Leon Adams

Associate Professor, MB BS PhD W.Aust., FRACP

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 10645 Citations
  • 39 h-Index
20052020

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Research Output

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Article
2020

Baseline and Post-treatment 18F-Fluorocholine PET/CT Predicts Outcomes in Hepatocellular Carcinoma Following Locoregional Therapy

Wallace, M. C., Sek, K., Francis, R. J., Samuelson, S., Ferguson, J., Tibballs, J., Asad, A., Preen, D. B., MacQuillan, G., Garas, G., Adams, L. A. & Jeffrey, G. P., Feb 2020, In : Digestive Diseases and Sciences. 65, 2, p. 647-657

Research output: Contribution to journalArticle

Bile acids associate with specific gut microbiota, low level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease

Adams, L. A., Wang, Z., Liddle, C., Melton, P. E., Ariff, A., Chandraratna, H., Tan, J., Ching, H., Coulter, S., de Boer, B., Christophersen, C. T., O'Sullivan, T. A., Morrison, M. & Jeffrey, G. P., 3 Apr 2020, In : Liver International.

Research output: Contribution to journalArticle

Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability

Mitchell, T., McKinnon, E., Ayonrinde, O., Adams, L. A., Trinder, D., Chua, A. C. G., Newton, R. U., Straker, L. & Olynyk, J. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1584-1591 8 p.

Research output: Contribution to journalArticle

Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Chen, F., Esmaili, S., Rogers, G. B., Bugianesi, E., Petta, S., Marchesini, G., Bayoumi, A., Metwally, M., Azardaryany, M. K., Coulter, S., Choo, J. M., Younes, R., Rosso, C., Liddle, C., Adams, L. A., Craxì, A., George, J. & Eslam, M., 1 Apr 2020, In : Hepatology. 71, 4, p. 1213-1227 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Long-term Liver-related Outcomes of Patients With Chronic Liver Diseases in Australia

Huang, Y., Joseph, J., de Boer, W. B., Cheng, W., Adams, L. A., MacQuillan, G., Garas, G., Raftopoulos, S. & Jeffrey, G. P., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 496-504.e3

Research output: Contribution to journalArticle

2 Citations (Scopus)

Screening for non-alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter-transient elastography

Teeratorn, N., Piyachaturawat, P., Thanapirom, K., Chaiteerakij, R., Sonsiri, K., Komolmit, P., Tangkijvanich, P., Rerknimitr, R., Adams, L. & Treeprasertsuk, S., Apr 2020, In : JGH Open. 4, 2, p. 245-250

Research output: Contribution to journalArticle

Open Access

The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study

Ayonrinde, O. T., Ayonrinde, O. A., Adams, L. A., Sanfilippo, F. M., O’ Sullivan, T. A., Robinson, M., Oddy, W. H. & Olynyk, J. K., 1 Dec 2020, In : Scientific Reports. 10, 1, 1646.

Research output: Contribution to journalArticle

Open Access
2019

ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis

Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Neil Guha, I., Kawaguchi, T., Torimura, T., McLeod, D., Akiba, J., Kaye, P., de Boer, B., Aithal, G. P., Adams, L. A. & George, J., 1 Mar 2019, In : Hepatology. 69, 3, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

Metwally, M., Bayoumi, A., Romero-Gomez, M., Thabet, K., John, M., Adams, L. A., Huo, X., Aller, R., García-Monzón, C., Teresa Arias-Loste, M., Bugianesi, E., Miele, L., Gallego-Durán, R., Fischer, J., Berg, T., Liddle, C., Qiao, L., George, J. & Eslam, M., 1 Mar 2019, In : Journal of Hepatology. 70, 3, p. 494-500 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Bowel patterns, gastrointestinal symptoms, and emotional well-being in adolescents - A cohort study: Gastrointestinal symptoms in adolescents

