Research output per year
Research output per year
Personal profile
Biography
* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established the Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC Career Development Award Fellow 2004 –2009
* ARC Future Fellow and Honorary NHMRC Senior Research Fellow 2011 - 2014
* NHMRC Senior Research Fellow 2015-16
NHMRC Senior Research Fellowship 2017-21
Funding overview
NHMRC Project Grant 2006-2008
NHMRC Project Grant 2009-2011
NHMRC Project Grant 2010-2012
NHMRC Project Grant 2011-2013
NHMRC Project Grant 2013-2015
NHMRC Project Grant 2014-2016
NHMRC Project Grant 2016-19
NHMRC Project Grant 2018-21
NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
ARC Future Fellowship
Current projects
PhD Students
- Mr Ashay Shah (Co-supervised with Assoc Prof Swaminathan Iyer)
- Mr Ian Chin (Co-supervised with Assoc Prof Yu Suk Choi)
- Dr Warren Pavey (Co-supervised with Dr KM Ho)
- Ms Laetitia Hughes (Co-supervised with Professor Aleksandra Filipovska)
-Ms Jessica Baker (Co-supervised with Professor Aleksandra Filipovska)
Postdoctoral staff
Dr Helena Viola
Dr Henrietta Cserne Szappanos
Dr Naaz Andharia
Research Assistant
Ms Tanya Solomon
Honours students/BPhil students
Mr Ege Eroglu
Potential Student Projects
- Improving efficacy of AID peptide in treatment of familial hypertrophic cardiomyopathy
- Elucidating structure/function of the L-type calcium channel alpha (Cav1.2) subunit
Collaborators
-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-Professor Christopher Semsarian, Centenary Institute Sydney
-Dr Adam Hill VCCRI
-Professors Kricket Seidman and Jon Seidman, Harvard University, USA
-Professor Swaminatha Iyer, Chemistry and Biochemistry, UWA
-Professor Nigel Laing, The Harry Perkins Institute for Medical Research
-Professor Aleksandra Filipovska, The Harry Perkins Institute for Medical Research
-Assoc Professor Marco Casarotto ANU
-Assoc Prof Evan Ingley, The Harry Perkins Institute for Medical Research
- Professor Ken Roos, University of California Los Angeles
- Professor Filip van Petegem University of British Columbia
Teaching overview
PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3002 Physiology of Cardiovascular and Respiratory Systems
Research
1. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research expertise keywords
- Cardiac electrophysiology
- Membrane transport
- Cardiovascular physiology
- Calcium transport
- Patch-clamp technology
- Echocardiography
- Cardiac physiology
Fingerprint
Dive into the research topics where Livia Hool is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Immune exhaustion in ME/CFS and long COVID
Eaton-Fitch, N., Rudd, P., Er, T., Hool, L., Herrero, L. & Marshall-Gradisnik, S., 22 Oct 2024, In: JCI Insight. 9, 20, 19 p., e183810.Research output: Contribution to journal › Article › peer-review
Open Access -
Physiology: A perspective from the Australian experience
Murphy, R., Lamon, S. & Hool, L., Sept 2024, In: Physiological Reports. 12, 17, e70045.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Citation (Scopus) -
Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy
Lim, S., Mangala, M. M., Holliday, M., Cserne Szappanos, H., Barratt-Ross, S., Li, S., Thorpe, J., Liang, W., Ranpura, G. N., Vandenberg, J. I., Semsarian, C., Hill, A. P. & Hool, L. C., Aug 2024, In: Disease models & mechanisms. 17, 8, 12 p., dmm050407.Research output: Contribution to journal › Article › peer-review
Open Access -
A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology
Viola, H. M., Richworth, C., Solomon, T., Chin, I. L., Szappanos, H. C., Sundararaj, S., Shishmarev, D., Casarotto, M. G., Choi, Y. S. & Hool, L. C., 3 Jan 2023, In: Communications Biology. 6, 1, 13 p., 4.Research output: Contribution to journal › Article › peer-review
Open Access -
Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy
