Research output per year
Research output per year
Personal profile
Biography
I am part of the Sarcoma Translational Research team in the Cancer Centre at Telethon Kids Institute. I am currently working on improving responses to immunotherapy by targeting novel targets in combination with standard care of immunotherapy.
I graduated from ITESM campus Guadalajara, in Mexico, in 2013 with a Bachelor of Science majoring in Biotechnology Engineering. I then completed a Master of Science in Stem Cell Technology in 2016 at the University of Nottingham in UK.
In 2018, I started my PhD at the National Centre for Asbestos Related Diseases in Perth, at the University of Western Australia, focusing on mesothelioma and identification of novel therapy targets.
Early in 2023, I completed my PhD in Biomedical Sciences. In 2022, while completing my PhD, I was hired as a Research Officer in the Sarcoma Translational Research team where I also work as Biological Lead in Setonix Pharmaceuticals, in the project ‘Enhancing immuno-oncology with small molecules drugs’, with the main goal of targeting specific molecules to improve immunotherapy outcomes for cancer patients.
Languages
Spanish (native), English (IELTS 8, C1)
Education/Academic qualification
Biomedical Sciences, PhD, Identifying novel therapeutic targets in mesothelioma, The University of Western Australia
Oct 2018 → Feb 2023
Award Date: 23 Feb 2023
Stem Cell Technology, MSc, : Investigation into the potential of corneal stromal stem cells as an anti-inflammatory therapy using an in vitro injury model, University of Nottingham
Sept 2015 → Sept 2016
Award Date: 13 Dec 2016
Biotechnology Engineering, BSc, Instituto Tecnologico y de Estudios Superiores de Monterrey, Campus Guadalajara
10 Aug 2009 → 15 Dec 2013
Award Date: 15 Dec 2013
External positions
Postdoctoral Researcher, The Kids Research Institute Australia (Telethon Kids Institute)
1 Jul 2023 → …
Research Officer, The Kids Research Institute Australia (Telethon Kids Institute)
1 Jul 2022 → 30 Jun 2023
Research expertise keywords
- Cancer immunotherapy
- Drug Targets
- Tumour Immunology
- Tumour microenvironment
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models
Orozco Morales, M. L., Lansley, S. M., Chin, W. L., Tilsed, C. M., Principe, N., Leslie, C., Vitali, B. J., Rwandamuriye, F. X., de Jong, E., Kidman, J., Zemek, R. M., Rinaldi, C. A., Lassmann, T., Bosco, A., Lee, Y. C. G., Lake, R. A., Chee, J. & Lesterhuis, W. J., Feb 2026, In: Scientific Reports. 16, 1, p. 1-14 14 p., 10473.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade
Principe, N., Phung, A. L., Stevens, K. L. P., Elaskalani, O., Wylie, B., Tilsed, C. M., Sheikh, F., Orozco Morales, M. L., Kidman, J., Marcq, E., Fisher, S. A., Nowak, A. K., McDonnell, A. M., Lesterhuis, W. J. & Chee, J., 28 Sept 2024, In: Journal for immunotherapy of cancer. 12, 9, 15 p., e008568.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Link opens in a new tab Citations (Scopus)78 Downloads (Pure) -
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade
Rwandamuriye, F. X., Wang, T., Zhang, H., Elaskalani, O., Kuster, J., Ye, X., Vitali, B., Schreurs, J., Orozco Morales, M. L., Norret, M., Evans, C. W., Zemek, R. M., Iyer, K. S., Lesterhuis, W. J. & Wylie, B., Aug 2024, In: OncoImmunology. 13, 1, 10 p., 2395067.Research output: Contribution to journal › Article › peer-review
Open Access -
Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner
Tilsed, C. M., Morales, M. L. O., Zemek, R. M., Gordon, B. A., Piggott, M. J., Nowak, A. K., Fisher, S. A., Lake, R. A. & Lesterhuis, W. J., 13 Feb 2024, In: BMC Cancer. 24, 1, 11 p., 203.Research output: Contribution to journal › Article › peer-review
Open Access -
Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Lee, Y. C. G., Zemek, R. M., Bosco, A., Lake, R. A. & Lesterhuis, W. J., May 2023, In: PLoS One. 18, 5, e0274364.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)
Datasets
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Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner
Tilsed, C. M. (Contributor), Morales, M. L. O. (Contributor), Zemek, R. M. (Contributor), Gordon, B. A. (Contributor), Piggott, M. J. (Contributor), Nowak, A. K. (Contributor), Fisher, S. A. (Contributor), Lake, R. A. (Contributor) & Lesterhuis, W. J. (Contributor), Figshare, 14 Feb 2024
DOI: 10.6084/m9.figshare.c.7073211
Dataset
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Refuelling the immune system to eliminate cancer cells
Orozco, L. (Investigator 01), Lesterhuis, J. (Investigator 02), Piggott, M. (Investigator 03), Elaskalani, O. (Investigator 04), Principe, N. (Investigator 05), Chee, J. (Investigator 06), King, J. (Investigator 07) & Scaffidi, A. (Investigator 08)
2/02/26 → 2/02/27
Project: Research
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Boosting the immune system to eliminate cancer cells: A new therapeutic approach
Orozco, L. (Investigator 01)
Department of Health (Western Australia)
28/10/24 → 28/02/26
Project: Research