Livia Hool

Professor, BSc PhD Macq., Professor

  • The University of Western Australia (M311), 35 Stirling Highway, Room 1.96, Physiology Building, Perth campus

    6009 Perth

    Australia

  • 1811 Citations
  • 24 h-Index
1993 …2020

Research output per year

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Personal profile

Biography

* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established the Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC Career Development Award Fellow 2004 –2009
* ARC Future Fellow and Honorary NHMRC Senior Research Fellow 2011 - 2014
* NHMRC Senior Research Fellow 2015-16

NHMRC Senior Research Fellowship 2017-21

Funding overview

NHMRC Project Grant 2006-2008
NHMRC Project Grant 2009-2011
NHMRC Project Grant 2010-2012
NHMRC Project Grant 2011-2013
NHMRC Project Grant 2013-2015
NHMRC Project Grant 2014-2016

NHMRC Project Grant 2016-19

NHMRC Project Grant 2018-21

NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
ARC Future Fellowship

Current projects

PhD Students

- Mr Ashay Shah (Co-supervised with Assoc Prof Swaminathan Iyer)

- Mr Ian Chin (Co-supervised with Assoc Prof Yu Suk Choi)
- Dr Warren Pavey (Co-supervised with Dr KM Ho)
- Ms Laetitia Hughes (Co-supervised with Professor Aleksandra Filipovska)


Postdoctoral staff
Dr Helena Viola
Dr Henrietta Cserne Szappanos
Dr Naaz Andharia

Research Assistant

Ms Tanya Solomon

Honours students/BPhil students
Mr Ege Eroglu

Potential Student Projects

-Which cysteines on the L-type calcium channel are modified by reactive oxygen species? (Hons/PhD level)
- Improving efficacy of AID peptide in treatment of familial hypertrophic cardiomyopathy
- Improving efficacy of uptake of oligomers in treatment of Duchenne Muscular Dystrophy cardiomyopathy
Collaborators

-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-Professor Boris Martinac, Victor Chang Cardiac Research Institute Sydney
-Professor Christopher Semsarian, Centenary Institute Sydney
-Professors Kricket Seidman and Jon Seidman, Harvard University, USA
-Professor Swaminatha Iyer, Chemistry and Biochemistry, UWA
-Professor Nigel Laing, The Harry Perkins Institute for Medical Research
-Professor Aleksandra Filipovska, The Harry Perkins Institute for Medical Research
-Assoc Prof Ben Corry, ANU
-Assoc Prof Evan Ingley, The Harry Perkins Institute for Medical Research
- Professor Ken Roos, University of California Los Angeles
- Dr Pilar Blancafort The Harry Perkins Institute for Medical Research
- Professors Sue Fletcher and Steve Wilton, Murdoch University
- Professor Susan Hamilton Baylor Medical Center Houston Texas

Teaching overview

PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3002 Physiology of Cardiovascular and Respiratory Systems

Research

1. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
2. Regulation of the L-type Ca2+ channel by adrenergic receptor stimulation during hypoxia and oxidative stress
3. Regulation of mitochondrial function by the L-type calcium channel and the role of the cytoskeleton
4. Targeting the L-type Ca2+ channel to prevent the development of cardiomyopathy
5. Use of nanoparticle technology to improve efficacy of therapy
6. Use of CRISPR-like technology to prevent hypertrophy
7. Improving efficacy of uptake of oligomers to treat Duchenne Muscular Dystrophy cardiomyopathy

Research expertise keywords

  • Cardiac electrophysiology
  • Membrane transport
  • Cardiovascular physiology
  • Calcium transport
  • Patch-clamp technology
  • Echocardiography
  • Cardiac physiology

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Research Output

L-type Ca2+ channel–mediated Ca2+ influx adjusts neuronal mitochondrial function to physiological and pathophysiological conditions

Hotka, M., Cagalinec, M., Hilber, K., Hool, L., Boehm, S. & Kubista, H., 14 Feb 2020, In : Science Signaling. 13, 618, eaaw6923.

Research output: Contribution to journalArticle

  • A Review of in vitro Platforms for Understanding Cardiomyocyte Mechanobiology

    Chin, I. L., Hool, L. & Choi, Y. S., 5 Jun 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 10 p., 133.

    Research output: Contribution to journalReview article

    Open Access

    Differences and Similarities between Millimetre Wave and Thermal Heating Effect on Action Potential Triggering in Leech Interneuron

    Romanenko, S., Siegel, P. H., Hool, L., Harvey, A. & Wallace, V., 2019, 2019 - 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz). USA: IEEE, Institute of Electrical and Electronics Engineers, 8873975. (International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz; vol. 2019-September).

    Research output: Chapter in Book/Conference paperConference paper

  • Fidelity of translation initiation is required for coordinated respiratory complex assembly

    Rudler, D. L., Hughes, L. A., Perks, K. L., Richman, T. R., Kuznetsova, I., Ermer, J. A., Abudulai, L. N., Shearwood, A-M. J., Viola, H. M., Hool, L. C., Siira, S. J., Rackham, O. & Filipovska, A., 20 Dec 2019, In : Science Advances. 5, 12, eaay2118.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)
    Open Access
  • 1 Citation (Scopus)

    Datasets

    Evidence for redox sensing by a human cardiac calcium channel

    Hool, L. (Creator), The University of Western Australia, 14 Apr 2016

    Dataset

    File

    Projects