• The University of Western Australia (M517), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1533 Citations
  • 22 h-Index
20052019

Research output per year

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Personal profile

Biography

My research interests have always been in the field of vision science and I have worked on developing and investigating gene therapy treatments for severe inherited retinal dystrophies along studies into understanding the cellular and molecular mechanisms behind age-related macular degeneration, uveitis, stem cells and AAV biology. My current focus is on creating research platforms in the area of retinal degeneration, gene therapy and cell death mechanisms.

Funding overview

ARC Discovery Early Career Research Award, Retina Australia

Current projects

1. Cone photoreceptor migration and cell death mechanisms during retinal degeneration
2. Voltage-gated potassium channels in inherited retinal dystrophy: disease mechanisms and treatment strategies

Research

Retinal gene therapy, Inherited retinal degeneration, photoreceptor biology, cell death, retinal development

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Research Output

Pathophysiology of voltage-gated potassium channels in a mouse model of cone-rod dystrophy

Jiang, X., Hunt, D. M. & Carvalho, L. S., Jul 2019, In : Investigative ophthalmology & visual science. 60, 9, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations

Hart, N. S., Mountford, J. K., Voigt, V., Fuller-Carter, P., Barth, M., Nerbonne, J. M., Hunt, D. M. & Carvalho, L. S., Feb 2019, In : eNeuro. 6, 1, 13 p., UNSP ENEURO.0032-19.2019.

Research output: Contribution to journalArticle

Open Access
  • 2 Citations (Scopus)

    Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo

    Carvalho, L. S., Xiao, R., Wassmer, S. J., Langsdorf, A., Zinn, E., Pacouret, S., Shah, S., Comander, J. I., Kim, L. A., Lim, L. & Vandenberghe, L. H., Jul 2018, In : Human Gene Therapy. 29, 7, p. 771-784 14 p.

    Research output: Contribution to journalArticle

  • 13 Citations (Scopus)

    Validation and comparison of Achromatopsia mouse lines expressing a fluorescent marker in cone photoreceptors

    Carvalho, L. S., Voigt, V., Schuster, I., Fuller-Carter, P., Quesada, J. P., Vasiliou, S. & Hunt, D. M., Jul 2018, In : Investigative ophthalmology & visual science. 59, 9, 3 p.

    Research output: Contribution to journalAbstract/Meeting Abstract

    Projects