Lorelei Masselot--Joubert

Lorelei Masselot--Joubert

BSc, MSc, Miss, Doctor of Philosophy Student

If you made any changes in Pure these will be visible here soon.

Personal profile


Structural characterization of capsular transporter proteins from Neisseria meningitidis  

Neisseria meningitidis is a Gram-negative bacterium which is the causative agent for bacterial meningitis. Pathogenic Neisseria is surrounded by a polysaccharide capsule, the building components of which are biologically synthesised in the cytoplasm and are then exported by an ABC-transporter-dependent system to the exterior of the bacterial cell. This polysaccharide exporter machinery is composed of four proteins: CtrCD the ABC-transporter anchored in the inner membrane, CtrB the polysaccharide copolymerase, anchored in the inner membrane and containing a periplasmic facing domain and CtrA, an outer membrane exporter. My project is focused on the structural and biophysical studies of this exporter machinery.  These studies will utilise methods including X-ray crystallography and cryo-electron microscopy.  These studies will provide important insights into the mechanism of polysaccharide transport across a membrane barrier.  As the polysaccharide capsule provides the bacterium with strength and rigidity, the potential to inhibit the transport machinery may be a means of weakening pathogenic bacteria and thus may provide for the future development of therapeutic approaches to treat Neisseria meningitidis.

Education/Academic qualification

English, Diploma, Université Clermont Auvergne

Sep 2016Jul 2018

Biochemistry, Master of Science, Université Laval

Sep 2014Aug 2016

Biology, Diploma, Aix-Marseille Université

Sep 2012Jul 2014

Biochemistry, License (Bachelor), Universite Claude Bernard Lyon 1

Sep 2012Jul 2014

1st Year Biology, Chemistry, Physics, Earth Sciences (Preparatory Class), equivalent to 1st year of bachelor, Lycée du Parc

Sep 2011Jul 2012


Dive into the research topics where Lorelei Masselot--Joubert is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles