham, L., Wolvetang, E., Wood, E. J., Yamaguchi, Y., Yamamoto, M., Yoneda, M., Yonekura, Y., Yoshida, S., Young, R., Zabierowski, S. E., Zhang, P., Zhao, X. & Zucchelli, S., 2015, In : Nucleic Acids Research. 43, p. 6787-6798

Research output: Contribution to journal › Article

Open Access

33 Citations (Scopus)

Gateways to the FANTOM5 promoter level mammalian expression atlas

Lizio, M., Harshbarger, J., Shimoji, H., Severin, J., Kasukawa, T., Sahin, S., Abugessaisa, I., Fukuda, S., Hori, F., Ishikawa-Kato, S., Mungall, C. J., Arner, E., Baillie, J. K., Bertin, N., Bono, H., De Hoon, M., Diehl, A. D., Dimont, E., Freeman, T. C., Fujieda, K. & 249 others, Hide, W., Kaliyaperumal, R., Katayama, T., Lassmann, T., Meehan, T. F., Nishikata, K., Ono, H., Rehli, M., Sandelin, A., Schultes, E. A., T Hoen, P. A. C., Tatum, Z., Thompson, M., Toyoda, T., Wright, D. W., Daub, C. O., Itoh, M., Carninci, P., Hayashizaki, Y., Forrest, A., Kawaji, H., Alam, I., Albanese, D., Altschuler, G., Andersson, R., Arakawa, T., Archer, J., Arner, P., Babina, M., Bajic, V., Baker, S., Balic, A., Balwierz, P., Beckhouse, A., Blake, J. A., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Burroughs, M., Califano, A., Cannistraci, C., Carbajo, D., Chen, Y., Chierici, M., Ciani, Y., Clevers, H., Dalla, E., Davis, C., De Lima Morais, D., Detmar, M., Dohi, T., Drabros, F., Edge, A., Edinger, M., Ekwall, K., Endoh, M., Enomoto, H., Fagiolini, M., Fairbairn, L., Fang, H., Farach-Carson, M. C., Faulkner, G., Favorov, A., Fisher, M., Francescatto, M., Frith, M., Fujita, R., Furlanello, C., Furuno, M., Furusawa, J-I., Geijtenbeek, T. B. H., Gibson, A., Gingeras, T., Goldowitz, D., Gough, J., Guhl, S., Guler, R., Gustincich, S., Ha, T., Haberle, V., Hamaguchi, M., Hara, M., Harbers, M., Hasegawa, A., Hasegawa, Y., Hashimoto, T., Herlyn, M., Heutink, P., Hitchens, K., Ho Sui, S., Hofmann, O., Hoof, I., Hume, D., Huminiecki, L., Ilda, K., Ikawa, T., Ishizu, Y., Jankovic, B., Jia, H., Jorgensen, M., Joshi, A., Jurman, G., Kaczkowski, B., Kai, C., Kaida, K., Kaiho, A., Kajiyama, K., Kanamori-Katayama, M., Kasianov, A., Katayama, S., Kawaguchi, S., Kawai, J., Kawamoto, H., Kawamura, Y., Kawashima, T., Kempfle, J., Kenna, T., Kere, J., Khachigian, L., Kitamura, T., Klinken, P., Knox, A., Kojima, M., Kojima, S., Kondo, N., Koseki, H., Koyasu, S., Krampitz, S., Kubosaki, A., Kulakovskiy, I., Kwon, A. T. J., Laros, J., Lenhard, B., Lennartsson, A., Li, K., Lilje, B., Lipovich, L., Mackay-Sim, A., Makeev, V., Manabe, R., Mar, J., Marchand, B., Mathelier, A., Medvedeva, Y., Mejhert, N., Meynert, A., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Motakis, E., Motohashi, H., Mummery, C., Murata, M., Nagao, S., Nakachi, Y., Nakahara, F., Nakamura, T., Nakamura, Y., Nakazato, K., Ninomiya, N., Nishiyori, H., Noma, S., Nozaki, T., Ogishima, S., Ohkura, N., Ohmiya, H., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okzaki, Y., Orlando, V., Ovchinnokov, D., Pain, A., Passier, R., Persson, H., Piazza, S., Plessy, C., Pradhan-Bhatt, S., Prendergast, J., Rackham, O., Ramilowski, J., Rashid, M., Ravasi, T., Rizzu, P., Roncador, M., Roy, S., Rye, M., Saijyo, E., Sajantila, A., Saka, A., Sakaguchi, S., Sakai, M., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schaefer, U., Schmeier, S., Schmidl, C., Schneider, C., Schulze-Tanzil, G., Schwegmann, A., Semple, C., Sengstag, T., Sheng, G., Shimoni, Y., Shin, J., Simon, C., Sugiyama, D., Sugiyama, T., Summers, K., Suzuki, H., Suzuki, M., Suzuki, N., Swoboda, R., Tagami, M., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Taylor, M., Toyoda, H., Valen, E., Van De Wetering, M., Van Den Berg, L., Van Nimwegen, E., Verardo, R., Vijayan, D., Vitezic, M., Vorontzov, I., Wasserman, W., Watanabe, S., Wells, C., Winteringham, L., Wolvetang, E., Wood, E. J., Yamaguchi, Y., Yamamoto, M., Yoneda, M., Yonekura, Y., Yoshida, S., Young, R., Zabierowski, S. E., Zhang, P., Zhao, X. & Zucchelli, S., 2015, In : Genome Biology. 16, p. 1-14

Research output: Contribution to journal › Article

Open Access