Ayonrinde, O. T., Sanfilippo, F. M., O'Sullivan, T. A., Adams, L. A., Ayonrinde, O. A., Robinson, M., Oddy, W. H. & Olynyk, J. K., 1 Jul 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, 11, p. 1946-1954 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effects of calcium supplementation on circulating osteocalcin and glycated haemoglobin in older women

Lewis, J. R., Brennan-Speranza, T. C., Levinger, I., Byrnes, E., Lim, E. M., Blekkenhorst, L. C., Sim, M., Hodgson, J. M., Zhu, K., Lim, W. H., Adams, L. A. & Prince, R. L., 1 Jan 2019, In : Osteoporosis International.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age

Hart, R. J., Doherty, D. A., Mori, T. A., Adams, L. A., Huang, R-C., Minaee, N., Handelsman, D. J., McLachlan, R., Norman, R. J., Dickinson, J. E., Olynyk, J. K. & Beilin, L. J., 1 Mar 2019, In : Human Reproduction. 34, 3, p. 389-402 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Hepatocellular carcinoma in Australia 1982-2014: Increasing incidence and improving survival

Wallace, M. C., Preen, D. B., Short, M. W., Adams, L. A. & Jeffrey, G. P., 1 Mar 2019, In : Liver International. 39, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

Calzadilla-Bertot, L., Jeffrey, G. P., Jacques, B., McCaughan, G., Crawford, M., Angus, P., Jones, R., Gane, E., Munn, S., Macdonald, G., Fawcett, J., Wigg, A., Chen, J., Fink, M. & Adams, L. A., Jan 2019, In : Liver Transplantation. 25, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials

Pai, R. K., Kleiner, D. E., Hart, J., Adeyi, O. A., Clouston, A. D., Behling, C. A., Jain, D., Kakar, S., Brahmania, M., Burgart, L., Batts, K. P., Valasek, M. A., Torbenson, M. S., Guindi, M., Wang, H. L., Ajmera, V., Adams, L. A., Parker, C. E., Feagan, B. G., Loomba, R. & 1 others, Jairath, V., Nov 2019, In : Alimentary pharmacology & therapeutics. 50, 10, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial

Properzi, C., O'Sullivan, T. A., Sherriff, J. L., Ching, H. L., Jeffrey, G. P., Buckley, R. F., Tibballs, J., MacQuillan, G. C., Garas, G. & Adams, L. A., 1 Nov 2018, In : Hepatology. 68, 5, p. 1741-1754 14 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Burden of non-alcoholic fatty liver disease in Australia

Mahady, S. E. & Adams, L. A., 1 Jun 2018, In : Journal of Gastroenterology and Hepatology (Australia). 33, p. 1-11 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
16 Citations (Scopus)

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study

Vilar-Gomez, E., Calzadilla-Bertot, L., Wai-Sun Wong, V., Castellanos, M., Aller-de la Fuente, R., Metwally, M., Eslam, M., Gonzalez-Fabian, L., Alvarez-Quiñones Sanz, M., Conde-Martin, A. F., De Boer, B., McLeod, D., Hung Chan, A. W., Chalasani, N., George, J., Adams, L. A. & Romero-Gomez, M., 1 Aug 2018, In : Gastroenterology. 155, 2, p. 443-457.e17

Research output: Contribution to journalArticle

108 Citations (Scopus)

Hepatic Iron Concentration Correlates With Insulin Sensitivity in Nonalcoholic Fatty Liver Disease

Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Stuart, K., Subramaniam, V. N., Jeffrey, G., St Pierre, T., House, M., Gummer, J., Trengove, R., Olynyk, J., Crawford, D. & Adams, L., Jun 2018, In : Hepatology Communications. 2, 6, p. 644-653 10 p.

Research output: Contribution to journalArticle

Open Access

Prevalence of restless legs syndrome in a tertiary cohort of ambulant patients with chronic liver disease

Ma, M. X., Huang, Y., Adams, L. A., Gilpin, R., Garas, G., MacQuillan, G., Jeffrey, G. P. & Nicholas, R. M., 1 Mar 2018, In : Internal Medicine Journal. 48, 3, p. 347-350 4 p.

