Livia Hool

Professor, BSc PhD Macq., Professor

  • The University of Western Australia (M309), 35 Stirling Highway,

    6009 Perth

    Australia

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Personal profile

Biography

* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established the Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC Career Development Award Fellow 2004 –2009
* ARC Future Fellow and Honorary NHMRC Senior Research Fellow 2011 - 2014
* NHMRC Senior Research Fellow 2015-16

NHMRC Senior Research Fellowship 2017-21

Funding overview

NHMRC Project Grant 2006-2008
NHMRC Project Grant 2009-2011
NHMRC Project Grant 2010-2012
NHMRC Project Grant 2011-2013
NHMRC Project Grant 2013-2015
NHMRC Project Grant 2014-2016

NHMRC Project Grant 2016-19

NHMRC Project Grant 2018-21

NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
ARC Future Fellowship

Current projects

PhD Students

- Mr Ashay Shah (Co-supervised with Assoc Prof Swaminathan Iyer)

- Mr Ian Chin (Co-supervised with Assoc Prof Yu Suk Choi)
- Dr Warren Pavey (Co-supervised with Dr KM Ho)
- Ms Laetitia Hughes (Co-supervised with Professor Aleksandra Filipovska)

-Ms Jessica Baker (Co-supervised with Professor Aleksandra Filipovska)


Postdoctoral staff
Dr Helena Viola
Dr Henrietta Cserne Szappanos
Dr Naaz Andharia

Research Assistant

Ms Tanya Solomon

Honours students/BPhil students
Mr Ege Eroglu

Potential Student Projects

- Improving efficacy of AID peptide in treatment of familial hypertrophic cardiomyopathy
- Elucidating structure/function of the L-type calcium channel alpha (Cav1.2) subunit


Collaborators

-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-Professor Christopher Semsarian, Centenary Institute Sydney

-Dr Adam Hill VCCRI
-Professors Kricket Seidman and Jon Seidman, Harvard University, USA
-Professor Swaminatha Iyer, Chemistry and Biochemistry, UWA
-Professor Nigel Laing, The Harry Perkins Institute for Medical Research
-Professor Aleksandra Filipovska, The Harry Perkins Institute for Medical Research
-Assoc Professor Marco Casarotto ANU
-Assoc Prof Evan Ingley, The Harry Perkins Institute for Medical Research
- Professor Ken Roos, University of California Los Angeles
- Professor Filip van Petegem University of British Columbia

Teaching overview

PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3002 Physiology of Cardiovascular and Respiratory Systems

Research

1. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy

Research expertise keywords

  • Cardiac electrophysiology
  • Membrane transport
  • Cardiovascular physiology
  • Calcium transport
  • Patch-clamp technology
  • Echocardiography
  • Cardiac physiology

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