Livia Hool

Associate Professor, BSc PhD Macq.

  • The University of Western Australia (M311), 35 Stirling Highway, Room 1.96, Physiology Building, Perth campus

    6009 Perth

    Australia

  • 1289 Citations
  • 20 h-Index
1993 …2021
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Personal profile

Biography

* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established the Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC Career Development Award Fellow 2004 –2009
* ARC Future Fellow and Honorary NHMRC Senior Research Fellow 2011 - 2014
* NHMRC Senior Research Fellow 2015

Funding overview

NHMRC Project Grant 2006-2008
NHMRC Project Grant 2009-2011
NHMRC Project Grant 2010-2012
NHMRC Project Grant 2011-2013
NHMRC Project Grant 2013-2015
NHMRC Project Grant 2014-2016
NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
ARC Future Fellowship

Current projects

PhD Students

- Stephanie Grehl - Use of rTMS in neurons (Co-supervised with Assoc Prof Jenny Rodger)
- Elizabeth Johnstone - G protein coupled receptors and disease (Co-supervised with Assoc Prof Kevin Pfleger)
- Padmapriya Muralidharan - Role of cysteines in redox modification of L type calcium channel function (Co-supervised with Assoc Prof Evan Ingley)


Postdoctoral staff
Dr Helena Viola
Dr Henrietta Cserne Szappanos
Dr Vicky Johnstone

Honours students/BPhil students
Mr Saiuj Bhat
Mr James Constantine
Mr Ashay Shah
Ms Emma Lu

Potential Student Projects

-Which cysteines on the L-type calcium channel are modified by reactive oxygen species? (Hons/PhD level)
- Improving efficacy of AID peptide in treatment of familial hypertrophic cardiomyopathy
- Improving efficacy of uptake of oligomers in treatment of Duchenne Muscular Dystrophy cardiomyopathy
Collaborators

-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-Professor Boris Martinac, Victor Chang Cardiac Research Institute Sydney
-Professor Christopher Semsarian, Centenary Institute Sydney
-Professors Kricket Seidman and Jon Seidman, Harvard University, USA
-Professor Swaminatha Iyer, Chemistry and Biochemistry, UWA
-Professor Nigel Laing, The Harry Perkins Institute for Medical Research
-Professor Aleksandra Filipovska, The Harry Perkins Institute for Medical Research
-Assoc Prof Ben Corry, ANU
-Assoc Prof Evan Ingley, The Harry Perkins Institute for Medical Research
- Professor Ken Roos, University of California Los Angeles
- Dr Pilar Blancafort The Harry Perkins Institute for Medical Research
- Professors Sue Fletcher and Steve Wilton, Murdoch University
- Professor Susan Hamilton Baylor Medical Center Houston Texas

Teaching overview

PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3002 Physiology of Cardiovascular and Respiratory Systems

Research

1. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy

Keywords

  • Cardiac electrophysiology
  • Membrane transport
  • Cardiovascular physiology
  • Calcium transport
  • Patch-clamp technology
  • Echocardiography
  • Cardiac physiology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 9 Similar Profiles
Calcium Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
L-Type Calcium Channels Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Oxidative Stress Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Calcium Channels Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1998 2021

Research Output 1993 2018

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy

Viola, H. M., Johnstone, V. P. A., Adams, A. M., Fletcher, S. & Hool, L. C., 1 Jun 2018, In : JACC: Basic to Translational Science. 3, 3, p. 391-402 12 p.

Research output: Contribution to journalArticle

Open Access
Morpholinos
Duchenne Muscular Dystrophy
Cardiomyopathies
Walking
Clinical Trials

A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery

Hoffmann, K., Milech, N., Juraja, S. M., Cunningham, P. T., Stone, S. R., Francis, R. W., Anastasas, M., Hall, C. M., Heinrich, T., Bogdawa, H. M., Winslow, S., Scobie, M. N., Dewhurst, R. E., Florez, L., Ong, F., Kerfoot, M., Champain, D., Adams, A. M., Fletcher, S., Viola, H. M. & 10 othersHool, L. C., Connor, T., Longville, B. A. C., Tan, Y. F., Kroeger, K., Morath, V., Weiss, G. A., Skerra, A., Hopkins, R. M. & Watt, P. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 12538.

Research output: Contribution to journalArticle

Open Access
Cell-Penetrating Peptides
Cytoplasm
Peptide Nucleic Acids
Cell Engineering
Bacterial Genomes
1 Citations

Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z

Siira, S. J., Rossetti, G., Richman, T. R., Perks, K., Ermer, J. A., Kuznetsova, I., Hughes, L., Shearwood, A. M. J., Viola, H. M., Hool, L. C., Rackham, O. & Filipovska, A., 1 Oct 2018, In : EMBO Reports. 19, 10, e46198.

Research output: Contribution to journalArticle

Nuclear RNA
Untranslated RNA
Transfer RNA
MicroRNAs
Small Nucleolar RNA
2 Citations

PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly

Perks, K. L., Rossetti, G., Kuznetsova, I., Hughes, L. A., Ermer, J. A., Ferreira, N., Busch, J. D., Rudler, D. L., Spahr, H., Schöndorf, T., Shearwood, A. M. J., Viola, H. M., Siira, S. J., Hool, L. C., Milenkovic, D., Larsson, N. G., Rackham, O. & Filipovska, A., 3 Apr 2018, In : Cell Reports. 23, 1, p. 127-142 16 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Organelle Biogenesis
Large Ribosome Subunits
Proteins
Premature Mortality
5 Citations

Adult-onset obesity is triggered by impaired mitochondrial gene expression

Perks, K. L., Ferreira, N., Richman, T. R., Ermer, J. A., Kuznetsova, I., Shearwood, A-M. J., Lee, R. G., Viola, H. M., Johnstone, V. P. A., Matthews, V., Hool, L. C., Rackham, O. & Filipovska, A., Aug 2017, In : Science Advances. 3, 8, p. e1700677

Research output: Contribution to journalArticle

Open Access
Haploinsufficiency
Mitochondrial Genes
Obesity
Gene Expression
RNA

Datasets

Evidence for redox sensing by a human cardiac calcium channel

Hool, L. (Creator), The University of Western Australia, 14 Apr 2016

Dataset

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