Research output: Contribution to journalArticle

Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

Huang, Y., Wallace, M. C., Adams, L. A., MacQuillan, G., Garas, G., Ferguson, J., Samuelson, S., Tibballs, J. & Jeffrey, G. P., Jul 2018, In : Journal of Clinical Gastroenterology. 52, 6, p. 551-556 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis

Alkhouri, N., Johnson, C., Adams, L., Kitajima, S., Tsuruno, C., Colpitts, T. L., Hatcho, K., Lawitz, E., Lopez, R. & Feldstein, A., 1 Aug 2018, In : PLoS One. 13, 8, e0202226.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
File
13 Citations (Scopus)
446 Downloads (Pure)
11 Citations (Scopus)
2017

HKLC Triages More Hepatocellular Carcinoma Patients to Curative Therapies Compared to BCLC and Is Associated with Better Survival

Wallace, M. C., Huang, Y., Preen, D. B., Garas, G., Adams, L. A., MacQuillan, G., Tibballs, J., Ferguson, J., Samuelson, S. & Jeffrey, G. P., Aug 2017, In : Digestive Diseases & Sciences. 62, 8, p. 2182-2192 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Improved Hepascore in hepatitis C predicts reversal in risk of adverse outcome

Jeffrey, A. W., Huang, Y., De Boer, W. B., Adams, L. A., MacQuillan, G., Speers, D., Joseph, J. & Jeffrey, G. P., 1 Jul 2017, In : World Journal of Hepatology. 9, 19, p. 850-856 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Improvement in liver histology due to lifestyle modification is independently associated with improved kidney function in patients with non-alcoholic steatohepatitis

Vilar-Gomez, E., Calzadilla-Bertot, L., Friedman, S. L., Gra-Oramas, B., Gonzalez-Fabian, L., Villa-Jimenez, O., Lazo-del Vallin, S., Diago, M., Adams, L. A., Romero-Gomez, M. & Chalasani, N., 1 Jan 2017, In : Alimentary Pharmacology and Therapeutics. 45, 2, p. 332-344 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents

Ayonrinde, O. T., Oddy, W. H., Adams, L. A., Mori, T. A., Beilin, L. J., de Klerk, N. & Olynyk, J. K., 1 Sep 2017, In : Journal of Hepatology. 67, 3, p. 568-576 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice

Cartland, S. P., Harith, H. H., Genner, S. W., Dang, L., Cogger, V. C., Vellozzi, M., Di Bartolo, B. A., Thomas, S. R., Adams, L. A. & Kavurma, M. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 1898.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Non-Alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Adams, L. A., Anstee, Q. M., Tilg, H. & Targher, G., 1 Jun 2017, In : Gut. 66, 6, p. 1138-1153 16 p.

Research output: Contribution to journalArticle

226 Citations (Scopus)
Open Access

Serum biomarkers can predict a change in liver fibrosis 1 year after lifestyle intervention for biopsy-proven NASH

Vilar-Gomez, E., Calzadilla-Bertot, L., Friedman, S. L., Gra-Oramas, B., Gonzalez-Fabian, L., Lazo-del Vallin, S., Diago, M. & Adams, L. A., 1 Dec 2017, In : Liver International. 37, 12, p. 1887-1896 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The ability of Hepascore to predict liver fibrosis in chronic liver disease: a meta-analysis

Huang, Y., Adams, L. A., Joseph, J., Bulsara, M. K. & Jeffrey, G. P., 1 Jan 2017, In : Liver International. 37, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
Open Access
7 Citations (Scopus)

TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival

Mridha, A. R., Haczeyni, F., Yeh, M. M., Haigh, W. G., Ioannou, G. N., Barn, V., Ajamieh, H., Adams, L., Hamdorf, J. M., Teoh, N. C. & Farrell, G. C., 15 Aug 2017, In : Clinical Science. 131, 16, p. 2145-2159 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Transition to adult care for pediatric liver transplant recipients: the Western Australian experience

