Livia Hool

Professor, BSc PhD Macq., Professor

  • The University of Western Australia (M311), 35 Stirling Highway, Room 1.96, Physiology Building, Perth campus

    6009 Perth

    Australia

  • 1645 Citations
  • 22 h-Index
1993 …2021
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Personal profile

Biography

* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established the Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC Career Development Award Fellow 2004 –2009
* ARC Future Fellow and Honorary NHMRC Senior Research Fellow 2011 - 2014
* NHMRC Senior Research Fellow 2015-16

NHMRC Senior Research Fellowship 2017-21

Funding overview

NHMRC Project Grant 2006-2008
NHMRC Project Grant 2009-2011
NHMRC Project Grant 2010-2012
NHMRC Project Grant 2011-2013
NHMRC Project Grant 2013-2015
NHMRC Project Grant 2014-2016

NHMRC Project Grant 2016-19

NHMRC Project Grant 2018-21

NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
ARC Future Fellowship

Current projects

PhD Students

- Mr Ashay Shah (Co-supervised with Assoc Prof Swaminathan Iyer)

- Mr Ian Chin (Co-supervised with Assoc Prof Yu Suk Choi)
- Dr Warren Pavey (Co-supervised with Dr KM Ho)
- Ms Laetitia Hughes (Co-supervised with Professor Aleksandra Filipovska)


Postdoctoral staff
Dr Helena Viola
Dr Henrietta Cserne Szappanos
Dr Naaz Andharia

Research Assistant

Ms Tanya Solomon

Honours students/BPhil students
Mr Ege Eroglu

Potential Student Projects

-Which cysteines on the L-type calcium channel are modified by reactive oxygen species? (Hons/PhD level)
- Improving efficacy of AID peptide in treatment of familial hypertrophic cardiomyopathy
- Improving efficacy of uptake of oligomers in treatment of Duchenne Muscular Dystrophy cardiomyopathy
Collaborators

-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-Professor Boris Martinac, Victor Chang Cardiac Research Institute Sydney
-Professor Christopher Semsarian, Centenary Institute Sydney
-Professors Kricket Seidman and Jon Seidman, Harvard University, USA
-Professor Swaminatha Iyer, Chemistry and Biochemistry, UWA
-Professor Nigel Laing, The Harry Perkins Institute for Medical Research
-Professor Aleksandra Filipovska, The Harry Perkins Institute for Medical Research
-Assoc Prof Ben Corry, ANU
-Assoc Prof Evan Ingley, The Harry Perkins Institute for Medical Research
- Professor Ken Roos, University of California Los Angeles
- Dr Pilar Blancafort The Harry Perkins Institute for Medical Research
- Professors Sue Fletcher and Steve Wilton, Murdoch University
- Professor Susan Hamilton Baylor Medical Center Houston Texas

Teaching overview

PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3002 Physiology of Cardiovascular and Respiratory Systems

Research

1. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy

Keywords

  • Cardiac electrophysiology
  • Membrane transport
  • Cardiovascular physiology
  • Calcium transport
  • Patch-clamp technology
  • Echocardiography
  • Cardiac physiology

Fingerprint Dive into the research topics where Livia Hool is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Calcium Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
L-Type Calcium Channels Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Cardiomyopathies Medicine & Life Sciences
Oxidative Stress Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2019

A Review of in vitro Platforms for Understanding Cardiomyocyte Mechanobiology

Chin, I. L., Hool, L. & Choi, Y. S., 5 Jun 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 10 p., 133.

Research output: Contribution to journalReview article

Open Access
Open Access
Hypertrophic Cardiomyopathy
Cardiac Myosins
Calcium
Drug therapy
Mutation

Millimeter wave radiation activates leech nociceptors via TRPV1-like receptor sensitization

Romanenko, S., Harvey, A. R., Hool, L., Fan, S. & Wallace, V. P., 25 Apr 2019, In : Biophysical Journal. p. 2331-2345 15 p.

Research output: Contribution to journalArticle

Leeches
Nociceptors
Heating
Action Potentials
Radiation

Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions

Olivé, M., Engvall, M., Ravenscroft, G., Cabrera-Serrano, M., Jiao, H., Bortolotti, C. A., Pignataro, M., Lambrughi, M., Jiang, H., Forrest, A. R. R., Benseny-Cases, N., Hofbauer, S., Obinger, C., Battistuzzi, G., Bellei, M., Borsari, M., Di Rocco, G., Viola, H. M., Hool, L. C., Cladera, J. & 24 othersLagerstedt-Robinson, K., Xiang, F., Wredenberg, A., Miralles, F., Baiges, J. J., Malfatti, E., Romero, N. B., Streichenberger, N., Vial, C., Claeys, K. G., Straathof, C. S. M., Goris, A., Freyer, C., Lammens, M., Bassez, G., Kere, J., Clemente, P., Sejersen, T., Udd, B., Vidal, N., Ferrer, I., Edström, L., Wedell, A. & Laing, N. G., 1 Dec 2019, In : Nature Communications. 10, 1, 1396.

Research output: Contribution to journalArticle

Open Access
myoglobin
Myoglobin
Muscular Diseases
inclusions
muscles
1 Citation (Scopus)

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy

Viola, H. M., Johnstone, V. P. A., Adams, A. M., Fletcher, S. & Hool, L. C., 1 Jun 2018, In : JACC: Basic to Translational Science. 3, 3, p. 391-402 12 p.

Research output: Contribution to journalArticle

Open Access
Morpholinos
Duchenne Muscular Dystrophy
Cardiomyopathies
Walking
Clinical Trials

Datasets

Evidence for redox sensing by a human cardiac calcium channel

Hool, L. (Creator), The University of Western Australia, 14 Apr 2016

Dataset

File

Projects 1998 2021