• The University of Western Australia (M517), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1450 Citations
  • 22 h-Index
20052020
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Research Output 2005 2019

2019

Pathophysiology of voltage-gated potassium channels in a mouse model of cone-rod dystrophy

Jiang, X., Hunt, D. M. & Carvalho, L. S., Jul 2019, In : Investigative ophthalmology & visual science. 60, 9, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citation (Scopus)

The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations

Hart, N. S., Mountford, J. K., Voigt, V., Fuller-Carter, P., Barth, M., Nerbonne, J. M., Hunt, D. M. & Carvalho, L. S., Feb 2019, In : eNeuro. 6, 1, 13 p., UNSP ENEURO.0032-19.2019.

Research output: Contribution to journalArticle

Open Access
Voltage-Gated Potassium Channels
Retinal Diseases
Gene Knockout Techniques
Knockout Mice
Mutation
2018
10 Citations (Scopus)

Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo

Carvalho, L. S., Xiao, R., Wassmer, S. J., Langsdorf, A., Zinn, E., Pacouret, S., Shah, S., Comander, J. I., Kim, L. A., Lim, L. & Vandenberghe, L. H., Jul 2018, In : Human Gene Therapy. 29, 7, p. 771-784 14 p.

Research output: Contribution to journalArticle

Primates
Retinal Cone Photoreceptor Cells
Retina
Retinal Pigment Epithelium
Genes

Validation and comparison of Achromatopsia mouse lines expressing a fluorescent marker in cone photoreceptors

Carvalho, L. S., Voigt, V., Schuster, I., Fuller-Carter, P., Quesada, J. P., Vasiliou, S. & Hunt, D. M., Jul 2018, In : Investigative ophthalmology & visual science. 59, 9, 3 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2017
13 Citations (Scopus)

Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting

Carvalho, L. S., Turunen, H. T., Wassmer, S. J., Luna-Velez, M. V., Xiao, R., Bennett, J. & Vandenberghe, L. H., 8 Sep 2017, In : Frontiers in Neuroscience. 11, 8 p., 503.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

Wassmer, S. J., Carvalho, L. S., György, B., Vandenberghe, L. H. & Maguire, C. A., 31 Mar 2017, In : Scientific Reports. 7, 45329.

Research output: Contribution to journalArticle

Open Access
Exosomes
Intravitreal Injections
Green Fluorescent Proteins
Retina
Genes
12 Citations (Scopus)

The genetic and evolutionary drives behind primate color vision

Carvalho, L. S., Pessoa, D. M. A., Mountford, J. K., Davies, W. I. L. & Hunt, D. M., 26 Apr 2017, In : Frontiers in Ecology and Evolution. 5, 34.

Research output: Contribution to journalReview article

Open Access
color vision
primate
pigment
Primates
pigments
2016

The Genetics of Color Vision and Congenital Color Deficiencies

Hunt, D. & dos Santos Carvalho, L., 16 Dec 2016, Human Color Vision. Kremers, J., Baraas, R. C. & Marshall, N. J. (eds.). Springer International Publishing Switzerland, p. 1-32

Research output: Chapter in Book/Conference paperChapter

Color Vision
Color Vision Defects
Color
Cone Opsins
Primates
2 Citations (Scopus)

Understanding Cone Photoreceptor Cell Death in Achromatopsia

Carvalho, L. S. & Vandenberghe, L. H., 2016, Retinal Degenerative Diseases: Mechanisms and Experimental Therapy. Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J. & Ash, J. (eds.). Springer, Vol. 854. p. 231-236 6 p. (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Conference paperConference paper

Color Vision Defects
Retinal Cone Photoreceptor Cells
Color Vision
Cell Death
Retinal Dystrophies
2015
17 Citations (Scopus)

Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease

Yazid, S., Gardner, P. J., Carvalho, L., Chu, C. J., Flower, R. J., Solito, E., Lee, R. W. J., Ali, R. R. & Dick, A. D., 1 Apr 2015, In : Journal of Autoimmunity. 58, p. 1-11 11 p.

Research output: Contribution to journalArticle

Annexin A1
Th17 Cells
Autoimmune Diseases
Retinal Diseases
Uveitis
10 Citations (Scopus)

Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age

Herrmann, P., Cowing, J. A., Cristante, E., Liyanage, S. E., Ribeiro, J., Duran, Y., Abelleira Hervas, L., Carvalho, L. S., Bainbridge, J. W. B., Luhmann, U. F. O. & Ali, R. R., Sep 2015, In : Neurobiology of Aging. 36, 9, p. 2637-2648 12 p.

Research output: Contribution to journalArticle

Open Access
Choroid
Retinal Pigment Epithelium
Alternative Complement Pathway
Light
Retinal Degeneration
41 Citations (Scopus)

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

Nishiguchi, K. M., Carvalho, L. S., Rizzi, M., Powell, K., Holthaus, S-M. K., Azam, S. A., Duran, Y., Ribeiro, J., Luhmann, U. F. O., Bainbridge, J. W. B., Smith, A. J. & Ali, R. R., Feb 2015, In : Nature Communications. 6, 7006.