Mitchell, T., Gooding, H., Mews, C., Adams, L., MacQuillan, G., Garas, G., Ravikumara, M., Lopez, A., Collins, M. & Jeffrey, G., 1 Feb 2017, In : Pediatric Transplantation. 21, 1, e12820.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
4 Citations (Scopus)
2016

Additive impact of pre-liver transplant metabolic factors on survival post-liver transplant

Adams, L., Arauz, O., Angus, P. W., Sinclair, M., Macdonald, G. A., Chelvaratnam, U., Wigg, A. J., Yeap, S., Shackel, N., Lin, L., Raftopoulos, S., Mccaughan, G. W., Jeffrey, G., Delriviere, L., Lynch, S., Jones, R., Munn, S. & Padbury, R., 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 5, p. 1016-1024

Research output: Contribution to journalArticle

11 Citations (Scopus)
Open Access
File
13 Citations (Scopus)
302 Downloads (Pure)

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

Eslam, M., Mangia, A., Berg, T., Chan, H. L. Y., Irving, W. L., Dore, G. J., Abate, M. L., Bugianesi, E., Adams, L., Najim, M. A. M., Miele, L., Weltman, M., Mollison, L., Cheng, W., Riordan, S., Fischer, J., Romero-Gomez, M., Spengler, U., Nattermann, J., Rahme, A. & 23 others, Sheridan, D., Booth, D. R., Mcleod, D., Powell, E., Liddle, C., Douglas, M. W., Van Der Poorten, D., George, J., White, R., Rojas, A., Gallego-Duran, R., Bassendine, M., Wong, V. W. S., Rosso, C., Mezzabotta, L., Leung, R., Malik, B., Matthews, G., Applegate, T., Grebely, J., Fragomeli, V., Jonsson, J. R. & Santaro, R., 22 Jun 2016, In : Hepatology. 64, 1, p. 34-46 13 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Effect of airplane transport of donor livers on post-liver transplantation survival retrospective cohort study

Huang, Y., Macquillan, G., Adams, L., Garas, G., Collins, M., Nwaba, A., Mou, L., Bulsara, M. K., Delriviere, L. & Jeffrey, G., 2016, In : World Journal of Gastroenterology. 22, 41, p. 9154-9161

Research output: Contribution to journalArticle

Open Access

FibroGENE: A gene-based model for staging liver fibrosis

Eslam, M., Hashem, A. M., Romero-Gomez, M., Berg, T., Dore, G. J., Mangia, A., Chan, H. L. Y., Irving, W. L., Sheridan, D., Abate, M. L., Adams, L., Weltman, M., Bugianesi, E., Spengler, U., Shaker, O., Fischer, J., Mollison, L., Cheng, W., Nattermann, J., Riordan, S. & 10 others, Miele, L., Kelaeng, K. S., Ampuero, J., Ahlenstiel, G., Mcleod, D., Powell, E., Liddle, C., Douglas, M. W., Booth, D. R. & George, J., Feb 2016, In : Journal of Hepatology. 64, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
4 Citations (Scopus)

Stereological analysis of liver biopsy histology sections as a reference standard for validating non-invasive liver fat fraction measurements by MRI

St Pierre, T., House, M. J., Bangma, S. J., Pang, W., Bathgate, A., Gan, E. K., Ayonrinde, O. T., Bhathal, P. S., Clouston, A., Olynyk, J. & Adams, L. A., 2016, In : PLoS One. 11, 8, e0160789.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

The association between chronic hepatitis C infection and cardiovascular risk

Pateria, P., Jeffrey, G., Macquillan, G., Speers, D., Ching, H., Chinnaratha, M. A., Watts, G. & Adams, L., 2016, In : Internal Medicine Journal. 46, 1, p. 63-70

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015
4 Citations (Scopus)