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Research

Structural characterization of capsular transporter proteins from Neisseria meningitidis  

Nesseria meningitis is a Gram-negative bacterium which is the causative agent for bacterial meningitis. Pathogenic Neisseria is surrounded by a polysaccharide capsule, the building components of which are biologically synthesised in the cytoplasm and are then exported by an ABC-transporter-dependent system to the exterior of the bacterial cell. This polysaccharide exporter machinery is composed of four proteins: CtrCD the ABC-transporter anchored in the inner membrane, CtrB the polysaccharide copolymerase, anchored in the inner membrane and containing a periplasmic facing domain and CtrA, an outer membrane exporter. My project is focused on the structural and biophysical studies of this exporter machinery.  These studies will utilise methods including X-ray crystallography and cryo-electron microscopy.  These studies will provide important insights into the mechanism of polysaccharide transport across a membrane barrier.  As the polysaccharide capsule provides the bacterium with strength and rigidity, the potential to inhibit the transport machinery may be a means of weakening pathogenic bacteria and thus may provide for the future development of therapeutic approaches to treat Neisseria meningitidis.

Education/Academic qualification

English, Diploma, Université Clermont Auvergne

Sep 2016Jul 2018

Biochemistry, Master of Science, Université Laval

Sep 2014Aug 2016

Biology, Diploma, Aix-Marseille Université

Sep 2012Jul 2014

Biochemistry, License (Bachelor), Universite Claude Bernard Lyon 1

Sep 2012Jul 2014

1st Year Biology, Chemistry, Physics, Earth Sciences (Preparatory Class), equivalent to 1st year of bachelor, Lycée du Parc

Sep 2011Jul 2012

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