Research output: Contribution to journalArticle

Open Access
gene therapy
Gene therapy
mutations
Genetic Therapy
mice
107 Citations (Scopus)
99 Downloads (Pure)

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

Zinn, E., Pacouret, S., Khaychuk, V., Turunen, H. T., Carvalho, L. S., Andres-Mateos, E., Shah, S., Shelke, R., Maurer, A. C., Plovie, E., Xiao, R. & Vandenberghe, L. H., 11 Aug 2015, In : Cell Reports. 12, 6, p. 1056-1068 13 p.

Research output: Contribution to journalArticle

Open Access
File
Gene therapy
Dependovirus
Viruses
Genetic Therapy
Computer Simulation
23 Citations (Scopus)

Promising and delivering gene therapies for vision loss

Carvalho, L. S. & Vandenberghe, L. H., Jun 2015, In : Vision Research. 111, Part B, p. 124-133 10 p.

Research output: Contribution to journalArticle

Open Access
Genetic Therapy
Inborn Genetic Diseases
Genetic Engineering
Technology
Safety
27 Citations (Scopus)

The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors

Luhmann, U. F. O., Carvalho, L. S., Holthaus, S-M. K., Cowing, J. A., Greenaway, S., Chu, C. J., Herrmann, P., Smith, A. J., Munro, P. M. G., Potter, P., Bainbridge, J. W. B. & Ali, R. R., 1 Jan 2015, In : Human Molecular Genetics. 24, 1, p. 128-141 14 p.

Research output: Contribution to journalArticle

Open Access
Pathology
Mutation
Telangiectasis
Genetic Association Studies
Retinal Dystrophies
2013
34 Citations (Scopus)

Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography

Chu, C. J., Herrmann, P., Carvalho, L. S., Liyanage, S. E., Bainbridge, J. W. B., Ali, R. R., Dick, A. D. & Luhmann, U. F. O., 2013, In : PLoS One. 8, 5, p. e63002

Research output: Contribution to journalArticle

Open Access
Optical tomography
tomography
Optical Coherence Tomography
mice
Histology
31 Citations (Scopus)

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration

Luhmann, U. F. O., Carvalho, L. S., Robbie, S. J., Cowing, J. A., Duran, Y., Munro, P. M. G., Bainbridge, J. W. B. & Ali, R. R., Feb 2013, In : Experimental Eye Research. 107, p. 80-87 8 p.

Research output: Contribution to journalArticle

Open Access
Retinal Degeneration
Chemokines
Macrophages
Microglia
Ophthalmoscopy
18 Citations (Scopus)

How parrots see their colours: Novelty in the visual pigments of Platycercus elegans

Knott, B., Davies, W., dos Santos Carvalho, L., Berg, M. L., Buchanan, K. L., Bowmaker, J. K., Bennett, A. T. D. & Hunt, D., 2013, In : Journal of Experimental Biology. 216, 23, p. 4454-4461

Research output: Contribution to journalArticle

Parrots
Retinal Pigments
parrots
Birds
pigment
224 Citations (Scopus)

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

Gonzalez-Cordero, A., West, E. L., Pearson, R. A., Duran, Y., Carvalho, L. S., Chu, C. J., Naeem, A., Blackford, S. J. I., Georgiadis, A., Lakowski, J., Hubank, M., Smith, A. J., Bainbridge, J. W. B., Sowden, J. C. & Ali, R. R., Aug 2013, In : Nature Biotechnology. 31, 8, p. 741-747 7 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Cell culture
Retina
Cell Culture Techniques
Open Access
2012
44 Citations (Scopus)

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling

Luhmann, U. F. O., Lange, C. A., Robbie, S. J., Munro, P. M. G., Cowing, J. A., Armer, H. E. J., Luong, V., Carvalho, L. S., MacLaren, R. E., Fitzke, F. W., Bainbridge, J. W. B. & Ali, R. R., 2012, In : PLoS One. 7, 4, p. e35551

Research output: Contribution to journalArticle

Open Access
Retinal Degeneration
chemokines
Chemokines
Knockout Mice
Modulation
38 Citations (Scopus)
2011
105 Citations (Scopus)

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy

Carvalho, L. S., Xu, J., Pearson, R. A., Smith, A. J., Bainbridge, J. W. B., Morris, L. M., Fliesler, S. J., Ding, X-Q. & Ali, R. R., 15 Aug 2011, In : Human Molecular Genetics. 20, 16, p. 3161-75 15 p.

