Research output per year
Research output per year
Personal profile
Biography
Louise Winteringham leads the Translational Cancer Research Program at the Perkins. Shas an extensive background in immunology and haematology focusing on the molecular and cellular biology of cancer, in particular haematological cancers. She completed her MSc in the Department of Clinical Immunology at Royal Perth Hospital investigating the impact of non-coding regions within the Major Histocompatibility Complex. Following three years working at St Bartholomew's Hospital in London, Louise was awarded the Richard Walter Gibbon Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at UWA to undertake her PhD so she returned to Perth where she joined the Leukemia Laboratory at WAIMR, headed by Professor Peter Klinken. Louise continued her work in cancer research focusing on the biochemical and cellular mechanisms that drive oncogenesis. She has identified several novel genes associated with the development and progression of cancer. In 2017 she initiated the Translational Cancer Research Program at The Perkins, developing collaborations with pathologists and surgeons to provide a co-ordinated approach to quickly move laboratory discoveries into cancer treatments. As part of this program, she has established pre-clinical models able to accurately evaluate new cancer treatments that modulate our own immune systems to fight cancer. These models are currently being used to develop precision oncology medicine in combination with several omics technologies.
Funding overview
2018-2023 CI A Forrest, 41 AIs including L Winteringham. The CRT Collaborative Cancer Research Grant: Enabling advanced single cell cancer genomics in Western Australia. Requested AUD 6.5M.
2013–2015 Development of a Murine Cell Model of Diamond Blackfan Anaemia
Klinken, P. & Winteringham, L. Captain Courageous Foundation AUD 259,927
2013-2015 Leukemia transcriptomics. Winteringham, L., Klinlen, S.P. McCusker Foundation AUD 600,000
2015 Illumina NeoPrep Library System. Morahan, G., Winteringham, L., Forrest, A., Lister, R., Heng, J., Fox, A. National Health & Medical Research Council NHMRC AUD 39,136
2014 Targeting Acute Myeloid Leukemia with micro RNAs
LWinteringham, L., Klinken, S.P. Rachael Doherty Foundation AUD 92,000
2010-2012 Characterization of Haemopoietic Lineage Determining Genes. Klinken, P, Bond, C., Winteringham, L., National Health & Medical Research Council NHMRC AUD 608,500
2013–2015 Development of a Murine Cell Model of Diamond Blackfan Anaemia
Klinken, P. & Winteringham, L. Captain Courageous Foundation AUD 259,927
2013-2015 Leukemia transcriptomics. Winteringham, L., Klinlen, S.P. McCusker Foundation AUD 600,000
2015 Illumina NeoPrep Library System. Morahan, G., Winteringham, L., Forrest, A., Lister, R., Heng, J., Fox, A. National Health & Medical Research Council NHMRC AUD 39,136
2014 Targeting Acute Myeloid Leukemia with micro RNAs
LWinteringham, L., Klinken, S.P. Rachael Doherty Foundation AUD 92,000
2010-2012 Characterization of Haemopoietic Lineage Determining Genes. Klinken, P, Bond, C., Winteringham, L., National Health & Medical Research Council NHMRC AUD 608,500
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Industry keywords
- Biotechnology
- Health
- Drug Discovery
- Medicine and Pharma
- Diagnostics
Research expertise keywords
- Cancer
- Novel cancer genes
- Red blood cells
- Cancer - translation
- Personalised medicine
- Humanised mice
- Pre-clinical models
- Leukemia
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor
He, B., Dymond, L., Wood, K. H., Bastow, E. R., Satiaputra, J., Li, J., Johansson-Percival, A., Hamzah, J., Kumarasinghe, M. P., Ballal, M., Foo, J., Johansson, M., Ee, H. C., White, S. W., Winteringham, L. & Ganss, R., 22 Sept 2024, In: OncoImmunology. 13, 1, 13 p., 2406576.Research output: Contribution to journal › Article › peer-review