Cserne Szappanos, H., Viola, H. M., Ito, D. W., Lim, S., Mangala, M., Holliday, M., Barratt Ross, S., Semsarian, C., Hill, A., Dixon, R. E. & Hool, L. C., Dec 2023, In: Scientific Reports. 13, 1, p. 11296 1 p., 11296.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Datasets
-
Evidence for redox sensing by a human cardiac calcium channel
Hool, L. (Creator), The University of Western Australia, 14 Apr 2016
Dataset
File -
Additional file 3 of Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Fear, V. S. (Creator), Forbes, C. A. (Creator), Shaw, N. C. (Creator), Farley, K. O. (Creator), Mantegna, J. L. (Creator), Htun, J. P. (Creator), Syn, G. (Creator), Viola, H. (Creator), Cserne Szappanos, H. (Creator), Hool, L. (Creator), Ward, M. (Creator), Baynam, G. (Creator) & Lassmann, T. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26649507, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Gene_editing_and_cardiac_disease_modelling_for_the_interpretation_of_genetic_variants_of_uncertain_significance_in_congenital_heart_disease/26649507
Dataset
-
Additional file 3 of Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Fear, V. S. (Creator), Forbes, C. A. (Creator), Shaw, N. C. (Creator), Farley, K. O. (Creator), Mantegna, J. L. (Creator), Htun, J. P. (Creator), Syn, G. (Creator), Viola, H. (Creator), Cserne Szappanos, H. (Creator), Hool, L. (Creator), Ward, M. (Creator), Baynam, G. (Creator) & Lassmann, T. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26649507.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Gene_editing_and_cardiac_disease_modelling_for_the_interpretation_of_genetic_variants_of_uncertain_significance_in_congenital_heart_disease/26649507/1
Dataset
-
A screening tool to determine children at risk of developing hypertrophic cardiomyopathy
Reinke, D. (Investigator 01) & Hool, L. (Investigator 02)
1/02/24 → 31/07/25
Project: Research
-
The Australian Functional Genomics Network
Laing, N. (Investigator 01), Hool, L. (Investigator 02), Sinclair, A. (Investigator 03), Christodoulou, J. (Investigator 04), Mattiske, T. (Investigator 05), Tan, T. (Investigator 06) & Stark, Z. (Investigator 07)
Medical Research Future Fund MRFF
1/06/21 → 31/05/26
Project: Research
-
Integrating biology and medicine to develop 3D-structure guided drug design for treatment of cardiovascular disease
Hool, L. (Investigator 01), Ingley, E. (Investigator 03) & Viola, H. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/21 → 31/12/25
Project: Research
-
Zeiss Celldiscoverer7 for automated high resolution imaging of complex biomedical samples
Fox, A. (Investigator 01), Choi, Y. S. (Investigator 02), Rodger, J. (Investigator 03), Tang, A. (Investigator 04), Hool, L. (Investigator 05), Pillow, J. (Investigator 06), Lister, R. (Investigator 07), Bond, C. (Investigator 08), Hodgetts, S. (Investigator 09), Chen, K. (Investigator 10), Blancafort, P. (Investigator 11), Redfern, A. (Investigator 12), Swaminatha Iyer, I. (Investigator 13), Smith, N. (Investigator 14), Marshall, A. (Investigator 15), Fear, M. (Investigator 16), Wood, F. (Investigator 17), Evans, C. (Investigator 18), Chooi, H. (Investigator 19) & Rassell, A. (Investigator 20)
NHMRC National Health and Medical Research Council
1/07/22 → 31/10/23
Project: Research
-
Press/Media
-
$15 million in funding to support health and medical research
Green, D., Ingley, E., Miller, K., Hool, L., Coffin, J., Dickinson, J., Richmond, P., Fuller, K., Erber, W., Fatovich, D., Winteringham, L., Naylor, L., Milroy, H., Wittek, A., Viola, H., Ganss, R., Zhu, K., Mullin, B., Johansson-Percival, A., Satiaputra, J., Chakera, A., Cabrera Serrano, M., Haynes, A., McCutcheon, D., Richards, T., Cross, D., Hui, H., McVeigh, J., Parizel, P. M. & Mulroney, K.
15/12/20 → 16/12/20
3 items of Media coverage
Press/Media: Press / Media