Research output: Contribution to journalArticle

Color Vision Defects
Genetic Therapy
Visual Acuity
Cone Opsins
Arrestin
30 Citations (Scopus)

Ultraviolet-sensitive vision in long-lived birds

dos Santos Carvalho, L., Knott, B., Berg, M. L., Bennett, A. T. D. & Hunt, D., 2011, In : Proceedings of the Royal Society B: Biological Sciences. 278, p. 107–114

Research output: Contribution to journalArticle

2009
23 Citations (Scopus)

Cone visual pigments in two species of South American marsupials

Hunt, D., Chan, J., dos Santos Carvalho, L., Hokoc, J., Ferguson, M., Arrese, C. & Beazley, L., 2009, In : Gene. 433, 1-2, p. 50-55

Research output: Contribution to journalArticle

Marsupialia
Retinal Pigments
Monodelphis
Cone Opsins
Opossums
128 Citations (Scopus)
Mammals
Retinal Pigments
Birds
Tuning
Genes
45 Citations (Scopus)

Into the blue: Gene duplication and loss underlie color vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii

Davies, W. L., dos Santos Carvalho, L., Tay, B-H., Brenner, S., Hunt, D. & Venkatesh, B., 2009, In : Genome Research. 19, p. 415-426

Research output: Contribution to journalArticle

42 Citations (Scopus)

Shedding Light on Serpent Sight: The Visual Pigments of Henophidian snakes

Davies, W., Cowing, J. A., Bowmaker, J. K., dos Santos Carvalho, L., Gower, D. J. & Hunt, D., 2009, In : Journal of Neuroscience. 29, 23, p. 7519-7525

Research output: Contribution to journalArticle

2008
94 Citations (Scopus)

The influence of ontogeny and light environment on the expression of visual pigment opsins in the retina of the black bream, Acanthopagrus butcheri

Shand, J., Davies, W. L., Thomas, N., Balmer, L., Cowing, J. A., Pointer, M., Carvalho, L. S., Trezise, A. E. O., Collin, S., Beazley, L. & Hunt, D., 2008, In : The Journal of Experimental Biology. 211, 9, p. 1495-1503

Research output: Contribution to journalArticle

Acanthopagrus
Opsins
opsin
Retinal Pigments
bream
2007
54 Citations (Scopus)

Functional characterization, tuning, and regulation of visual pigment gene expression in an anadromous lamprey

Davies, W. L., Cowing, J. A., dos Santos Carvalho, L., Potter, I. C., Trezise, A. E. O., Hunt, D. & Collin, S., 2007, In : The FASEB Journal. 21, p. 2713-2724

Research output: Contribution to journalArticle

69 Citations (Scopus)

Spectral tuning of Shortwave-sensitive Visual Pigments in Vertebrates

Hunt, D., dos Santos Carvalho, L., Cowing, J. A., Parry, J. W. L., Wilkie, S. E., Davies, W. L. & Bowmaker, J. K., 2007, In : Photochemistry and Photobiology. 83, p. 303-310

Research output: Contribution to journalArticle

12 Citations (Scopus)

SPLICE: a technique for generating in vitro spliced coding sequences from genomic DNA

Davies, W. L., Carvalho, L. S. & Hunt, D. M., Dec 2007, In : BioTechniques. 43, 6, p. 785-789 5 p.

Research output: Contribution to journalArticle

Exons
Genes
Polymerase Chain Reaction
DNA
Lemur
45 Citations (Scopus)

The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments

dos Santos Carvalho, L., Cowing, J. A., Wilkie, S. E., Bowmaker, J. K. & Hunt, D., 2007, In : Molecular Biology and Evolution. 24, p. 1843-1852

Research output: Contribution to journalArticle

19 Citations (Scopus)

The visual pigments of a deep-sea teleost, the pearl eye Scopelarchus analis

Pointer, M. A., dos Santos Carvalho, L., Cowing, J. A., Bowmaker, J. K. & Hunt, D., 2007, In : Journal of Experimental Biology. 210, p. 2829-2835

Research output: Contribution to journalArticle

52 Citations (Scopus)

Visual pigments of the platypus: A novel route to mammalian colour vision

Davies, W., dos Santos Carvalho, L., Cowing, J. A., Beazley, L., Hunt, D. & Arrese, C. A., 2007, In : Current Biology. 17, 5, p. 161-163

Research output: Contribution to journalArticle

2006
44 Citations (Scopus)

Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle [1]

Carvalho, L. D. S., Cowing, J. A., Wilkie, S. E., Bowmaker, J. K. & Hunt, D. M., 7 Feb 2006, In : Current Biology. 16, 3

Research output: Contribution to journalLetter

2005
14 Citations (Scopus)

Color vision in Leontopithecus chrysomelas: A behavioral study

Pessoa, D. M. A., Perini, E. S., Carvalho, L. S., Tomaz, C. & Pessoa, V. F., Feb 2005, In : International Journal of Primatology. 26, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

Leontopithecus chrysomelas
color vision
Callitrichidae
color
Leontopithecus