Open Access -
ECM Depletion Is Required to Improve the Intratumoral Uptake of Iron Oxide Nanoparticles in Poorly Perfused Hepatocellular Carcinoma
Yeow, Y. L., Wu, J., Wang, X., Winteringham, L., Feindel, K. W., Tirnitz-Parker, J. E. E., Leedman, P. J., Ganss, R. & Hamzah, J., 22 Feb 2022, In: Frontiers in Oncology. 12, 837234.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
FANTOM Consortium, 1 Dec 2021, In: Nature Communications. 12, 1, 3297.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Enhanced Detection of Desmoplasia by Targeted Delivery of Iron Oxide Nanoparticles to the Tumour-Specific Extracellular Matrix
Chopra, M., Wu, J., Yeow, Y. L., Winteringham, L., Clemons, T. D., Saunders, M., Kotamraju, V. R., Ganss, R., Feindel, K. W. & Hamzah, J., 12 Oct 2021, In: Pharmaceutics. 13, 10, 16 p., 1663.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Expression Levels of Therapeutic Targets as Indicators of Sensitivity to Targeted Therapeutics
Roy, R., Winteringham, L. N., Lassmann, T. & Forrest, A. R. R., Dec 2019, In: Molecular Cancer Therapeutics. 18, 12, p. 2480-2489 10 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Web of Science)
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Building a clinical tool to deliver a precision medicine approach for liver cancer
Winteringham, L. (Investigator 01), Donnellan, A. (Investigator 02), Wallace, M. (Investigator 03), Dwyer, B. (Investigator 04), Tirnitz-Parker, N. (Investigator 05), Leedman, P. (Investigator 06) & Carter, K. (Investigator 07)
Department of Health (Western Australia)
6/01/25 → 31/12/26
Project: Research
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REPROGRAMMING STRESS-INDUCED CELLULAR SIGNALING TO IMPROVE THERAPY RESPONSES IN OVARIAN CANCER
Blancafort, P. (Investigator 01), Golden, E. (Investigator 02), Redfern, A. (Investigator 03), Cheasley, D. (Investigator 04), Curtis, C. (Investigator 05) & Winteringham, L. (Investigator 06)
NHMRC National Health and Medical Research Council
1/01/25 → 1/01/29
Project: Research
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Targeting an alternate nuclear receptor to treat aggressive breast cancers.
Woo, A. (Investigator 01), Leedman, P. (Investigator 02), Blancafort, P. (Investigator 03), Wang, E. (Investigator 04), Winteringham, L. (Investigator 05), Redfern, A. (Investigator 06) & Artzi, N. (Investigator 07)
1/07/24 → 30/12/25
Project: Research
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Therapeutic exploitation of Rab12, a novel tumour and metastasis suppressor in breast cancer
Wang, E. (Investigator 01), Blancafort, P. (Investigator 02), Redfern, A. (Investigator 03), Winteringham, L. (Investigator 04), Woo, A. (Investigator 05) & Khinsar, K. H. (Investigator 06)
1/01/24 → 30/06/25
Project: Research
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Therapeutic exploitation of Rab12, a novel tumour and metastasis suppressor in breast cancer
Wang, E. (Chief Investigator), Blancafort, P. (CoPI), Khinsar, K. H. (CoPI), Murthy, N. (CoPI), Redfern, A. (CoPI), Sharma, R. (CoPI) & Winteringham, L. (CoPI)
The University of Western Australia
8/01/24 → 31/12/24
Project: Research
Press/Media
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$15 million in funding to support health and medical research
Green, D., Ingley, E., Miller, K., Hool, L., Coffin, J., Dickinson, J., Richmond, P., Fuller, K., Erber, W., Fatovich, D., Winteringham, L., Naylor, L., Milroy, H., Wittek, A., Viola, H., Ganss, R., Zhu, K., Mullin, B., Johansson-Percival, A., Satiaputra, J., Chakera, A., Cabrera Serrano, M., Haynes, A., McCutcheon, D., Richards, T., Cross, D., Hui, H., McVeigh, J., Parizel, P. M. & Mulroney, K.
15/12/20 → 16/12/20
3 items of Media coverage
Press/Media: Press / Media